Devarajan Lab

Albert, C; Zapf, A; Haase, M; Röver, C; Pickering, JW; Albert, A; Bellomo, R; Breidthardt, T; Camou, F; Chen, Z; et al. Neutrophil Gelatinase-Associated Lipocalin Measured on Clinical Laboratory Platforms for the Prediction of Acute Kidney Injury and the Associated Need for Dialysis Therapy: A Systematic Review and Meta-analysis. American Journal of Kidney Diseases. 2020; 76:826-841.e1.

Rudman-Melnick, V; Adam, M; Potter, A; Chokshi, SM; Ma, Q; Drake, KA; Schuh, MP; Matthew Kofron, J; Devarajan, P; Steven Potter, S. Single-cell profiling of AKI in a murine model reveals novel transcriptional signatures, profibrotic phenotype, and epithelial-to-stromal crosstalk. Journal of the American Society of Nephrology : JASN. 2020; 31:2793-2814.

Zappitelli, M; Parikh, CR; Kaufman, JS; Go, AS; Kimmel, PL; Hsu, CY; Coca, SG; Chinchilli, VM; Greenberg, JH; Moxey-Mims, MM; et al. Acute kidney injury and risk of CKD and hypertension after pediatric cardiac surgery. Clinical journal of the American Society of Nephrology : CJASN. 2020; 15:1403-1412.

Benoit, SW; Ciccia, EA; Devarajan, P. Cystatin C as a biomarker of chronic kidney disease: latest developments. Expert Review of Molecular Diagnostics: new diagnostic technologies are set to revolutionise healthcare. 2020; 20:1019-1026.

Steubl, D; Buzkova, P; Garimella, PS; Ix, JH; Devarajan, P; Bennett, MR; Chaves, PH M; Shlipak, MG; Bansal, N; Sarnak, MJ. Association of serum uromodulin with mortality and cardiovascular disease in the elderly—the Cardiovascular Health Study. Nephrology Dialysis Transplantation. 2020; 35:1399-1405.

Roy, J; Devarajan, P. Acute Kidney Injury: Diagnosis and Management. The Indian Journal of Pediatrics. 2020; 87:600-607.

Steubl, D; Buzkova, P; Ix, JH; Devarajan, P; Bennett, MR; Chaves, PH M; Shlipak, MG; Bansal, N; Sarnak, MJ; Garimella, PS. Association of serum and urinary uromodulin and their correlates in older adults—The Cardiovascular Health Study. Nephrology. 2020; 25:522-526.

Chui, H; Caldwell, J; Yordanova, M; Cockovski, V; Fredric, D; Harel-Sterling, M; Haasz, M; Al-Ismaili, Z; Pizzi, M; Ma, Q; et al. Tubular injury and cell-cycle arrest biomarkers to predict acute kidney injury in noncritically ill children receiving aminoglycosides. Biomarkers in medicine. 2020; 14:879-894.

Devarajan, P. The Current State of the Art in Acute Kidney Injury. Frontiers in Pediatrics. 2020; 8.

Stark, JE; Opoka, AM; Mallela, J; Devarajan, P; Ma, Q; Levinsky, NC; Stringer, KF; Wong, HR; Alder, MN. Juvenile OLFM4-null mice are protected from sepsis. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY. 2020; 318:F809-F816.

Hsu, C; Chinchilli, VM; Coca, S; Devarajan, P; Ghahramani, N; Go, AS; Hsu, RK; Ikizler, TA; Kaufman, J; Liu, KD; et al. Post-Acute Kidney Injury Proteinuria and Subsequent Kidney Disease Progression: The Assessment, Serial Evaluation, and Subsequent Sequelae in Acute Kidney Injury (ASSESS-AKI) Study. JAMA Internal Medicine. 2020; 180:402-410.

Steubl, D; Buzkova, P; Garimella, PS; Ix, JH; Devarajan, P; Bennett, MR; Chaves, PH M; Shlipak, MG; Bansal, N; Sarnak, MJ. Association of Serum Uromodulin With ESKD and Kinney Function Decline in the Elderly: The Cardiovascular Health Study. American Journal of Kidney Diseases. 2019; 74:501-509.

