Grom-Thornton Lab

Grom AA, Ilowite N, Brunner HI, Ruperto N, Martinin A, Lovell D, Pascual V, Lheritier K, Abrams K. Rate and Clinical Presentation of Macrophage Activation Syndrome in Patients With Systemic Juvenile Idiopathic Arthritis Treated With Canakinumab. 2016 Jan;68(1):218-28.

Schulert GS, Grom AA. Pathogenesis of macrophage activation syndrome and potential for cytokine-directed therapies. Annu Rev Med. 2015;66:145-59.

Schulert GS, Bobe K, McMasters  R, Campbell K, Leslie N, Grom AA. 11-Month-Old Infant With Periodic Fevers, Recurrent Liver Dysfunction, and Perforin Gene Polymorphism. Arthritis Care Res. 2015 Aug;67(8):1173-9. 

Raghu H, Cruz C, Rewerts CL, Frederick MD, Thornton S, Mullins ES, Schoenecker JG, Degen JD, Flick MJ. Transglutaminase factor XIII promotes arthritis in mice through mechanisms linked to inflammation and bone erosion. Blood. 2015 Jan 15;125(3):427-37. 

Kaufman KM, Linghu B, Joseph D. Szustakowski JD, A Husami, Yang F,  Zhang K, Filipovich A, Fall N, Harley JB, Nirmala NR, and Grom AA. Whole Exome Sequencing Reveals Overlap Between  Macrophage Activation Syndrome in Systemic Juvenile Idiopathic Arthritis and Familial Hemophagocytic Lymphohistiocytosis. Arthritis& Rheum. 2014 66:3486-95.

Grom AA. Canakinumab for systemic juvenile idiopathic arthritis. Expert Rev Clin Immunol. 2014 101427-35.

Minoia F, Davì S, Horne A, Demirkaya E, Bovis F, Li C, Lehmberg K, Weitzman S, Insalaco A, Wouters C, Shenoi S, Espada G, Ozen S, Anton J, Khubchandani R, Russo R, Pal P, Kasapcopur O, Miettunen P, Maritsi D, Merino R, Shakoory B, Alessio M, Chasnyk V, Sanner H, Gao Y, Huasong Z, Kitoh T, Avcin T, Fischbach M, Frosch M, Grom AA, Huber A, Jelusic M, Sawhney S, Uziel Y, Ruperto N, Martini A, Cron RQ, Ravelli A. Clinical features, treatment and outcome of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis A multinational, multicenter study of 362 patients. Arthritis Rheumatol. 2014 66:3160-9.

Canna SW, Almeida de Jesus A, Gouni S, Brooks SR, Marrero B, Liu Y, Dimattia M, Zaal KJM, Montealegre-Sanchez G, Kim H, Chapelle D, Plass N, Huang Y, Biancotto A, Fleisher TA, J. Duncan A, O’Shea JJ, Benseler S, Grom AA, Laxer RM, and R Goldbach-Mansky. An activating NLRC4 inflammasome mutation causes a novel autoinflammatory syndrome presenting with recurrent Macrophage Activation Syndrome. Nature Genetics. 2014 Oct;46(10):1140-6.

Schulert GS, Grom AA. Macrophage activation syndrome and cytokine directed therapy. Best Pract Res Clin Rheumatol. 2014 Apr;28(2):277-92.

Chu Z, LaSance K, Blanco V, Stevens A, Kwon C-H, Kaur B, Frederick M, Thornton S, Lemen L, Qi X. In vivo optical imaging of brain tumors and arthritis using fluorescent SapC-DOPS nanovesicles. JoVEJ Vis Exp. 2014 May 2;(87).

Raghu H, Jone A, Cruz C, Frederick MD, Thornton S, Degen JL, Flick MJ. Plasminogen is a joint-specific positive or negative determinant of arthritis pathogenesis in mice. Arthritis Rheumatotol. 2014 Jun; 66(6): 1504-16.

Sumegi J, Nestheide SV, Barnes MG, Villanueva J, Zhang K, Grom AA, Filipovich AH. Gene Expression Signatures Differ Between Different Clinical Forms Of Familial Hemophagocytic Lymphohistiocytosis. Blood. 2013 Feb 14;121(7):e14-24.

