Pathology

Clinical

Dr. Bove has been a career academic pediatric pathologist at Cincinnati Children's since 1968. He functions as a surgical pathologist, autopsy consultant and electron microscopist with diverse clinical interests. His collaborations with faculty and fellows in many divisions have resulted in more than 180 peer-reviewed and more than 120 publications.

Research

Dr. Bove's current research focus is on pathogenesis of biliary atresia and other cholestatic disorders of infancy. He has long term research interests in the early stages of childhood neoplasia and childhood diseases of skeletal muscle and heart.

Biography

Kevin E. Bove, MD, has 32 years experience as a pediatric pathologist at Cincinnati Children's Hospital Medical Center.

Dr. Bove has achieved national recognition as an expert in tumors; neuromuscular diseases; liver diseases of children and performance / interpretation of pediatric autopsies.

Dr. Bove has and continues to be involved in leadership positions in the Society for Pediatric Pathology and the College of American Pathologists.

MD: State University of New York, Buffalo, NY.

Residency: Rotating Intern, Cincinnati General Hospital, 1961-1962; Pathology, Cincinnati General Hospital, 1962-1966.

Certification: American Board of Pathology in Anatomic and Clinical Pathology, 1967 and 1968; Pediatric Pathology, 1990.

Margaret H. Collins, MD

Margaret H. Collins, MD, is a pediatric pathologist specializing in pediatric gastrointestinal pathology, especially eosinophilic gastrointestinal diseases. She has provided biopsy analyses, including primary study endpoints, for several clinical trials testing novel therapies to treat eosinophilic esophagitis in children. She also performs clinical research in other disorders of bowel immunity, and bowel motility disorders.

513-636-4261 margaret.collins@cchmc.org

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Margaret H. Collins, MD

Academic Affiliations

Professor, UC Department of Pathology & Laboratory Medicine

Phone 513-636-4261

Fax 513-636-3924

Email margaret.collins@cchmc.org

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Pediatric gastrointestinal pathology; eosinophilic gastrointestinal diseases; biopsy analyses; primary study endpoints; novel therapies to treat eosinophilic esophagitis in children; disorders of bowel immunity; bowel motility disorders

Biography

In 2011, Dr. Collins was named one of the Top Doctors in Pathology by U.S. News & World Report.

BS: Fordham University, NY, 1972.

MD: Georgetown University, Washington, D.C., 1977.

Residency: Pathology, New York Hospital, NY, 1977-80; Pathology, Columbia-Presbyterian Medical Center, NY, 1980-83.

Fellowship: Research, New York Lung Association, Columbia-Presbyterian Medical Center, N.Y., 1983-85; Research, American Lung Association, Columbia-Presbyterian Medical Center, NY, 1985-87.

Certification: Pathology, 1981; Pediatric Pathology, 1991.

Nikolaidis NM, Kulkarni RM, Gray JK, Collins MH, Waltz SE. Ron receptor deficient alveolar myeloid cells exacerbate LPS-induced acute lung injury in the murine lung. Innate Immun. 2010 Nov 18.

Sherrill JD, Gao PS, Stucke EM, Blanchard C, Collins MH, Putnam PE, Franciosi JP, Kushner JP, Abonia JP, Assa'ad AH, Kovacic MB, Biagini Myers JM, Bochner BS, He H, Hershey GK, Martin LJ, Rothenberg ME. Variants of thymic stromal lymphopoietin and its receptor associate with eosinophilic esophagitis. J Allergy Clin Immunol. 2010 Jul;126(1):160-5.e3.

DeBrosse CW, Collins MH, Buckmeier Butz BK, Allen CL, King EC, Assa'ad AH, Abonia JP, Putnam PE, Rothenberg ME, Franciosi JP. Identification, epidemiology, and chronicity of pediatric esophageal eosinophilia, 1982-1999. J Allergy Clin Immunol. 2010 Jul;126(1):112-9.

Abonia JP, Blanchard C, Butz BB, Rainey HF, Collins MH, Stringer K, Putnam PE, Rothenberg ME. Involvement of mast cells in eosinophilic esophagitis. J Allergy Clin Immunol. 2010 Jul;126(1):140-9.

Caldwell JM, Blanchard C, Collins MH, Putnam PE, Kaul A, Aceves SS, Bouska CA, Rothenberg ME. Glucocorticoid-regulated genes in eosinophilic esophagitis: a role for FKBP51. J Allergy Clin Immunol. 2010 Apr;125(4):879-888.e8.

Rothenberg ME, Spergel JM, Sherrill JD, Annaiah K, Martin LJ, Cianferoni A, Gober L, Kim C, Glessner J, Frackelton E, Thomas K, Blanchard C, Liacouras C, Verma R, Aceves S, Collins MH, Brown-Whitehorn T, Putnam PE, Franciosi JP, Chiavacci RM, Grant SF, Abonia JP, Sleiman PM, Hakonarson H. Common variants at 5q22 associate with pediatric eosinophilic esophagitis. Nat Genet. 2010 Apr;42(4):289-91.

Blanchard C, Stucke EM, Burwinkel K, Caldwell JM, Collins MH, Ahrens A, Buckmeier BK, Jameson SC, Greenberg A, Kaul A, Franciosi JP, Kushner JP, Martin LJ, Putnam PE, Abonia JP, Wells SI, Rothenberg ME. Coordinate interaction between IL-13 and epithelial differentiation cluster genes in eosinophilic esophagitis. J Immunol. 2010 Apr 1;184(7):4033-41.

