The Cancer and Blood Diseases Institute at Cincinnati Children’s provides expert care for children with newly diagnosed and relapsed / refractory neuroblastoma. Our Neuroblastoma Advanced Therapies Center offers patients and families a multidisciplinary team approach that consists of medical, surgical, radiation and diagnostic care, fertility preservation and supportive services.

The directors of the Neuroblastoma Advanced Therapies Center are Brian Weiss, MD, and Daniel von Allmen, MD. Weiss is a national leader in the study of improved treatments for neuroblastoma. His research focuses on new approaches to targeting and killing neuroblastoma cells. Weiss leads national studies on neuroblastoma therapies and is a leader in the Children's Oncology Group's (COG) neuroblastoma committee and the New Approaches to Neuroblastoma Therapy (NANT) consortium.

Advancing Targeted Radiation Therapies

Cincinnati Children’s is a leading center for the development and clinical testing of new approaches to neuroblastoma treatment. Our physicians and researchers are involved in many national and international research studies and develop their own protocols when treating neuroblastoma in children and infants. This work provides our patients with early access to new anticancer therapies, sometimes years before they become widely available elsewhere.

Such therapies include 131I-MIBG therapy, which targets radiation directly to neuroblastoma cells while sparing healthy tissue. Cincinnati Children’s is one of just a few pediatric centers in the country to offer the technically demanding 131I-MIBG therapy, which requires special facilities for radiation safety and a collaborative approach to care across multiple divisions.

In addition, Cincinnati Children’s Proton Therapy Center offers one of the most precise and advanced forms of radiation therapy available in the world today. In the hands of the expert cancer team at Cincinnati Children’s, this specialized pencil beam technology destroys cancer cells while minimizing damage to surrounding healthy tissues and organs.

We also specialize in blood and marrow transplantation. Our transplant team has performed more than 2,200 blood and marrow transplants, including more than 225 for advanced neuroblastoma. The pediatric Bone Marrow Transplantation Program at Cincinnati Children’s is one of the largest in the country.

Multidisciplinary Clinic Provides Convenience

At many hospitals, patients and families must travel to different floors or even different buildings to see various specialists. Our multidisciplinary clinic within the Cancer and Blood Diseases Institute brings these specialists together, making visits more convenient and enabling the highest level of communication and coordination of care. Leading the team are oncologists and blood and marrow transplant specialists, who have extensive experience in caring for pediatric neuroblastoma patients and in conducting clinical research. Other members of the team include physicians specializing in:

New patients undergo a comprehensive evaluation in our clinic. Our team then develops a detailed assessment and treatment recommendations. We provide referring physicians with regular updates to ensure coordinated care.

Depending on your child’s needs, the team may include other Cincinnati Children’s specialists, including experts in:

Our Mission

  • Develop systemic changes to provide the best care possible for patients with neuroblastoma
  • Develop clinical research and quality improvement projects that can directly impact patients with neuroblastoma
  • Develop laboratory research ideas to further our understanding of, and therapy for, neuroblastoma
  • Foster collaboration between clinical, quality improvement, and research efforts for neuroblastoma