Gorelik M, Fall N, Altaye M, Barnes M, Thompson S, Grom AA, Hirsch R. Follistatin-Like Protein 1 and the Ferritin – Erythrocyte Sedimentation Rate ratio are potential Biomarkers for Dysregulated Gene Expression and Macrophage Activation Syndrome in Systemic Juvenile Idiopathic Arthritis. J Rheumatol. 2013 Jul;40(7):1191-9.

Wojton, J., Chu, Z., Matsyaraja, H., Meisen, W.H., Denton, N., Kwon, C-H, Chow, L., Palascak, M., Franco, R., Bourdeau, T., Thornton, S., Ostrowski, MC, Kaur, B., and Qi, X. Systemic delivery of SapC-DOPS has antiangiogenic and antitumor effects against glioblastoma. Mol Ther. 2013 Aug;21(8):1517-25.

Sikora K, Fall N, Thornton S, Grom, AA. The Limited Role of Interferon-γ in Systemic Juvenile idiopathic Arthritis Cannot Be Explained by Cellular Hyporesponsiveness. Arthritis Rheum. 2012 Nov;64(11):3799-808.

Qi X, Flick MJ, Frederick M, Chu Z, Mason R, DeLay M, Thornton S. Saposin C Coupled Lipid Nanovesicles Specifically Target Arthritic Mouse Joints for Optical Imaging of Disease Severity. PLoS ONE. 2012;7(3):e33966.

Ercan A, Barnes MG, Hazen M, Tory H, Henderson L, Dedeoglu F, Fuhlbrigge RC, Grom AA, Holm IA, Kellogg M, Kim S, Adamczyk B, Rudd PM, Son MB, Sundel RP, Foell D, David N. Glass DN, Thompson SD, and PA. Nigrovic. Multiple juvenile idiopathic arthritis subtypes demonstrate pro-inflammatory IgG glycosylation. Arthritis Rheum. 2012 Sep;64(9):3025-33.

De Benedetti F, Brunner HI, Ruperto N, Kenwright, A, Ravelli A, Schneider, Woo P, Wouters C, Zemel, L, Burgos-Vargos R, Dolezalova P, Grom AA, Wulffraat N, Zuber Z, Zulian F, Lovell D and Martini A. Tocilizumab in systemic juvenile idiopathic arthritis:a randomized trial. New Engl J Med. 2012 Dec 20;367(25):2385-95.

 Ravelli A, Grom AA, Behrens E, and RQ Cron. Macrophage Activation Syndrome as Part of Systemic Juvenile Idiopathic Arthritis: Diagnosis, Genetics, Pathophysiology, and Treatment. Genes & Immunity. 2012 Jun;13(4):289-98.

Giannini EH, Ilowite NT, Sandborg CI, Feldman BM, Grom AA, Schanberg LE, Wallace CA, Schneider R, Kenney K, Gottlieb BS, Hashkes PJ, Imundo LF, Kimura Y, Lang BA, Miller ML, Milojevic D, O'Neil KM, Punaro MG, Ruth NM, Singer NG, Vehe RK, Verbsky J, Woodward A, and LS Zemel. Algorithm Development for Corticosteroid Management in Systemic Juvenile Idiopathic Arthritis Trial Using Consensus Methodology. Pediatric Rheumatology. 2012 Aug 29;10(1):31.

Ruperto N, Brunner HI, Quartier P, Constantin T, Wulfraat N, Horneff G, Brik R, McCann L, Nistala K, Wouters C, Cimaz R, Ferrandiz MA, Flato B, Grom AA, Magnusson, Ozen S, Abrams K, Kim D, Martini A, Lovell DJ. Canakinumab in systemic juvenile arthritis with active systemic features. New Engl J Med. 2012 Dec 20;367(25):2396-406.

Grom AA. Macrophage Activation Syndrome. In: Isenberg DA, Maddison PJ, Woo P, Glass DN, Breedveld FC (eds) Oxford Textbook of Rheumatology, Oxford University Press, Oxford. 2012.