Miller SJ, Lan ZD, Hardiman A, Wu J, Kordich JJ, Patmore DM, Hegde RS, Cripe TP, Cancelas JA, Collins MH, Ratner N. Inhibition of Eyes Absent Homolog 4 expression induces malignant peripheral nerve sheath tumor necrosis. Oncogene. 2010 Jan 21;29(3):368-79.

Vicario M, Blanchard C, Stringer KF, Collins MH, Mingler MK, Ahrens A, Putnam PE, Abonia JP, Santos J, Rothenberg ME. Local B cells and IgE production in the oesophageal mucosa in eosinophilic oesophagitis. Gut. 2010 Jan;59(1):12-20.

Prosperi JR, Becher KR, Willson TA, Collins MH, Witte DP, Goss KH. The APC tumor suppressor is required for epithelial integrity in the mouse mammary gland. J Cell Physiol. 2009 Aug;220(2):319-31.

Christine Fuller, MD

513-636-4261

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Christine Fuller, MD

Academic Affiliations

Professor, UC Department of Pathology & Laboratory Medicine

Phone 513-636-4261

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Clinical

Neuropathology; pediatric brain tumors; genetic basis of brain tumors.

Research

Molecular characterization of pediatric brain tumors.

Biography

As a board-certified neuropathologist, Dr. Fuller's primary area of expertise is in the gross and microscopic presentations of a wide variety of nervous system diseases. Through her clinical work and numerous collaborative projects, she's had the opportunity to examine thousands of brain tissue samples from both human and various rodent models.

Dr. Fuller has authored and co-authored numerous peer-reviewed articles in scientific journals (case reports and series, and basic and translational research), as well as multiple review articles, book chapters, and an atlas on a variety of brain neoplasms and other neuropathologic entities. She has in the past and now continue to be a part of large group translational collaborations that help provide crucial insight into the molecular alterations and potential therapeutic targets involved in the tumorigenesis of gliomas, ependymomas, and CNS embryonal tumors.

Dr. Fuller has expertise in novel fluorescence in situ hybridization (FISH) probe development and evaluation for gene copy number alterations, and she has broad knowledge of a variety of molecular techniques aimed at the genetic characterization of neoplasms.

Lastly, Dr. Fuller has broad administrative experience, serving as both clinical director of Autopsy and Neuropathology at VCU, as well as residency program director and neuropathology fellowship director at that same institution.

MD: SUNY Upstate Medical University, Syracuse, NY, 1995.

Residency: Anatomic and Clinical Pathology, SUNY Upstate Medical University, Syracuse, NY, 1999.

Fellowships: Surgical Pathology, Washington University School of Medicine, Barnes-Jewish Hospital, Saint Louis, MO, 2000; Neuropathology, Washington University School of Medicine, Barnes-Jewish Hospital, Saint Louis, MO, 2002.

Kegelman TP, Das SK, Hu B, Bacolod MD, Fuller CE, Menezes ME, Emdad L, Dasgupta S, Baldwin AS, Bruce JN, Dent P, Pellecchia M, Sarkar D, Fisher PB. MDA-9/Syntenin is a key regulator of glioma pathogenesis. Neuroonc. 2014;16(1):50-61.

Broniscer A, Baker SJ, West AN, Fraser MM, Kocak M, Dalton J, Zambetti GP, Gajjar A, Gilbertson RJ, Fuller CE. Clinical and molecular characteristics of malignant transformation of low-grade glioma in children: the St. Jude Children’s Research Hospital experience. J Clin Oncol. 2007;25:682-689.

Thompson MC, Fuller C, Hogg T, Dalton J, Finkelstein D, Lau C, Chintagumpala M, Adesina A, Ashley DM, Kellie SJ, Taylor MD, Curran T, Gajjar A, Gilbertson RJ. Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations. J Clin Oncol. 2006;24(12):1924-31.

Taylor MD, Poppleton H, Fuller C, Su X, Liu X, Jensen P, Magdelano S, Dalton J, Board J, MacDonald T, Rutka J, Guha A, Gajjar A, Curran T, Gilbertson RJ. Radial glia cells are candidate stem cells of ependymoma. Cancer Cell. 2005;8:323-335.

Tekautz T, Fuller C, Fouladi M, Broniscer A, Merchant T, Krasin M, Dalton J, Hale G, Kun L, Wallace D, Gilbertson R, Gajjar A. Atypical teratoid/rhabdoid tumors (ATRT): Improved survival in children 3 years of age and older with radiation therapy and high-dose alkylator-based chemotherapy. J Clin Oncol. 2005;23(7):1491-9.

Romer J, Kimura H, Magdaleno S, Fuller C, Baines H, Connelly M, Gould S, Rubin L, Curran T. Suppression of the Shh pathway using a small molecular inhibitor eliminates medulloblastoma in Ptc+/- p53-/- mice. Cancer Cell. 2004;6(3):229-240.

Gajjar A, Hernan R, Kocak M, Fuller CE, Lee Y, McKinnon PJ, Wallace D, Lau C, Chintagumpala M, Ashley D, Kellie S, Kun L, Gilbertson R. Clinical, histopathological and molecular markers of prognosis: toward a new disease risk stratification system for medulloblastoma. J Clin Oncol. 2004;22(6):984-93.

Fuller CE, Schmidt RE, Roth KA, Burger PC, Scheithauer BW, Banerjee R, Trinkaus K, Lytle R, Perry A. Clinical utility of fluorescence in situ hybridization (FISH) in morphologically ambiguous gliomas with hybrid oligodendroglial/astrocytic features. J Neuropathol Exp Neurol. 2003;62(11):1118-1128.

