Grom-Thornton Lab

Aljaberi, N; Tronconi, E; Schulert, G; Grom, AA; Lovell, DJ; Huggins, JL; Henrickson, M; Brunner, HI. The use of S100 proteins testing in juvenile idiopathic arthritis and autoinflammatory diseases in a pediatric clinical setting: A retrospective analysis. Pediatric Rheumatology Online Journal. 2020; 18.

Lin, B; Berard, R; Al Rasheed, A; Aladba, B; Kranzusch, PJ; Henderlight, M; Grom, A; Kahle, D; Torreggiani, S; Aue, AG; et al. A novel STING1 variant causes a recessive form of STING-associated vasculopathy with onset in infancy (SAVI). Journal of Allergy and Clinical Immunology. 2020; 146:1204-1208.e6.

Box, A; Delay, M; Tighe, S; Chittur, SV; Bergeron, A; Cochran, M; Lopez, P; Meyer, EM; Saluk, A; Thornton, S; et al. Evaluating the effects of cell sorting on gene expression. Journal of biomolecular techniques : JBT. 2020; 31:100-111.

Box, A; DeLay, M; Tighe, S; Chittur, SV; Bergeron, A; Cochran, M; Lopez, P; Meyer, EM; Saluk, A; Thornton, S; et al. Evaluating the Effects of Cell Sorting on Gene Expression. Journal of biomolecular techniques : JBT. 2020; 31:100-111.

Brundage, K; Abshari, M; Adams, D; Bispo, C; Bowen, S; Cochran, M; Harley, R; Hassel, C; Heyward, F; Kollipara, A; et al. Single cell sorting - a survey of practices. Journal of biomolecular techniques : JBT. 2020; 31.

Canna, SW; Schulert, GS; de Jesus, A; Pickering, A; Brunner, H; Gadina, M; Levine, S; Goldbach-Mansky, R; Boutelle, J; Sinha, R; et al. Proceedings from the 2^ndNext Gen Therapies for Systemic Juvenile Idiopathic Arthritis and Macrophage Activation Syndrome symposium held on October 3-4, 2019. Pediatric Rheumatology Online Journal. 2020; 18.

Henderson, LA; Canna, SW; Schulert, GS; Volpi, S; Lee, PY; Kernan, KF; Caricchio, R; Mahmud, S; Hazen, MM; Halyabar, O; et al. On the Alert for Cytokine Storm: Immunopathology in COVID-19. Arthritis and Rheumatology. 2020; 72:1059-1063.

Locatelli, F; Jordan, MB; Allen, C; Cesaro, S; Rizzari, C; Rao, A; Degar, B; Garrington, TP; Sevilla, J; Putti, M; et al. Emapalumab in children with primary hemophagocytic lymphohistiocytosis. The New England journal of medicine. 2020; 382:1811-1822.

de Jesus, AA; Hou, Y; Brooks, S; Malle, L; Biancotto, A; Huang, Y; Calvo, KR; Marrero, B; Moir, S; Oler, AJ; et al. Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases. Journal of Clinical Investigation. 2020; 130:1669-1682.

Verweyen, E; Holzinger, D; Weinhage, T; Hinze, C; Wittkowski, H; Pickkers, P; Albeituni, S; Verbist, K; Nichols, KE; Schulert, G; et al. Synergistic Signaling of TLR and IFNα/β Facilitates Escape of IL-18 Expression from Endotoxin Tolerance. American Journal of Respiratory and Critical Care Medicine. 2020; 201:526-539.

Yasin, S; Fall, N; Brown, RA; Henderlight, M; Canna, SW; Girard-Guyonvarc'h, C; Gabay, C; Grom, AA; Schulert, GS. IL-18 as a biomarker linking systemic juvenile idiopathic arthritis and macrophage activation syndrome. Rheumatology. 2020; 59:361-366.

Yasin, S; Solomon, K; Canna, SW; Girard-Guyonvarc'h, C; Gabay, C; Schiffrin, E; Sleight, A; Grom, AA; Schulert, GS. IL-18 as therapeutic target in a patient with resistant systemic juvenile idiopathic arthritis and recurrent macrophage activation syndrome. Rheumatology. 2020; 59:442-445.

