Devarajan Lab

Publications

Brunner, HI; Cody, EM; Devarajan, P; Huang, B; Chen, C; Sinibaldi, D; Ramaswamy, M; Knagenhjelm, J; Jones, F; Brohawn, PZ; Tummala, R; Lindholm, C; White, WI. The Renal Activity Index for Lupus Identifies Active Renal Disease and Treatment Response in Adult Patients With Systemic Lupus Erythematosus and Lupus Nephritis. Arthritis Care and Research. 2026; 78(6):723-732.

Lim, YJ; Thachil, A; Mcmahon, K; Tsuyuki, RT; Rassekh, SR; Mitchell, LG; Devarajan, P; Mammen, C; Carleton, BC; Cuvelier, GDE; Bouffet, E; Lemaire, M; Blydt-Hansen, TD; Urquhart, BL. Metabolomic investigation of cisplatin-induced acute kidney injury in paediatric cancer patients. British Journal of Clinical Pharmacology. 2026; e70587.

Albert, A; Blume, L; Di Somma, S; Hur, M; Bellomo, R; Devarajan, P; Breidthardt, T; Camou, F; Chocron, S; Cruz, D; Stieger, P; Zapf, A; Braun-Dullaeus, RC; Albert, C. Difference of Admission Neutrophil Gelatinase-Associated Lipocalin Concentration Between Patients Developing and Not Developing Acute Kidney Injury or Need for Acute Dialysis: An Ancillary Individual-Study Data Meta-Analysis (INDICATE-AKI). Kidney Medicine. 2026; 8(5):101280.

O'connor, SK; Devarajan, P; Liu, J; Maldonado, MA; Sproles, A; Rose, J; Thornton, S; Chen, C; Huang, B; Brunner, HI. The Renal Activity Index for Lupus: Validation for Prediction of Kidney Inflammation in Adult Patients With Lupus Nephritis. Journal of Rheumatology. 2026; 53(3):283-291.

Defoor, W; Lee, J; Schulte, M; Libs, A; Huesman, S; Hulme, C; Devarajan, P. Dietary intervention in medically complex stone forming children with enteric hyperoxaluria. Journal of Pediatric Urology. 2025; 21(6):1420-1425.

Hasson, DC; Clover-Brown, I; Zepeda-Orozco, D; Pascal, E; Martin, SD; Krallman, K; Kempton, KM; Bennett, A; Muszynski, J; Lutmer, J; Sargel, C; Devarajan, P; Standage, SW; Alder, MN; Goldstein, SL. Urine Olfactomedin 4 Predicts Furosemide Response and Kidney Replacement Therapy in Critically Ill Children. Critical Care Explorations. 2025; 7(12):e1356.

Cummins, TD; Mariani, LH; Wilkey, DW; Jortani, SA; Helmuth, M; Rane, MJ; Merchant, ML; Kamigaki, Y; Theesfeld, C; Mccown, PJ; Kretzler, M; Sumner, SJ; Smoyer, WE; Klein, JB. Defining subgroups of pediatric nephrotic patients with urine proteomics. Scientific Reports. 2025; 15(1):25064.

Verghese, PS; Bobrowski, A; Carter, C; Dharnidharka, VR; Gattineni, J; Goodwin, JE; Kershaw, DB; Mauch, TJ; Nelson, R; Subtirelu, M; Flynn, J; Feig, D. Pediatric Nephrology Practice in the United States: Survey of Pediatric Nephrology Division Directors. American Journal of Kidney Diseases. 2025; 86(1):74-83.

Zhao, J; Zhao, X; Mizuno, T; Irie, K; Devarajan, P; Brunner, HI; Setchell, KDR. Volumetric Absorptive Microsampling Combined with Mass Spectrometry to Support Pharmacokinetically-Guided Precision Dosing of Mycophenolate Mofetil in Pediatric Lupus Nephritis Patients. Journal of Applied Laboratory Medicine. 2025; 10(4):806-819.

Cody, EM; Sproles, A; Rose, J; Huang, B; Devarajan, P; Brunner, HI; Thornton, S. Development and Validation of Multiplex Assays for Lupus Nephritis Activity Biomarkers. Kidney International Reports. 2025; 10(7):2255-2264.