Fuller CE, Wang H, Zhang W, Fuller GN, Perry A. High-throughput molecular profiling of high-grade astrocytomas: Utility of fluorescence in-situ hybridization on tissue microarrays (TMA-FISH). J Neuropathol Exp Neurol. 2002;61(12):1078-1084.

Fuller CE, Pfeifer J, Humphrey P, Bruch LA, Dehner LP, Perry A. Chromosome 22 alterations in composite extrarenal rhabdoid tumors: Clonal evolution or a phenotypic mimic? Hum Pathol. 2001;32:1102-1108.

Anita Gupta, MD Staff Pathologist, Division of Pathology

Anita Gupta, MD, is a career academic pediatric pathologist at who functions as a surgical pathologist and electron microscopist. Current research focuses on liver tumors, cardiac transplants, vascular anomalies, and cilia abnormalities.

513-636-4261 anita.gupta@cchmc.org

Anita Gupta, MD

Staff Pathologist, Division of Pathology

Academic Affiliations

Associate Professor, UC Department of Pediatrics

UC Department of Pathology and Laboratory Medicine

Phone 513-636-4261

Fax 513-636-3924

Email anita.gupta@cchmc.org

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Clinical

Pediatric pathology; surgical pathology; electron microscopy.

Research

Liver tumors; cardiac transplants; vascular anomalies; cilia abnormalities.

MD: Mahadevappa Rampure Medical College, Gulbarga, Karnataka, India, 1997.

Residency: Northwestern Memorial Hospital, Chicago, IL, 2001-2005.

Fellowship: The Children's Hospital, Denver, CO, 2006.

Hammill AM, Wentzel M, Gupta A, Nelson S, Lucky A, Elluru R, Dasgupta R, Azizkhan RG, Adams DM. Sirolimus for the treatment of complicated vascular anomalies in children. Pediatr Blood Cancer. 2011 Dec 1;57 (6):1018-24

Maugans T, Sheridan RM, Adams D, Gupta A. Cutaneous vascular anomalies associated with neural tube defects: nomenclature and pathology revisited. Neurosurgery. 2011 Jul;69(1):112-8

Gupta A, Kozakewich H. Histopathology of vascular anomalies. Clin Plast Surg. 2011 Jan;38(1):31-44.

Bischoff A, Gupta A, D'Mello S, Mezoff A, Podberesky D, Barnett S, Keswani S, Frischer JS. Crohn's disease limited to the appendix: a case report in a pediatric patient. Pediatr Surg Int. 2010 Nov;26(11):1125-8.

Stevenson CB, Leach JL, Gupta A, Crone KR. Cystic degeneration of the cerebellar tonsils in pediatric patients with Chiari Type I malformation. J Neurosurg Pediatr. 2009 Dec;4(6):557-63.

Zynger DL, Gupta A, Luan C, Chou PM, Yang GY, Yang XJ. Expression of glypican 3 in hepatoblastoma: an immunohistochemical study of 65 cases. Hum Pathol. 2008; 39 (2):224-30.

Adley BP, Gupta A, Lin F, Luan C, Teh BT, Yang XJ. Expression of Kidney-Specific Cadherin in Chromophobe Renal Cell Carcinoma. Am J Clin Pathol. 2006 Jul; 126(1): 79-85.

Blecha MJ, Gupta A, Hoover JD, Madonna MB. Chronic abdominal pain secondary to a mucous cystadenoma of the appendix in a 10-year-old boy. J Pediatr Surg. 2005 Nov; 40(11): 1792-4.

Salanitri G, Huo E, Miller F, Gupta A, Pereles S. MRI of Mycotic Sinus of Valsalva Pseudoaneurysm Secondary to Aspergillus Pericarditis. Amer J Roentgenology. 2005; 184: S25-S27

Gupta A, Madallozo J, Win Htin T, Shah A, Chou PM. Spindle cell rhabdomyosarcoma of the tongue in an infant. Pathol Research and Practice. 2004; 200: 537-543.

Stephanie Kinney, MD Medical Director of Transfusion Services, Division of Pathology and Laboratory Medicine

513-636-3182 stephanie.kinney@cchmc.org

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Stephanie Kinney, MD

Medical Director of Transfusion Services, Division of Pathology and Laboratory Medicine

Academic Affiliations

Assistant Professor, UC Department of Pathology & Laboratory Medicine

Phone 513-636-3182

Email stephanie.kinney@cchmc.org

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Clinical pathology; transfusion medicine

MD: Indiana University School of Medicine, Indianapolis, IN, 2012.

Residency: Anatomic and Clinical Pathology, Indiana University School of Medicine, Indianapolis, IN, 2016.

Fellowship: Blood Banking/Transfusion Medicine, University of Minnesota, MN, 2017.

Certification: Anatomic and Clinical Pathology, 2016.

Gorlin J, Kinney S, Fung MK, Tinmouth A. Prothrombin complex concentrate for emergent reversal of warfarin: an international survey of hospital protocols. Vox Sang. 2017 Jun 21.

Kinney SN, Slayten J, Waxman D. The Need for Education in Molecular Immunohematology: A Survey of Specialists in Blood Banking. Lab Med. 2016 Nov;47(4):330-337.

Kinney SN, Hes O, Williamson SR, Eble JN, Grignon DJ, Wang M, Zhang S, Baldrige L, Martignoni G, Brunelli M, Wang L, Comparat E, MacLennan GT, Cheng L. Metanephric Adenoma: The Utility of Immunohistochemical and Cytogenetic Analyses in Differential Diagnosis. Mod Pathol. 2015;28(9):1236-48.

