A photo of Punam Malik.

Punam Malik, MD

  • Director, Cincinnati Comprehensive Sickle Cell Center
  • Program Leader, Hematology and Gene Therapy Program
  • Marjory J. Johnson Chair, Gene and Cell Therapy
  • Professor, UC Department of Pediatrics


MBBS: University of Delhi, New Delhi, India, 1985.

MD: University of Delhi, New Delhi, India, 1989.

MS: University of Maryland, Baltimore, MD, 1991.

Fellowship: Children's Hospital Los Angeles, University of Southern California, 1995.

Services and Specialties

Cancer and Blood Diseases, Sickle Cell and Hemoglobin Disorders

Research Areas

Experimental Hematology and Cancer Biology, Cancer and Blood Diseases, Hematology

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Towards access for all: 1st Working Group Report for the Global Gene Therapy Initiative (GGTI). Adair, JE; Androski, L; Bayigga, L; Bazira, D; Brandon, E; Dee, L; Deeks, S; Draz, M; Dubé, K; Dybul, M; et al. Gene Therapy (Basingstoke). 2023; 30:216-221.

Future Directions and Resource Needs for National Heart, Lung, and Blood Institute (NHLBI) Gene Therapy Research: A Report of an NHLBI Workshop. McDonald, CL; Qasba, P; Anderson, DG; Bao, G; Colvin, RA; Kohn, DB; Malik, P; Mitchell, MJ; Pu, WT; Rawlings, DJ; et al. Human Gene Therapy. 2023; 34:83-89.

Preclinical Evaluation of Foamy Virus Vector-Mediated Gene Addition in Human Hematopoietic Stem/Progenitor Cells for Correction of Leukocyte Adhesion Deficiency Type 1. Smith, RH; Bloomer, H; Fink, D; Keyvanfar, K; Nasimuzzaman, M; Sancheznieto, F; Dutta, R; Guenther Bui, K; Alvarado, LJ; Bauer, TR; et al. Human Gene Therapy. 2022; 33:1293-1304.

NRASQ61R mutation in human endothelial cells causes vascular malformations. Boscolo, E; Pastura, P; Schrenk, S; Goines, J; Kang, R; Pillis, D; Malik, P; Le Cras, TD. Angiogenesis. 2022; 25:331-342.

Differential CXCR4 expression on hematopoietic progenitor cells versus stem cells directs homing and engraftment. Felker, S; Shrestha, A; Bailey, J; Pillis, DM; Siniard, D; Malik, P. JCI insight. 2022; 7:e151847.

Successful use of veno-venous extracorporeal membrane oxygenation for acute chest syndrome in a child with sickle cell disease and SARS-CoV-2. Koh, W; Malik, P; Whitehead, J; Morales, DL S; Hayes, D. Pediatric Pulmonology. 2022; 57:1096-1099.

Rapid and automated quantitation of dense red blood cells: A robust biomarker of hydroxyurea treatment response. Sadaf, A; Quinn, CT; Korpik, JB; Pfeiffer, A; Reynaud, M; Niss, O; Malik, P; Ware, RE; Kalfa, TA; McGann, PT. Blood Cells, Molecules, and Diseases. 2021; 90:102576.

Early initiation of hydroxyurea (hydroxycarbamide) using individualised, pharmacokinetics-guided dosing can produce sustained and nearly pancellular expression of fetal haemoglobin in children with sickle cell anaemia. Quinn, CT; Niss, O; Dong, M; Pfeiffer, A; Korpik, J; Reynaud, M; Bonar, H; Kalfa, TA; Smart, LR; Malik, P; et al. British Journal of Haematology. 2021; 194:617-625.

Cardiac pathophysiology in sickle cell disease. Gbotosho, OT; Taylor, M; Malik, P. Journal of Thrombosis and Thrombolysis. 2021; 52:248-259.

Implementation of near-universal hydroxyurea uptake among children with sickle cell anemia: A single-center experience. Karkoska, K; Todd, K; Niss, O; Clapp, K; Fenchel, L; Kalfa, TA; Malik, P; Quinn, CT; Ware, RE; McGann, PT. Pediatric Blood and Cancer. 2021; 68:e29008.

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