Saper, VE; Chen, G; Deutsch, GH; Guillerman, RP; Birgmeier, J; Jagadeesh, K; Canna, S; Schulert, G; Deterding, R; Xu, J; et al. Emergent high fatality lung disease in systemic juvenile arthritis. Annals of the Rheumatic Diseases. 2019; 78:1722-1731.

Leong, JY; Chen, P; Yeo, JG; Ally, F; Chua, C; Hazirah, SN; Poh, SL; Pan, L; Lai, L; Lee, ES C; et al. Immunome perturbation is present in patients with juvenile idiopathic arthritis who are in remission and will relapse upon anti-TNFα withdrawal. Annals of the Rheumatic Diseases. 2019; 78:1712-1721.

Loof, N; Mehrnoosh, A; Bergeron, A; Saluk, A; Box, A; Brundage, K; Adams, D; Dwyer, K; Meyer, E; Cochran, M; et al. FCRG - Fixation and Sorting for RNA. Journal of biomolecular techniques : JBT. 2019; 30.

Schulert, GS; Yasin, S; Carey, B; Chalk, C; Do, T; Schapiro, AH; Husami, A; Watts, A; Brunner, HI; Huggins, J; et al. Systemic Juvenile Idiopathic Arthritis-Associated Lung Disease: Characterization and Risk Factors. Arthritis and Rheumatology. 2019; 71:1943-1954.

Hinze, CH; Foell, D; Johnson, AL; Spalding, SJ; Gottlieb, BS; Morris, PW; Kimura, Y; Onel, K; Li, SC; Grom, AA; et al. Serum S100A8/A9 and S100A12 Levels in Children With Polyarticular Forms of Juvenile Idiopathic Arthritis: Relationship to Maintenance of Clinically Inactive Disease During Anti-Tumor Necrosis Factor Therapy and Occurrence of Disease Flare After Discontinuation of Therapy. Arthritis and Rheumatology. 2019; 71:451-459.

Thornton, S; Tan, R; Sproles, A; Do, T; Schick, J; Grom, AA; DeLay, M; Schulert, GS. A Multiparameter Flow Cytometry Analysis Panel to Assess CD163 mRNA and Protein in Monocyte and Macrophage Populations in Hyperinflammatory Diseases. Journal of immunology (Baltimore, Md. : 1950). 2019; 202:1635-1643.

Turnier, JL; Brunner, HI; Bennett, M; Aleed, A; Gulati, G; Haffey, WD; Thornton, S; Wagner, M; Devarajan, P; Witte, D; et al. Discovery of SERPINA3 as a candidate urinary biomarker of lupus nephritis activity. Rheumatology. 2019; 58:321-330.

Grom, AA. Genetics of Macrophage Activation Syndrome in Systemic Juvenile Idiopathic Arthritis. CYTOKINE STORM SYNDROME. : Springer International Publishing; Springer International Publishing; 2019.

Brown, RA; Henderlight, M; Do, T; Yasin, S; Grom, AA; Delay, M; Thornton, S; Schulert, GS. Neutrophils From Children With Systemic Juvenile Idiopathic Arthritis Exhibit Persistent Proinflammatory Activation Despite Long-Standing Clinically Inactive Disease. Frontiers in Immunology. 2018; 9.

Angeles-Han, ST; Yeh, S; Patel, P; Duong, D; Jenkins, K; Rouster-Stevens, KA; Altaye, M; Fall, N; Thornton, S; Prahalad, S; et al. Discovery of tear biomarkers in children with chronic non-infectious anterior uveitis: a pilot study. Journal of Ophthalmic Inflammation and Infection. 2018; 8.

Lovell, DJ; Johnson, AL; Huang, B; Gottlieb, BS; Morris, PW; Kimura, Y; Onel, K; Li, SC; Grom, AA; Taylor, J; et al. Risk, Timing, and Predictors of Disease Flare After Discontinuation of Anti-Tumor Necrosis Factor Therapy in Children With Polyarticular Forms of Juvenile Idiopathic Arthritis With Clinically Inactive Disease. Arthritis and Rheumatology. 2018; 70:1508-1518.

