Xu Lab

Xu Lab

Guo, M; Morley, MP; Jiang, C; Wu, Y; Li, G; Du, Y; Zhao, S; Wagner, A; Cakar, AC; Kouril, M; et al. Guided construction of single cell reference for human and mouse lung. Nature Communications. 2023; 14:4566.

Uehara, Y; Tanaka, Y; Zhao, S; Nikolaidis, NM; Pitstick, LB; Wu, H; Yu, JJ; Zhang, E; Hasegawa, Y; Noel, JG; et al. Insights into pulmonary phosphate homeostasis and osteoclastogenesis emerge from the study of pulmonary alveolar microlithiasis. Nature Communications. 2023; 14:1205.

Bian, F; Lan, YW; Zhao, S; Deng, Z; Shukla, S; Acharya, A; Donovan, J; Le, T; Milewski, D; Bacchetta, M; et al. Lung endothelial cells regulate pulmonary fibrosis through FOXF1/R-Ras signaling. Nature Communications. 2023; 14:2560.

Guo, M; Wikenheiser-Brokamp, KA; Kitzmiller, JA; Jiang, C; Wang, G; Wang, A; Preissl, S; Hou, X; Buchanan, J; Karolak, JA; et al. Single Cell Multiomics Identifies Cells and Genetic Networks Underlying Alveolar Capillary Dysplasia. American Journal of Respiratory and Critical Care Medicine. 2023; 208:709-725.

Sikkema, L; Ramírez-Suástegui, C; Strobl, DC; Gillett, TE; Zappia, L; Madissoon, E; Markov, NS; Zaragosi, LE; Ji, Y; Ansari, M; et al. An integrated cell atlas of the lung in health and disease. Nature Medicine. 2023; 29:1563-1577.

Olatoke, T; Wagner, A; Astrinidis, A; Zhang, EY; Guo, M; Zhang, AG; Mattam, U; Kopras, EJ; Gupta, N; Smith, EP; et al. Single-cell multiomic analysis identifies a HOX-PBX gene network regulating the survival of lymphangioleiomyomatosis cells. Science Advances. 2023; 9:eadf8549.

Astrinidis, A; Li, C; Zhang, EY; Zhao, X; Zhao, S; Guo, M; Olatoke, T; Mattam, U; Huang, R; Zhang, AG; et al. Upregulation of acid ceramidase contributes to tumor progression in tuberous sclerosis complex. JCI insight. 2023; 8:e166850.

Minor, BM N; LeMoine, D; Seger, C; Gibbons, E; Koudouovoh, J; Taya, M; Kurtz, D; Xu, Y; Hammes, SR. Estradiol Augments Tumor-Induced Neutrophil Production to Promote Tumor Cell Actions in Lymphangioleiomyomatosis Models. Endocrinology. 2023; 164:bqad061.

Hudock, KM; Collins, MS; Imbrogno, MA; Kramer, EL; Brewington, JJ; Ziady, A; Zhang, N; Snowball, J; Xu, Y; Carey, BC; et al. Alpha-1 antitrypsin limits neutrophil extracellular trap disruption of airway epithelial barrier function. Frontiers in Immunology. 2023; 13:1023553.

Du, Y; Guo, M; Wu, Y; Wagner, A; Perl, AK; Wikenheiser-Brokamp, K; Yu, J; Gupta, N; Kopras, E; Krymskaya, V; et al. Lymphangioleiomyomatosis (LAM) Cell Atlas. Thorax. 2023; 78:85-87.

Stevens, J; Steinmeyer, S; Bonfield, M; Peterson, L; Wang, T; Gray, J; Lewkowich, I; Xu, Y; Du, Y; Guo, M; et al. The balance between protective and pathogenic immune responses to pneumonia in the neonatal lung is enforced by gut microbiota. Science Translational Medicine. 2022; 14:eabl3981.

Toth, A; Steinmeyer, S; Kannan, P; Gray, J; Jackson, CM; Mukherjee, S; Demmert, M; Sheak, JR; Benson, D; Kitzmiller, J; et al. Inflammatory blockade prevents injury to the developing pulmonary gas exchange surface in preterm primates. Science Translational Medicine. 2022; 14:eabl8574.