Mellins ED, Macubas C, Grom AA. Pathogenesis of systemic juvenile idiopathic arthritis: some answers, more questions. Nature Reviews Rheumatology. 2011 Jun 7;7(7):416-26.

Sumegi J, Barnes MG, Lee S, Villanueva J, Zhang K, Nestheide SV, Risma K, Grom AA, and AH Filipovich. Gene Expression Profiling of peripheral blood mononuclear cells from patients with untreated familial hemophagocytic lymphohistiocytosis. Blood. 2011 Apr 14;117(15):e151-60.

Davi S, Consolaro A, Guseinova D, Pistorio A, Ruperto N, Martini, Cron RQ, Ravelli A and MAS Study Group (Behrens EM, Benseler S, Grom AA, Katsikas M, Lang B, Miettunen P, Ozen S, Ramanan A, Russo R, Schneider R, Sterba G, Wouters C). An International Consensus Survey of Diagnostic Criteria for Macrophage Activation Syndrome in Systemic Juvenile Idiopathic Arthritis. J Rheumatol. 2011 38:764-768.

Flick MJ, Chauhan AK, Frederick M, Talmage KE, Kombrinck KW, Miller W, Mullins ES, Palumbo JS, Zheng X, Esmon NL, Esmon CT, Thornton S, Becker A, Pelc LA, Di Cera E, Wagner DD, Degen JL. The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A. Blood. 2011 Jun 9;117(23):6326-37.

Barnes MG, Grom AA, Thompson SD, Griffin TA, Luyrink LK, Colbert, RA, David N, Glass DN. Biologic similarities based on age at onset in oligoarticular and polyarticular subtypes of juvenile idiopathic arthritis. Arthritis Rheum. 2010 Nov;62(11):3249-58.

Hinze CH, Fall N, Thornton S, Griffin TA, Thompson SD, Colbert RA, Glass DN, Michael G, Barnes BG, Grom AA. Immature cell populations and an erythropoiesis gene-expression signature in systemic juvenile idiopathic arthritis: implications for pathogenesis. Arthritis Res Ther. 2010;12(3):R123.

Barnes BG, Grom AA, Griffin TA, Colbert RA, Thompson SD. Gene expression profiles from peripheral blood mononuclear cells are sensitive to short processing delays. Biopreservation and Biobanking. 2010 Sep 29;8(3):153-162.

Parodi A, Davì S, Pringe AB, Pistorio A, Ruperto N,  Magni-Manzoni S, MD, Miettunen P, Bader-Meunier B, Espada G, Sterba G, Ozen S, Wright D, Saad Magalhães C,  Khubchandani R, Michels H, Woo P, Toro Gutiérrez CE, Guseinova D, Cortis E,  Kristen Hayward, Wouters C, Grom AA, Vivarelli M, Fischer KA,  Martini A,  Ravelli A. Macrophage Activation Syndrome in Juvenile Systemic Lupus Erythematosus: a multinational multicenter study of 38 patients. Arthritis Rheum. 2009 Nov;60(11):3388-99.

Barnes MG, Grom AA, Thompson SD, Ilowite NT, Olson JC, Sherry DD, Gottlieb BS, Aronow BJ, Pavlidis P, Hinze C, Thornton S, Griffin TA, Colbert CA, DN Glass. Gene Expression Signatures in new onset untreated juvenile idiopathic arthritis. Arthritis Rheum. 2009 60:2102-12.

Griffin TA, Barnes MG, Ilowite NT, Olson JC, Sherry DD, Gottlieb BS, Aronow BJ, Pavlidis P, Hinze C, Thornton S, Thompson SD, Grom AA, Colbert CA, DN Glass. Gene Expression Signatures in Polyarticular Juvenile Idiopathic Arthritis Demonstrate Disease Heterogeneity and Offer a Molecular Classification of Disease Subsets. Arthritis Rheum. 2009 Jul;60(7):2113-23.