Nehus, E; Schulte, M; Devarajan, P; Defoor, W. Alkaline urine is associated with increased risk of calcium phosphate nephrolithiasis in medically complex children receiving enteral nutrition. Journal of Pediatric Urology. 2025; 21(3):591-597.

Stowers, K; Rudman-Melnick, V; Ma, Q; Devarajan, P. Prolonged unilateral renal ischemia-reperfusion as a model for acute to chronic kidney injury in female mice. American Journal of Physiology - Renal Physiology. 2025; 328(5):F684-F690.

Rudman-Melnick, V; Vanhoutte, D; Stowers, K; Sargent, M; Adam, M; Ma, Q; Perl, AKT; Miethke, AG; Burg, A; Shi, T; Hildeman, DA; Woodle, ESS; Kofron, JM; Devarajan, P. Gucy1α1 specifically marks kidney, heart, lung and liver fibroblasts. Scientific Reports. 2024; 14(1):29307.

Huang, RS; Mcmahon, KR; Wang, S; Chui, H; Lebel, A; Lee, J; Cockovski, V; Rassekh, SR; Schultz, KR; Blydt-Hansen, TD; Tsuyuki, RT; Ross, CJD; Palijan, A; Zappitelli, M. Tubular Injury Biomarkers to Predict CKD and Hypertension at 3 Months Post-Cisplatin in Children. Kidney360. 2024; 5(6):821-833.

Chakradhar, A; Baron, RM; Vera, MP; Devarajan, P; Chawla, L; Hou, PC. Plasma renin as a novel prognostic biomarker of sepsis-associated acute respiratory distress syndrome. Scientific Reports. 2024; 14(1):6667.

Fuhrman, DY; Stanski, NL; Krawczeski, CD; Greenberg, JH; Arikan, AAA; Basu, RK; Goldstein, SL; Gist, KM. A proposed framework for advancing acute kidney injury risk stratification and diagnosis in children: a report from the 26th Acute Disease Quality Initiative (ADQI) conference. Pediatric Nephrology. 2024; 39(3):929-939.

Starr, MC; Barreto, E; Charlton, J; Vega, M; Brophy, PD; Ray Bignall, ON; Sutherland, SM; Menon, S; Devarajan, P; Akcan Arikan, A; Basu, R; Goldstein, S; Soranno, DE. Advances in pediatric acute kidney injury pathobiology: a report from the 26th Acute Disease Quality Initiative (ADQI) conference. Pediatric Nephrology. 2024; 39(3):941-953.

Mottes, T; Menon, S; Conroy, A; Jetton, J; Dolan, K; Arikan, AA; Basu, RK; Goldstein, SL; Symons, JM; Alobaidi, R; Ronco, C; Mehta, RL; Kellum, J; Ostermann, M. Pediatric AKI in the real world: changing outcomes through education and advocacy-a report from the 26th Acute Disease Quality Initiative (ADQI) consensus conference. Pediatric Nephrology. 2024; 39(3):1005-1014.

Selewski, DT; Barhight, MF; Bjornstad, EC; Ricci, Z; De Sousa Tavares, M; Akcan-Arikan, A; Goldstein, SL; Basu, R; Bagshaw, SM. Fluid assessment, fluid balance, and fluid overload in sick children: a report from the Pediatric Acute Disease Quality Initiative (ADQI) conference. Pediatric Nephrology. 2024; 39(3):955-979.

Neumayr, TM; Bayrakci, B; Chanchlani, R; Deep, A; Morgan, J; Arikan, AA; Basu, RK; Goldstein, SL; Askenazi, DJ. Programs and processes for advancing pediatric acute kidney support therapy in hospitalized and critically ill children: a report from the 26th Acute Disease Quality Initiative (ADQI) consensus conference. Pediatric Nephrology. 2024; 39(3):993-1004.

Wong Vega, M; Starr, MC; Brophy, PD; Devarajan, P; Soranno, DE; Akcan-Arikan, A; Basu, R; Goldstein, SL; Charlton, JR; Barreto, E. Advances in pediatric acute kidney injury pharmacology and nutrition: a report from the 26th Acute Disease Quality Initiative (ADQI) consensus conference. Pediatric Nephrology. 2024; 39(3):981-992.

