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Natasha Pillay Smiley, DO


  • Pediatric Neuro-Oncologist, Cancer and Blood Diseases Institute
  • Associate Professor, UC Department of Pediatrics

About

Biography

I completed my medical training at Chicago College of Osteopathic Medicine and Pediatrics Residency at Advocate Children's Lutheran General Hospital in the Chicago area. I went on to the Pediatric Hematology/Oncology/Stem Cell Transplant Fellowship at Nationwide Children's Hospital in Columbus, OH before returning to Chicago for a Pediatric Neuro-Oncology Fellowship and the start of my career at Northwestern University/Ann & Robert H. Lurie Children's Hospital.

Interests

Pediatric CNS disease; CNS specific survivorship; CNS specific cancer predisposition including NF-1 and NF-2

Insurance Information

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Publications

A multi-institutional report of children with atypical teratoid rhabdoid tumor treated with intensive multimodal therapy. Margol, AS; Hoffman, LM; Ronsley, R; Tran, J; Malvar, J; Chi, Y-Y; Leary, S; Stevens, J; Faulk, KE; Salloum, R; Gilheeney, S; Szalontay, L; Reddy, AT; Dhall, G. Neuro-Oncology Practice. 2026; 13(4):807-815.

ID #890 Multi-institutional analysis of outcomes of pediatric patients with high-risk (HR) WNT-subtype medulloblastoma. Michaiel, G; Evans, N; Raghuram, N; Nobre, L; Vanan, MI; Hassan, H; Felton, K; Cacciotti, C; Zelcer, S; Fleming, A; Dvir, R; Abdelbaki, M; Ramaswamy, V; Cheng, S. Neuro-Oncology Pediatrics. 2026; 2(Supplement_1):wuag026.384.

ID #854 Updated findings from a phase 1 study of savolitinib in recurrent, progressive, or refractory medulloblastoma (MB), high-grade glioma (HGG), diffuse intrinsic pontine glioma (DIPG), and central nervous system (CNS) tumors harboring MET aberrations: A Pediatric Brain Tumor Consortium Trial: PBTC-049. Salloum, R; Stewart, C; Schieffer, K; Balow, S; Leino, D; Lenzen, A; Waanders, A; Baxter, P; Lindsay, H; Poussaint, T; Onar-Thomas, A; O’Halloran, K; Fouladi, M; Dunkel, I. Neuro-Oncology Pediatrics. 2026; 2(Supplement_1):wuag026.360.

ID #761 Feasibility study of hypofractionated radiotherapy in the setting of recurrent diffuse intrinsic pontine glioma. Smiley, NP; Freese, C; Frankart, A; Breneman, J; Vatner, R; Takiar, V; Pater, L. Neuro-Oncology Pediatrics. 2026; 2(Supplement_1):wuag026.320.

ID #651 A phase 1/2 and surgical Pediatric Brain Tumor Consortium (PBTC) study evaluating the casein kinase 2 (CK2) inhibitor CX-4945 (silmitasertib sodium) in children and adults with recurrent sonic hedgehog (SHH) medulloblastoma (MB): PBTC-053. Salloum, R; Purzner, T; Stewart, C; Wang, Y; Leino, D; Cottrell, C; Jamal, B; Abdullaev, Z; Poussaint, T; Li, G; Fangusaro, J; Fouladi, M; Onar, A; Dunkel, I. Neuro-Oncology Pediatrics. 2026; 2(Supplement_1):wuag026.260.

ID #634 Case Series of the Use of Trihexyphenidyl for Tremors in Pediatric Brain Tumors. Miller, C; Smiley, NP; Wied, H. Neuro-Oncology Pediatrics. 2026; 2(Supplement_1):wuag026.247.

ID #476 Increased Prevalence of Optic Nerve Hypoplasia in Neurofibromatosis Type 1. Rawashdeh, M; Gilene, S; Hummel, T; Smiley, NP; Graham, R; Mochizuki, A; Raskin, S; Shah, V; De Blank, P. Neuro-Oncology Pediatrics. 2026; 2(Supplement_1):wuag026.170.

ID #472 Burnout Among Advanced Practice Providers in a Pediatric Oncology Setting. Miller, C; Smiley, NP; Melchers, J; Omaley, M; Feist, S. Neuro-Oncology Pediatrics. 2026; 2(Supplement_1):wuag026.168.

ID #1028 A Retrospective Review Characterizing the Toxicities, Outcomes, and Molecular Characteristics of Adolescent and Young Adult Patients with Medulloblastoma. Reiff, S; Cronk, J; Graham, R; Hummel, T; Mochizuki, A; Smiley, NP; De Blank, P; Raskin, S. Neuro-Oncology Pediatrics. 2026; 2(Supplement_1):wuag026.457.

ID #1002 Hematologic Toxicity during Proton Radiation: a Review of Weekly CBC Results at a Single Center. Miller, C; Camardo, H; Fohl, D; Davis, J; Hummel, T; Mochizuki, A; Smiley, NP; Graham, R; Raskin, S; Frankart, A; Pater, L; De Blank, P. Neuro-Oncology Pediatrics. 2026; 2(Supplement_1):wuag026.440.

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