Liver Transplant Center

Clinical

Pediatric gastroenterology; pediatric hepatology

Research

Genetic/metabolic liver diseases; biliary atresia; pediatric liver transplantation; developmental biology of liver

MD: Nagoya University, Nagoya, Japan, 2003.

PhD: Tokyo University, Tokyo, Japan, 2008.

Residency: Pediatrics, Columbia University, New York, NY.

Certification: Pediatrics, 2010.

Fellowship: Pediatric Gastroenterology, Hepatology and Nutrition, Northwestern University, Chicago, IL.

Certification: Pediatric Gastroenterology, Hepatology and Nutrition, 2013.

Asai A, Kohli R. Familial homozygous hypercholesterolemia: When to turn to transplant? Pediatric Transplantation. 2015;19: 577–579.

Asai A, Miethke A, Bezerra J. Pathogenesis of biliary atresia: defining biology to understand clinical phenotypes. Nat Rev Gastroenterol Hepatol. 2015 Jun;12(6):342-352.

Asai A, Malladi S, Misch J, Pan X, Malladi P, Diehl AM, Whitington PF. Elaboration of tubules with active Hedgehog drives parenchymal fibro genesis in gestational alloimmune liver disease. Human Pathology. 2015 Jan;46(1):84-93.

Asai A, Chou PM, Bu HF, Wang X, Rao MS, Jiang A, DiDonato CJ, Tan XD. Dissociation of hepatic insulin resistance from susceptibility of nonalcoholic fatty liver disease induced by a high-fat and high-carbohydrate diet in mice. Am J Physiol Gastrointest Liver Physiol. 2014 Mar;306(6):G496-504.

Wang X, Bu HF, Zhong W, Asai A, Zhou Z, Tan XD. MFG-E8 and HMGB1 are involved in the mechanism underlying alcohol-induced impairment of macrophage engulfing apoptotic cells. Mol Med. 2013 Jul 24;19:170-82.

Asai A, Sahani N, Kaneki M, Ouchi Y, Martyn JJ, Yasuhara S. Primary Role of Functional Ischemia, Quantitative Evidence of Two-Hit Mechanism, and Phosphodiesterase-5 Inhibitor Therapy in Mouse Muscular Dystrophy. PLoS One. 2007 Aug 29;2(8):e806.

Asai A, Sahani N, Ouchi Y, Martyn JJ, Yasuhara S. In vivo Micro-circulation Measurement in Skeletal Muscle by Intra-vital Microscopy. J Vis Exp. 2007;(4):210.

William F. Balistreri, MD Dorothy M. M. Kersten Professor of Pediatrics 513-636-4594 william.balistreri@cchmc.org

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William F. Balistreri, MD

Dorothy M. M. Kersten Professor of Pediatrics

Director Emeritus, Pediatric Liver Care Center

Medical Director Emeritus, Liver Transplantation

Program Director Emeritus, Fellowship in Transplant Hepatology

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-4594

Fax 513-636-7805

Email william.balistreri@cchmc.org

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Liver disease (cholestasis, viral hepatitis, metabolic liver disease; liver transplantation); celiac disease.

Biography

Through more than 550 publications, Balistreri has helped to clarify the understanding of many aspects of liver diseases in children.

Balistreri has been editor of The Journal of Pediatrics since 1995. He is the former editor-in-chief of the Journal of Pediatric Gastroenterology and Nutrition, and co-editor, associate editor, guest editor, reviewer and member of numerous editorial boards of several journals. He is co-editor of the prestigious text Liver Disease in Children.

In 2000, Balistreri became the first pediatrician to serve as president of the American Association for the Study of Liver Diseases. He has received numerous awards. These include the Distinguished Leadership Award from the CCFA; the Andrew Sass-Kortsak Memorial Award from the Canadian Liver Foundation and the Canadian Association for the Study of Liver; the Murray Davidson Award from the American Academy of Pediatrics; the prestigious Shwachman Award from the NASPGHAN; the Founder's Award, Cincinnati Pediatric Society; The Distinguished Alumnus Award, University of Buffalo; The Daniel Drake Medal, University of Cincinnati, College of Medicine; the Distinguished Service Award from AASLD; and the Distinguished Educator Award from the American Gastroenterological Association. He received the Outstanding Pediatrician award from the Ohio Chapter of the American Academy of Pediatrics for distinguished achievements in pediatric care and in the education of patients and physicians.

In 2012, NASPGHAN established the William F. Balistreri, MD, Prize for Excellence in Pediatric Gastroenterology, Hepatology and Nutrition. This award will recognize outstanding achievement in an area relevant to the field to be bestowed each year at the annual NASPGHAN meeting.

Balistreri joined Cincinnati Children's in 1978. He served as division director of Pediatric Gastroenterology, Hepatology, and Nutrition for 25 years.

Balistreri has been listed multiple times in Best Doctors in America.

BA: State University of New York at Buffalo, NY, 1966.

MD: University of Buffalo School of Medicine, NY, 1970.

Internship: Cincinnati Children's Hospital Medical Center (University of Cincinnati School of Medicine), Cincinnati, OH, 1970 to 1972.

Residency: Cincinnati Children's Hospital Medical Center (University of Cincinnati School of Medicine), Cincinnati, OH, 1971 to 1972.

Fellowship: Pediatric Gastroenterology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1973 to 1974.

Research Fellowship: Gastroenterology, Mayo Foundation, Mayo Clinic, Rochester, MN, 1973 to 1975.

Certification: Pediatrics, 1975 (renewed 1992); Pediatric Gastroenterology and Nutrition, 1990 (certificate #2; renewed 1997, 2004, and 2014).

