I strive to help families and patients manage their health through education, while we navigate the investigation and treatment options that will provide the best possible outcome.
Joseph J. Palermo, MD, PhD



I knew early on that I was interested in pediatrics and working with children and their families. Gastroenterology drew me in because of its breadth of diagnoses and the body systems involved. The gastroenterology attending I worked with during my intern year of residency solidified my decision.

My general pediatric gastroenterology and nutrition practice focuses on conditions such as inflammatory bowel disease, celiac disease and the gastrointestinal (GI) manifestations of cystic fibrosis, including cystic fibrosis liver disease. I also treat patients with Fontan-associated liver disease and intestinal polyposis syndromes including familial adenomatous polyposis.

I strive to help families and patients manage their health through education, while we navigate the investigation and treatment options that will provide the best possible outcome. My patients’ and families’ concerns are my concerns.

In association with the Cystic Fibrosis Foundation, my research focuses on the pathophysiology of liver disease that is associated with other chronic conditions, such as cystic fibrosis or congenital heart disease.

In my free time, I enjoy woodworking and coaching my children in soccer and baseball.

MD: University of Cincinnati, Cincinnati, OH, 1997.

PhD: University of Cincinnati, Cincinnati, OH, 1997.

Residency: Pediatrics, St. Louis Children’s Hopsital and Washington University, St. Louis, MO.

Fellowship: Pediatric Gastroenterology, Hepatology and Nutrition, Washington University, St. Louis, MO.

Certification: Pediatric Gastroenterology, 2001.


Pancreatic disorders; cystic fibrosis related GI and liver disorders; intestinal polyposis syndromes; general gastroenterology

Services and Specialties

Gastroenterology GI, Fontan Management, Rare Lung Diseases


Acute, recurrent and chronic pancreatitis; cystic fibrosis related liver disease

Research Areas

Gastroenterology Hepatology and Nutrition

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FONTAN-ASSOCIATED LIVER DISEASE: REVIEW OF SURVEILLANCE PRACTICES FOR HEPATOCELLULAR CARCINOMA. Rubadeux, D; Dillman, J; Trout, A; Bari, K; Eichelbrenner, F; Lubert, A; Opotowsky, AS; Palermo, J; Morin, C. Journal of the American College of Cardiology. 2024; 83:1617.

Associations of Liver Stiffness Measured by Ultrasound Shear-Wave Elastography With Portal Hypertension and Circulatory Failure in Individuals With Fontan Circulation. Derinkuyu, BE; Dillman, JR; Lubert, AM; Palermo, JJ; Opotowsky, AR; Trout, AT. American Journal of Roentgenology. 2024; 222:e2329640.

Prospective study of quantitative liver MRI in cystic fibrosis: feasibility and comparison to PUSH cohort ultrasound. Towbin, AJ; Ye, W; Huang, S; Karmazyn, BW; Molleston, JP; Masand, P; Leung, DH; Chang, S; Narkewicz, MR; Alazraki, AL; Karnsakul, WW; Magee, JC; Tkach, J; Palermo, JJ. Pediatric Radiology: roentgenology, nuclear medicine, ultrasonics, CT, MRI. 2023; 53:2210-2220.

Heterogeneous liver on research ultrasound identifies children with cystic fibrosis at high risk of advanced liver disease. Siegel, MJ; Leung, DH; Molleston, JP; Ye, W; Paranjape, SM; Freeman, AJ; Palermo, JJ; Stoll, J; Masand, P; Karmazyn, B; Green, N; Otto, RK; Magee, JC; Narkewicz, MR. Journal of Cystic Fibrosis. 2023; 22:745-755.

The impact of the COVID-19 pandemic on individuals with Fontan circulation: Focus on gaps in care. Mahendran, A; Fahnhorst, S; Alexander, C; Brown, N; Cnota, JF; Divanovic, A; Heydarian, H; Hirsch, R; Opotowsky, AR; Palermo, JJ; Szugye, C; Lubert, AM. International journal of cardiology congenital heart disease. 2023; 11:100439.

Long-term follow-up and liver outcomes in children with cystic fibrosis and nodular liver on ultrasound in a multi-center study. Leung, DH; Ye, W; Schwarzenberg, SJ; Freeman, AJ; Palermo, JJ; Weymann, A; Alonso, EM; Karnsakul, WW; Murray, KF; Stoll, JM; Navarro, OM; Harned, RK; Narkewicz, MR; Molleston, JP. Journal of Cystic Fibrosis. 2023; 22:248-255.

Abstract 15299: Association Between Change in Liver Stiffness and Adverse Outcomes in Individuals With Fontan Circulation. Brayer, SW; Palermo, JJ; Bari, K; Opotowsky, AR; Morin, CE; Trout, AT; Dillman, JR; Lubert, AM. Circulation. 2022; 146:a15299.

Health-related Quality of Life in a Prospective Study of Ultrasound to Detect Cystic Fibrosis-related Liver Disease in Children. Schwarzenberg, SJ; Palermo, JJ; Ye, W; Huang, S; Magee, JC; Alazraki, A; Freeman, AJ; Harned, R; Karmazyn, B; Karnsakul, W; Stoll, J; Towbin, AJ; Narkewicz, MR; Alonso, EM. Journal of Pediatric Gastroenterology and Nutrition. 2022; 75:635-642.

Using Human Induced Pluripotent Stem Cell-Derived Organoids to Identify New Pathologies in Patients With PDX1 Mutations. Krishnamurthy, M; Kechele, DO; Broda, T; Zhang, X; Enriquez, JR; McCauley, HA; Sanchez, JG; McCracken, K; Palermo, J; Bernieh, A; Neef, HC; Heider, A; Dauber, A; Wells, JM. Gastroenterology. 2022; 163:1053-1063.e7.

Abdominal CT and MRI Findings of Portal Hypertension in Children and Adults with Fontan Circulation. Zafar, F; Lubert, AM; Trout, AT; Katz, DA; Palermo, JJ; Opotowsky, AR; Lorts, A; Chin, C; Powell, AW; Villa, CR; Anwar, N; Morales, DL; Dillman, JR; Alsaied, T. Radiology. 2022; 303:557-565.

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