Brain and Spinal Tumors Research Studies

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Neurofibromatosis Plexiform Neurofibroma

GSK-MEK116540: An Open-Label, Dose-Escalation, Phase I/II Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of the MEK Inhibitor Trametinib in Children and Adolescents Subjects with Cancer or Plexiform Neurofibromas and Trametinib in Combination with Dabrafenib in Children and Adolescents with Cancers Harboring V600 Mutations

  • Conditions: Brain Spinal Neurofibromatosis Plexiform Neurofibroma, Sarcoma Ewing Relapse, Sarcoma Osteosarcoma Relapse, Sarcoma Rhabdomyosarcoma Relapse, Neuroblastoma Relapse - Refractory, Liver Relapse - Refractory, Kidney Relapse - Refractory, Solid Tumor Retinoblastoma Relapse - Refractory, Solid Tumor Germ Cell Tumor Relapse - Refractory, Solid Tumor Melanoma Relapse - Refractory, Solid Tumor Neurofibromatosis OPG Low Grade Glioma, Solid Tumors - All Other, Solid Tumor Neurofibromatosis Plexiform Neurofibroma

PURPOSE: This is a 3-part (Part A, Part B, Part C), Phase I/IIa, multi-center, open label, study in pediatric subjects with refractory or recurrent tumors. Part A is a repeat dose, dose escalation monotherapy study that will identify the recommended phase II dose (RP2D) on the continuous dosi ...More

MEKINHIBITOR: A Phase I Study of the Mitogen Activated Protein Kinase Kinase (MEK) 1 Inhibitor AZD6244 Hydrogen Sulfate in Children with Neurofibromatosis Type 1 (NF1) and Inoperable Plexiform Neurofibromas (PN).

  • Conditions: Brain Spinal Neurofibromatosis Plexiform Neurofibroma, Solid Tumor Neurofibromatosis Plexiform Neurofibroma

Background: Plexiform neurofibromas are tumors that grow in and around nerves. The only way to treat them is with surgery. Some of these tumors cannot be completely removed. The tumors may be too large, too numerous, or in a bad location for surgery. An experimental drug called AZD6244 hydrogen sul ...More

NF105: A Phase II Study of Cabozantinib (XL184) for Plexiform Neurofibromas in Subjects With Neurofibromatosis Type 1 Age 16 Years or Greater

  • Conditions: Brain Spinal Neurofibromatosis Plexiform Neurofibroma, Solid Tumor Neurofibromatosis Plexiform Neurofibroma, Adult - Brain Spinal Neurofibromatosis Plexiform Neurofibroma, Adult - Solid Tumor Neurofibromatosis Plexiform Neurofibroma

PURPOSE: This study, "A Phase II Study of Cabozantinib (XL l84) for Plexiform Neurofibromas in Subjects with Neurofibromatosis Type I Age 16 years or greater" is for participants that have been diagnosed with Neurofibromatosis Type 1 (NF1) and have a type of tumor called a plexiform neurofibroma. Ne ...More