De Oliveira, BD; Xu, K; Shen, TH; Callahan, M; Kiryluk, K; D'Agati, VD; Tatonetti, NP; Barasch, J; Devarajan, P. Molecular nephrology: types of acute tubular injury. Nature Reviews Nephrology. 2019; 15:599-612.

Bowers, SL K; Davis-Rodriguez, S; Thomas, ZM; Rudomanova, V; Bacon, WC; Beiersdorfer, A; Ma, Q; Devarajan, P; Blaxall, BC. Inhibition of fibronectin polymerization alleviates kidney injury due to ischemia-reperfusion. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY. 2019; 316:F1293-F1298.

Schuh, MP; Bennett, MR; Lane, A; Jodele, S; Laskin, BL; Devarajan, P. Haptoglobin degradation product as a novel serum biomarker for hematopoietic stem cell transplant-associated thrombotic microangiopathy. Pediatric Nephrology. 2019; 34:865-871.

Aljaberi, N; Bennett, M; Brunner, HI; Devarajan, P. Proteomic profiling of urine: implications for lupus nephritis. Expert Review of Proteomics. 2019; 16:303-313.

Forster, CS; Haffey, WD; Bennett, M; Greis, KD; Deyarajan, P. Identification of Urinary CD44 and Prosaposin as Specific Biomarkers of Urinary Tract Infections in Children With Neurogenic Bladders. Biomarker Insights. 2019; 14:1177271919835570-117727191983557.

Turnier, JL; Brunner, HI; Bennett, M; Aleed, A; Gulati, G; Haffey, WD; Thornton, S; Wagner, M; Devarajan, P; Witte, D; et al. Discovery of SERPINA3 as a candidate urinary biomarker of lupus nephritis activity. Rheumatology. 2019; 58:321-330.

Carpenter, SL; Goldman, J; Sherman, AK; Selewski, DT; Kallash, M; Tran, CL; Seamon, M; Katsoufis, C; Ashoor, I; Hernandez, J; et al. Association of infections and venous thromboembolism in hospitalized children with nephrotic syndrome. Pediatric Nephrology. 2019; 34:261-267.

Brunner, HI; Gulati, G; Klein-Gitelman, MS; Rouster-Stevens, KA; Tucker, L; Ardoin, SP; Onel, KB; Mainville, R; Turnier, J; Aydin, PO A; et al. Urine biomarkers of chronic kidney damage and renal functional decline in childhood-onset systemic lupus erythematosus. Pediatric Nephrology. 2019; 34:117-128.

Parameswaran, P; Devarajan, P. Cellular and Molecular Mechanisms of Acute Kidney Injury. Critical Care Nephrology: Third Edition. : Elsevier; Elsevier; 2019.

Chihanga, T; Ruby, HN; Ma, Q; Bashir, S; Devarajan, P; Kennedy, MA. NMR-based urine metabolic profiling and immunohistochemistry analysis of nephron changes in a mouse model of hypoxia-induced acute kidney injury. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY. 2018; 315:F1159-F1173.

Albert, C; Albert, A; Bellomo, R; Kropf, S; Devarajan, P; Westphal, S; Baraki, H; Kutschka, I; Butter, C; Haase, M; et al. Urinary neutrophil gelatinase-associated lipocalin-guided risk assessment for major adverse kidney events after open-heart surgery. Biomarkers in medicine. 2018; 12:975-985.

Lang, J; Katz, R; Ix, JH; Gutierrez, OM; Peralta, CA; Parikh, CR; Satterfield, S; Petrovic, S; Devarajan, P; Bennett, M; et al. Association of serum albumin levels with kidney function decline and incident chronic kidney disease in elders. Nephrology Dialysis Transplantation. 2018; 33:986-992.

Greenberg, JH; Devarajan, P; Thiessen-Philbrook, HR; Krawczeski, C; Parikh, CR; Zappitelli, M; Consortium, TR I B E-A K. Kidney injury biomarkers 5 years after AKI due to pediatric cardiac surgery. Pediatric Nephrology. 2018; 33:1069-1077.

Benoit, SW; Devarajan, P. Acute kidney injury: emerging pharmacotherapies in current clinical trials. Pediatric Nephrology. 2018; 33:779-787.