Throm, AA; Moncrieffe, H; Orandi, AB; Pingel, JT; Geurs, TL; Miller, HL; Daugherty, AL; Malkova, ON; Lovell, DJ; Thompson, SD; et al. Identification of enhanced IFN-gamma signaling in polyarticular juvenile idiopathic arthritis with mass cytometry. JCI insight. 2018; 3.

Harry, O; Schulert, GS; Frenck, RW; Shapiro, AH; Woltmann, JL; Smith, JA; Grom, AA. Cat-Scratch Disease, a Diagnostic Consideration for Chronic Recurrent Multifocal Osteomyelitis. Journal of Clinical Rheumatology: practical reports on rheumatic and musculoskeletal disease. 2018; 24:287-290.

Arthur, VL; Shuldiner, E; Remmers, EF; Hinks, A; Grom, AA; Foell, D; Martini, A; Gattorno, M; Ozen, S; Prahalad, S; et al. IL1RN Variation Influences Both Disease Susceptibility and Response to Recombinant Human Interleukin-1 Receptor Antagonist Therapy in Systemic Juvenile Idiopathic Arthritis. Arthritis and Rheumatology. 2018; 70:1319-1330.

Harry, O; Schulert, GS; Jr, FR W; Shapiro, AH; Woltmann, JL; Smith, JA; Grom, AA. Cat-Scratch Disease, a Diagnostic Consideration for Chronic Recurrent Multifocal Osteomyelitis. Journal of Clinical Rheumatology: practical reports on rheumatic and musculoskeletal disease. 2018; 24:287-290.

Schulert, GS; Zhang, M; Husami, A; Fall, N; Brunner, H; Zhang, K; Cron, RQ; Grom, AA. Novel UNC13D Intronic Variant Disrupting an NF-kappa B Enhancer in a Patient With Recurrent Macrophage Activation Syndrome and Systemic Juvenile Idiopathic Arthritis. Arthritis and Rheumatology. 2018; 70:963-970.

Prencipe, G; Caiello, I; Pascarella, A; Grom, AA; Bracaglia, C; Chatel, L; Ferlin, WG; Marasco, E; Strippoli, R; de Min, C; et al. Neutralization of IFN-gamma reverts clinical and laboratory features in a mouse model of macrophage activation syndrome. Journal of Allergy and Clinical Immunology. 2018; 141:1439-1449.

Giannelou, A; Wang, H; Zhou, Q; Park, YH; Abu-Asab, MS; Ylaya, K; Stone, DL; Sediva, A; Sleiman, R; Sramkova, L; et al. Aberrant tRNA processing causes an autoinflammatory syndrome responsive to TNF inhibitors. Annals of the Rheumatic Diseases. 2018; 77:612-619.

Weiss, ES; Girard-Guyonvarc'h, C; Holzinger, D; de Jesus, AA; Tariq, Z; Picarsic, J; Schiffrin, EJ; Foell, D; Grom, AA; Ammann, S; et al. Interleukin-18 diagnostically distinguishes and pathogenically promotes human and murine macrophage activation syndrome. Blood. 2018; 131:1442-1455.

Schulert, GS; Minoia, F; Bohnsack, J; Cron, RQ; Hashad, S; Kone-Paut, I; Kostik, M; Lovell, D; Maritsi, D; Nigrovic, PA; et al. Effect of Biologic Therapy on Clinical and Laboratory Features of Macrophage Activation Syndrome Associated With Systemic Juvenile Idiopathic Arthritis. Arthritis Care and Research. 2018; 70:409-419.

Do, T; Tan, R; Bennett, M; Medvedovic, M; Grom, AA; Shen, N; Thornton, S; Schulert, GS. MicroRNA networks associated with active systemic juvenile idiopathic arthritis regulate CD163 expression and anti-inflammatory functions in macrophages through two distinct mechanisms. Journal of Leukocyte Biology. 2018; 103:71-85.

Grom, AA; Horne, AC; De Benedetti, F. Macrophage activation syndrome in rheumatic diseases (MAS-HLH). Histiocytic Disorders. : Springer International Publishing; Springer International Publishing; 2018.

