Grom-Thornton Lab

Angeles-Han, ST; Miraldi Utz, V; Thornton, S; Schulert, G; Rodriguez-Smith, J; Kauffman, A; Sproles, A; Mwase, N; Hennard, T; Grom, A; et al. S100 Proteins, Cytokines, and Chemokines as Tear Biomarkers in Children with Juvenile Idiopathic Arthritis-associated Uveitis. Ocular Immunology and Inflammation. 2021; 1-5.

Gao, DK; Salomonis, N; Henderlight, M; Woods, C; Thakkar, K; Grom, AA; Thornton, S; Jordan, MB; Wikenheiser-Brokamp, KA; Schulert, GS. IFN-γ is essential for alveolar macrophage-driven pulmonary inflammation in macrophage activation syndrome. JCI insight. 2021; 6.

Rodriguez-Smith, JJ; Verweyen, EL; Clay, GM; Esteban, YM; de Loizaga, SR; Baker, EJ; Do, T; Dhakal, S; Lang, SM; Grom, AA; et al. Inflammatory biomarkers in COVID-19-associated multisystem inflammatory syndrome in children, Kawasaki disease, and macrophage activation syndrome: a cohort study. The Lancet. Rheumatology. 2021; 3:e574-e584.

Verweyen, EL; Pickering, A; Grom, AA; Schulert, GS. Distinct Gene Expression Signatures Characterize Strong Clinical Responders Versus Nonresponders to Canakinumab in Children With Systemic Juvenile Idiopathic Arthritis. Arthritis and Rheumatology. 2021; 73:1334-1340.

Cheung, P; Schaffert, S; Chang, SE; Dvorak, M; Donato, M; Macaubas, C; Foecke, MH; Li, TM; Zhang, L; Coan, JP; et al. Repression of CTSG, ELANE and PRTN3-mediated histone H3 proteolytic cleavage promotes monocyte-to-macrophage differentiation. Nature Immunology. 2021; 22:711-722.

Luo, S; Clarke, SL N; Ramanan, AV; Thompson, SD; Langefeld, CD; Marion, MC; Grom, AA; Schooling, CM; Gaunt, TR; Yeung, SL A; et al. Platelet Glycoprotein Ib α-Chain as a Putative Therapeutic Target for Juvenile Idiopathic Arthritis: A Mendelian Randomization Study. Arthritis and Rheumatology. 2021; 73:693-701.

Aspland, AM; Douagi, I; Filby, A; Jellison, ER; Martinez, L; Shinko, D; Smith, AL; Tang, VA; Thornton, S. Biosafety during a pandemic: shared resource laboratories rise to the challenge. Cytometry. Part A : the journal of the International Society for Analytical Cytology. 2021; 99:68-80.

Daniels, K; Conway, A; Gardner, R; Martinez, L; Price, KM; Schneider, S; Sheridan, R; Srivastava, J; Thornton, S. Remote Training of SRL Users and Staff in a Global Pandemic. Cytometry. Part A : the journal of the International Society for Analytical Cytology. 2021; 99:42-50.

Aljaberi, N; Tronconi, E; Schulert, G; Grom, AA; Lovell, DJ; Huggins, JL; Henrickson, M; Brunner, HI. The use of S100 proteins testing in juvenile idiopathic arthritis and autoinflammatory diseases in a pediatric clinical setting: a retrospective analysis. Pediatric Rheumatology. 2020; 18.

Lin, B; Berard, R; Al Rasheed, A; Aladba, B; Kranzusch, PJ; Henderlight, M; Grom, A; Kahle, D; Torreggiani, S; Aue, AG; et al. A novel STING1 variant causes a recessive form of STING-associated vasculopathy with onset in infancy (SAVI). Journal of Allergy and Clinical Immunology. 2020; 146:1204-1208.e6.

Box, A; Delay, M; Tighe, S; Chittur, SV; Bergeron, A; Cochran, M; Lopez, P; Meyer, EM; Saluk, A; Thornton, S; et al. Evaluating the Effects of Cell Sorting on Gene Expression. Journal of Biomolecular Techniques. 2020.

Box, A; DeLay, M; Tighe, S; Chittur, SV; Bergeron, A; Cochran, M; Lopez, P; Meyer, EM; Saluk, A; Thornton, S; et al. Evaluating the Effects of Cell Sorting on Gene Expression. Journal of Biomolecular Techniques. 2020; 31:100-111.

Brundage, K; Abshari, M; Adams, D; Bispo, C; Bowen, S; Cochran, M; Harley, R; Hassel, C; Heyward, F; Kollipara, A; et al. Single cell sorting - a survey of practices. Journal of Biomolecular Techniques. 2020; 31.