Sutherland, SM; Alobaidi, R; Gorga, SM; Iyengar, A; Morgan, C; Heydari, E; Arikan, AAA; Basu, RK; Goldstein, SL; Zappitelli, M. Epidemiology of acute kidney injury in children: a report from the 26th Acute Disease Quality Initiative (ADQI) consensus conference. Pediatric Nephrology. 2024; 39(3):919-928.

Rudman-Melnick, V; Adam, M; Stowers, K; Potter, A; Ma, Q; Chokshi, SM; Vanhoutte, D; Valiente-Alandi, I; Lindquist, DM; Nieman, ML; Kofron, JM; Chung, E; Park, J-S; Potter, SS; Devarajan, P. Single-cell sequencing dissects the transcriptional identity of activated fibroblasts and identifies novel persistent distal tubular injury patterns in kidney fibrosis. Scientific Reports. 2024; 14(1):439.

Chui, H; Mcmahon, KR; Rassekh, SR; Schultz, KR; Blydt-Hansen, TD; Mammen, C; Pinsk, M; Cuvelier, GDE; Carleton, BC; Tsuyuki, RT; Wang, S; Cockovski, V; Palijan, A; Zappitelli, M. Urinary TIMP-2*IGFBP-7 to diagnose acute kidney injury in children receiving cisplatin. Pediatric Nephrology. 2024; 39(1):269-282.

Wang, C-S; Glenn, DA; Helmuth, M; Smith, AR; Bomback, AS; Canetta, PA; Coppock, GM; Khalid, M; Tuttle, KR; Bou-Matar, R; Smoyer, WE; Rheault, MN; Gipson, D; Mariani, LH. Association of COVID-19 Versus COVID-19 Vaccination With Kidney Function and Disease Activity in Primary Glomerular Disease: A Report of the Cure Glomerulonephropathy Study. American Journal of Kidney Diseases. 2024; 83(1):37-46.

Zhang, Y; Chen, C; Mitsnefes, M; Huang, B; Devarajan, P. Evaluation of diagnostic accuracy of urine neutrophil gelatinase-associated lipocalin in patients with symptoms of urinary tract infections: a meta-analysis. Frontiers in Pediatrics. 2024; 12:1368583.

Sagcal-Gironella, ACP; Merritt, A; Mizuno, T; Dharnidharka, VR; Mcdonald, J; Deguzman, M; Wahezi, D; Goilav, B; Onel, K; Kim, S; Hersh, A; Huang, B; Devarajan, P; Brunner, H. Efficacy and Safety of Pharmacokinetically-Driven Dosing of Mycophenolate Mofetil for the Treatment of Pediatric Proliferative Lupus Nephritis-A Double-Blind Placebo Controlled Clinical Trial (The Pediatric Lupus Nephritis Mycophenolate Mofetil Study). Journal of Clinical Trials. 2024; 14(4).

Devarajan, P. Vigorous Exercise. In: Nelson Textbook of Pediatrics Volume 1 2. 2024:3218-3218.e2.

Devarajan, P. Vascular Abnormalities. In: Nelson Textbook of Pediatrics Volume 1 2. 2024:3211-3212.e1.

Devarajan, P. Tubulointerstitial Nephritis. In: Nelson Textbook of Pediatrics Volume 1 2. 2024:3205-3210.e1.

Devarajan, P. Trauma. In: Nelson Textbook of Pediatrics Volume 1 2. 2024:3213-3217.e2.

Devarajan, P. Toxic Nephropathy. In: Nelson Textbook of Pediatrics Volume 1 2. 2024:3196-3204.e2.

Devarajan, P. Sickle Cell Nephropathy. In: Nelson Textbook of Pediatrics Volume 1 2. 2024:3211-3212.e1.

Devarajan, P. Renal Vein Thrombosis. In: Nelson Textbook of Pediatrics Volume 1 2. 2024:3211-3212.e1.

Devarajan, P. Pyelonephritis. In: Nelson Textbook of Pediatrics Volume 1 2. 2024:3205-3210.e1.

Devarajan, P. Papillary Necrosis. In: Nelson Textbook of Pediatrics Volume 1 2. 2024:3205-3210.e1.