Zhang K, Biroscak J, Glass DN, Thompson S, Finkel T, Murray P, Binstadt B, Filipovich A, Grom AA. Macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis is associated with MUNC13D polymorphisms. Arthritis Rheum. 2008 Sep;58(9):2892-6.

Hazen MM, Woodward AL, Hofman I, Degar BA, Grom AA, Filipovich AH, Binstadt BA. Mutations of the hemophagocytosis-associated gene UNC13D in a patient with systemic juvenile idiopathic arthritis. Arthritis Rheum. 2008 Feb;58(2):567-70.

Fall N, Barnes M, Thornton S, Luyrink L, Olson J, Ilowite NT, Gottlieb E, Griffin T, Sherry DD, Thompson S, Glass DN, Colbert RA, Grom AA. Gene expression profiling in peripheral blood from patients with  untreated new-onset systemic juvenile idiopathic arthritis reveals molecular heterogeneity that may predict macrophage activation syndrome. Arthritis Rheum. 2007 Nov;56(11):3793-804.

Shishov M, Henrickson M, Burgos-Vargas R, Rubio-Perez NE, Baca V, Romero-Feregrino R, Solis-Vallejo, Huang B, Grom AA, Lovell DJ. Systemic features and early prognostic factors in Hispanic and non-Hispanic children from the United States and Mexico with systemic juvenile idiopathic arthritis. Clin Exp Rhematol. 2007 Nov-Dec;25(6):907-14.

Bleesing J, Prada E, Siegel DM, Villanueva J, Olson J, Ilowite N, Brunner HI, Griffin T, Graham TB, Sherry DD, Passo MH, Filipovich A, Grom AA. The diagnostic significance of soluble CD163 and soluble interleukin-2 receptor alpha-chain in macrophage activation syndrome and untreated new-onset systemic juvenile idiopathic arthritis. Arthritis Rheum. 2007 Mar;56(3):965-71.

Flick, MJ, La Jeunesse CM, Talmage KE, Witte DP, Palumbo JS, Pinkerton MD, Thornton S, Degen JL. Fibrin(ogen) exacerbates inflammatory joint disease through a mechanism linked to the integrin alphaMbeta2 binding motif. J Clin Invest. 2007 Nov;117(11):3224-35.

Pasternak B, Grom AA, Yazigi N, Cohen M. Suppurative Peripheral Arthritis in Inflammatory Bowel Disease. J Pediatr Gastroenterology & Nutrition. 2007 Jul;45(1):117-20.

Brunner HI, Mueller M, Rutherford C, Passo MH, Grom AA, Mishra J, Devarajan P. Urinary Neutrophil Gelatinase Associated Lipocalin (NGAL) as a Biomarker of Nephritis in Childhood-onset Systemic Lupus Erythematosus. Arthritis Rheum. 2006 Aug;54(8):2577-84.

Fall N, Bove KE, Stringer KF, Lovell DJ, Brunner HI, Weiss J, Higgins GC, Bowyer SL, Graham TB, Thornton S, Grom AA. Association between lack of angiogenic response in muscle tissue and high expression of angiostatic ELR-negative CXC chemokines in patients with juvenile dermatomyositis: possible link to vasculopathy.Arthritis Rheum. 2005 Oct;52(10):3175-80.

Ramanan AV, Grom AA. Does systemic-onset juvenile idiopathic arthritis belong under juvenile idiopathic arthritis. Rheumatology (Oxford). 2005 Nov;44(11):1350-3.

Herman LM, Pinkerton M, Jennings, Yang L, Grom AA, Sowders D, Kersten S, Witte D, Hirsch R, Thornton S. Angiopoietin-like-4 is a potential angiogenic mediator in arthritis. Clin Immunol. 2005 Apr;115(1):93-101.

Villanueva J, Lee S, Giannini EH, Graham TB, Passo MH Filipovich AH, Grom AA. Natural killer cell dysfunction is a distinguishing feature of systemic onset juvenile rheumatoid arthritis and macrophage activation syndrome. Arthritis Res Ther. 2005;7(1):R30-7.