Subspecialty Certification: 2006, American Board of Pediatrics (certificate #004 Pediatric Transplant Hepatology).

Xanthakos SA, Podberesky DJ, Serai S, Miles L, King EC, Balistreri WF, Kohli R. Use of magnetic resonance elastography to assess hepatic fibrosis in children with chronic liver disease. The Journal of Pediatrics. 2014 Jan;164(1):186-8.

Balistreri WF, Master’s Perspective. Growth and Development of a New Subspecialty: Pediatric Hepatology. HEPATOLOGY. 2013;58:458-476.

Molleston JP, Mellman W, Narkewicz MR, Balistreri WF, Gonzalez-Peralta RP, Jonas M, Lobritto SJ, Mohan P, Murray KF, Rosenthal P, Robuck PR, Barton BA, Schwarz KB, Haber B for the PEDS-C Clinical Research Network. Auto-antibodies and Autoimmune Disease During Treatment of Children with Hepatitis C. J Pediatr Gastroenterol Nutr. 2013;56:304-310.

Jonas MM, Balistreri W, González-Peralta RP, Haber B, Lobritto S, Mohan P, Molleston JP, Murray KF, Narkewicz MR, Rosenthal P, Schwarz KB, Barton BA, Shepherd J, Robuck PR, Mitchell PD, Duggan C. Peginterferon for Chronic Hepatitis C in Children affects growth and body composition: Results from the Pediatric Study of Hepatitis C (PEDS-C) Trial. Hepatology. 2012 Aug;56(2):523-31.

Schwarz KB, Gonzalez-Peralta R, Murray K, Molleston J, Haber B, Jonas M, Mohan P, Balistreri W, Rosenthal P, Narkewicz M, Smith L, Robuck P, Barton B for the PEDS C Clinical Research Network. The combination of ribavirin and peginterferon is superior to perinterferon and placebo for Children and Adolescents with Chronic Hepatitis C: The Peds-C Trial. Gastroenterology. 2011;140:450-458.

Kohli R, Kirby M, Xanthakos SA, Softic S, Feldstein AE, Saxena V, Tang PH, Miles L, Miles MV, Balistreri WF, Woods SC, Seeley RJ. High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis. Hepatology. 2010 Sep;52(3):934-44.

Kohli R, Kirby M, Setchell KD, Jha P, Klustaitis K, Woollett LA, Pfluger PT, Balistreri WF, Tso P, Jandacek RJ, Woods SC, Heubi JE, Tschoep MH, D'Alessio DA, Shroyer NF, Seeley RJ. Intestinal adaptation after ileal interposition surgery increases bile acid recycling and protects against obesity-related comorbidities. Am J Physiol Gastrointest Liver Physiol. 2010 Sep;299(3):G652-60.

Kohli R, Boyd T, Lake K, Dietrich K, Nicholas L, Balistreri WF, Ebach D, Shashidhar H, Xanthakos SA. Rapid progression of NASH in childhood. J Pediatr Gastroenterol Nutr. 2010 Apr;50(4):453-6.

Leonis MA, Balistreri WF. Evaluation and management of end-stage liver disease in children. Gastroenterology. 2008 May;134(6):1741-51.

Ryckman FC, Bucuvalas JC, Nathan J, Alonso M, Tiao G, Balistreri WF. Outcomes following liver transplantation. Semin Pediatr Surg. 2008 May;17(2):123-30.

Jorge A. Bezerra, MD Director, Division of Gastroenterology, Hepatology and Nutrition 513-636-3008 jorge.bezerra@cchmc.org

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Jorge A. Bezerra, MD

Director, Division of Gastroenterology, Hepatology and Nutrition

Medical Director, Pediatric Liver Care Center

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-3008

Fax 513-636-5581

Email jorge.bezerra@cchmc.org

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Research Interests

Visit the Bezerra Lab.

Biography

Jorge A. Bezerra, MD, joined the Cincinnati Children's Hospital Medical Center Division of Gastroenterology, Hepatology and Nutrition in 1990, when he began his fellowship training in pediatric gastroenterology and nutrition and graduated in 1993.

From 1992-1994, Dr. Bezerra was a research scholar in the Division of Basic Sciences. He was appointed to the division in 1994 as an assistant professor within the UC Department of Pediatrics.

Dr. Bezerra completed his residency in pediatrics at the University of Arizona in Tucson, Arizona.

Dr. Bezerra has an active research career with his primary interests in molecular control of liver regeneration, biliary atresia, and genetic basis of intrahepatic cholestasis.

In addition to his research work, Dr. Bezerra is an active clinician for the outpatient GI clinical service and the inpatient liver service.

MD: Federal University Rio Grande Norte, Natal, Brazil, 1984.

Residency: University of Arizona, Tuscon, AZ, 1989.

Fellowship: Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, 1994.

Certification: Pediatrics, Pediatric Gastroenterology, Hepatology and Nutrition.

Bezerra JA. Biliary atresia in Brazil: where we are and where we are going. J Pediatr (Rio J). 2010 Nov-Dec;86(6):445-7.

Moyer K, Kaimal V, Pacheco C, Mourya R, Xu H, Shivakumar P, Chakraborty R, Rao M, Magee JC, Bove K, Aronow BJ, Jegga AG, Bezerra JA. Staging of biliary atresia at diagnosis by molecular profiling of the liver. Genome Med. 2010 May 13;2(5):33.

Kumar Mohanty S, Ivantes CA, Mourya R, Pacheco C, Bezerra JA. Macrophages are targeted by rotavirus in experimental biliary atresia and induce neutrophil chemotaxis via Mip2/Cxcl2. Pediatr Res. 2010 Jan 6.