Devarajan, P. Infectious Causes of Cystitis and Urethritis. In: Nelson Textbook of Pediatrics Volume 1 2. 2024:3218-3218.e2.

Devarajan, P. Autosomal Recessive Polycystic Kidney Disease. In: Nelson Textbook of Pediatrics Volume 1 2. 2024:3213-3217.e2.

Devarajan, P. Acute Tubular Necrosis. In: Nelson Textbook of Pediatrics Volume 1 2. 2024:3205-3210.e1.

Devarajan, P. Acute Kidney Injury. In: Nelson Textbook of Pediatrics Volume 1 2. 2024:3242-3253.e1.

Devarajan, P. IgA Vasculitis Nephritis. In: Nelson Textbook of Pediatrics Volume 1 2. 2024:3196-3204.e2.

Devarajan, P. Idiopathic Hypercalciuria. In: Nelson Textbook of Pediatrics Volume 1 2. 2024:3211-3212.e1.

Devarajan, P. Hemorrhagic Cystitis. In: Nelson Textbook of Pediatrics Volume 1 2. 2024:3218-3218.e2.

Devarajan, P. Hemolytic-Uremic Syndrome. In: Nelson Textbook of Pediatrics Volume 1 2. 2024:3196-3204.e2.

Devarajan, P. Goodpasture Disease. In: Nelson Textbook of Pediatrics Volume 1 2. 2024:3196-3204.e2.

Devarajan, P. Glomerulonephritis Associated with Systemic Lupus Erythematosus. In: Nelson Textbook of Pediatrics Volume 1 2. 2024:3196-3204.e2.

Devarajan, P. Cortical Necrosis. In: Nelson Textbook of Pediatrics Volume 1 2. 2024:3196-3204.e2.

Devarajan, P. Congenital Anomalies. In: Nelson Textbook of Pediatrics Volume 1 2. 2024:3213-3217.e2.

Devarajan, P. Coagulopathies and Thrombocytopenia. In: Nelson Textbook of Pediatrics Volume 1 2. 2024:3196-3204.e2.

Devarajan, P. Chronic Infections. In: Nelson Textbook of Pediatrics Volume 1 2. 2024:3196-3204.e2.

Wen, Y; Su, E; Xu, L; Menez, S; Moledina, DG; Obeid, W; Palevsky, PM; Mansour, SG; Devarajan, P; Cantley, LG; Cahan, P; Parikh, CR. Analysis of the human kidney transcriptome and plasma proteome identifies markers of proximal tubule maladaptation to injury. Science Translational Medicine. 2023; 15(726):eade7287.

Rheault, MN; Mclaughlin, HM; Mitchell, A; Blake, LE; Devarajan, P; Warady, BA; Gibson, KL; Lieberman, KV. COL4A gene variants are common in children with hematuria and a family history of kidney disease. Pediatric Nephrology. 2023; 38(11):3625-3633.

Stone, HK; Huang, B; Chen, C; Ma, Q; Bennett, MR; Devarajan, P. External Validation of a Urinary Biomarker Risk Score for the Prediction of Steroid Responsiveness in Adults With Nephrotic Syndrome. Kidney International Reports. 2023; 8(11):2458-2468.

Rudman-Melnick, V; Devarajan, P. Single-Cell Sequencing Identifies Novel Activated Fibroblast Marker, Distal Spatial Tubular Injury Pattern, and Functionally Significant Nephrogenic Program Reactivation in Adult AKI-to-CKD Transition. Journal of the American Society of Nephrology. 2023; 34(11S):699-700.

Hasson, DC; Zhang, B; Krallman, K; Rose, JE; Kempton, KM; Steele, P; Devarajan, P; Goldstein, SL; Alder, MN. Acute kidney injury biomarker olfactomedin 4 predicts furosemide responsiveness. Pediatric Nephrology. 2023; 38(9):3153-3161.

Cody, EM; Wenderfer, SE; Sullivan, KE; Kim, AHJ; Figg, W; Ghumman, H; Qiu, T; Huang, B; Devarajan, P; Brunner, HI. Urine biomarker score captures response to induction therapy with lupus nephritis. Pediatric Nephrology. 2023; 38(8):2679-2688.