Canna, SW; Schulert, GS; de Jesus, A; Pickering, A; Brunner, H; Gadina, M; Levine, S; Goldbach-Mansky, R; Boutelle, J; Sinha, R; et al. Proceedings from the 2nd Next Gen Therapies for Systemic Juvenile Idiopathic Arthritis and Macrophage Activation Syndrome symposium held on October 3-4, 2019. Pediatric Rheumatology. 2020; 18.

Henderson, LA; Canna, SW; Schulert, GS; Volpi, S; Lee, PY; Kernan, KF; Caricchio, R; Mahmud, S; Hazen, MM; Halyabar, O; et al. On the Alert for Cytokine Storm: Immunopathology in COVID-19. Arthritis and Rheumatology. 2020; 72:1059-1063.

Locatelli, F; Jordan, MB; Allen, C; Cesaro, S; Rizzari, C; Rao, A; Degar, B; Garrington, TP; Sevilla, J; Putti, M; et al. Emapalumab in Children with Primary Hemophagocytic Lymphohistiocytosis. New England Journal of Medicine. 2020; 382:1811-1822.

de Jesus, AA; Hou, Y; Brooks, S; Malle, L; Biancotto, A; Huang, Y; Calvo, KR; Marrero, B; Moir, S; Oler, AJ; et al. Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases. Journal of Clinical Investigation. 2020; 130:1669-1682.

Verweyen, E; Holzinger, D; Weinhage, T; Hinze, C; Wittkowski, H; Pickkers, P; Albeituni, S; Verbist, K; Nichols, KE; Schulert, G; et al. Synergistic Signaling of TLR and IFNα/β Facilitates Escape of IL-18 Expression from Endotoxin Tolerance. American Journal of Respiratory and Critical Care Medicine. 2020; 201:526-539.

Yasin, S; Fall, N; Brown, RA; Henderlight, M; Canna, SW; Girard-Guyonvarc'h, C; Gabay, C; Grom, AA; Schulert, GS. IL-18 as a biomarker linking systemic juvenile idiopathic arthritis and macrophage activation syndrome. Rheumatology. 2020; 59:361-366.

Yasin, S; Solomon, K; Canna, SW; Girard-Guyonvarc'h, C; Gabay, C; Schiffrin, E; Sleight, A; Grom, AA; Schulert, GS. IL-18 as therapeutic target in a patient with resistant systemic juvenile idiopathic arthritis and recurrent macrophage activation syndrome. Rheumatology. 2020; 59:442-445.

Saper, VE; Chen, G; Deutsch, GH; Guillerman, RP; Birgmeier, J; Jagadeesh, K; Canna, S; Schulert, G; Deterding, R; Xu, J; et al. Emergent high fatality lung disease in systemic juvenile arthritis. Annals of the Rheumatic Diseases. 2019; 78:1722-1731.

Leong, JY; Chen, P; Yeo, JG; Ally, F; Chua, C; Hazirah, SN; Poh, SL; Pan, L; Lai, L; Lee, ES C; et al. Immunome perturbation is present in patients with juvenile idiopathic arthritis who are in remission and will relapse upon anti-TNFα withdrawal. Annals of the Rheumatic Diseases. 2019; 78:1712-1721.

Loof, N; Mehrnoosh, A; Bergeron, A; Saluk, A; Box, A; Brundage, K; Adams, D; Dwyer, K; Meyer, E; Cochran, M; et al. FCRG - Fixation and Sorting for RNA. Journal of Biomolecular Techniques. 2019; 30.

Schulert, GS; Yasin, S; Carey, B; Chalk, C; Do, T; Schapiro, AH; Husami, A; Watts, A; Brunner, HI; Huggins, J; et al. Systemic Juvenile Idiopathic Arthritis-Associated Lung Disease: Characterization and Risk Factors. Arthritis and Rheumatology. 2019; 71:1943-1954.

Grom, AA. Genetics of Macrophage Activation Syndrome in Systemic Juvenile Idiopathic Arthritis. Cytokine Storm Syndrome. 2019.

Brunner, HI; Holland, MJ; Beresford, MW; Ardoin, SP; Appenzeller, S; Silva, CA; Flores, F; Aydin, PO A; Wenderfer, SE; Levy, DM; et al. American College of Rheumatology Provisional Criteria for Clinically Relevant Improvement in Children and Adolescents With Childhood-Onset Systemic Lupus Erythematosus. Arthritis Care and Research. 2019; 71:579-590.

