A photo of Iris Gutmark-Little.

Associate Professor, UC Department of Pediatrics


My Biography & Research


As a pediatric endocrinologist, I focus my care on children and adolescents with thyroid disease, growth problems and disorders of puberty. I also treat girls with Turner syndrome, and I practice general pediatric endocrinology as well.

Children are funny, smart and resilient, and I always knew I wanted to work with them. I love interacting with their families. Pediatric endocrinology lets me see many different types of patients, and since there are treatments for many of the diseases we treat, I see children return to health.

I practice patient-centered care and education. I put myself in the shoes of the family and child and listen carefully to everything they say. I work very hard to make sure the family and patient understand my thought process for the treatment plan I am recommending.

I’ve been taking care of girls with Turner syndrome for more than 10 years. In collaboration with families, I focus on the specific things that affect their child’s life the most, while making sure we cover all of the screening and treatment needs. In my research, we are trying to learn why patients with Turner syndrome are at risk for cardiovascular disease.

In my free time, I have three wonderful children who keep me busy and happy. I love to exercise, specifically weight-lifting. I also enjoy good food and drink — especially coffee!

Clinical Interests

Turner syndrome; general pediatric endocrinology; growth; puberty; hypopituitarism


Research Interests

Cardiovascular disease in Turner syndrome

Academic Affiliation

Associate Professor, UC Department of Pediatrics

Clinical Divisions


Research Divisions


My Locations

My Education

BS: Louisiana State University, Baton Rouge, LA, 2000.

MD: Johns Hopkins University School of Medicine, Baltimore, MD, 2004.

Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2007.

Fellowship: Pediatric Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2010.

Certification: General Pediatrics, American Board of Pediatrics, 2008; Pediatric Endocrinology, American Board of Pediatrics, pending 2011.

My Publications

Hemodynamics and tissue biomechanics of the thoracic aorta with a trileaflet aortic valve at different phases of valve opening. Sundstrom, E; Jonnagiri, R; Gutmark-Little, I; Gutmark, E; Critser, P; Taylor, MD; Tretter, JT. International Journal for Numerical Methods in Biomedical Engineering. 2020; 36.

Congenital heart defects associated with aneuploidy syndromes: New insights into familiar associations. Lin, AE; Santoro, S; High, FA; Goldenberg, P; Gutmark-Little, I. American Journal of Medical Genetics, Part C: Seminars in Medical Genetics. 2020; 184:53-63.

Effects of Normal Variation in the Rotational Position of the Aortic Root on Hemodynamics and Tissue Biomechanics of the Thoracic Aorta. Sundstrom, E; Jonnagiri, R; Gutmark-Little, I; Gutmark, E; Critser, P; Taylor, MD; Tretter, JT. Cardiovascular Engineering and Technology. 2020; 11:47-58.

Sex Hormone Phenotypes in Young Girls and the Age at Pubertal Milestones. Fassler, CS; Gutmark-Little, I; Xie, C; Giannini, CM; Chandler, DW; Biro, FM; Pinney, SM. Journal of Clinical Endocrinology and Metabolism. 2019; 104:6079-6089.

Aortic growth rates are not increased in Turner syndrome - A prospective CMR study. Mortensen, KH; Wen, J; Erlandsen, M; Trolle, C; Ringgaard, S; Gutmark, EJ; Gutmark-Little, I; Andersen, NH; Gravholt, CH. European Heart Journal Cardiovascular Imaging. 2019; 20:1164-1170.

Impaired aortic distensibility and elevated central blood pressure in Turner Syndrome: a cardiovascular magnetic resonance study. Wen, J; Trolle, C; Viuff, MH; Ringgaard, S; Laugesen, E; Gutmark, EJ; Subramaniam, DR; Backeljauw, P; Gutmark-Little, I; Andersen, NH; et al. Journal of Cardiovascular Magnetic Resonance. 2018; 20.

Isolated growth hormone deficiency due to the R183H mutation in GH1: Clinical analysis of a four-generation family. Cabrera-Salcedo, C; Shah, AS; Andrew, M; Tyzinski, L; Hwa, V; Gutmark-Little, I; Backeljauw, P; Dauber, A. Clinical Endocrinology. 2017; 87:874-876.

Increased Non-High-Density Lipoprotein Cholesterol in Children and Young Adults with Turner Syndrome Is Not Explained By BMI Alone. Kelley, JC; Gutmark-Little, I; Backeljauw, P; Bamba, V. Hormone Research in Paediatrics: from developmental endocrinology to clinical research. 2017; 88:208-214.

Clinical practice guidelines for the care of girls and women with Turner syndrome: proceedings from the 2016 Cincinnati International Turner Syndrome Meeting. Gravholt, CH; Andersen, NH; Conway, GS; Dekkers, OM; Geffner, ME; Klein, KO; Lin, AE; Mauras, N; Quigley, CA; Rubin, K; et al. European Journal of Endocrinology. 2017; 177:G1-G70.

Continuous measurement of aortic dimensions in Turner syndrome: a cardiovascular magnetic resonance study. Subramaniam, DR; Stoddard, WA; Mortensen, KH; Ringgaard, S; Trolle, C; Gravholt, CH; Gutmark, EJ; Mylavarapu, G; Backeljauw, PF; Gutmark-Little, I. Journal of Cardiovascular Magnetic Resonance. 2017; 19.