De Fontnouvelle, C; Zappitelli, M; Thiessen-Philbrook, HR; Jia, Y; Kimmel, PL; Kaufman, JS; Devarajan, P; Parikh, CR; Greenberg, JH. Biomarkers of eGFR decline after cardiac surgery in children: findings from the ASSESS-AKI study. Pediatric Nephrology. 2023; 38(8):2851-2860.

Chen, DP; Helmuth, ME; Smith, AR; Canetta, PA; Ayoub, I; Mucha, K; Kallash, M; Kopp, JB; Gbadegesin, R; Gillespie, BW; Mottl, AK; Gipson, DS; Srivastava, T; Twombley, KE. Age of Onset and Disease Course in Biopsy-Proven Minimal Change Disease: An Analysis From the Cure Glomerulonephropathy Network. American Journal of Kidney Diseases. 2023; 81(6):695-706.e1.

Devarajan, P. Pathogenesis of intrinsic acute kidney injury. Current Opinion in Pediatrics. 2023; 35(2):234-238.

Defoor, W; Lee, J; Edward, N; Schulte, M; Huesman, S; Libs, A; Devarajan, P. MP10-02 DIETARY INTERVENTION IN ENTERIC HYPEROXALURIA. Investigative Urology. 2023; 209(Supplement 4):e114.

Devarajan, P. Acute Kidney Injury: Pathophysiology, Diagnosis and Prevention. In: Pediatric Kidney Disease. Springer Nature; 2023:1365-1411.

Defoor, W; Nehus, E; Schulte, M; Huesman, S; Libs, A; Niehaus, R; Devarajan, P. Enteral nutrition and the risk of nephrolithiasis in complex pediatric patients. Journal of Pediatric Urology. 2022; 18(6):743.e1-743.e6.

Kharnaf, M; Hogue, S; Wilkes, Z; Reagor, JA; Leino, DG; Gourley, B; Rosenfeldt, L; Ma, Q; Devarajan, P; Palumbo, JS; Tweddell, JS; Zafar, F. A Murine Model of Veno-Arterial Extracorporeal Membrane Oxygenation. ASAIO Journal. 2022; 68(12):e243-e250.

Flannery, AH; Ortiz-Soriano, VM; Devarajan, P; Neyra, JA. Insights Into Urinary Renin in AKI. Journal of the American Society of Nephrology. 2022; 33(11S):56-57.

Rudman-Melnick, V; Adam, M; Devarajan, P. Single-Cell Transcriptomic Profiling of Kidney Fibrosis Identifies a Novel Fibroblast Marker and Putative Disease Target. Journal of the American Society of Nephrology. 2022; 33(11S):591-592.

Cody, E; Rose, J; Hopkins, R; Quinlan-Waters, M; Robben, CE; Qiu, T; Huang, B; Devarajan, P; Brunner, H. Stability of Novel Urinary Biomarkers Used for Lupus Nephritis. Journal of the American Society of Nephrology. 2022; 33(11S):961-962.

Hasson, DC; Krallman, KA; Zhang, B; Vandenheuvel, KA; Menon, S; Kempton, KM; Devarajan, P; Goldstein, S; Alder, MN. Olfactomedin 4 as a Loop of Henle-Specific AKI Biomarker That Predicts Furosemide Response. Journal of the American Society of Nephrology. 2022; 33(11S):72-72.

Hasson, DC; Watanabe-Chailland, M; Romick-Rosendale, L; Koterba, A; Miner, DS; Lahni, P; Ma, Q; Goldstein, SL; Devarajan, P; Standage, SW. Choline supplementation attenuates experimental sepsis-associated acute kidney injury. American Journal of Physiology - Renal Physiology. 2022; 323(3):F255-F271.

Hasson, DC; Krallman, K; Vandenheuvel, K; Menon, S; Piraino, G; Devarajan, P; Goldstein, SL; Alder, MN. Olfactomedin 4 as a novel loop of Henle-specific acute kidney injury biomarker. Physiological Reports. 2022; 10(18):e15453.