Slemp SN, Slayton J, Cipkala D, Waxman D. Two Case Studies and Review of Paroxysmal Cold Hemoglobinuria. Lab Medicine. 2014;(45):253-258.

Robert B. Lorsbach, MD, PhD Director, Hematopathology Service, Division of Pathology

513-636-4261 robert.lorsbach@cchmc.org

Robert B. Lorsbach, MD, PhD

Director, Hematopathology Service, Division of Pathology

Academic Affiliations

Professor, UC Department of Pathology & Laboratory Medicine

Phone 513-636-4261

Email robert.lorsbach@cchmc.org

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MD: University of Kansas, Lawrence, KS.

PhD: Experimental Pathology, University of Kansas, Lawrence, KS.

Post-Doctoral Training: Residency, Fellowship in Hematopathology, Post doctoral fellow, Department of Pathology, Brigham & Women's Hospital, Boston, MA.

Myers K, Nelson A, Sheehan B, Malsch M, Furutani E, Towers G, Lorsbach RB, Shimamura A. Germline and Somatic Genetic Characterization of Shwachman-Diamond Syndrome. Pediatric Blood & Canter. 2017;64:S26.

Niss O, Christakopoulos G, Lorsbach R, Trump L, Reynolds M, Johnson C, Lorsbach RB, Kalfa T. CDAR: The First Registry for Patients with Congenital Dyserythropoietic Anemia in North America. Pediatric Blood & Canter. 2017;64:S19.

Lee LH, Gasilina A, Roychoudhury J, Clark J, McCormack FX, Pressey J, Lorsbach RB, Kumar AR. Real-time genomic profiling of histiocytoses identifies early-kinase domain BRAF alterations while improving treatment outcomes. JCI Insight. 2017;2(3):e89473.

Bakeer N, Nakar C, Fasipe F, Gunning W, Lorsbach R, Zhang K, Kalfa T. Congenital Dyserythropoietic Anemia Type I Due to Novel CDAN1 Mutations. Pediatric Blood & Canter. 2016;63:S61.

Lorsbach RB, Yared M. Plasma cell neoplasms: Pathogenesis, diagnosis and laboratory evaluation. Springer International Publishing. 2016.

Pandey S, Lorsbach RB. Morphologic and immunohistochemical evaluation of plasma cell neoplasms. In Plasma Cell Neoplasms: Pathogenesis, Diagnosis and Laboratory Evaluation. Springer International Publishing. 2016;35-77.

Yared M, Lorsbach RB. Introduction. In Plasma Cell Neoplasms: Pathogenesis, Diagnosis and Laboratory Evaluation. Springer International Publishing. 2016;1-7.

Cetin N, Pandey S, Lorsbach RB. Immature lymphoid cells are a consistent feature of chylothorax in neonates and infants: cytologic features and flow cytometry aid in its distinction from lymphoblastic leukemia/lymphoma. Diagn Cytopathol. 2015;43(4):335-338.

Cole AJ, Chen C, Lorsbach RB, Honnebier BM, Gardner JM, Shalin SC. Extranodal Rosai-Dorfman disease in the scrotum of a 13-month male: a unique anatomic presentation. Am J Dermatopathol. 2015;37(1):88-90.

Morgan H. McCoy, PhD, MD Associate Medical Director, Clinical Laboratories, Division of Pathology and Laboratory Medicine

513-803-8878 morgan.mccoy@cchmc.org

Joel E. Mortensen, PhD Director, Diagnostic Infectious Diseases Testing Laboratory (Microbiology and Virology)

Joel E. Mortensen, PhD, currently focuses is antimicrobial susceptibility testing of fastidious pediatric pathogens.

513-636-5310 joel.mortensen@cchmc.org

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Joel E. Mortensen, PhD

Director, Diagnostic Infectious Diseases Testing Laboratory (Microbiology and Virology)

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-5310

Fax 513-636-8850

Email joel.mortensen@cchmc.org

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Clinical

Application of rapid testing methods into the clinical microbiology laboratory and outpatient settings; LEAN manufacturing processes applied to clinical microbiology.

Research

Antimicrobial susceptibility testing of fastidious pediatric pathogens.

Biography

Dr. Mortensen is a career academic clinical microbiologist in the Department of Pathology and Laboratory Medicine at Cincinnati Children's since 1991. Beyond providing consultation to the medical staff in clinical microbiology, his clinical interests include the application of rapid testing methods into the clinical microbiology laboratory and outpatient settings and LEAN manufacturing processes applied to clinical microbiology. His collaborations with faculty and fellows have resulted in more than 100 peer-reviewed publications, case studies and text chapters.

BS: Mount Union College, Alliance, OH, 1979.

PhD: The Ohio State University, Columbus, OH, 1983.

Residency: Accredited Postdoctoral Residence Program in Medical and Public Health Microbiology; Baylor College of Medicine, University of Texas Medical School, Pathology, Houston, TX, 1983-85.

Certification: Certified Laboratory Consultant, American Medical Technologists, 1998.

Shiva K. Shanmukhappa, DVM, PhD, Diplomate ACVP

Motley WW, Melson AT, Mortensen JE. Pediatric Metarhizium anisopliae keratitis. J AAPOS. 2011 Feb 10.