Schulert, GS; Grom, AA. Fever and the Inflammatory Response. Principles and Practice of Pediatric Infectious Diseases. : Elsevier; Elsevier; 2018.

Brachat, AH; Grom, AA; Wulffraat, N; Brunner, HI; Quartier, P; Brik, R; McCann, L; Ozdogan, H; Rutkowska-Sak, L; Schneider, R; et al. Early changes in gene expression and inflammatory proteins in systemic juvenile idiopathic arthritis patients on canakinumab therapy. Arthritis Research and Therapy. 2017; 19.

Turnier, JL; Fall, N; Thornton, S; Witte, D; Bennett, MR; Appenzeller, S; Klein-Gitelman, MS; Grom, AA; Brunner, HI. Urine S100 proteins as potential biomarkers of lupus nephritis activity. Arthritis Research and Therapy. 2017; 19.

Grom, AA. Primary Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome: The Importance of Timely Clinical Differentiation. The Journal of Pediatrics. 2017; 189:19-21.e1.

Minoia, F; Bovis, F; Davì, S; Insalaco, A; Lehmberg, K; Shenoi, S; Weitzman, S; Espada, G; Gao, YJ; Anton, J; et al. Development and Initial Validation of the Macrophage Activation Syndrome/Primary Hemophagocytic Lymphohistiocytosis Score, a Diagnostic Tool that Differentiates Primary Hemophagocytic Lymphohistiocytosis from Macrophage Activation Syndrome. The Journal of Pediatrics. 2017; 189:72-78.e3.

Moncrieffe, H; Bennett, MF; Tsoras, M; Luyrink, LK; Johnson, AL; Xu, H; Dare, J; Becker, ML; Prahalad, S; Rosenkranz, M; et al. Transcriptional profiles of JIA patient blood with subsequent poor response to methotrexate. Rheumatology. 2017; 56:1542-1551.

Kopec, AK; Abrahams, SR; Thornton, S; Palumbo, JS; Mullins, ES; Divanovic, S; Weiler, H; III, OA P; Mackman, N; Goss, A; et al. Thrombin promotes diet-induced obesity through fibrin-driven inflammation. Journal of Clinical Investigation. 2017; 127:3152-3166.

Kessel, C; Lippitz, K; Weinhage, T; Hinze, C; Wittkowski, H; Holzinger, D; Fall, N; Grom, AA; Gruen, N; Foell, D. Proinflammatory Cytokine Environments Can Drive Interleukin-17 Overexpression by gamma/delta T Cells in Systemic Juvenile Idiopathic Arthritis. Arthritis and Rheumatology. 2017; 69:1480-1494.

Ombrello, MJ; Arthur, VL; Remmers, EF; Hinks, A; Tachmazidou, I; Grom, AA; Foell, D; Martini, A; Gattorno, M; Ozen, S; et al. Genetic architecture distinguishes systemic juvenile idiopathic arthritis from other forms of juvenile idiopathic arthritis: clinical and therapeutic implications. Annals of the Rheumatic Diseases. 2017; 76:906-913.

Shaw, MA; Gao, Z; McElhinney, KE; Thornton, S; Flick, MJ; Lane, A; Degen, JL; Ryu, JK; Akassoglou, K; Mullins, ES. Plasminogen Deficiency Delays the Onset and Protects from Demyelination and Paralysis in Autoimmune Neuroinflammatory Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2017; 37:3776-3788.

Thornton, S; Raghu, H; Cruz, C; Frederick, MD; Palumbo, JS; Mullins, ES; Almholt, K; Usher, PA; Flick, MJ. Urokinase plasminogen activator and receptor promote collagen-induced arthritis through expression in hematopoietic cells. Blood Advances. 2017; 1:545-556.

Brachat, AH; Grom, AA; Wulffraat, N; Brunner, HI; Quartier, P; Brik, R; McCann, L; Ozdogan, H; Rutkowska-Sak, L; Schneider, R; et al. Early changes in gene expression and inflammatory proteins in systemic juvenile idiopathic arthritis patients on canakinumab therapy. Arthritis Research and Therapy. 2017; 19.