Bottasso-Arias, N; Leesman, L; Burra, K; Snowball, J; Shah, R; Mohanakrishnan, M; Xu, Y; Sinner, D. BMP4 and Wnt signaling interact to promote mouse tracheal mesenchyme morphogenesis. American Journal of Physiology: Lung Cellular and Molecular Physiology. 2022; 322:L224-L242.

Sun, X; Perl, AK; Li, R; Bell, SM; Sajti, E; Kalinichenko, VV; Kalin, TV; Misra, RS; Deshmukh, H; Clair, G; et al. A census of the lung: CellCards from LungMAP. Developmental Cell. 2022; 57:112-145.e2.

Gaddis, N; Fortriede, J; Guo, M; Bardes, EE; Kouril, M; Tabar, S; Burns, K; Ardini-Poleske, ME; Loos, S; Schnell, D; et al. LungMAP Portal Ecosystem: Systems-Level Exploration of the Lung. 2021; Preprint:2021.12.05.471312.

Gokey, JJ; Snowball, J; Sridharan, A; Sudha, P; Kitzmiller, JA; Xu, Y; Whitsett, JA. YAP regulates alveolar epithelial cell differentiation and AGER via NFIB/KLF5/NKX2-1. iScience. 2021; 24:102967.

Wang, G; Wen, B; Ren, X; Li, E; Zhang, Y; Guo, M; Xu, Y; Whitsett, JA; Kalin, TV; Kalinichenko, VV. Generation of Pulmonary Endothelial Progenitor Cells for Cell-based Therapy Using Interspecies Mouse-Rat Chimeras. American Journal of Respiratory and Critical Care Medicine. 2021; 204:326-338.

Sitaraman, S; Martin, EP; Na, CL; Zhao, S; Green, J; Deshmukh, H; Perl, AK T; Bridges, JP; Xu, Y; Weaver, TE. Surfactant protein C mutation links postnatal type 2 cell dysfunction to adult disease. JCI insight. 2021; 6:e142501.

Gokey, JJ; Snowball, J; Green, J; Waltamath, M; Spinney, JJ; Black, KE; Hariri, LP; Xu, Y; Perl, AK. Pretreatment of aged mice with retinoic acid supports alveolar regeneration via upregulation of reciprocal PDGFA signalling. Thorax. 2021; 76:456-467.

Milewski, D; Shukla, S; Gryder, BE; Pradhan, A; Donovan, J; Sudha, P; Vallabh, S; Pyros, A; Xu, Y; Barski, A; et al. FOXF1 is required for the oncogenic properties of PAX3-FOXO1 in rhabdomyosarcoma. Oncogene: Including Oncogene Reviews. 2021; 40:2182-2199.

Muus, C; Luecken, MD; Eraslan, G; Sikkema, L; Waghray, A; Heimberg, G; Kobayashi, Y; Vaishnav, ED; Subramanian, A; Smillie, C; et al. Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics. Nature Medicine. 2021; 27:546-559.

Wen, B; Li, E; Ustiyan, V; Wang, G; Guo, M; Na, CL; Kalin, GT; Galvan, V; Xu, Y; Weaver, TE; et al. In Vivo Generation of Lung and Thyroid Tissues from Embryonic Stem Cells Using Blastocyst Complementation. American Journal of Respiratory and Critical Care Medicine. 2021; 203:471-483.

Du, Y; Ouyang, W; Kitzmiller, JA; Guo, M; Zhao, S; Whitsett, JA; Xu, Y. Lung Gene Expression Analysis Web Portal Version 3: Lung-at-a-Glance. American Journal of Respiratory Cell and Molecular Biology. 2021; 64:146-149.

Guo, M; Yu, JJ; Perl, AK; Wikenheiser-Brokamp, KA; Riccetti, M; Zhang, EY; Sudha, P; Adam, M; Potter, A; Kopras, EJ; et al. Single-Cell Transcriptomic Analysis Identifies a Unique Pulmonary Lymphangioleiomyomatosis Cell. American Journal of Respiratory and Critical Care Medicine. 2020; 202:1373-1387.