Major TA, Panmanee W, Mortensen JE, Gray LD, Hoglen N, Hassett DJ. Sodium nitrite-mediated killing of the major cystic fibrosis pathogens Pseudomonas aeruginosa, Staphylococcus aureus, and Burkholderia cepacia under anaerobic planktonic and biofilm conditions. Antimicrob Agents Chemother. 2010 Nov;54(11):4671-7.

Chhabra MS, Motley WW 3rd, Mortensen JE. Eikenella corrodens as a causative agent for neonatal conjunctivitis. J AAPOS. 2008 Oct;12(5):524-5.

Huppert JS, Mortensen JE, Reed JL, Kahn JA, Rich KD, Hobbs MM. Mycoplasma genitalium detected by transcription-mediated amplification is associated with Chlamydia trachomatis in adolescent women. Sex Transm Dis. 2008 Mar;35(3):250-4.

Huppert JS, Mortensen JE, Reed JL, Kahn JA, Rich KD, Miller WC, Hobbs MM. Rapid antigen testing compares favorably with transcription-mediated amplification assay for the detection of Trichomonas vaginalis in young women. Clin Infect Dis. 2007 Jul 15;45(2):194-8.

Huppert JS, Biro F, Lan D, Mortensen JE, Reed J, Slap GB. Urinary symptoms in adolescent females: STI or UTI? J Adolesc Health. 2007 May;40(5):418-24.

Iyer SB, Gerber MA, Pomerantz WJ, Mortensen JE, Ruddy RM. Effect of point-of-care influenza testing on management of febrile children. Acad Emerg Med. 2006 Dec;13(12):1259-68.

Huppert JS, Gerber MA, Deitch HR, Mortensen JE, Staat MA, Adams Hillard PJ. Vulvar ulcers in young females: a manifestation of aphthosis. J Pediatr Adolesc Gynecol. 2006 Jun;19(3):195-204.

Mortensen JE, Gerrety MJ, Gray LD. Surveillance of antimicrobial resistance in Neisseria meningitidis from patients in the Cincinnati Tri-State region (Ohio, Kentucky, and Indiana). J Clin Microbiol. 2006 Apr;44(4):1592-3.

Yoon SS, Coakley R, Lau GW, Lymar SV, Gaston B, Karabulut AC, Hennigan RF, Hwang SH, Buettner G, Schurr MJ, Mortensen JE, Burns JL, Speert D, Boucher RC, Hassett DJ. Anaerobic killing of mucoid Pseudomonas aeruginosa by acidified nitrite derivatives under cystic fibrosis airway conditions. J Clin Invest. 2006 Feb;116(2):436-46.

Shiva K. Shanmukhappa, DVM, PhD, Diplomate ACVP, is an assistant professor for the UC Department of Pathology and Laboratory Medicine with board certification in comparative veterinary anatomic pathology. He provides pathology support to investigators and also is core pathologist for the Digestive Health Center. His primary research interests have been in studying molecular mechanisms involved in liver repair and regeneration, NASH and metabolic complications in HIV. Additional research interests include virus host interaction, tumor development, neurodegenerative diseases and aging.

513-803-4289 shiva.shanmukhappa@cchmc.org

Shiva K. Shanmukhappa, DVM, PhD, Diplomate ACVP

Academic Affiliations

Assistant Professor, UC Department of Pathology & Laboratory Medicine

Phone 513-803-4289

Email shiva.shanmukhappa@cchmc.org

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Research Interests

Liver repair and regeneration; NASH; metabolic complication of HIV; sickle cell disease; nephropathy.

Biography

Shiva Kumar Shanmukhappa joined the Cincinnati Children's Division of Pathology and Laboratory Medicine in 2012 as an assistant professor within the UC Department of Pathology and Laboratory Medicine overseeing the research pathology core.

From 2009-2012, Dr. Shanmukhappa was a comparative pathology fellow in the Division of Comparative Pathology, New England Primate Research Center, Harvard Medical School.

Dr. Shanmukhappa was a research fellow in the Division of Gastroenterology, Hepatology and Nutrition from 2003 to 2009 where he primarily worked on understanding the molecular mechanism involved in liver repair and regeneration as well as the induction of pancreatic cells in liver during defective liver repair. He identified the role of plasmin in liver repair. He has shown that plasmin mediates liver repair through the activation of HGF-MET signaling mainly affecting cell motility.

Dr. Shanmukhappa has an active research career with his primary interests in molecular control of liver repair, regeneration, biliary atresia, NASH and metabolic complications of HIV.

DVM: Veterinary College, University of Agricultural Sciences, Bangalore, India,1996.

PhD: Department of Veterinary Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, 2002.

Residency: Comparative Pathology, New England Primate Research Center, Harvard Medical School, Southborough, MA.

Certification: Veterinary Anatomic Pathology, 2013.

Bessho K, Shanmukhappa K, Sheridan R, Shivakumar P, Mourya R, Walters S, Kaimal V, Dilbone E, Jegga AG, Bezerra JA. Integrative genomics identifies candidate microRNAs for pathogenesis of experimental biliary atresia. BMC Syst Biol. 2013 Oct 20;7:104.

Marzioni M, Saccomanno S, Agostinelli L, Rychlicki C, De Minicis S, Pierantonelli I, Trauner M, Fickert P, Müller T, Shanmukhappa K, Trozzi L, Candelaresi C, Baroni GS, Benedetti A. PDX-1/Hes-1 interactions determine cholangiocyte proliferative response to injury in rodents: possible implications for sclerosing cholangitis. J Hepatol. 2013 Apr;58(4):750-6.

