Daniel G. Leino, MD, MPH

ID #854 Updated findings from a phase 1 study of savolitinib in recurrent, progressive, or refractory medulloblastoma (MB), high-grade glioma (HGG), diffuse intrinsic pontine glioma (DIPG), and central nervous system (CNS) tumors harboring MET aberrations: A Pediatric Brain Tumor Consortium Trial: PBTC-049. Salloum, R; Stewart, C; Schieffer, K; Balow, S; Leino, D; Lenzen, A; Waanders, A; Baxter, P; Lindsay, H; Poussaint, T; Onar-Thomas, A; O’Halloran, K; Fouladi, M; Dunkel, I. Neuro-Oncology Pediatrics. 2026; 2(Supplement_1):wuag026.360.

ID #651 A phase 1/2 and surgical Pediatric Brain Tumor Consortium (PBTC) study evaluating the casein kinase 2 (CK2) inhibitor CX-4945 (silmitasertib sodium) in children and adults with recurrent sonic hedgehog (SHH) medulloblastoma (MB): PBTC-053. Salloum, R; Purzner, T; Stewart, C; Wang, Y; Leino, D; Cottrell, C; Jamal, B; Abdullaev, Z; Poussaint, T; Li, G; Fangusaro, J; Fouladi, M; Onar, A; Dunkel, I. Neuro-Oncology Pediatrics. 2026; 2(Supplement_1):wuag026.260.

ID #18 CHD7-associated CHARGE Syndrome and a spinal schwannoma with a SH3PXD2A::HTRA1 fusion: A case report. Reel, S; Roy, S; Leino, D; Gatts, J; Raskin, S. Neuro-Oncology Pediatrics. 2026; 2(Supplement_1):wuag026.001.

The first described report of a patient with CHD7-associated CHARGE syndrome and a spinal schwannoma with a SH3PXD2A::HTRA1 fusion; a case report and review of literature. Reel, SM; Roy, S; Leino, D; Gatts, J; Raskin, S. Neuro-Oncology Pediatrics. 2026; 2(2):wuag034.

Diagnostic pitfall: BCOR immunoreactivity in a molecularly confirmed astroblastoma, MN1-altered (HGNET-MN1). Nisarga, P; Rathore, B; Hodjat, P; Derinkuyu, BE; Graham, RT; Skoch, J; Leino, D; Gupta, K. Clinical Neuropathology. 2026; 45(1):32-35.

A novel POT1-TPD presentation: A germline pathogenic POT1 variant discovered in a patient with newly diagnosed posterior fossa ependymoma. Gilene, S; Knapke, S; Leino, D; Roy, S; Raskin, S. Cancer Genetics. 2025; 292-293:38-43.

Prothrombin prevents fatal T cell-dependent anemia during chronic virus infection of mice. Cantrell, R; Feldman, HA; Rosenfeldt, L; Ali, A; Gourley, B; Sprague, C; Leino, D; Crosby, J; Revenko, A; Monia, B; Waggoner, SN; Palumbo, JS. JCI Insight. 2025; 10(4).

The human and non-human primate developmental GTEx projects. Coorens, THH; Guillaumet-Adkins, A; Kovner, R; Linn, RL; Roberts, VHJ; Sule, A; Van Hoose, PM. Nature. 2025; 637(8046):557-564.

Factor XII promotes the thromboinflammatory response in a rat model of venoarterial extracorporeal membrane oxygenation. Kharnaf, M; Zafar, F; Hogue, S; Rosenfeldt, L; Cantrell, RL; Sharma, BK; Pearson, A; Sprague, C; Leino, D; Abplanalp, WA; Morales, D; Tweddell, J; Qualls, JE; Palumbo, JS. Journal of Thoracic and Cardiovascular Surgery. 2024; 168(2):e37-e53.

Use of Teduglutide in the Management of Gastrointestinal Graft-versus-Host Disease in Children and Young Adults. Ramos, KN; Leino, D; Luebbering, N; Grimley, MS; Badia, P; Davies, SM; Khandelwal, P. Transplantation and Cellular Therapy. 2024; 30(4):454.e1-454.e6.