Barnes M, Aronow B, Luyrink L, Moroldo M, Pavlidis P, Passo MH, Grom AA, Hirsch R, Giannini EH, Colbert R, Glass DN, Thompson S. Gene expression in juvenile arthritis and spondyloarthropathy:  pro-angiogenic ELR+ chemokine genes relate to course of arthritis. Rheumatology (Oxford). 2004 Aug;43(8):973-9.

Thornton S, Sowders D, Aronow B, Witte DP, Brunner HI, Giannini EH, Hirsch R. DNA microarray analysis reveals novel gene expression profiles in collagen-induced arthritis. Clinical Immunology. 2002 Nov;105(2):155-68.

Grom AA. Macrophage Activation Syndrome.  In: Cassidy, Petty, Laxer Lindsley, eds. Textbook of Pediatric Rheumatology, Chapter 49, 7th edition 2014.

Schulert GS and Grom AA. Macrophage activation syndrome and cytokine directed therapies. Best Practice &Research Clin Rheumatol 2014;28:277-92.

Nirmala N, Grom AA, Gram H. Biomarkers in Systemic Juvenile Idiopathic Arthritis: a Comparison with Biomarkers in Cryopyrin-associated Periodic Syndromes. Curr Opin Rheumatol 2014 (in press).

Schulert GS and Grom AA. Pathogenesis of Macrophage Activation Syndrome and Potential for Cytokine-directed Therapies. Ann Rev Med 2015 (in press)

Grom AA. Juvenile Idiopathic Arthritis: Genetics. In: MacKay I, Rose NR (eds). Encyclopedia of Medical Immunology Springer-Verlag New York, LLC, 2013

Grom AA.  Macrophage Activation Syndrome. In: Isenberg DA, Maddison PJ, Woo P, Glass DN, Breedveld FC (eds) Oxford Textbook of Rheumatology, Oxford University Press, Oxford, 2012 (in press).

Grom AA. Systemic Juvenile Idiopathic Arthritis: Pathogenesis and Targets for Biologic Therapy. Current Pediatrics (Moscow) 2012;11:28-33.

Sikora KA, Grom AA. Update on Pathophysiology and Treatment of Systemic Juvenile Idiopathic Arthritis. Current Opin Pediatr 2011;23:640-6.

Grom AA . Fever and the inflammatory response. In: Long, Pickering, and Prober (eds) Principles and Practice of Pediatric Infectious Diseases, Fourth Edition, Elsevier, New York, 2011 (Chapter 11).

Grom AA and Glass DN. Juvenile Idiopathic Arthritis: Epidemiology and Pathogenesis. UpToDate®.

Grom AA and Jordan MB. In Nabel EG and Fox D. ACP Medicine 2011. Section 6, Immunology/Allergy. Chapter 10. Disorders of Antigen-Presenting Cells.

Grom AA, Mellins ED. Macrophage activation syndrome: advances towards understanding pathogenesis. Curr Opin Rheumatol. 2010.

Thompson SD, Barnes MG, Griffin TA , Grom AA, Glass DN. Heterogeneity in juvenile idiopathic arthritis: impact of molecular profiling based on DNA polymorphism and gene expression patterns. Arthritis Rheum. 2010.

Grom AA. Macrophage Activation Syndrome. In: Cassidy, Petty, Laxer Lindsley, eds. Textbook of Pediatric Rheumatology, 6th edition. 2009.

Filipovich A, McClain K, Grom AA. Histiocytic Disorders: recent insights into pathophysiology and practical guidelines. Biol Blood Marrow Transplant. 16:S82-89. 2009.

Vastert SJ, Kuis W, Grom AA. Systemic Juvenile Idiopathic Arthritis: new developments in the understanding of the pathophysiology and therapy. Best Pract Res Clin Rheumatol. 23:655-64. 2009.

 Hinze C, Grom AA. B cell depletion: on the rise. J Pediatr. 2007 Apr;150(4):335-7.

Grom AA. Fever and the inflammatory response. In: Long, Pickering, and Prober (eds). Principles and Practice of Pediatric Infectious Diseases, Third Edition, Elsevier, New York, (Chapter 11), p 94-98. 2006.