Hinze, CH; Foell, D; Johnson, AL; Spalding, SJ; Gottlieb, BS; Morris, PW; Kimura, Y; Onel, K; Li, SC; Grom, AA; et al. Serum S100A8/A9 and S100A12 Levels in Children With Polyarticular Forms of Juvenile Idiopathic Arthritis: Relationship to Maintenance of Clinically Inactive Disease During Anti-Tumor Necrosis Factor Therapy and Occurrence of Disease Flare After Discontinuation of Therapy. Arthritis and Rheumatology. 2019; 71:451-459.

Thornton, S; Tan, R; Sproles, A; Do, T; Schick, J; Grom, AA; DeLay, M; Schulert, GS. A Multiparameter Flow Cytometry Analysis Panel to Assess CD163 mRNA and Protein in Monocyte and Macrophage Populations in Hyperinflammatory Diseases. Journal of Immunology. 2019; 202:1635-1643.

Turnier, JL; Brunner, HI; Bennett, M; Aleed, A; Gulati, G; Haffey, WD; Thornton, S; Wagner, M; Devarajan, P; Witte, D; et al. Discovery of SERPINA3 as a candidate urinary biomarker of lupus nephritis activity. Rheumatology. 2019; 58:321-330.

Angeles-Han, ST; Yeh, S; Patel, P; Duong, D; Jenkins, K; Rouster-Stevens, KA; Altaye, M; Fall, N; Thornton, S; Prahalad, S; et al. Discovery of tear biomarkers in children with chronic non-infectious anterior uveitis: a pilot study. Journal of Ophthalmic Inflammation and Infection. 2018; 8.

Lovell, DJ; Johnson, AL; Huang, B; Gottlieb, BS; Morris, PW; Kimura, Y; Onel, K; Li, SC; Grom, AA; Taylor, J; et al. Risk, Timing, and Predictors of Disease Flare After Discontinuation of Anti-Tumor Necrosis Factor Therapy in Children With Polyarticular Forms of Juvenile Idiopathic Arthritis With Clinically Inactive Disease. Arthritis and Rheumatology. 2018; 70:1508-1518.

Throm, AA; Moncrieffe, H; Orandi, AB; Pingel, JT; Geurs, TL; Miller, HL; Daugherty, AL; Malkova, ON; Lovell, DJ; Thompson, SD; et al. Identification of enhanced IFN-γ signaling in polyarticular juvenile idiopathic arthritis with mass cytometry. JCI insight. 2018; 3.

Harry, O; Schulert, GS; Frenck, RW; Shapiro, AH; Woltmann, JL; Smith, JA; Grom, AA. Cat-Scratch Disease, a Diagnostic Consideration for Chronic Recurrent Multifocal Osteomyelitis. Journal of Clinical Rheumatology. 2018; 24:287-290.

Arthur, VL; Shuldiner, E; Remmers, EF; Hinks, A; Grom, AA; Foell, D; Martini, A; Gattorno, M; Ozen, S; Prahalad, S; et al. IL1RN Variation Influences Both Disease Susceptibility and Response to Recombinant Human Interleukin-1 Receptor Antagonist Therapy in Systemic Juvenile Idiopathic Arthritis. Arthritis and Rheumatology. 2018; 70:1319-1330.

Schulert, GS; Zhang, M; Husami, A; Fall, N; Brunner, H; Zhang, K; Cron, RQ; Grom, AA. Brief Report: Novel UNC13D Intronic Variant Disrupting an NF-κB Enhancer in a Patient With Recurrent Macrophage Activation Syndrome and Systemic Juvenile Idiopathic Arthritis. Arthritis and Rheumatology. 2018; 70:963-970.

Prencipe, G; Caiello, I; Pascarella, A; Grom, AA; Bracaglia, C; Chatel, L; Ferlin, WG; Marasco, E; Strippoli, R; de Min, C; et al. Neutralization of IFN-γ reverts clinical and laboratory features in a mouse model of macrophage activation syndrome. Journal of Allergy and Clinical Immunology. 2018; 141:1439-1449.

Giannelou, A; Wang, H; Zhou, Q; Park, YH; Abu-Asab, MS; Ylaya, K; Stone, DL; Sediva, A; Sleiman, R; Sramkova, L; et al. Aberrant tRNA processing causes an autoinflammatory syndrome responsive to TNF inhibitors. Annals of the Rheumatic Diseases. 2018; 77:612-619.

Weiss, ES; Girard-Guyonvarc'h, C; Holzinger, D; de Jesus, AA; Tariq, Z; Picarsic, J; Schiffrin, EJ; Foell, D; Grom, AA; Ammann, S; et al. Interleukin-18 diagnostically distinguishes and pathogenically promotes human and murine macrophage activation syndrome. Blood. 2018; 131:1442-1455.

