Principal Investigator
Energy sensing and metabolic pathways in neural cells, neural stem cells, brain cancer stem cells. Mouse models of high grade human brain tumor (glioma) and mechanisms of resistance of brain cancer cells.
Molecular hubs of nutrient sensing, oxygen sensing, oncogene and tumor suppressor signaling in glioma.
Molecular mechanisms of energy-dependent and independent functions of the cellular energy sensor AMP Kinase in mammalian brain development, cell fate chose and differentiation, cell survival, metabolic stress, cell division and mobility.
Identification of new druggable targets in brain cancer.
biplab.dasgupta@cchmc.org