Greenberg, JH; Zappitelli, M; Jia, Y; Thiessen-Philbrook, HR; de Fontnouvelle, CA; Wilson, FP; Coca, S; Devarajan, P; Parikh, CR. Biomarkers of AKI Progression after Pediatric Cardiac Surgery. Journal of the American Society of Nephrology : JASN. 2018; 29:1549-1556.

Bennett, MR; Devarajan, P. The future role of proteomics in the understanding of acute kidney injury. Expert Review of Proteomics. 2018; 15:191-192.

Bennett, MR; Pyles, O; Ma, Q; Devarajan, P. Preoperative levels of urinary uromodulin predict acute kidney injury after pediatric cardiopulmonary bypass surgery. Pediatric Nephrology. 2018; 33:521-526.

Chihanga, T; Ma, Q; Nicholson, JD; Ruby, HN; Edelmann, RE; Devarajan, P; Kennedy, MA. NMR spectroscopy and electron microscopy identification of metabolic and ultrastructural changes to the kidney following ischemia-reperfusion injury. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY. 2018; 314:F154-F166.

Goldstein, BH; Goldstein, SL; Devarajan, P; Zafar, F; Kwiatkowski, DM; Marino, BS; Morales, DL S; Krawczeski, CD; Cooper, DS. First-stage palliation strategy for univentricular heart disease may impact risk for acute kidney injury. Cardiology in the Young. 2018; 28:93-100.

Dong, L; Ma, Q; Bennett, M; Devarajan, P. Urinary biomarkers of cell cycle arrest are delayed predictors of acute kidney injury after pediatric cardiopulmonary bypass. Pediatric Nephrology. 2017; 32:2351-2360.

de Fontnouvelle, CA; Greenberg, JH; Thiessen-Philbrook, HR; Zappitelli, M; Roth, J; Kerr, KF; Devarajan, P; Shlipak, M; Coca, S; Parikh, CR; et al. Interleukin-8 and Tumor Necrosis Factor Predict Acute Kidney Injury After Pediatric Cardiac Surgery. Annals of Thoracic Surgery. 2017; 104:2072-2079.

Jr, VC D; Goldstein, SL; Devarajan, P; Basu, RK. Impact of Near Real-Time Urine Neutrophil Gelatinase–Associated Lipocalin Assessment on Clinical Practice. Kidney International Reports. 2017; 2:1243-1249.

Bennett, MR; Ma, Q; Ying, J; Devarajan, P; Brunner, H. Effects of age and gender on reference levels of biomarkers comprising the pediatric Renal Activity Index for Lupus Nephritis (p-RAIL). Pediatric Rheumatology Online Journal. 2017; 15.

Sterling, M; Al-Ismaili, Z; McMahon, KR; Piccioni, M; Pizzi, M; Mottes, T; Lands, LC; Abish, S; Fleming, AJ; Bennett, MR; et al. Urine biomarkers of acute kidney injury in noncritically ill, hospitalized children treated with chemotherapy. Pediatric Blood and Cancer. 2017; 64:e26538-e26538.

Nehus, E; Kaddourah, A; Bennett, M; Pyles, O; Devarajan, P. Subclinical Kidney Injury in Children Receiving Nonsteroidal Anti-Inflammatory Drugs After Cardiac Surgery. The Journal of Pediatrics. 2017; 189:175-180.

Quinn, CT; Saraf, SL; Gordeuk, VR; Fitzhugh, CD; Creary, SE; Bodas, P; George, A; Raj, AB; Nero, AC; Terrell, CE; et al. Losartan for the nephropathy of sickle cell anemia: A phase-2, multicenter trial. American Journal of Hematology. 2017; 92:E520-E528.

Pleasant, L; Ma, Q; Devarajan, M; Parameswaran, P; Drake, K; Siroky, B; Shay-Winkler, K; Robbins, J; Devarajan, P. Increased susceptibility to structural acute kidney injury in a mouse model of presymptomatic cardiomyopathy. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY. 2017; 313:F699-F705.

Gulati, G; Bennett, MR; Abulaban, K; Song, H; Zhang, X; Ma, Q; Brodsky, SV; Nadasdy, T; Haffner, C; Wiley, K; et al. Prospective validation of a novel renal activity index of lupus nephritis. Lupus. 2017; 26:927-936.