Shivakumar P, Sabla GE, Whitington P, Chougnet CA, Bezerra JA. Neonatal NK cells target the mouse duct epithelium via Nkg2d and drive tissue-specific injury in experimental biliary atresia. J Clin Invest. 2009 Aug;119(8):2281-90.

Shanmukhappa K, Matte U, Degen JL, Bezerra JA. Plasmin-mediated proteolysis is required for hepatocyte growth factor activation during liver repair. J Biol Chem. 2009 May 8;284(19):12917-23.

Erickson N, Mohanty SK, Shivakumar P, Sabla G, Chakraborty R, Bezerra JA. Temporal-spatial activation of apoptosis and epithelial injury in murine experimental biliary atresia. Hepatology. 2008 May;47(5):1567-77.

Shivakumar P, Sabla G, Mohanty S, McNeal M, Ward R, Stringer K, Caldwell C, Chougnet C, Bezerra JA. Effector role of neonatal hepatic CD8+ lymphocytes in epithelial injury and autoimmunity in experimental biliary atresia. Gastroenterology. 2007 Jul;133(1):268-77.

Liu C, Aronow BJ, Jegga AG, Wang N, Miethke A, Mourya R, Bezerra JA. Novel resequencing chip customized to diagnose mutations in patients with inherited syndromes of intrahepatic cholestasis. Gastroenterology. 2007 Jan;132(1):119-26.

Campbell KM, Arya G, Ryckman FC, Alonso M, Tiao G, Balistreri WF, Bezerra JA. High prevalence of alpha-1-antitrypsin heterozygosity in children with chronic liver disease. J Pediatr Gastroenterol Nutr. 2007 Jan;44(1):99-103.

Shanmukhappa K, Sabla GE, Degen JL, Bezerra JA. Urokinase-type plasminogen activator supports liver repair independent of its cellular receptor. BMC Gastroenterol. 2006 Nov 29;6:40.

John C. Bucuvalas, MD Director, Integrated Solid Organ Transplant Program 513-636-4415 john.bucuvalas@cchmc.org

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John C. Bucuvalas, MD

Director, Integrated Solid Organ Transplant Program

Associate Medical Director, Pediatric Liver Care Center

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-4415

Fax 513-636-7805

Email john.bucuvalas@cchmc.org

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Liver disease; transplantation; outcomes research

Improving the quality of health care delivery.

Visit the Bucuvalas Lab.

Biography

John Bucuvalas, MD, came to Cincinnati Children's Hospital Medical Center in 1982 as a fellow in gastroenterology. He joined the faculty in 1986. He graduated from Harvard College in 1974 and Harvard Medical School in 1978. He completed a pediatric residency at Massachusetts General Hospital and served there as chief resident from 1981 to 1982.

Over the last 10 years, the focus his patient care and research efforts have been outcomes research and improving the care delivery system for children with chronic liver disease who then may undergo liver transplantation. He has focused on integration of research into patient care and improving the care delivery system. Along the way, he has gained significant content knowledge through traditional research but additionally have learned how to improve processes, understand the system that is academic medicine, interpret variation and recognize the role of leadership both for research and clinical efforts. Dr. Bucuvalas has made significant contributions in the clinical and research arenas towards improving care, enhancing the delivery care and optimizing the outcome of children with chronic liver disease and pediatric liver transplant recipients.

Dr. Bucuvalas has been recognized as a leader in the field of pediatric hepatology and liver transplantation at a local, regional and national level.

AB: Harvard College, Cambridge, MA, 1974.

MD: Harvard Medical School, Boston, MA, 1978.

Residency: Pediatrics, Massachusetts General Hospital, Boston, MA, 1978 to 1981.

Chief Residency: Pediatrics, Massachusetts General Hospital, Boston, MA, 1981 to 1982.

Fellowship: Gastroenterology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1982 to 1985.

Research Scholar: Gastroenterology, Children's Hospital Research Foundation, Cincinnati, OH, 1985 to 1986.

Certification: Pediatrics, 1983; Pediatric Gastroenterology, 1990; recertified, 1997, 2004.

Campbell K, Ng V, Martin S, Magee J, Goebel J, Anand R, Martz K, Bucuvalas J; SPLIT Renal Function Working Group. Glomerular filtration rate following pediatric liver transplantation--the SPLIT experience. Am J Transplant. 2010 Dec;10(12):2673-82.

Campbell KM, Bucuvalas JC. Renal function in the long term after pediatric liver transplantation: is there a need for protocol kidney biopsies? Curr Opin Organ Transplant. 2010 Oct;15(5):608-13.

Bucuvalas J. Long-term outcomes in pediatric liver transplantation. Liver Transpl. 2009 Nov;15 Suppl 2:S6-11.

Bucuvalas JC, Anand R; Studies of Pediatric Liver Transplantation Research Group. Treatment with immunoglobulin improves outcome for pediatric liver transplant recipients. Liver Transpl. 2009 Nov;15(11):1564-9.

Bucuvalas JC, Alonso E, Magee JC, Talwalkar J, Hanto D, Doo E. Improving long-term outcomes after liver transplantation in children. Am J Transplant. 2008 Dec;8(12):2506-13.

Bucuvalas JC, Alonso E. Long-term outcomes after liver transplantation in children. Curr Opin Organ Transplant. 2008 Jun;13(3):247-51. Review.

Ryckman FC, Bucuvalas JC, Nathan J, Alonso M, Tiao G, Balistreri WF. Outcomes following liver transplantation. Semin Pediatr Surg. 2008 May;17(2):123-30.

Bucuvalas JC, Campbell KM, Cole CR, Guthery SL. Outcomes after liver transplantation: keep the end in mind. J Pediatr Gastroenterol Nutr. 2006 Jul;43 Suppl 1:S41-8.