Do, T; Tan, R; Bennett, M; Medvedovic, M; Grom, AA; Shen, N; Thornton, S; Schulert, GS. MicroRNA networks associated with active systemic juvenile idiopathic arthritis regulate CD163 expression and anti-inflammatory functions in macrophages through two distinct mechanisms. Journal of Leukocyte Biology. 2018; 103:71-85.

Grom, AA; Horne, AC; De Benedetti, F. Macrophage Activation Syndrome in Rheumatic Diseases (MAS-HLH). Histiocytic Disorders. 2018.

Schulert, GS; Grom, AA. Fever and the Inflammatory Response. Principles and Practice of Pediatric Infectious Diseases. 2018.

Schulert, GS; Grom, AA. 10 Fever and the Inflammatory Response. Principles and Practice of Pediatric Infectious Diseases. 2018.

Brachat, AH; Grom, AA; Wulffraat, N; Brunner, HI; Quartier, P; Brik, R; McCann, L; Ozdogan, H; Rutkowska-Sak, L; Schneider, R; et al. Early changes in gene expression and inflammatory proteins in systemic juvenile idiopathic arthritis patients on canakinumab therapy. Arthritis Research and Therapy. 2017; 19.

Turnier, JL; Fall, N; Thornton, S; Witte, D; Bennett, MR; Appenzeller, S; Klein-Gitelman, MS; Grom, AA; Brunner, HI. Urine S100 proteins as potential biomarkers of lupus nephritis activity. Arthritis Research and Therapy. 2017; 19.

Grom, AA. Primary Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome: The Importance of Timely Clinical Differentiation. Journal of Pediatrics. 2017; 189:19-21.e1.

Minoia, F; Bovis, F; Davì, S; Insalaco, A; Lehmberg, K; Shenoi, S; Weitzman, S; Espada, G; Gao, YJ; Anton, J; et al. Development and Initial Validation of the Macrophage Activation Syndrome/Primary Hemophagocytic Lymphohistiocytosis Score, a Diagnostic Tool that Differentiates Primary Hemophagocytic Lymphohistiocytosis from Macrophage Activation Syndrome. Journal of Pediatrics. 2017; 189:72-78.e3.

Moncrieffe, H; Bennett, MF; Tsoras, M; Luyrink, LK; Johnson, AL; Xu, H; Dare, J; Becker, ML; Prahalad, S; Rosenkranz, M; et al. Transcriptional profiles of JIA patient blood with subsequent poor response to methotrexate. Rheumatology. 2017; 56:1542-1551.

Kopec, AK; Abrahams, SR; Thornton, S; Palumbo, JS; Mullins, ES; Divanovic, S; Weiler, H; III, OA P; Mackman, N; Goss, A; et al. Thrombin promotes diet-induced obesity through fibrin-driven inflammation. Journal of Clinical Investigation. 2017; 127:3152-3166.

Kessel, C; Lippitz, K; Weinhage, T; Hinze, C; Wittkowski, H; Holzinger, D; Fall, N; Grom, AA; Gruen, N; Foell, D. Proinflammatory Cytokine Environments Can Drive Interleukin-17 Overexpression by γ/δ T Cells in Systemic Juvenile Idiopathic Arthritis. Arthritis and Rheumatology. 2017; 69:1480-1494.

Valieva, S; Bzarova, T; Nikishina, I; Rodionovskaya, S; Mizuta, M; Yachie, A; Sugita, Y; Okamoto, N; Shabana, K; Murata, T; et al. Proceedings of the 23rd Paediatric Rheumatology European Society Congress: part two. Pediatric Rheumatology. 2017; 15.

Ombrello, MJ; Arthur, VL; Remmers, EF; Hinks, A; Tachmazidou, I; Grom, AA; Foell, D; Martini, A; Gattorno, M; Ozen, S; et al. Genetic architecture distinguishes systemic juvenile idiopathic arthritis from other forms of juvenile idiopathic arthritis: clinical and therapeutic implications. Annals of the Rheumatic Diseases. 2017; 76:906-913.

Shaw, MA; Gao, Z; McElhinney, KE; Thornton, S; Flick, MJ; Lane, A; Degen, JL; Ryu, JK; Akassoglou, K; Mullins, ES. Plasminogen Deficiency Delays the Onset and Protects from Demyelination and Paralysis in Autoimmune Neuroinflammatory Disease. Journal of Neuroscience. 2017; 37:3776-3788.

Thornton, S; Raghu, H; Cruz, C; Frederick, MD; Palumbo, JS; Mullins, ES; Almholt, K; Usher, PA; Flick, MJ. Urokinase plasminogen activator and receptor promote collagen-induced arthritis through expression in hematopoietic cells. Blood Advances. 2017; 1:545-556.