A photo of Punam Malik.

Director, Cincinnati Comprehensive Sickle Cell Center

Director, Translational Core Laboratory

Marjory J. Johnson Chair, Gene and Cell Therapy

Professor, UC Department of Pediatrics



Board Certified

My Biography & Research

Academic Affiliation

Professor, UC Department of Pediatrics


Cancer and Blood Diseases, Sickle Cell and Hemoglobin Disorders, Experimental Hematology and Cancer Biology, Cancer and Blood Diseases

Science Blog

My Locations

My Education

MBBS: University of Delhi, New Delhi, India, 1985.

MD: University of Delhi, New Delhi, India, 1989.

MS: University of Maryland, Baltimore, MD, 1991.

Fellowship: Children's Hospital Los Angeles, University of Southern California, 1995.

My Publications

Robust clinical and laboratory response to hydroxyurea using pharmacokinetically guided dosing for young children with sickle cell anemia. McGann, PT; Niss, O; Dong, M; Marahatta, A; Howard, TA; Mizuno, T; Lane, A; Kalfa, TA; Malik, P; Quinn, CT; et al. American Journal of Hematology. 2019; 94:871-879.

Abnormal submaximal cardiopulmonary exercise parameters predict impaired peak exercise performance in sickle cell anemia patients. Powell, AW; Alsaied, T; Niss, O; Fleck, RJ; Malik, P; Quinn, CT; Mays, WA; Taylor, MD; Chin, C. Pediatric Blood and Cancer. 2019; 66.

Elimination of the fibrinogen integrin aMb2-binding motif improves renal pathology in mice with sickle cell anemia. Nasimuzzaman, M; Arumugam, PI; Mullins, ES; James, JM; Vanden Heuvel, K; Narciso, MG; Shaw, MA; McGraw, S; Aronow, BJ; Malik, P. Blood Advances. 2019; 3:1519-1532.

Therapeutic strategies for sickle cell disease: towards a multi-agent approach. Telen, MJ; Malik, P; Vercellotti, GM. Nature Reviews Drug Discovery. 2019; 18:139-158.

A Versatile Tool for the Quantification of CRISPR/Cas9-Induced Genome Editing Events in Human Hematopoietic Cell Lines and Hematopoietic Stem/Progenitor Cells. Jayavaradhan, R; Pillis, DM; Malik, P. Journal of Molecular Biology. 2019; 431:102-110.

Diastolic dysfunction is associated with exercise impairment in patients with sickle cell anemia. Alsaied, T; Niss, O; Powell, AW; Fleck, RJ; Cnota, JF; Chin, C; Malik, P; Quinn, CT; Taylor, MD. Pediatric Blood and Cancer. 2018; 65:e27113-e27113.

Angiotensin receptor signaling in sickle cell anemia has a reno-protective effect on urine concentrating ability but results in sickle glomerulopathy. Roy, S; Rai, P; Mpollo, ME M; Chang, K; Rizvi, T; Shanmukhappa, SK; VandenHeuvel, K; Aronow, B; Inagami, T; Cancelas, JA; et al. American Journal of Hematology. 2018; 93:E177-E181.

Genetic Therapies for Sickle Cell Disease. Jayavaradhan, R; Malik, P. Pediatric Clinics of North America. 2018; 65:465-480.

Production and Purification of Baculovirus for Gene Therapy Application. Nasimuzzaman, M; van der Loo, JC M; Malik, P. Jove-Journal of Visualized Experiments. 2018; 2018.

Placenta growth factor mediated gene regulation in sickle cell disease. Kalra, VK; Zhang, S; Malik, P; Tahara, SM. Blood Reviews. 2018; 32:61-70.