Sasseville VG, Mansfield KG, Mankowski JL, Tremblay C, Terio KA, Mätz-Rensing K, Gruber-Dujardin E, Delaney MA, Schmidt LD, Liu D, Markovits JE, Owston M, Harbison C, Shanmukhappa SK, Miller AD, Kaliyaperumal S, Assaf BT, Kattenhorn L, Macri SC, Simmons HA, Baldessari A, Sharma P, Courtney C, Bradley A, Cline JM, Reindel JF, Hutto DL, Montali RJ, Lowenstine LJ. Meeting report: Spontaneous lesions and diseases in wild, captive-bred, and zoo-housed nonhuman primates and in nonhuman primate species used in drug safety studies. Vet Pathol. 2012 Nov;49(6):1057-69.

Sheridan R, Lampe K, Shanmukhappa SK, Putnam P, Keddache M, Divanovic S, Bezerra J, Hoebe K. Lampe1: an ENU-germline mutation causing spontaneous hepatosteatosis identified through targeted exon-enrichment and next-generation sequencing. PLoS One. 2011;6(7):e21979.

Mann EA, Shanmukhappa K, Cohen MB. Lack of guanylate cyclase C results in increased mortality in mice following liver injury. BMC Gastroenterol. 2010 Aug 2;10:86.

Marzioni M, Saccomanno S, Candelaresi C, Rychlicki C, Agostinelli L, Shanmukhappa K, Trozzi, L, Pierantonelli I, De Minicis S, Benedetti A. Pancreatic Duodenal Homeobox-1 de novo expression drives cholangiocyte neuroendocrine-like transdifferentiation. J Hepatol. 2010 Oct;53(4):663-70.

Shanmukhappa K, Degen J, Bezerra J. Plasmin-mediated proteolysis is required for hepatocyte growth factor activation during liver repair. J Biol Chem. 2009 May 8;284(19): 12917-12923.

Shanmukhappa K, Kim JK and Kapil S. Role of CD151, A tetraspanin, in porcine reproductive and respiratory syndrome virus infection. Virol J. 2007; 4: 62.

Shanmukhappa K, Sabla GE, Degen JL, Bezerra JA. Urokinase-type plasminogen activator supports liver repair independent of its cellular receptor. BMC Gastroenterol. 2006 Nov 29;6:40.

Kim JK, Fahad AM, Shanmukhappa K, Kapil S. Defining the cellular target(s) of porcine reproductive and respiratory syndrome virus blocking monoclonal antibody 7G10. J Virol. 2006 Jan;80(2):689-96.

Grants

12.5 % effort, Digestive Health Center, Cincinnati Children’s Hospital Medical Center. Public Health Service Grant. Jan 2013–Current. P30 DK078392.

Jerzy W. Stanek, MD, PhD

Jerzy Stanek MD, PhD, investigates the placental features of in-utero hypoxia and infections and clinical correlations thereof.

513-636-8158 jerzy.stanek@cchmc.org

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Jerzy W. Stanek, MD, PhD

Academic Affiliations

Professor, UC Department of Pathology & Laboratory Medicine

UC Department of Pediatrics

Phone 513-636-8158

Fax 513-636-3924

Email jerzy.stanek@cchmc.org

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Clinical

Perinatal autopsy and placental pathology

Research

Pathogenesis of in-utero hypoxia

Biography

Jerzy Stanek, MD, PhD, is co-author of two textbooks on clinical perinatology. As a gynecologist, he described a new method of operative treatment of female urinary incontinence.
As a placental pathologist, he described several placental hypoxia-related lesions (laminar necrosis of placental membranes, chorionic microcysts of placental membranes and chorionic disc, increased amount of extravillous trophoblasts, occult placenta accreta and perivascular stem edema).

MD: College of Medicine, Jagiellonian University, Kraków, Poland, 1968.

Internship: Jagiellonian University Hospital, Kraków, Poland, 1968-1970.

PhD: College of Medicine, Jagiellonian University, Kraków, Poland, 1974.

Residencies: University Hospital of Obstetrics and Gynecology, Jagiellonian University, Kraków, Poland, 1970-1976; Georgetown University Medical Center, Washington, DC, and Rush Presbyterian-St.Luke's Medical Center, Chicago, IL, 1990-1994.

Fellowship: Reproductive Endocrinology, Jagiellonian University Hospital of Obstetrics and Gynecology, Kraków, Poland; 1976-1977; Postgraduate Medical Center, Warsaw, Poland.

Certifications: Obstetrics and Gynecology, Polish Board of Obstetrics and Gynecology, 1976; Endocrinology, Postgraduate Medical Center, Poland, 1977; Anatomic and Clinical Pathology, American Board of Pathology, 1994; Pediatric Pathology, American Board of Pathology, 1999.

Stanek J. Association of coexisting morphological umbilical cord abnormality and clinical cord compromise with hypoxic and thrombotic placental histology. Virchows Arch. 2016;468:723-32.

Stanek J. Chorangiosis of chorionic villi: what does it really mean? Arch Pathol Lab Med. 2016;140: 588-593.

Stanek J, Biesiada J. Clustering and classical analysis of clinical and placental phenotypes in fetal growth restriction and constitutional fetal smallness. Placenta. 2016;42:93-105.

Stanek J. Placental hypoxic overlap lesions: A clinicoplacental correlation. J Obstet Gynaecol Res. 2015;41:358-369.

Stanek J, Biesiada J. Relation of placental diagnosis in stillbirth to fetal maceration and gestational age at delivery. J Perinat Med. 2014;42:457-71.