Wang, A; Chiou, J; Poirion, OB; Buchanan, J; Valdez, MJ; Verheyden, JM; Hou, X; Kudtarkar, P; Narendra, S; Newsome, JM; et al. Single-cell multiomic profiling of human lungs reveals cell-type-specific and age-dynamic control of SARS-CoV2 host genes. eLife. 2020; 9:e62522.

Hudock, KM; Collins, MS; Imbrogno, M; Snowball, J; Kramer, EL; Brewington, JJ; Gollomp, K; McCarthy, C; Ostmann, AJ; Kopras, EJ; et al. Neutrophil extracellular traps activate IL-8 and IL-1 expression in human bronchial epithelia. American Journal of Physiology: Lung Cellular and Molecular Physiology. 2020; 319:L137-L147.

Sungnak, W; Huang, N; Bécavin, C; Berg, M; Queen, R; Litvinukova, M; Talavera-López, C; Maatz, H; Reichart, D; Sampaziotis, F; et al. SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. Nature Medicine. 2020; 26:681-687.

Oherle, K; Acker, E; Bonfield, M; Wang, T; Gray, J; Lang, I; Bridges, J; Lewkowich, I; Xu, Y; Ahlfeld, S; et al. Insulin-like Growth Factor 1 Supports a Pulmonary Niche that Promotes Type 3 Innate Lymphoid Cell Development in Newborn Lungs. Immunity. 2020; 52:275-294.e9.

Guo, M; Du, Y; Gokey, JJ; Ray, S; Bell, SM; Adam, M; Sudha, P; Perl, AK; Deshmukh, H; Potter, SS; et al. Single cell RNA analysis identifies cellular heterogeneity and adaptive responses of the lung at birth. Nature Communications. 2019; 10:37.

Ren, X; Ustiyan, V; Guo, M; Wang, G; Bolte, C; Zhang, Y; Xu, Y; Whitsett, JA; Kalin, TV; Kalinichenko, VV. Postnatal Alveologenesis Depends on FOXF1 Signaling in c-KIT+ Endothelial Progenitor Cells. American Journal of Respiratory and Critical Care Medicine. 2019; 200:1164-1176.

Guo, M; Yu, JJ; Perl, AK; Wikenheiser-Brokamp, KA; Riccetti, M; Zhang, EY; Sudha, P; Adam, M; Potter, A; Kopras, EJ; et al. Identification of the Lymphangioleiomyomatosis Cell and Its Uterine Origin. 2019.

Du, Y; Clair, GC; Al Alam, D; Danopoulos, S; Schnell, D; Kitzmiller, JA; Misra, RS; Bhattacharya, S; Warburton, D; Mariani, TJ; et al. Integration of transcriptomic and proteomic data identifies biological functions in cell populations from human infant lung. American Journal of Physiology: Lung Cellular and Molecular Physiology. 2019; 317:L347-L360.

Schmidt, AF; Kannan, PS; Bridges, JP; Filuta, A; Lipps, D; Kemp, M; Miller, LA; Kallapur, SG; Xu, Y; Whitsett, JA; et al. Dosing and formulation of antenatal corticosteroids for fetal lung maturation and gene expression in rhesus macaques. Scientific Reports. 2019; 9:9039.

Domany, KA; He, Z; Nava-Guerra, L; Khoo, MC K; Xu, Y; Hossain, MM; DiFrancesco, M; McConnell, K; Amin, RS. The effect of adenotonsillectomy on ventilatory control in children with obstructive sleep apnea. Sleep. 2019; 42:zsz045.

Prasse, A; Binder, H; Schupp, JC; Kayser, G; Bargagli, E; Jaeger, B; Hess, M; Rittinghausen, S; Vuga, L; Lynn, H; et al. BAL Cell Gene Expression Is Indicative of Outcome and Airway Basal Cell Involvement in Idiopathic Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine. 2019; 199:622-630.