Campbell KM, Yazigi N, Ryckman FC, Alonso M, Tiao G, Balistreri WF, Atherton H, Bucuvalas JC. High prevalence of renal dysfunction in long-term survivors after pediatric liver transplantation. J Pediatr. 2006 Apr;148(4):475-80.

Xanthakos S, Miles L, Bucuvalas J, Daniels S, Garcia V, Inge T. Histologic spectrum of nonalcoholic fatty liver disease in morbidly obese adolescents. Clin Gastroenterol Hepatol. 2006 Feb;4(2):226-32.

Kathleen M. Campbell, MD Medical Director, Liver Transplant Program 513-636-4415 kathleen.campbell@cchmc.org

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Kathleen M. Campbell, MD

Medical Director, Liver Transplant Program

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-636-4415

Fax 513-636-7805

Email kathleen.campbell@cchmc.org

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Clinical

Diagnosis and management of pediatric liver disease, particularly biliary atresia and other forms of neonatal cholestasis; liver transplantation and post-transplant renal dysfunction.

Research

Clinical and genetic determinants of calcineurin inhibitor induced post-transplant nephrotoxicity; disease modifiers in biliary atresia

Biography

Kathleen M. Campbell, MD, joined the Division of Gastroenterology, Hepatology and Nutrition as a fellow in 2000, after completing her pediatric residency training at Cincinnati Children's Hospital Medical Center. Following the completion of her fellowship, she pursued an additional year of training in pediatric hepatology under the mentoring of Dr. William Balistreri and the physicians and surgeons of the Pediatric Liver Care Center, becoming one of the first in her specialty to obtain focused training in this field.

In 2004, Dr. Campbell was appointed assistant professor of pediatrics in the Division of Gastroenterology, Hepatology and Nutrition and the Pediatric Liver Care Center within the UC Department of Pediatrics. Her clinical and translational research interests include post-transplant renal dysfunction and genetic modifiers of disease in biliary atresia.

MD: University of Tennessee College of Medicine, Memphis, TN, 1997.

Residency: Pediatrics, University of Cincinnati and Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2000.

Fellowship: Pediatric Gastroenterology, Hepatology and Nutrition, University of Cincinnati and Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2003.

Advanced Fellowship: Pediatric Hepatology, University of Cincinnati and Cincinnati Children's Hospital Medical Center, 2004.

Certification: Pediatrics, 2000; Pediatric Gastroenterology, Hepatology and Nutrition, 2003.

Choquette M, Goebel JW, Campbell KM. Nonimmune complications after transplantation. Pediatr Clin North Am. 2010 Apr;57(2):505-21, table of contents. Review.

Pacheco MC, Campbell KM, Bove KE. Ductal plate malformation-like arrays in early explants after a Kasai procedure are independent of splenic malformation complex (heterotaxy). Pediatr Dev Pathol. 2009 Sep-Oct;12(5):355-60.

Calvo-Garcia MA, Campbell KM, O'Hara SM, Khoury P, Mitsnefes MM, Strife CF. Acquired renal cysts after pediatric liver transplantation: association with cyclosporine and renal dysfunction. Pediatr Transplant. 2008 Sep;12(6):666-71.

Bucuvalas JC, Campbell KM, Cole CR, Guthery SL. Outcomes after liver transplantation: keep the end in mind. J Pediatr Gastroenterol Nutr. 2006 Jul;43 Suppl 1:S41-8.

Shivakumar P, Campbell KM, Sabla GE, Miethke A, Tiao G, McNeal MM, Ward RL, Bezerra JA. Obstruction of extrahepatic bile ducts by lymphocytes is regulated by IFN-gamma in experimental biliary atresia. J Clin Invest. 2004 Aug;114(3):322-9.

Campbell KM, Sabla GE, Bezerra JA. Transcriptional reprogramming in murine liver defines the physiologic consequences of biliary obstruction. J Hepatol. 2004 Jan;40(1):14-23.

Book Chapters

Campbell KM and Balistreri WF. Inflammatory Bowel Disease. Comprehensive Pediatrics. 1st edition. 2001.

Monique L. Goldschmidt, MD Staff Physician, Division of Gastroenterology, Hepatology and Nutrition 513-636-6155 monique.goldschmidt@cchmc.org

James E. Heubi, MD Director, Center for Clinical and Translational Science and Training 513-636-4415 james.heubi@cchmc.org

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James E. Heubi, MD

Director, Center for Clinical and Translational Science and Training

Associate Dean, Clinical and Translational Research

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-4415

Fax 513-803-1039

Email james.heubi@cchmc.org

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Clinical

Inflammatory bowel disease; cholestatic liver disease; malabsorption

Research

Cholesterol absorption; cholesterol metabolism; inborn errors of bile acid metabolism; bone metabolism in health and disease; TPN-related cholestasis and its treatment

Biography

James E. Heubi, MD, has been a practicing pediatric gastroenterologist since 1979, when he joined the staff at Cincinnati Children's Hospital Medical Center.

Dr. Heubi's practice includes the treatment of all disorders affecting the gastrointestinal tract, liver and biliary tract and pancreas.

Dr. Heubi's areas of practice interests include liver disease and complications related to end-stage liver disease and liver transplantation and the management of patients with "short gut" or compromised gut function requiring prolonged enteral or parenteral nutritional support.

Dr. Heubi is the associate dean for clinical research at the University of Cincinnati College of Medicine.

MD: Indiana University School of Medicine, Indianapolis, IN, 1973.

Residency: James Whitcomb Riley Hospital for Children, Indiana University, Indianapolis, IN, 1973 to 1975.

