A photo of Bradley Keller.

Co-Director, Greater Louisville and Western KY Practice, Heart Institute

Professor, UC Department of Pediatrics


Board Certified

My Biography & Research


Dr. Keller is a clinician-investigator who provides care to children and adults with congenital heart disease throughout Kentucky. He is also an expert in the causes of congenital heart disease and in the development and testing of novel technologies for children and adults with heart disease. On March 1, 2020, Dr. Brad Keller joined the Cincinnati Children's Heart Institute and Dr. Juan Villafañe, as co-director of Cincinnati Children’s Heart Institute – Greater Louisville and Western Kentucky practices, and is at our offices throughout the region. He brings more than 30 years of clinical and administrative congenital heart care experience including prior roles as division chief of Pediatric Cardiology at the University of Kentucky and at the Children’s Hospital of Pittsburgh.

Clinical Interests

Pediatric and adult congenital heart disease

Research Interests

Clinical translation of outpatient telemedicine

Academic Affiliation

Professor, UC Department of Pediatrics

Clinical Divisions

Adolescent and Adult Congenital Heart Disease, Heart Institute, Cardiology Clinic

Research Divisions

Heart Institute

My Locations

My Education

Pediatric Cardiology Fellowship: University of Rochester Medical Center, Rochester, NY, 1988-1991.

Pediatric Residency: Johns Hopkins Hospital, Baltimore, MD, 1985-1988.

MD: Pennsylvania State University School of Medicine, Hershey, PA, 1981-1985.

BS: University of Pennsylvania, Philadelphia, PA, 1977-1981.

My Publications

Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence. Tan, Y; Zhang, Z; Zheng, C; Wintergerst, KA; Keller, BB; Cai, L. Nature Reviews Cardiology. 2020; 17:585-607.

Validating the Paradigm That Biomechanical Forces Regulate Embryonic Cardiovascular Morphogenesis and Are Fundamental in the Etiology of Congenital Heart Disease. Keller, BB; Kowalski, WJ; Tinney, JP; Tobita, K; Hu, N. Journal of Cardiovascular Development and Disease. 2020; 7.

Preparation of mesh-shaped engineered cardiac tissues derived from human ips cells for in vivo myocardial repair. Nakane, T; Abulaiti, M; Sasaki, Y; Kowalski, WJ; Keller, BB; Masumoto, H. Jove-Journal of Visualized Experiments. 2020; 2020:1-7.

Zinc protects against cadmium-induced toxicity in neonatal murine engineered cardiac tissues via metallothionein-dependent and independent mechanisms. Yu, H; Zhen, J; Xu, J; Cai, L; Leng, J; Ji, H; Keller, BB. Acta Pharmacologica Sinica. 2020; 41:638-649.

Sulforaphane prevents right ventricular injury and reduces pulmonary vascular remodeling in pulmonary arterial hypertension. Kang, Y; Zhang, G; Huang, EC; Huang, J; Cai, J; Cai, L; Wang, S; Keller, BB. American Journal of Physiology: Heart and Circulatory Physiology. 2020; 318:H853-H866.

Nrf2: Redox and Metabolic Regulator of Stem Cell State and Function. Dai, X; Yan, X; Wintergerst, KA; Cai, L; Keller, BB; Tan, Y. Trends in Molecular Medicine. 2020; 26:185-200.

Progress in the generation of multiple lineage human-iPSC-derived 3D-engineered cardiac tissues for cardiac repair. Ye, F; Setozaki, S; Kowalski, WJ; Dwenger, M; Yuan, F; Tinney, JP; Nakane, T; Masumoto, H; Keller, BB. Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension. : Springer Singapore; Springer Singapore; 2020.

Neonatal murine engineered cardiac tissue toxicology model: Impact of dexrazoxane on doxorubicin induced injury. Zhen, J; Yu, H; Ji, H; Cai, L; Leng, J; Keller, BB. Life Sciences. 2019; 239:117070-117070.

Chronic optical pacing conditioning of h-iPSC engineered cardiac tissues. Dwenger, M; Kowalski, WJ; Ye, F; Yuan, F; Tinney, JP; Setozaki, S; Nakane, T; Masumoto, H; Campbell, P; Guido, W; et al. Journal of Tissue Engineering. 2019; 10:2041731419841748-204173141984174.

Utilizing Contrast-Enhanced Ultrasound Imaging for Evaluating Fatty Liver Disease Progression in Pre-clinical Mouse Models. Pandit, H; Tinney, JP; Li, Y; Cui, G; Li, S; Keller, BB; II, MR C G. Ultrasound in Medicine and Biology. 2019; 45:549-557.