Stanek J, Biesiada J, Trzeszcz M. Clinicoplacental phenotypes vary with gestational age: An analysis by classical and clustering methods. Acta Obstet Gynecol Scand. 2014;93:392-398.

Stanek J. Hypoxic patterns of placental injury: a review. Arch Pathol Lab Med. 2013;137:706-720.

Stanek J, Biesiada J. Clustering of maternal/fetal clinical conditions and outcomes and placental lesions. Am J Obstet Gynecol. 2012;206:493.e1-8.

Stanek J. Chorionic disc extravillous trophoblasts in placental diagnosis. Am J Clin Pathol. 2011;136:540-547.

Stanek J, Weng E. Microscopic Chorionic Pseudocysts in Placental Membranes: A Histologic Lesion of In Utero Hypoxia. Pediatr Dev Pathol. 2007;10:192-8.

Keith F. Stringer, MD Pathologist, Division of Pathology and Laboratory Medicine

Keith F. Stringer, MD, focuses on the application of the techniques of modern morphology in assessing diseased tissues. His work with these techniques, such as immunofluorescence microscopy and in situ hybridization, have contributed to dozens of publications elucidating features of the pathogenesis of allergic, neoplastic, developmental, and other disease processes.

513-636-4261 keith.stringer@cchmc.org

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Keith F. Stringer, MD

Pathologist, Division of Pathology and Laboratory Medicine

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-636-4261

Fax 513-636-3924

Email keith.stringer@cchmc.org

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Microscopic techniques for assessing mRNA expression; protein production and cellular identity in eukaryotic tissues; stem cell development and differentiation using animal models such as the zebrafish

BSc: University of British Columbia, Vancouver, British Columbia, Canada.

MSc: University of Toronto, Toronto, Ontario, Canada.

MD: University of Calgary, Calgary, Alberta, Canada, 1995.

DABP: Anatomic and Pediatric Pathology.

Xu YH, Jia L, Quinn B, Zamzow M, Stringer K, Aronow B, Sun Y, Zhang W, Setchell KD, Grabowski GA. Global gene expression profile progression in Gaucher disease mouse models. BMC Genomics. 2011 Jan 11;12:20.

Sivaprasad U, Askew DJ, Ericksen MB, Gibson AM, Stier MT, Brandt EB, Bass SA, Daines MO, Chakir J, Stringer KF, Wert SE, Whitsett JA, Le Cras TD, Wills-Karp M, Silverman GA, Khurana Hershey GK. A nonredundant role for mouse Serpinb3a in the induction of mucus production in asthma. J Allergy Clin Immunol. 2011 Jan;127(1):254-61, 261.e1-6.

Shi Z, Dragin N, Miller ML, Stringer KF, Johansson E, Chen J, Uno S, Gonzalez FJ, Rubio CA, Nebert DW. Oral benzo[a]pyrene-induced cancer: two distinct types in different target organs depend on the mouse Cyp1 genotype. Int J Cancer. 2010 Nov 15;127(10):2334-50.

Abonia JP, Blanchard C, Butz BB, Rainey HF, Collins MH, Stringer K, Putnam PE, Rothenberg ME. Involvement of mast cells in eosinophilic esophagitis. J Allergy Clin Immunol. 2010 Jul;126(1):140-9.

Vicario M, Blanchard C, Stringer KF, Collins MH, Mingler MK, Ahrens A, Putnam PE, Abonia JP, Santos J, Rothenberg ME. Local B cells and IgE production in the oesophageal mucosa in eosinophilic oesophagitis. Gut. 2010 Jan;59(1):12-20.

Qi X, Chu Z, Mahller YY, Stringer KF, Witte DP, Cripe TP. Cancer-selective targeting and cytotoxicity by liposomal-coupled lysosomal saposin C protein. Clin Cancer Res. 2009 Sep 15;15(18):5840-51.

Ahrens R, Waddell A, Seidu L, Blanchard C, Carey R, Forbes E, Lampinen M, Wilson T, Cohen E, Stringer K, Ballard E, Munitz A, Xu H, Lee N, Lee JJ, Rothenberg ME, Denson L, Hogan SP. Intestinal macrophage/epithelial cell-derived CCL11/eotaxin-1 mediates eosinophil recruitment and function in pediatric ulcerative colitis. J Immunol. 2008 Nov 15;181(10):7390-9.

Blanchard C, Mingler MK, McBride M, Putnam PE, Collins MH, Chang G, Stringer K, Abonia JP, Molkentin JD, Rothenberg ME. Periostin facilitates eosinophil tissue infiltration in allergic lung and esophageal responses. Mucosal Immunol. 2008 Jul;1(4):289-96.

Collins MH, Blanchard C, Abonia JP, Kirby C, Akers R, Wang N, Putnam PE, Jameson SC, Assa'ad AH, Konikoff MR, Stringer KF, Rothenberg ME. Clinical, pathologic, and molecular characterization of familial eosinophilic esophagitis compared with sporadic cases. Clin Gastroenterol Hepatol. 2008 Jun;6(6):621-9.

Shivakumar P, Sabla G, Mohanty S, McNeal M, Ward R, Stringer K, Caldwell C, Chougnet C, Bezerra JA. Effector role of neonatal hepatic CD8+ lymphocytes in epithelial injury and autoimmunity in experimental biliary atresia. Gastroenterology. 2007 Jul;133(1):268-77.

Peter H. Tang, PhD Director, Special Chemistry

Peter H. Tang, PhD, focuses on the diagnosis of mitochondrial dysfunction, metabolic disorder, neurodegenerative disease, hemoglobin disorder, neurogenesis, and therapeutic drug monitoring. He has long term research interests in inventing novel approaches for clinical diagnosis by using HPLC and LC/MS.