Fellowship: Children's Hospital Medical Center, Cincinnati, OH, 1975 to 1978.

Certification: Pediatric Gastroenterology and Nutrition, 1990.

Heubi JE, Setchell KD, Jha P, Buckley D, Zhang W, Rosenthal P, Potter C, Horslen S, Suskind D. Treatment of bile acid amidation defects with glycocholic acid. Hepatology. 2014 Aug 28.

Setchell KDR, Heubi JE, Shah S, Lavine JE, Suskind D, Al-Edressi M, Potter C, Russell DW, O'Connell NC, Wolfe B, Jha P, Zhang W, Bove KE, Knisely AS, Hoffman AF, Rosenthal P, Bull LN. Genetic defects in bile acid conjugation cause fat soluble vitamin deficiency. Gastroenterology. 2013;144:945-955.

Mizukawa B, George A, Pushkaran S, Weckbach L, Kalinyak K, Heubi JE, Kalfa TA. Cooperating G6PD mutations associated with severe neonatal hyperbillirubinemia and cholestasis. Pediatr Blood Cancer. 2011 May;56(5):840-2.

Heubi, JE. Child health research and the Clinical Translational Science Awards: where have we been and where are we going? Clin Transl Sci. 2010 Jun;3(3):67-8.

Hommel KA, McGraw KL, Ammerman RT, Heubi JE, Hansen M, Dunlap E, Beidel DC. Psychosocial functioning in children and adolescents with gastrointestinal complaints and disorders. J Clin Psychol Med Settings. 2010 Jun;17(2):159-66.

Setchell KD, Zhao X, Jha P, Heubi JE, Brown NM. The pharmacokinetic behavior of the soy isoflavone metabolite S-(-)equol and its diastereoisomer R-(+)equol in healthy adults determined by using stable-isotope-labeled tracers. Am J Clin Nutr. 2009 Oct;90(4):1029-37.

Wooldridge JL, Heubi JE, Amaro-Galvez R, Boas SR, Blake KV, Nasr SZ, Chatfield B, McColley SA, Woo MS, Hardy KA, Kravitz RM, Straforini C, Anelli M, Lee C. EUR-1008 pancreatic enzyme replacement is safe and effective in patients with cystic fibrosis and pancreatic insufficiency. J Cyst Fibros. 2009 Dec;8(6):405-17.

Graham RC, Heubi JE, Cohen MB, Li B. Teaching and tomorrow: a novel recruitment program for a pediatric subspecialty. J Pediatr Gastroenterol Nutr. 2009 Nov;49(5):594-8.

Burke KT, Horn PS, Tso P, Heubi JE, Woollett LA. Hepatic bile acid metabolism in the neonatal hamster: expansion of the bile acid pool parallels increased Cyp7a1 expression levels. Am J Physiol Gastrointest Liver Physiol. 2009 Jul;297(1):G144-51.

Samuel A. Kocoshis, MD Medical Director, Intestinal Care Center 513-636-4415 samuel.kocoshis@cchmc.org

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Samuel A. Kocoshis, MD

Medical Director, Intestinal Care Center

Medical Director, Small Bowel Transplantation Program

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-4415

Fax 513-636-7805

Email samuel.kocoshis@cchmc.org

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Clinical

Management of complex intestinal and liver disease; small bowel transplantation; general disorders of the gastrointestinal tract

Research

Altered bile acid metabolism in gastrointestinal disease; small bowel transplantation; inflammatory bowel disease; short bowel syndrome

Biography

Samuel Kocoshis, MD, is an expert in the management of complex intestinal and liver disease at Cincinnati Children's Hospital Medical Center.

Dr. Kocoshis is the director of the Pediatric Nutrition and Intestinal Care Center in the Division of Gastroenterology, Hepatology and Nutrition, and is also the medical director of the Small Intestinal Transplantation Program. In addition, he is professor of pediatrics at the University of Cincinnati College of Medicine.

Dr. Kocoshis' long-standing research interest has been altered bile acid metabolism in gastrointestinal disease. His current clinical research program focuses upon intestinal adaptation following massive small intestinal resection, as well as the immunology of intestinal transplantation.

Prior to joining Cincinnati Children's, Dr. Kocoshis was chief of Pediatric Gastroenterology and co-director of the Intestinal Care Center at Children's Hospital of Pittsburgh, and professor of pediatrics at the University of Pittsburgh School of Medicine.

Dr. Kocoshis earned his bachelor's degree from DePauw University and his medical degree from the Medical College of Wisconsin. He completed an internship in pediatrics at the West Virginia University Medical Center; a residency in pediatrics at Children's Hospital of Pittsburgh; and a clinical fellowship in gastroenterology at Yale University School of Medicine.

BS: DePauw University, Greencastle, IN.

MD: Medical College of Wisconsin, Milwaukee, WI.

Residency: Children's Hospital of Pittsburgh, Pittsburgh, PA.

Fellowship: Yale University School of Medicine, New Haven, CT.

Kocoshis SA. Medical management of pediatric intestinal failure. Semin Pediatr Surg. 2010 Feb;19(1):20-6. Review.

Wessel JJ, Kocoshis SA. Nutritional management of infants with short bowel syndrome. Semin Perinatol. 2007 Apr;31(2):104-11. Review.

Nathan JD, Rudolph JA, Kocoshis SA, Alonso MH, Ryckman FC, Tiao GM. Isolated liver and multivisceral transplantation for total parenteral nutrition-related end-stage liver disease. J Pediatr Surg. 2007 Jan;42(1):143-7.

Kocoshis S. Small Intestinal Failure in Children. Curr Treat Options Gastroenterol. 2001 Oct;4(5):423-432.

