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A photo of Steven Crone.

Assistant Professor, UC Department of Pediatrics

513-803-9275

Biography & Affiliation

Biography

Steven Crone, PhD, is an assistant professor in the Division of Pediatric Neurosurgery within the UC Department of Surgery. He received his BS with honors from The Pennsylvania State University in 1995. He received his PhD from the University of California, San Diego while performing his thesis research at The Salk Institute for Biological Studies.

His thesis research demonstrated that the ErbB2 receptor tyrosine kinase is essential for maintenance of the enteric nervous system and prevention of dilated cardiomyopathy. His research has important implications for the treatment of Hirschsprung’s disease, heart disease and ErbB2/Her2 dependent breast cancer.

Dr. Crone performed his postdoctoral work at the University of Chicago where he used transgenic mouse models to label, ablate or alter gene expression in specific interneurons to establish that V2a neurons coordinate limb movement during locomotion and promote a normal breathing rhythm.

He joined Cincinnati Children’s Hospital Medical Center in September of 2012 where his laboratory will investigate how motor circuits are altered by injury or disease.

Academic Affiliation

Assistant Professor, UC Department of Pediatrics

Departments

Developmental Biology, Neurosurgery, Neuromuscular Development

Education

BS: The Pennsylvania State University, University Park, PA, 1995.

PhD: University of California, San Diego and The Salk Institute for Biological Studies, San Diego, CA, 2003.

Postdoctoral: University of Chicago, Chicago, IL, 2012.

Publications

V2a neurons constrain extradiaphragmatic respiratory muscle activity at rest. Jensen, VN; Seedle, K; Turner, SM; Lorenz, JN; Crone, SA. eNeuro. 2019; 6:ENEURO.0492-18.2019.

Corticospinal Circuits from the Sensory and Motor Cortices Differentially Regulate Skilled Movements through Distinct Spinal Interneurons. Ueno, M; Nakamura, Y; Li, J; Gu, Z; Niehaus, J; Maezawa, M; Crone, SA; Goulding, M; Baccei, ML; Yoshida, Y. Cell Reports. 2018; 23:1286-1300.e7.

Repeated Measurement of Respiratory Muscle Activity and Ventilation in Mouse Models of Neuromuscular Disease. Jensen, VN; Romer, SH; Turner, SM; Crone, SA. Jove-Journal of Visualized Experiments. 2017; 2017.

Accessory respiratory muscles enhance ventilation in ALS model mice and are activated by excitatory V2a neurons. Romer, SH; Seedle, K; Turner, SM; Li, J; Baccei, ML; Crone, SA. Experimental Neurology. 2017; 287:192-204.