513-636-3357 peter.tang@cchmc.org

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Peter H. Tang, PhD

Director, Special Chemistry

Clinical Chemist

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-636-3357

Fax 513-636-8850

Email peter.tang@cchmc.org

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Clinical

In vitro diagnostics; disease monitoring procedures

Research

Mitochondrial dysfunction; metabolic disorders; neurodegenerative diseases; hemoglobin disorders; neurogenesis; and therapeutic drug monitoring

PhD: Analytical Chemistry, University of Cincinnati, Cincinnati, OH, 1990.

MS: Biochemistry, Northeast Louisiana University, Monroe, LA, 1985.

BS: Pharmacy, Taipei Medical College, Taipei, Taiwan, 1978.

Graham DL, Grace CE, Braun AA, Schaefer TL, Skelton MR, Tang PH, Vorhees CV, Williams MT. Effects of developmental stress and lead (Pb) on corticosterone after chronic and acute stress, brain monoamines, and blood Pb levels in rats. Int J Dev Neurosci. 2011 Feb;29(1):45-55.

Miles MV, Putnam PE, Miles L, Tang PH, DeGrauw AJ, Wong BL, Horn PS, Foote HL, Rothenberg ME. Acquired coenzyme Q10 deficiency in children with recurrent food intolerance and allergies. Mitochondrion. 2011 Jan;11(1):127-35.

Kohli R, Kirby M, Xanthakos SA, Softic S, Feldstein AE, Saxena V, Tang PH, Miles L, Miles MV, Balistreri WF, Woods SC, Seeley RJ. High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis. Hepatology. 2010 Sep;52(3):934-44.

Miles MV, Tang PH, Miles L, Steele PE, Moye MJ, Horn PS. Validation and application of an HPLC-EC method for analysis of coenzyme Q10 in blood platelets. Biomed Chromatogr. 2008 Dec;22(12):1403-8.

Tang PH. Drug monitoring and toxicology: a simple procedure for the monitoring of felbamate by HPLC-UV detection. J Anal Toxicol. 2008 Jun;32(5):373-8.

Herring NR, Schaefer TL, Tang PH, Skelton MR, Lucot JP, Gudelsky GA, Vorhees CV, Williams MT. Comparison of time-dependent effects of (+)-methamphetamine or forced swim on monoamines, corticosterone, glucose, creatine, and creatinine in rats. BMC Neurosci. 2008 May 30;9:49.

Miles MV, Miles L, Tang PH, Horn PS, Steele PE, DeGrauw AJ, Wong BL, Bove KE. Systematic evaluation of muscle coenzyme Q10 content in children with mitochondrial respiratory chain enzyme deficiencies. Mitochondrion. 2008 Mar;8(2):170-80.

Miles MV, Patterson BJ, Chalfonte-Evans ML, Horn PS, Hickey FJ, Schapiro MB, Steele PE, Tang PH, Hotze SL. Coenzyme Q10 (ubiquinol-10) supplementation improves oxidative imbalance in children with trisomy 21. Pediatr Neurol. 2007 Dec;37(6):398-403.

Tang PH, Miles MV, Steele P, Davidson BS, Geraghty SR, Morrow AL. Determination of coenzyme Q10 in human breast milk by high-performance liquid chromatography. Biomed Chromatogr. 2006 Dec;20(12):1336-43.

Tang PH. Determination of coenzyme Q10 in over-the-counter dietary supplements by high-performance liquid chromatography with coulometric detection. J AOAC Int. 2006 Jan-Feb;89(1):35-9.

Katherine A. VandenHeuvel, MD

513-636-4261 katherine.vandenheuvel@cchmc.org

Kathryn A. Wikenheiser-Brokamp, MD, PhD Director, Residency Research Program

Kathryn A. Wikenheiser-Brokamp, MD, PhD, investigates pediatric and adult lung diseases, including cancer, which are characterized by aberrant epithelial cell growth and differentiation. A major focus is the molecular mechanisms underlying Rb/p16, p53, and Dicer1 pathway function in lung development and the pathogenesis of lung disease. The ultimate goal is to identify new diagnostic, prognostic and therapeutic targets for common pulmonary disorders.

513-803-0239 kathryn.wikenheiser-brokamp@cchmc.org

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Kathryn A. Wikenheiser-Brokamp, MD, PhD

Director, Residency Research Program

Associate Director, Medical Scientist Training Program

Academic Affiliations

Associate Professor, UC Department of Pathology & Laboratory Medicine

Phone 513-803-0239

Fax 513-636-7868

Email kathryn.wikenheiser-brokamp@cchmc.org

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Pathology; pulmonary pathology

BS: Mathematics/Natural Science, Secondary Education Minor, University of Mary, Bismarck, ND, 1988.

PhD: Developmental Biology, Developmental Biology and Medical Science Scholars Programs, University of Cincinnati, Cincinnati, OH, 1994.

MD: Medical Science Scholars Program, University of Cincinnati, Cincinnati, OH, 1996.

Residency: Anatomic Pathology, Department of Pathology and Immunology, Washington University-Barnes/Jewish Hospital, St. Louis, MO, 1996-2002.

Clinical Training/Postdoctoral Research: Department of Pathology and Immunology, Washington University, St. Louis, MO, 1999-2002.

Licensure: State of Ohio, 2003.

Certification: Anatomic Pathology, The American Board of Pathology, 1999.