Mike A. Leonis, MD, PhD 513-636-4415 mike.leonis@cchmc.org

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Mike A. Leonis, MD, PhD

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-636-4415

Fax 513-636-7805

Email mike.leonis@cchmc.org

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Pediatric hepatology, especially acute liver failure; inflammatory disease processes of the liver; hepatoblastoma; mechanisms of hepatic tumor formation

MD: Washington University School of Medicine, St. Louis, MO, 1996.

PhD: Washington University School of Medicine, St. Louis, MO, 1996.

Procter Scholar: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2002-2005.

Fellowship: Cincinnati Children's, Cincinnati, OH, 1999-2002.

Residency: Primary Children's Hospital Medical Center, University of Utah School of Medicine, Salt Lake City, UT, 1996-1999.

Certification: American Board of Pediatrics, 1999; Pediatric Gastroenterology, Hepatology and Nutrition, 2003.

Stuart WD, Kulkarni RM, Gray JK, Vasiliauskas J, Leonis MA, Waltz SE. Ron receptor regulates Kupffer cell-dependent cytokine production and hepatocyte survival following endotoxin exposure in mice. Hepatology. 2011 May;53(5):1618-28.

Kenny AP, Crimmins NA, Mackay DJ, Hopkin RJ, Bove KE, Leonis MA. Concurrent course of transient neonatal diabetes with cholestasis and paucity of interlobular bile ducts: a case report. Pediatr Dev Pathol. 2009 Sep-Oct;12(5):417-20.

Leonis MA, Balistreri WF. Evaluation and management of end-stage liver disease in children. Gastroenterology. 2008 May;134(6):1741-51.

Caldwell CC, Martignoni A, Leonis MA, Ondiveeran HK, Fox-Robichaud AE, Waltz SE. Ron receptor tyrosine kinase-dependent hepatic neutrophil recruitment and survival benefit in a murine model of bacterial peritonitis. Crit Care Med. 2008 May;36(5):1585-93.

Leonis MA, Thobe MN, Waltz SE. Ron-receptor tyrosine kinase in tumorigenesis and metastasis. Future Oncol. 2007 Aug;3(4):441-8. Review.

Zinser GM, Leonis MA, Toney K, Pathrose P, Thobe M, Kader SA, Peace BE, Beauman SR, Collins MH, Waltz SE. Mammary-specific Ron receptor overexpression induces highly metastatic mammary tumors associated with beta-catenin activation. Cancer Res. 2006 Dec 15;66(24):11967-74.

Wetzel CC, Leonis MA, Dent A, Olson MA, Longmeier AM, Ney PA, Boivin GP, Kader SA, Caldwell CC, Degen SJ, Waltz SE. Short-form Ron receptor is required for normal IFN-gamma production in concanavalin A-induced acute liver injury. Am J Physiol Gastrointest Liver Physiol. 2007 Jan;292(1):G253-61.

Leonis MA, Toney-Earley K, Degen SJ, Waltz SE. Deletion of the Ron receptor tyrosine kinase domain in mice provides protection from endotoxin-induced acute liver failure. Hepatology. 2002 Nov;36(5):1053-60.

Alexander G. Miethke, MD 513-636-8948 alexander.miethke@cchmc.org

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Alexander G. Miethke, MD

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-636-8948

Email alexander.miethke@cchmc.org

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Clinical

Pediatric liver disease including biliary atresia, inherited liver diseases, autoimmune hepatitis, and primary sclerosing cholangitis; gastrointestinal problems in children with bone marrow failure syndromes

Research

Immune mediated liver injury, specifically the role of regulatory T cells in biliary atresia and primary sclerosing cholangitis; genetic basis for intrahepatic cholestasis in children; acute liver failure in infants with mitochondrial disorders

Biography

Alexander G. Miethke, MD, joined the Division of Gastroenterology, Hepatology and Nutrition as a fellow in 2005, after completing his Pediatric Residency Training at Cincinnati Children's Hospital Medical Center. Following the completion of his fellowship, he pursued an additional year of training in pediatric transplant hepatology under the mentorship of Dr. William Balistreri and the physicians and surgeons of the Pediatric Liver Care Center.

In 2009, Dr. Miethke was appointed assistant professor of pediatrics in the Division of Gastroenterology, Hepatology and Nutrition and the Pediatric Liver Care Center at Cincinnati Children's within the UC Department of Pediatrics. His basic science research interests include the role of regulatory T cells in biliary atresia and other immune mediated liver diseases and the genetic basis of chronic cholestasis syndromes.

MD: Humboldt-University, Berlin, Germany, 2000.

Residency: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2002-2004.

Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2005-2007.

Advanced Fellowship: Pediatric Transplant Hepatology, University of Cincinnati and Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2009.

Certification: Pediatrics, 2005; Pediatric Gastroenterology, 2009; Pediatric Transplant Hepatology, 2010.

Evason K, Bove KE, Finegold MJ, Knisely AS, Rhee S, Rosenthal P, Miethke AG, Karpen SJ, Ferrell LD, Kim GE. Morphologic findings in progressive familial intrahepatic cholestasis 2 (PFIC2): correlation with genetic and immunohistochemical studies. Am J Surg Pathol. 2011;35:687-96.

Miethke AG, Saxena V, Shivakumar P, Sabla GE, Simmons J, Chougnet CA. Post-natal paucity of regulatory T cells and control of NK cell activation in experimental biliary atresia. J Hepatol. 2010 May;52(5):718-26.