Brunner, HI; Bennett, MR; Gulati, G; Abulaban, K; Klein-Gitelman, MS; Ardoin, SP; Tucker, LB; Rouster-Stevens, KA; Witte, D; Ying, J; et al. Urine Biomarkers to Predict Response to Lupus Nephritis Therapy in Children and Young Adults. The Journal of rheumatology. 2017; 44:1239-1248.

Devarajan, P. Kidney attack: Is NGAL set to take the stage with troponins?. Cardio-Nephrology: Confluence of the Heart and Kidney in Clinical Practice. : Springer International Publishing; Springer International Publishing; 2017.

Garimella, PS; Bartz, TM; Ix, JH; Chonchol, M; Shlipak, MG; Devarajan, P; Bennett, MR; Sarnak, MJ. Urinary Uromodulin and Risk of Urinary Tract Infections: The Cardiovascular Health Study. American Journal of Kidney Diseases. 2017; 69:744-751.

Palermo, J; Dart, AB; De Mello, A; Devarajan, P; Gottesman, R; Guerra, GG; Hansen, G; Joffe, AR; Mammen, C; Majesic, N; et al. Biomarkers for Early Acute Kidney Injury Diagnosis and Severity Prediction: A Pilot Multicenter Canadian Study of Children Admitted to the ICU. Pediatric Critical Care Medicine. 2017; 18:e235-e244.

Garimella, PS; Katz, R; Ix, JH; Fried, LF; Kritchevsky, SB; Devarajan, P; Bennett, MR; Parikh, CR; Shlipak, MG; Harris, TB; et al. Association of urinary uromodulin with kidney function decline and mortality: the health ABC study. Clinical Nephrology. 2017; 87:278-286.

Ciccia, E; Devarajan, P. Pediatric acute kidney injury: Prevalence, impact and management challenges. International Journal of Nephrology and Renovascular Disease. 2017; Volume 10:77-84.

Bennett, MR; Pleasant, L; Haffner, C; Ma, Q; Haffey, WD; Ying, J; Wagner, M; Greis, KD; Devarajan, P. A novel biomarker panel to identify steroid resistance in childhood idiopathic nephrotic syndrome. Biomarker Insights. 2017; 12:1177271917695832-117727191769583.

Forster, CS; Devarajan, P. Neutrophil gelatinase-associated lipocalin: utility in urologic conditions. Pediatric Nephrology. 2017; 32:377-381.

Devarajan, P. Acute kidney injury: still misunderstood and misdiagnosed. Nature Reviews Nephrology. 2017; 13:137-138.

Devarajan, P. Acute kidney injury: Prevention and diagnosis. Pediatric Kidney Disease: Second Edition. : Springer Berlin Heidelberg; Springer Berlin Heidelberg; 2017.

Wikenheiser-Brokamp, KA; Klein, M; Hershey, GK K; Devarajan, P; DeWitt, TG; Loch, J; Strauss, AW; Muglia, LJ; Hostetter, MK. Evaluation of Fellows' CrossTalk Effectiveness in Promoting Transdisciplinary Networking and Research. The Journal of Pediatrics. 2017; 181:5-6.e3.

Garimella, PS; Jaber, BL; Tighiouart, H; Liangos, O; Bennett, MR; Devarajan, P; El-Achkar, TM; Sarnak, MJ. Association of Preoperative Urinary Uromodulin with AKI after Cardiac Surgery. Clinical journal of the American Society of Nephrology : CJASN. 2017; 12:10-18.

Kamal, FA; Travers, JG; Schafer, AE; Ma, Q; Devarajan, P; Blaxall, BC. G Protein-Coupled Receptor-G-Protein beta gamma-Subunit Signaling Mediates Renal Dysfunction and Fibrosis in Heart Failure. Journal of the American Society of Nephrology : JASN. 2017; 28:197-208.

Lau, L; Al-Ismaili, Z; Harel-Sterling, M; Pizzi, M; Caldwell, JS; Piccioni, M; Lands, LC; Mottes, T; Devarajan, P; Goldstein, SL; et al. Serum cystatin C for acute kidney injury evaluation in children treated with aminoglycosides. Pediatric Nephrology. 2017; 32:163-171.

Devarajan, P; Basu, RK. Sepsis-associated acute kidney injury-is it possible to move the needle against this syndrome?. Jornal de Pediatria. 2017; 93:1-3.

