A photo of Daniel Leino.

Daniel G. Leino, MD, MPH

  • Staff Pathologist, Division of Pathology
  • Assistant Professor, UC Department of Pathology and Laboratory Medicine


MPH: Tropical Medicine / Emerging Disease; Certificate Infection Control; South Florida University College of Public Health, Tampa, FL, 2002.

MD: State University of New York; Upstate Medical University, Syracuse, NY, 2008.

Residency: Anatomic and Clinical Pathology, University of Michigan Hospitals, Ann Arbor, MI.

Fellowships: Hematopathology, University of Michigan Hospitals, Ann Arbor, MI, 2012-2013; Pediatric Pathology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2013-2015.

Certification: American Board of Pathology AP/CP, 2013; Pediatric Pathology Subspeciality, 2014; Hematopathology Subspecialty, 2016.


Pediatric pathology; hematopathology

Services and Specialties



Immune checkpoint regulation; solid organ, soft tissue, and bone tumor pathobiology; graft versus host disease and thrombotic microangiopathy; developmental biology of vasculature (zebrafish models) and intracerebral aneurysms; collagen mutation biology

Research Areas



Use of Teduglutide in the Management of Gastrointestinal Graft-versus-Host Disease in Children and Young Adults. Ramos, KN; Leino, D; Luebbering, N; Grimley, MS; Badia, P; Davies, SM; Khandelwal, P. Transplantation and cellular therapy. 2024; 30:454.e1-454.e6.

Transcriptome analysis in acute gastrointestinal graft-versus host disease reveals a unique signature in children and shared biology with pediatric inflammatory bowel disease. Khandelwal, P; Lounder, DT; Bartlett, A; Haberman, Y; Jegga, AG; Ghandikota, S; Koo, J; Luebbering, N; Leino, D; Abdullah, S; Karns, R; Nelson, AS; Denson, LA; Davies, SM. Haematologica: the hematology journal. 2023; 108:1803-1816.

T-cell infiltrate intensity is associated with delayed response to treatment in late acute cellular rejection in pediatric liver transplant recipients. Peters, AL; Rogers, M; Begum, G; Sun, Q; Fei, L; Leino, D; Hildeman, D; Woodle, ES. Pediatric Transplantation. 2023; 27:e14475.

Targeting the contact system in a rabbit model of extracorporeal membrane oxygenation. Tweddell, JS; Kharnaf, M; Zafar, F; Riggs, KW; Reagor, JA; Monia, BP; Revenko, A; Leino, DG; Owens, AP; Martin, JK; Gourley, B; Rosenfeldt, L; Palumbo, JS. Blood Advances. 2023; 7:1404-1417.

A Murine Model of Veno-Arterial Extracorporeal Membrane Oxygenation. Kharnaf, M; Hogue, S; Wilkes, Z; Reagor, JA; Leino, DG; Gourley, B; Rosenfeldt, L; Ma, Q; Devarajan, P; Palumbo, JS; Tweddell, JS; Zafar, F. ASAIO Journal. 2022; 68:e243-e250.

Ingested Foreign Bodies Can Cause Appendicitis and Perforation: A Multi-Institutional Case Series. Fuller, MY; Leino, DG; Reyes-Múgica, M; Kovach, AE; Velázquez Vega, JE; Caltharp, S; Bhatti, T; Gonzalez, RS. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. 2022; 25:499-503.

Lethal Pediatric Cerebral Vasculitis Triggered by Severe Acute Respiratory Syndrome Coronavirus 2. Poisson, KE; Zygmunt, A; Leino, D; Fuller, CE; Jones, BV; Haslam, D; Staat, MA; Clay, G; Ting, TV; Wesselkamper, K; Day, ME; McNeal, M; Stevenson, CB; Vawter-Lee, M. Pediatric Neurology. 2022; 127:1-5.

ALK-positive histiocytosis: a new clinicopathologic spectrum highlighting neurologic involvement and responses to ALK inhibition. Kemps, PG; Picarsic, J; Durham, BH; Hélias-Rodzewicz, Z; Hiemcke-Jiwa, L; van den Bos, C; van de Wetering, MD; van Noesel, CJ M; van Laar, JA M; Verdijk, RM; van Halteren, AG S; Abla, O; Diamond, EL; Emile, JF. Blood. 2022; 139:256-280.

Immuno-transcriptomic profiling of extracranial pediatric solid malignancies. Brohl, AS; Sindiri, S; Wei, JS; Milewski, D; Chou, HC; Song, YK; Wen, X; Kumar, J; Reardon, HV; Mudunuri, US; Teicher, BA; Magnan, H; Ladanyi, M; Khan, J. Cell Reports. 2021; 37:110047.

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