Pediatric Hepatobiliary Surgery

Maria H. Alonso, MD Co-Surgical Director, Intestinal Transplant Surgery 513-636-4371 maria.alonso@cchmc.org

Alexander Bondoc, MD 513-636-4371 alex.bondoc@cchmc.org

Jaimie D. Nathan, MD Surgical Director, Pancreas Care Center 513-636-4371 jaimie.nathan@cchmc.org

High Res

Jaimie D. Nathan, MD

Surgical Director, Pancreas Care Center

Surgical Director, Kidney and Intestinal Transplant Programs

Associate Surgical Director, Liver Transplant Program

Academic Affiliations

Assistant Professor, UC Department of Surgery

UC Department of Pediatrics

Phone 513-636-4371

Fax 513-636-7657

Email jaimie.nathan@cchmc.org

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Hepatobiliary and pancreatic disease; liver, kidney, and intestinal transplantation; pediatric surgical oncology; neonatal surgery; minimally invasive surgery

BS: Yale University, New Haven, CT, 1993.

MD: Yale University, New Haven, CT, 1998.

Residency: General Surgery, Duke University Medical Center, Durham, NC, 1998-2000 and 2002-2005.

Surgical Research Fellowship: Duke University Medical Center, Durham, NC, 2000-2002.

Pediatric Surgery Fellowship: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2005-2007.

Transplant Surgery Fellowship: University of Cincinnati, Cincinnati, OH, 2007-2009.

Certification: American Board of Surgery, General Surgery, 2007; American Board of Surgery, Pediatric Surgery, 2008; American Society of Transplant Surgeons Certification, 2009.

Prada CE, Kaul A, Hopkin RJ, Page KI, Nathan JD, Bartholomew DW, Cohen MB, Heubi JE, Leslie ND, Burrow TA. Recurrent pancreatitis in ornithine transcarbamylase deficiency. Mol Genet Metab. 2012 Aug;106(4):482-484.

Bondoc AJ, Taylor JA, Alonso MH, Nathan JD, Wang Y, Balistreri WF, Bezerra JA, Ryckman FC, Tiao GM. The beneficial impact of revision of Kasai portoenterostomy for biliary atresia: an institutional study. Ann Surg. 2012 Mar;255(3):570-576.

Shin CR, Nathan J, Alonso M, Yazigi N, Kocoshis S, Tiao G, Davies SM. Incidence of acute and chronic graft-versus-host disease and donor T-cell chimerism after small bowel or combined organ transplantation. J Pediatr Surg. 2011 Sep;46(9):1732-1738.

Vigna SR, Shahid RA, Nathan JD, McVey DC, Liddle RA. Leukotriene B4 mediates inflammation via TRPV1 in duct obstruction-induced pancreatitis in rats. Pancreas. 2011 Jul;40(5):708-714.

Nathan JD, Romac J, Peng RY, Peyton M, Rockey DC, Liddle RA. Protection against chronic pancreatitis and pancreatic fibrosis in mice overexpressing pancreatic secretory trypsin inhibitor. Pancreas. 2010 Jan;39(1):e24-30.

Ryckman FC, Bucuvalas JC, Nathan J, Alonso M, Tiao G, Balistreri WF. Outcomes following liver transplantation. Semin Pediatr Surg. 2008 May;17(2):123-30.

Follmar KE, Condron SA, Turner II, Nathan JD, Ludwig KA. Treatment of metronidazole-refractory Clostridium difficile enteritis with vancomycin. Surg Infect. 2008 9:195-200.

Patel MB, Nathan JD, Frush DP, Rice HE. Nonoperative management of asymptomatic traumatic pulmonary hernia in a young child. J Trauma. 2007 62:234-235.

Nathan JD, Romac J, Peng RY, Peyton M, MacDonald RJ, Liddle RA. Transgenic expression of pancreatic secretory trypsin inhibitor-I ameliorates secretagogue-induced pancreatitis in mice. Gastroenterology. 2005 128:717-727.

Greg M. Tiao, MD Director, Division of General and Thoracic Surgery 513-636-4371 greg.tiao@cchmc.org

High Res

Greg M. Tiao, MD

Director, Division of General and Thoracic Surgery

Richard and Geralyn Azizkhan Chair in Pediatric Surgery

Surgical Director, Liver Transplantation

Associate Director, Pediatric Surgery Fellowship

Academic Affiliations

Professor, UC Department of Surgery

UC Department of Pediatrics

Phone 513-636-4371

Fax 513-636-7657

Email greg.tiao@cchmc.org

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Biliary atresia

Biography

As a pediatric surgeon and a transplant surgeon, Dr. Tiao is involved in the care of children afflicted with biliary atresia from the time of presentation and diagnosis to the initial Kasai portoenterostomy to the liver transplant, when necessary. He sees the many challenges children and their families experience when diagnosed with this life threatening disease process. From that perspective, defining the basis of this disease process such that therapeutic strategies can be developed eliminating these complex interventions is his career goal. His short term goal is to develop an independent research laboratory investigating the pathogenesis of virus induced biliary atresia specifically seeking to determine the mechanistic basis of this disease so that new treatment strategies can be developed to salvage the native liver.

Dr. Tiao's overarching hypothesis is that biliary atresia results from the infection of cholangiocytes by a virus triggering immune-mediated biliary obstruction. His focus is to determine the mechanisms used by RRV to infect cholangiocytes, how RRV undergoes replication within the cholangiocyte, and how infected cholangiocytes modify the microenvironment, activating the immune system resulting in biliary obstruction. Determination of the mechanistic basis of these inter-related events is essential to understanding the pathogenesis of virus induced BA. By focusing on the basis for the viral insult in the initiation of biliary atresia, he has defined an area of independence from Dr. Jorge Bezerra, his primary research mentor.

BS: Northwestern University, Evanston, IL, 1986.