Goldstein, SL; Akcan-Arikan, A; Alobaidi, R; Askenazi, DJ; Bagshaw, SM; Barhight, M; Barreto, E; Bayrakci, B; Bignall, ONR; Bjornstad, E; Mehta, RL; Kellum, J; Ostermann, M; Basu, RK. Consensus-Based Recommendations on Priority Activities to Address Acute Kidney Injury in Children: A Modified Delphi Consensus Statement. JAMA Network Open. 2022; 5(9):e2229442.

Pode-Shakked, N; Devarajan, P. Human Stem Cell and Organoid Models to Advance Acute Kidney Injury Diagnostics and Therapeutics. International Journal of Molecular Sciences. 2022; 23(13).

Lieberman, KV; Chang, AR; Block, GA; Robinson, K; Bristow, SL; Morales, A; Mitchell, A; Mccalley, S; Mckay, J; Pollak, MR; Aradhya, S; Warady, BA. The KIDNEYCODE Program: Diagnostic Yield and Clinical Features of Individuals with CKD. Kidney360. 2022; 3(5):900-909.

Odum, JD; Standage, S; Alder, M; Zingarelli, B; Devarajan, P; Wong, HR. Candidate Biomarkers for Sepsis-Associated Acute Kidney Injury Mechanistic Studies. Shock. 2022; 57(5):687-693.

Dillman, JR; Benoit, SW; Gandhi, DB; Trout, AT; Tkach, JA; Vandenheuvel, K; Devarajan, P. Multiparametric quantitative renal MRI in children and young adults: comparison between healthy individuals and patients with chronic kidney disease. Abdominal Radiology. 2022; 47(5):1840-1852.

Aljaberi, N; Wenderfer, SE; Mathur, A; Qiu, T; Jose, S; Merritt, A; Rose, J; Devarajan, P; Huang, B; Brunner, H. Clinical measurement of lupus nephritis activity is inferior to biomarker-based activity assessment using the renal activity index for lupus nephritis in childhood-onset systemic lupus erythematosus. Lupus Science and Medicine. 2022; 9(1).

Devarajan, P; Chertow, GM; Susztak, K; Levin, A; Agarwal, R; Stenvinkel, P; Chapman, AB; Warady, BA. Emerging Role of Clinical Genetics in CKD. Kidney Medicine. 2022; 4(4):100435.

Elitok, S; Devarajan, P; Bellomo, R; Isermann, B; Haase, M; Haase-Fielitz, A. NGAL/hepcidin-25 ratio and AKI subtypes in patients following cardiac surgery: a prospective observational study. Journal of Nephrology. 2022; 35(2):597-605.

Chalhoub, NE; Wenderfer, SE; Levy, DM; Rouster-Stevens, K; Aggarwal, A; Savani, SI; Ruth, NM; Arkachaisri, T; Qiu, T; Merritt, A; Al-Mayouf, SM; Devarajan, P; Huang, B; Brunner, HI. International Consensus for the Dosing of Corticosteroids in Childhood-Onset Systemic Lupus Erythematosus With Proliferative Lupus Nephritis. Arthritis & Rheumatology. 2022; 74(2):263-273.

Mcmahon, KR; Chui, H; Rassekh, SR; Schultz, KR; Blydt-Hansen, TD; Mammen, C; Pinsk, M; Cuvelier, GDE; Carleton, BC; Tsuyuki, RT; Wang, S; Cockovski, V; Palijan, A; Zappitelli, M. Urine Neutrophil Gelatinase-Associated Lipocalin and Kidney Injury Molecule-1 to Detect Pediatric Cisplatin-Associated Acute Kidney Injury. Kidney360. 2022; 3(1):37-50.

Jeyaraju, M; Mccurdy, MT; Levine, AR; Devarajan, P; Mazzeffi, MA; Mullins, KE; Reif, M; Yim, DN; Parrino, C; Lankford, AS; Chow, JH. Renin Kinetics Are Superior to Lactate Kinetics for Predicting In-Hospital Mortality in Hypotensive Critically Ill Patients. Critical Care Medicine. 2022; 50(1):50-60.

Cody, EM; Rose, JE; Huang, B; Qiu, T; Brunner, HI; Devarajan, P. Stability of novel urinary biomarkers used for lupus nephritis. Frontiers in Pediatrics. 2022; 10:974049.