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Biplab Dasgupta, PhD, did doctoral research in molecular biology and immunology from the Indian Institute of Chemical Biology, Calcutta, and postdoctoral research at Washington University School of Medicine, St. Louis. Dasgupta joined Cincinnati Children’s in 2009 as a tenure track assistant professor of pediatrics within the University of Cincinnati College of Medicine. He rose through the ranks and is now a tenured associate professor of pediatrics.
Broadly, he is interested in understanding the mechanisms of cancer development and progression. Using various state-of-the-art techniques and brain tumor as a model, his lab examines cancer stem cell metabolism, bioenergetics, signal transduction and the potential link between and cell-intrinsic and cell-extrinsic factors that influence cancer incidence and penetrance.
I am Abitha Sukumaran, a biomedical researcher in the Department of Oncology at Cincinnati Children’s Hospital Medical Center. My doctoral and postdoctoral studies at Christian Medical College and Hospital, India and Yale University School of Medicine, USA, respectively, involved studying disorders of iron metabolism using cells in culture, mouse models and human subjects. In the DasGupta laboratory, my research work involves deciphering the role of AMPK-mTOR signaling axis in normal cells and gliomas, in an attempt to better understand the pathogenesis of brain tumors. We envisage that this would lead to the development of better treatment strategies. In another project I am beginning to examine the interactions between extrinsic factors and mutations during cancer initiation and progression.
Research Assistant III
I am a Research Assistant in the Dasgupta laboratory. I have done my Masters in Pharmacology from the Institute of Chemical Technology, Mumbai, India and previously worked as a research assistant at the Medical University of Vienna, Austria. I have gained expertise in handling and maintaining different animal models like zebra fish used for neurological studies and genetically modified mouse models. I am also experienced in in-vivo techniques like mouse embryo and oocyte injections with stem cells. My current research is focused on understanding the mechanisms of biguanide sensitivity and resistance of patient derived glioblastoma lines. I also assist other lab members in various ways including genotyping transgenic mice, maintaining mouse colonies, cell culture and molecular techniques. I am also involved in ordering lab supplies, reagents and lab organization.
I obtained my Bachelor of Science in Molecular and Cellular Biology and Bachelor of Arts in German Studies from the University of Arizona. Currently I’m working toward a PhD in the Cancer and Cell Biology Graduate Program at University of Cincinnati. My research interests include examining passenger deletions that engender therapeutic vulnerabilities in adult high grade gliomas, and examining the role of metabolic regulators including the cellular energy sensor AMPK in mouse models of pediatric high grade glioma.
I am an undergraduate at the University of Cincinnati majoring in medical sciences with a minor in Spanish. In the Dasgupta laboratory, I extract DNA from tails or ears of transgenic mice and run polymerase chain reactions for genotyping of the mouse strains used by other members of the lab for their projects. I also help with the maintenance of mouse colonies in the animal house by weaning and separating pups and adult mice. I prepare different reagents and sterilize (autoclave) various types of equipment used in the lab. With my experience in the Dasgupta lab, I hope to work in research projects through SURF or other programs.
I graduated in 2012 from Indiana University with a Bachelor of Science degree in Biology, and I worked as a pharmaceutical chemist for 5 years. I am currently a PhD student in the Cancer and Cell Biology Graduate Program at University of Cincinnati and I joined the Dasgupta Lab in March 2019. My current research focuses on the pediatric glioma DIPG, where I have performed integrative analyses on transcriptomic and metabolomic datasets to uncover previously unknown mechanisms that create an environment that is favorable for tumor progression. We are actively investigating some of the pathways that have been uncovered through these analyses, including the de novo and salvage purine pathways among others.
I am currently an undergraduate student, majoring in Biological Sciences with a minor in Chemistry, at the University of Cincinnati. I joined the Dasgupta lab in July of 2020. In the Dasgupta lab, I complete DNA extractions from mice ears and tails. I run polymerase chain reactions so that I can genotype different mouse strains. These results are used by other lab members for the furtherance of their projects. I also prepare various buffers and reagents, as well as, autoclave glassware and other lab equipment. Additionally, I restock different items in the lab that are commonly used. Being a part of the lab has been a great experience as I have already learned so much from other lab members and their projects and from completing my own tasks. My position as laboratory aide has strengthened my passion and interest for biology and research.
Research Assistant II
I have a bachelor in Biological Sciences from the University of Cincinnati. I joined the Dasgupta laboratory in November 2020 as Research Assistant. In the lab, I am involved in the hyperglycemia project, I assist with glucose measurement, handling, managing and feeding mice. I assist other lab members by helping with cell culture, genotyping genetically modified mouse model, and molecular techniques. I am also involved in managing laboratory inventories. Being a member of this lab is a great experience as I am learning a lot new techniques.
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