Philippe F. Backeljauw, MD

Fellowship Program Director, Division of Endocrinology

Clinical Director, Cincinnati Growth Center

Director, Turner Syndrome Center of Cincinnati

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-8444

Fax 513-636-7486



Pediatric endocrinology; growth disorders; Turner syndrome


Growth disorders; Turner syndrome 

Dr. Backeljauw's research has focused on clinical trials evaluating the efficacy and safety of recombinant human IGF-I in patients with growth hormone insensitivity syndrome. These studies have led to the USFDA approval of IGF-I as a treatment for growth failure associated with primary IGF-I deficiency. The studies ended in 2012, and results have been published. He has also been involved in other multicenter studies of IGF-I therapy or combined growth hormone plus IGF-I therapy for idiopathic short stature. In collaboration with Dr. Meilan Rutter, they recently finished a comprehensive study looking at the efficacy and safety of IGF-I therapy in patients with Duchenne muscular dystrophy.

Another area of research for Dr. Backeljauw, during the last five years, is related to activities in the Turner Syndrome Center. We now have conducted several clinical research projects evaluating the cardiovascular pathology, hypertension, attention deficit disorder status, gonadectomy surgery outcomes, and, in particular, vasculopathy prevalence in our large cohort of patients with Turner syndrome.

MD: University of Ghent, Belgium.

Residency: Pediatric and Adolescent Medicine, Cleveland Clinic Foundation Children's Hospital, Cleveland, OH.

Fellowship: Pediatric Endocrinology, University of North Carolina, Chapel Hill, NC.

Certification: Pediatrics, 1992; recertified, 1999, 2007; Pediatric Endocrinology, 1995; recertified, 2003, 2013.

View PubMed Publications

Gravholt CH, Backeljauw P. New international Turner syndrome guideline – a multi-society. European Journal of Endocrinology. 2017.

Gravholt CH, Andersen NH, Conway GS, Dekkers OM, Geffner ME, Klein KO, Lin AE, Mauras N, Quigley CA, Rubin K, Sandberg DE, Sas TCJ, Silberbach M, Söderström-Anttila V, Stochholm K, van Alfen-van derVelden JA, Woelfle J, Backeljauw PF. Clinical practice guidelines for the care of girls and women with Turner syndrome. European Journal of Endocrinology. 2017;177:G1–G70.

Kelley JC, Gutmark-Little I, Backeljauw P, Bamba V. Increased Non-High-Density Lipoprotein Cholesterol in Children and Young Adults with Turner Syndrome Is Not Explained By BMI Alone. Horm Res Paediatr. 2017 Aug 2.

Cabrera-Salcedo C, Shah AS, Andrew M, Tyzinski L, Hwa V, Gutmark-Little I, Backeljauw P, Dauber A. Isolated Growth Hormone Deficiency due to R183H Mutation in GH1: Clinical Analysis of a Four-Generation Family. Clin Endocrinol (Oxf). 2017 Jun 19.

Gonzales Ballesteros LF, Ma NS, Gordon RJ, Ward L, Backeljauw P, Wasserman H, Weber DR, DiMeglio LA, Gagne J, Stein S, Cody D, Simmons K, Zimakas P, Topor LS, Agrawal S, Calabiria A, Tebben P, Faircloth R, Imel EA, Casey L, Carpenter TO. Hypophosphatemia and Bone Disease associated with Elemental Formula Use in Infants and Children. Bone. 2017.

Subramaniam DR, Stoddard WA, Mortensen KR, Ringgaard S, Trolle C, Gravholt CH, Gutmark EJ, Mylavarapu G, Backeljauw PF, Gutmark-Little I. Continuous measurement of aortic dimensions in Turner syndrome: a cardiovascular magnetic resonance study. JCMR. 2017.

Ocaranza P, Golekoh MC, Andrew SF, Guo MH, Kaplowitz P, Saal H, Rosenfeld RG, Dauber A, Cassorla F, Backeljauw PF, Hwa V. Expanding Genetic and Functional Diagnoses of IGF1R Haploinsufficiencies. Horm Res Paediatr. 2017 Apr 10.

Vairamani K, Merjaneh L, Casano-Sancho P, Emecen Sanli M, David A, Metherell LA, Savage MO, del Pozo S, Backeljauw PF, Rosenfeld RG, Aisenberg J, Dauber A, Hwa V. Novel Dominant-Negative GH Receptor Mutations Expands the Spectrum of GHI and IGF-I Deficiency. J Endocr. 2017;1(4):345-358.

van den hoven AT, Duijnhouwer AL, Eicken A, Aboulhosn J, deBruin C, Backeljauw PF, Demulier L, Chessa M, Uebing A, Veldtman GR, Armstrong A, van den Bosch AE, Witsenburg M, Roos-Hesselink JW. Adverse outcome of coarctation stenting in patients with Turner syndrome. Catheter Cardiovasc Interv. 2016 Sep 15.

Wasserman H, Ikomi C, Hafberg ET, Miethke AG, Bove KE, Backeljauw PF. Two Case Reports of FGF23-Induced Hypophosphatemia in Childhood Biliary Atresia. Pediatrics. 2016 Aug;138(2).

Long-acting GH in GH deficient children (3 studies). Principal Investigator. Versartis, Novo Nordisk, Opko. Ongoing.

IGF-I therapy in PAPP-A2 patients. Co-Principal Investigator. Ipsen. Ongoing.