A photo of Paul Kingma.

Director, Bronchopulmonary Dysplasia (BPD) Center

Associate Professor, UC Department of Pediatrics

513-636-7868

513-636-7868

Board Certified

My Biography & Research

Biography

Paul S. Kingma, MD, PhD, serves as an attending physician in the Cincinnati Children’s NICU and as neonatal director of the Cincinnati Fetal Center. Dr Kingma leads several basic science and translation research projects that focus on four primary goals.

The first goal is to improve our understanding of pathogenesis of congenital diaphragmatic hernia (CDH). To this end, Dr. Kingma’s laboratory is developing novel methods for measuring lung injury in CHD infants and he has advanced the use of airway pressure release ventilation as a method of reducing lung injury in infants with CDH. In addition, as part of a collaboration with Dr. Jason Woods, Dr. Kingma is using novel MRI-based methods to measure lung growth and function in CDH infants.

The second goal is to improve our understanding of the formation, repair and prognosis of tracheal esophageal (TE) defects. Dr. Kingma is using novel MRI techniques for evaluating tracheal and esophageal morphology in infants with TE defects. In addition, Dr. Kingma is leading an effort to gather detailed anatomic, genetic and clinical outcome data on a large cohort of patients with TE defects in order enhance diagnosis, predict patients at risk for complications, and ultimately improve treatment.

The third goal is to develop effective clinical management strategies to prevent and treat intestinal dysfunction and feeding intolerance in infants with gastroschisis. Dr. Kingma is currently leading a Gerber Foundation funded study that is using MRI to quantify intestinal factors that lead to enteral feeding intolerance.

The final goal of is to improve our understanding of the molecular pathogenesis of neonatal lung injury. Specifically, Dr. Kingma is evaluating the role of the Surfactant Protein D (SP-D) and the pulmonary innate immune system. In addition, Dr. Kingma is part of a Cincinnati Children's Hospital Medical Center collaboration that is developing SP-D as a therapeutic agent designed to improve surfactant function and reduce lung injury in premature infants.

Clinical Interests

Neonatology; fetal care; neonatal care of infants with congenital malformations including congenital diaphragmatic hernia, tracheal-esophageal defects and gastroschisi

Research Interests

Innate immune systems; surfactant protein D; Neonatal lung growth; genetic basis of congenital malformations

Academic Affiliation

Associate Professor, UC Department of Pediatrics

Clinical Divisions

Congenital Diaphragmatic Hernia, Newborn Intensive Care NICU, Neonatology, Perinatal, Bronchopulmonary Dysplasia BPD

Research Divisions

Neonatology, Pulmonary Biology

My Locations

My Education

BS: Calvin College, MI, 1992.

MD: Vanderbilt University, TN, 2000.

PhD: Vanderbilt University, TN, 2000.

Residency: Cincinnati Children's Hospital Medical Center, 2003.

Fellowship: Cincinnati Children's Hospital Medical Center, 2005.

My Publications

Selected Publication

Feeding Tolerance, Intestinal Motility, and Superior Mesenteric Artery Blood Flow in Infants with Gastroschisis. Williams, SL; Tkach, JA; Rattan, MS; South, AP; Wessel, J; Kingma, PS. Neonatology: foetal and neonatal research. 2020; 117:95-101.

Neonatal lung growth in congenital diaphragmatic hernia: evaluation of lung density and mass by pulmonary MRI. Adaikalam, SA; Higano, NS; Tkach, JA; Lim, FY; Haberman, B; Woods, JC; Kingma, PS. Pediatric Research. 2019; 86:635-640.

Evaluation of Lung Injury in Infants with Congenital Diaphragmatic Hernia. Marks, KT; Landis, MW; Lim, FY; Haberman, B; Kingma, PS. Journal of Pediatric Surgery. 2019; 54:2443-2447.

Pre- and post-operative visualization of neonatal esophageal atresia/tracheoesophageal fistula via magnetic resonance imaging. Higano, NS; Bates, AJ; Tkach, JA; Fleck, RJ; Lim, FY; Woods, JC; Kingma, PS. Journal of Pediatric Surgery Case Reports. 2018; 29:5-8.

Evaluation of Neonatal Lung Volume Growth by Pulmonary Magnetic Resonance Imaging in Patients with Congenital Diaphragmatic Hernia. Schopper, MA; Walkup, LL; Tkach, JA; Higano, NS; Lim, FY; Haberman, B; Woods, JC; Kingma, PS. The Journal of Pediatrics. 2017; 188:96-102.e1.

Factors that Influence Longitudinal Growth from Birth to 18 Months of Age in Infants with Gastroschisis. Nair, N; Merhar, S; Wessel, J; Hall, E; Kingma, PS. American Journal of Perinatology: neonatal and maternal-fetal medicine. 2020; 37:1438-1445.

Cardiovascular magnetic resonance imaging derived septal curvature in neonates with bronchopulmonary dysplasia associated pulmonary hypertension. Critser, PJ; Higano, NS; Lang, SM; Kingma, PS; Fleck, RJ; Hirsch, R; Taylor, MD; Woods, JC. Journal of Cardiovascular Magnetic Resonance. 2020; 22.

Magentic Resonance Imaging Evaluation of Regional Lung Vts in Severe Neonatal Bronchopulmonary Dysplasia. Gouwens, KR; Higano, NS; Marks, KT; Stimpfl, JN; Hysinger, EB; Woods, JC; Kingma, PS. American Journal of Respiratory and Critical Care Medicine. 2020; 202:1024-1031.

Contemporary Outcomes of Patients with Isolated Bilateral Renal Agenesis with and without Fetal Intervention. Riddle, S; Habli, M; Tabbah, S; Lim, FY; Minges, M; Kingma, P; Polzin, W. Fetal Diagnosis and Therapy: clinical advances and basic research. 2020; 47:675-681.

Functional characterization of the different oligomeric forms of human surfactant protein SP-D. Arroyo, R; Echaide, M; Moreno-Herrero, F; Perez-Gil, J; Kingma, PS. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS. 2020; 1868:140436-140436.