A photo of Paul Kingma.

Paul S. Kingma, MD, PhD


  • Director, Bronchopulmonary Dysplasia (BPD) Center
  • Associate Professor, UC Department of Pediatrics

About

Biography

Paul S. Kingma, MD, PhD, serves as an attending physician in the Cincinnati Children’s NICU and as neonatal director of the Cincinnati Fetal Center. Dr Kingma leads several basic science and translation research projects that focus on four primary goals.

The first goal is to improve our understanding of pathogenesis of congenital diaphragmatic hernia (CDH). To this end, Dr. Kingma’s laboratory is developing novel methods for measuring lung injury in CHD infants and he has advanced the use of airway pressure release ventilation as a method of reducing lung injury in infants with CDH. In addition, as part of a collaboration with Dr. Jason Woods, Dr. Kingma is using novel MRI-based methods to measure lung growth and function in CDH infants.

The second goal is to improve our understanding of the formation, repair and prognosis of tracheal esophageal (TE) defects. Dr. Kingma is using novel MRI techniques for evaluating tracheal and esophageal morphology in infants with TE defects. In addition, Dr. Kingma is leading an effort to gather detailed anatomic, genetic and clinical outcome data on a large cohort of patients with TE defects in order enhance diagnosis, predict patients at risk for complications, and ultimately improve treatment.

The third goal is to develop effective clinical management strategies to prevent and treat intestinal dysfunction and feeding intolerance in infants with gastroschisis. Dr. Kingma is currently leading a Gerber Foundation funded study that is using MRI to quantify intestinal factors that lead to enteral feeding intolerance.

The final goal of is to improve our understanding of the molecular pathogenesis of neonatal lung injury. Specifically, Dr. Kingma is evaluating the role of the Surfactant Protein D (SP-D) and the pulmonary innate immune system. In addition, Dr. Kingma is part of a Cincinnati Children's Hospital Medical Center collaboration that is developing SP-D as a therapeutic agent designed to improve surfactant function and reduce lung injury in premature infants.

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Publications

Selected

Feeding Tolerance, Intestinal Motility, and Superior Mesenteric Artery Blood Flow in Infants with Gastroschisis. Williams, SL; Tkach, JA; Rattan, MS; South, AP; Wessel, J; Kingma, PS. Neonatology. 2020; 117:95-101.

Selected

Evaluation of Lung Injury in Infants with Congenital Diaphragmatic Hernia. Marks, KT; Landis, MW; Lim, FY; Haberman, B; Kingma, PS. Journal of Pediatric Surgery. 2019; 54:2443-2447.

Selected

Neonatal lung growth in congenital diaphragmatic hernia: evaluation of lung density and mass by pulmonary MRI. Adaikalam, SA; Higano, NS; Tkach, JA; Lim, FY; Haberman, B; Woods, JC; Kingma, PS. Pediatric Research. 2019; 86:635-640.

Selected

Pre- and post-operative visualization of neonatal esophageal atresia/tracheoesophageal fistula via magnetic resonance imaging. Higano, NS; Bates, AJ; Tkach, JA; Fleck, RJ; Lim, FY; Woods, JC; Kingma, PS. Journal of Pediatric Surgery Case Reports. 2018; 29:5-8.

Selected

Evaluation of Neonatal Lung Volume Growth by Pulmonary Magnetic Resonance Imaging in Patients with Congenital Diaphragmatic Hernia. Schopper, MA; Walkup, LL; Tkach, JA; Higano, NS; Lim, FY; Haberman, B; Woods, JC; Kingma, PS. Journal of Pediatrics. 2017; 188:96-102.e1.

Surfactant protein D and bronchopulmonary dysplasia: a new way to approach an old problem. Arroyo, R; Kingma, PS. Respiratory Research. 2021; 22.

Magnetic Resonance Imaging Assessment of Pulmonary Vascularity in Infants with Congenital Diaphragmatic Hernia: A Novel Tool for Direct Assessment of Severity of Pulmonary Hypertension and Hypoplasia. Mukthapuram, S; Beebe, J; Tkach, JA; Arya, S; Haberman, B; Peiro, J; Lim, FY; Woods, JC; Kingma, PS. Journal of Pediatrics. 2021; 239:89-94.

Developmental basis of trachea-esophageal birth defects. Edwards, NA; Shacham-Silverberg, V; Weitz, L; Kingma, PS; Shen, Y; Wells, JM; Chung, WK; Zorn, AM. Developmental Biology. 2021; 477:85-97.

Venovenous versus venoarterial extracorporeal membrane oxygenation among infants with hypoxic-ischemic encephalopathy: is there a difference in outcome?. Agarwal, P; Rintoul, N; Zaniletti, I; Keene, S; Mietzsch, U; Massaro, AN; Billimoria, Z; Dirnberger, D; Hamrick, S; Seabrook, RB; et al. Journal of Perinatology. 2021; 41:1916-1923.

Full-Length Recombinant hSP-D Binds and Inhibits SARS-CoV-2. Arroyo, R; Grant, SN; Colombo, M; Salvioni, L; Corsi, F; Truffi, M; Ottolina, D; Hurst, B; Salzberg, M; Prosperi, D; et al. Biomolecules. 2021; 11.

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