Bennett, MR; Devarajan, P. Characteristics of an Ideal Biomarker of Kidney Diseases. BIOMARKERS OF KIDNEY DISEASE, 2ND EDITION. : Elsevier; Elsevier; 2017.

McMahon, KR; Rassekh, SR; Schultz, KR; Pinsk, M; Blydt-Hansen, T; Mammen, C; Tsuyuki, RT; Devarajan, P; Cuvelier, GD E; Mitchell, LG; et al. Design and methods of the pan-canadian applying biomarkers to minimize long-term effects of childhood/adolescent cancer treatment (ABLE) nephrotoxicity study: A prospective observational cohort study. Canadian Journal of Kidney Health and Disease. 2017; 4:2054358117690338-205435811769033.

Wang, Z; Ma, S; Zappitelli, M; Parikh, C; Wang, C; Devarajan, P. Penalized count data regression with application to hospital stay after pediatric cardiac surgery. Statistical Methods in Medical Research. 2016; 25:2685-2703.

Minevich, E; Devarajan, P; Lorenzo, AJ; Goldstein, SL; DeFoor, WR; Koyle, MA. Pediatric renal tumors. Clinical Pediatric Nephrology: Third Edition. : CRC Press; CRC Press; 2016.

Soto, K; Campos, P; Pinto, I; Rodrigues, B; Frade, F; Papoila, AL; Devarajan, P. The risk of chronic kidney disease and mortality are increased after community-acquired acute kidney injury. Kidney International. 2016; 90:1090-1099.

Greenberg, JH; Zappitelli, M; Devarajan, P; Thiessen-Philbrook, HR; Krawczeski, C; Li, S; Garg, AX; Coca, S; Parikh, CR; Consortium, TR I B E-A K. Kidney Outcomes 5 Years After Pediatric Cardiac Surgery The TRIBE-AKI Study. JAMA Pediatrics. 2016; 170:1071-1078.

Liu, KD; Siew, ED; Reeves, WB; Himmelfarb, J; Go, AS; Hsu, C; Bennett, MR; Devarajan, P; Ikizler, TA; Kaufman, JS; et al. Storage Time and Urine Biomarker Levels in the ASSESS-AKI Study. PLoS ONE. 2016; 11:e0164832-e0164832.

Ma, Q; Devarajan, SR; Devarajan, P. Amelioration of cisplatin-induced acute kidney injury by recombinant neutrophil gelatinase-associated lipocalin. Renal Failure. 2016; 38:1476-1482.

Nadkarni, GN; Rao, V; Ismail-Beigi, F; Fonseca, VA; Shah, SV; Simonson, MS; Cantley, L; Devarajan, P; Parikh, CR; Coca, SG. Association of urinary biomarkers of inflammation, injury, and fibrosis with renal function decline: The ACCORD trial. Clinical journal of the American Society of Nephrology : CJASN. 2016; 11:1343-1352.

Brunner, HI; Bennett, MR; Abulaban, K; Klein-Gitelman, MS; O'Neil, KM; Tucker, L; Ardoin, SP; Rouster-Stevens, KA; Onel, KB; Singer, NG; et al. Development of a Novel Renal Activity Index of Lupus Nephritis in Children and Young Adults. Arthritis Care and Research. 2016; 68:1003-1011.

Belley-Cote, EP; Parikh, CR; Shortt, CR; Coca, SG; Garg, AX; Eikelboom, JW; Kavsak, P; McArthur, E; Thiessen-Philbrook, H; Whitlock, RP; et al. Association of cardiac biomarkers with acute kidney injury after cardiac surgery: A multicenter cohort study. Journal of Thoracic and Cardiovascular Surgery. 2016; 152:245-251.e4.

Devarajan, P; Jefferies, JL. Progression of chronic kidney disease after acute kidney injury. Progress in Pediatric Cardiology. 2016; 41:33-40.

Jefferies, JL; Devarajan, P. Early detection of acute kidney injury after pediatric cardiac surgery. Progress in Pediatric Cardiology. 2016; 41:9-16.

Erkan, E; Zhao, X; Setchell, K; Devarajan, P. Distinct urinary lipid profile in children with focal segmental glomerulosclerosis. Pediatric Nephrology. 2016; 31:581-588.