Bracaglia, C; de Graaf, K; Marafon, DP; Guilhot, F; Ferlin, W; Prencipe, G; Caiello, I; Davi, S; Schulert, G; Ravelli, A; et al. Elevated circulating levels of interferon-gamma and interferon-gamma-induced chemokines characterise patients with macrophage activation syndrome complicating systemic juvenile idiopathic arthritis. Annals of the Rheumatic Diseases. 2017; 76:166-172.

Abulaban, KM; Fall, N; Nunna, R; Ying, J; Devarajan, P; Grom, A; Bennett, M; Ardoin, SP; Brunner, HI. Relationship of cell-free urine MicroRNA with lupus nephritis in children. Pediatric Rheumatology Online Journal. 2016; 14.

Schulert, GS; Fall, N; Harley, JB; Shen, N; Lovell, DJ; Thornton, S; Grom, AA. Monocyte MicroRNA Expression in Active Systemic Juvenile Idiopathic Arthritis Implicates MicroRNA-125a-5p in Polarized Monocyte Phenotypes. Arthritis and Rheumatology. 2016; 68:2300-2313.

Zeft, AS; Prahalad, S; Schneider, R; Dedeoglu, F; Weiss, PF; Grom, AA; Mix, C; III, PC A. Systemic onset juvenile idiopathic arthritis and exposure to fine particulate air pollution. Clinical and Experimental Rheumatology. 2016; 34:946-952.

Santimov, A; Grom, AA. Other Biological Therapies for Pediatric Rheumatic Diseases. In: Cimaz R; Lehman TJA, Ed. PEDIATRICS IN SYSTEMIC AUTOIMMUNE DISEASES, 2ND EDITION. Philadelphia: Elsevier; 2016.

Strait, RT; Thornton, S; Finkelman, FD. C gamma 1 Deficiency Exacerbates Collagen-Induced Arthritis. Arthritis and Rheumatology. 2016; 68:1780-1787.

Grom, AA; Horne, A; De Benedetti, F. Macrophage activation syndrome in the era of biologic therapy. Nature reviews. Rheumatology. 2016; 12:259-268.

Schulert, GS; Zhang, M; Fall, N; Husami, A; Kissell, D; Hanosh, A; Zhang, K; Davis, K; Jentzen, JM; Napolitano, L; et al. Whole-Exome Sequencing Reveals Mutations in Genes Linked to Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome in Fatal Cases of H1N1 Influenza. Journal of Infectious Diseases. 2016; 213:1180-1188.

Zhang, M; Bracaglia, C; Prencipe, G; Bemrich-Stolz, CJ; Beukelman, T; Dimmitt, RA; Chatham, WW; Zhang, K; Li, H; Walter, MR; et al. A Heterozygous RAB27A Mutation Associated with Delayed Cytolytic Granule Polarization and Hemophagocytic Lymphohistiocytosis. Journal of immunology (Baltimore, Md. : 1950). 2016; 196:2492-2503.

Ravelli, A; Minoia, F; Davi, S; Horne, A; Bovis, F; Pistorio, A; Arico, M; Avcin, T; Behrens, EM; De Benedetti, F; et al. 2016 Classification Criteria for Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis A European League Against Rheumatism/American College of Rheumatology/Paediatric Rheumatology International Trials Organisation Collaborative Initiative. Arthritis and Rheumatology. 2016; 68:566-576.

Ravelli, A; Minoia, F; Davi, S; Horne, A; Bovis, F; Pistorio, A; Arico, M; Avcin, T; Behrens, EM; De Benedetti, F; et al. 2016 Classification Criteria for Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis A European League Against Rheumatism/American College of Rheumatology/Paediatric Rheumatology International Trials Organisation Collaborative Initiative. Annals of the Rheumatic Diseases. 2016; 75:481-489.

Thornton, S; Strait, RT. Head-to-head comparison of protocol modifications for the generation of collagen-induced arthritis in a specific-pathogen free facility using DBA/1 mice. BioTechniques: the journal of laboratory technology for bioresearch. 2016; 60:119-128.