MD: University of Illinois, Chicago, IL, 1990.

Residency: Loyola University, Maywood, IL, 1991-1992; Senior Resident, Department of Surgery, University of Cincinnati, Cincinnati, OH, 1995-1997; Chief Resident, Department of Surgery, University of Cincinnati, Cincinnati, OH, 1997-1998.

Fellowships: Research Fellow, University of Cincinnati, Cincinnati, OH, 1992-1995; Transplant Surgery Fellow, University of Cincinnati, Cincinnati, OH, 2000-2002; Pediatric Surgery Fellow, Los Angeles Children's Hospital, Los Angeles, CA, 1998-2000.

Certification: Pediatric Surgeon, 2000; Transplant Surgeon, 2002.

Coots A, Donnelly B, Mohanty S, Tiao G. Rotavirus Infection of Human Cholangiocytes Parallels the Murine Model of Biliary Atresia. J Surg Res. 2012 Oct;177(2):275-81. 2012.

Meyers RL, Tiao GM, Dunn SP, Langham Jr, MR. Liver transplantation in the management of unresectable hepatoblastoma in children. Front Biosci (Elite Ed). 2012 Jan;E4:1293-302.

Fernandez KS, Baum R, Fung B, Yeager N, Leonis MA, Wagner LM, Tiao G, Ross ME. Chemoresistant Hepatoblastoma in a Patient with Mosaic Trisomy 18 Treated with Orthotopic Liver Transplantation. Peditr Blood Cancer. 2011;56:498-500.

Superina R, Magee J, Brandt M, Healey P, Tiao G, Ryckman F, Karrer F, Iyer K, Fecteau A, West K, Burns R, Flake A, Hammin L, Lowell J, Dillon P, Columbani P, Ricketts R, Yun L, Moore J, Kasper W. Childhood Liver Research and Education Network. AnnSurg. 2011.

Bondoc A, Taylor J, Alonso M, Nathan, J, Wang Y, Balistreri W, Bezerra J, Ryckman F, Tiao G. The Beneficial Impact of Revision of Kasai Portoenterostomy for Biliary Atresia: An Institutional Study. AnnSurg. 2012;255(3):570-6.

Wang W, Donnelly B, Bondoc A, Mohanty SK, McNeal M, Ward R, Sestak K, Zheng S, Tiao G. The rhesus rotavirus gene encoding VP4 is a major determinant in the pathogenesis of biliary atresia in newborn mice. J Virol. 2011 Sep;85(17):9069-77.

Jafri M, Donnelly B, Bondoc A, Allen S, Tiao G. Cholangiocyte secretion of chemokines in experimental biliary atresia. J Pediatr Surg. 2009;44(3):500-7.

Bondoc AJ, Jafri MA, Donnelly B, Mohanty SK, McNeal MM, Ward, RL, Tiao GM. Prevention of the murine model of biliary atresia after live rotavirus vaccination of dams. J Pediatr Surg. 2009;44(8):1479-90.

Grants

The Molecular Determinants of Virus Induced Biliary Induced Biliary Asteria. Principal Investigator. Apr 2011-Mar 2016.

Nycomed Liver Trial. Principal Investigator. 2012-present.TC-2402-040-SP.

Multidisciplinary Team

Kimberly Sue Bailey, MSN, APRN, CNP Nurse Practitioner, Division of Gastroenterology, Hepatology and Nutrition 513-636-2750 kim.bailey@cchmc.org

Lisa Belle, MSW, LSW Social Worker II, Liver Transplant Center 513-636-9097 lisa.belle@cchmc.org

Siobahn M. Cooper, APRN, CPNP Nurse Practitioner, Division of Gastroenterology, Hepatology and Nutrition 513-803-7472 siobhan.cooper@cchmc.org

Kristen A. Dekok, RN, MSN, CPN Liver Transplant Coordinator, Liver Transplant Center 513-636-4955 kristen.dekok@cchmc.org

Laura Hatcher, APRN, CNP Nurse Practitioner, Division of Gastroenterology, Hepatology and Nutrition 513-636-4415 laura.hatcher@cchmc.org

Rebecca L. Rengering, RN, BSN, CPN Liver Transplant Coordinator, Liver Transplant Center 513-636-4955 becky.rengering@cchmc.org

Julie Sheehan, MSW, LSW Social Worker, Liver Transplant Center 513-803-8974 julie.brunsman@cchmc.org

Shalonda K. Slater, PhD Pediatric Psychologist, Clinical, Behavioral Medicine and Clinical Psychology 513-636-4336 shalonda.slater@cchmc.org

High Res

Shalonda K. Slater, PhD

Pediatric Psychologist, Clinical, Behavioral Medicine and Clinical Psychology

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-636-4336

Fax 513-636-7756

Email shalonda.slater@cchmc.org

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Clinical

Behavioral pain management; coping with chronic illness; psychosocial adjustment to transplant

Research

Family adjustment to chronic illness; child adjustment to chronic pain

Biography

Shalonda K. Slater, PhD, is an assistant professor in the Department of Pediatrics at Cincinnati Children’s Hospital Medical Center within the UC Department of Pediatrics.

She provides clinical care for children with chronic pain including children with headache, sickle cell disease and children awaiting transplantation. She is also a consultant for a NIH-funded pediatric chronic headache clinical trial which involves implementing a cognitive-behavioral-based intervention which focuses on coping and adherence.

She is a member of the Pain Quality Improvement team, part of a hospital-wide initiative aimed at integrating quality improvement science.

PhD: University of Florida, Gainesville, FL, 2007.

Internship: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH.

Fellowship: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH.

Certification: Licensed Psychologist.