Paul S. Kingma, MD, PhD

My Biography & Research

Biography

Paul S. Kingma, MD, PhD, serves as an attending physician in the Cincinnati Children’s NICU and as neonatal director of the Cincinnati Fetal Center. Dr Kingma leads several basic science and translation research projects that focus on four primary goals.

The first goal is to improve our understanding of pathogenesis of congenital diaphragmatic hernia (CDH). To this end, Dr. Kingma’s laboratory is developing novel methods for measuring lung injury in CHD infants and he has advanced the use of airway pressure release ventilation as a method of reducing lung injury in infants with CDH. In addition, as part of a collaboration with Dr. Jason Woods, Dr. Kingma is using novel MRI-based methods to measure lung growth and function in CDH infants.

The second goal is to improve our understanding of the formation, repair and prognosis of tracheal esophageal (TE) defects. Dr. Kingma is using novel MRI techniques for evaluating tracheal and esophageal morphology in infants with TE defects. In addition, Dr. Kingma is leading an effort to gather detailed anatomic, genetic and clinical outcome data on a large cohort of patients with TE defects in order enhance diagnosis, predict patients at risk for complications, and ultimately improve treatment.

The third goal is to develop effective clinical management strategies to prevent and treat intestinal dysfunction and feeding intolerance in infants with gastroschisis. Dr. Kingma is currently leading a Gerber Foundation funded study that is using MRI to quantify intestinal factors that lead to enteral feeding intolerance.

The final goal of is to improve our understanding of the molecular pathogenesis of neonatal lung injury. Specifically, Dr. Kingma is evaluating the role of the Surfactant Protein D (SP-D) and the pulmonary innate immune system. In addition, Dr. Kingma is part of a Cincinnati Children's Hospital Medical Center collaboration that is developing SP-D as a therapeutic agent designed to improve surfactant function and reduce lung injury in premature infants.

Clinical Interests

Neonatology; fetal care; neonatal care of infants with congenital malformations including congenital diaphragmatic hernia, tracheal-esophageal defects and gastroschisi

Research Interests

Innate immune systems; surfactant protein D; Neonatal lung growth; genetic basis of congenital malformations

Academic Affiliation

Associate Professor, UC Department of Pediatrics

Departments

Neonatology, Pulmonary Biology, Congenital Diaphragmatic Hernia, Newborn Intensive Care NICU, Neonatology, Perinatal, Fetal Care, Bronchopulmonary Dysplasia BPD

My Locations

Burnet Campus

Burnet Campus

3333 Burnet Ave.

Cincinnati, Ohio 45229-3039

513-636-4200

Directions From

My Education

BS: Calvin College, MI, 1992.

MD: Vanderbilt University, TN, 2000.

PhD: Vanderbilt University, TN, 2000.

Residency: Cincinnati Children's Hospital Medical Center, 2003.

Fellowship: Cincinnati Children's Hospital Medical Center, 2005.

My Publications

Fu T, Kingma PS. Diagnosing Infection in a Neonate Using Whole-Body Screening Magnetic Resonance Imaging. Pediatrics. 2016.

Higano N, Hahn A, Tkach J, Cao X, Walkup L, Thomen R, Merhar S, Kingma P, Fain S, Woods J. Retrospective Respiratory self-gating and removal of bulk motion in pulmonary UTE MRI of neonates and adults. Magnetic Resonance in Medicine. 2016.

Coleman A, Phithakwatchara N, Shaaban A, Keswani S, Kline-Fath B, Kingma P, Haberman B, Lim FY. Fetal lung growth represented by longitudinal changes in MRI-derived fetal lung volume parameters predicts survival in isolated left-sided congenital diaphragmatic hernia. Prenat Diagn. 2015;35(2):160-6.

Lynema S, Marmer D, Hall E, Meinzen-Derr, J, Kingma PS. Neutrophil CD64 as a diagnostic marker of sepsis: impact on neonatal care. Am J Perinatology. 2015;32(4):331-6.

Landis MW, Butler D, Lim FY, Keswani SG, Frischer JS, Haberman BE, Kingma PS. Octreotide for chylous effusions in congenital diaphragmatic hernia. J Pediatr Surg. 2013;48(11):2226-9.

Wetzel EA, Kingma PS. Subgaleal hemorrhage in a neonate with Factor X deficiency following a non-traumatic cesarean section. J Perinatol. 2012;32(4):304-5.

Le LD, Keswani SG, Biesiada J, Lim FY, Kingma PS, Haberman BE, Frischer J, Habli M, Crombleholme TM. The congenital diaphragmatic hernia composite prognostic index correlates with survival in left-sided congenital diaphragmatic hernia. J Pediatr Surg. 2012;47(1):57-62.

King BA, Boyd JT, Kingma PS. Pulmonary maturational arrest and death in a patient with pulmonary interstitial glycogenosis. Pediatr Pulmonol. 2011;46(11):1142-5.

Lee TC, Lim FY, Keswani SG, Frischer JS, Haberman B, Kingma PS, Habli M, Jaekle RK, Sharp G, Kline-Fath B, Rubio EI, Calvo M, Guimaraes C, Crombleholme TM. Late gestation fetal magnetic resonance imaging-derived total lung volume predicts postnatal survival and need for extracorporeal membrane oxygenation support in isolated congenital diaphragmatic hernia. J Pediatr Surg. 2011;46(6):1165-71.

King BA, Kingma PS. Surfactant Protein D deficiency increases lung injury during endotoxemia. Am J Respir Cell Mol Bio. 2011;44(5):709-15.