A photo of Natasha Pillay-Smiley.

Natasha Pillay Smiley, DO

  • Pediatric Neuro-Oncologist, Cancer and Blood Diseases Institute
  • Assistant Professor, UC Department of Pediatrics



Dr. Pillay Smiley completed her medical training at Chicago College of Osteopathic Medicine and Pediatrics Residency at Advocate Children's Lutheran General Hospital in the Chicago area. She went on to the Pediatric Hematology/Oncology/Stem Cell Transplant Fellowship at Nationwide Children's Hospital in Columbus, OH before returning to Chicago for a Pediatric Neuro-Oncology Fellowship and the start of her career at Northwestern University/Ann & Robert H. Lurie Children's Hospital.

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Cardiac dysfunction in medulloblastoma survivors treated with photon irradiation. Cacciotti, C; Chordas, C; Valentino, K; Allen, R; Lenzen, A; Burns, K; Nagarajan, R; Manley, P; Pillay-Smiley, N. 2022; 9:338-343.

Phase I study of ribociclib and everolimus in children with newly diagnosed DIPG and high-grade glioma: A CONNECT pediatric neuro-oncology consortium report. Dewire, M; Lazow, M; Campagne, O; Leach, J; Fuller, C; Senthil Kumar, S; Stanek, J; De Blank, P; Hummel, TR; Pillay-Smiley, N; et al. Neuro-Oncology Advances. 2022; 4.

Trametinib-associated Hyponatremia in a Child With Low-grade Glioma is Not Seen Following Treatment With Alternative MEK Inhibitor. Lazow, MA; Lawson, SA; Salloum, R; Hummel, TR; Pillay Smiley, N; Dewire-Schottmiller, MD; Fouladi, M; De Blank, P. Journal of Pediatric Hematology/Oncology. 2021; 43:e550-e553.

Parental attitudes regarding the need for genetic services in a pediatric brain tumor survivorship program. Zalan, A; Maga, T; Perpich, M; Pillay Smiley, N; Weiss McQuaid, S. Journal of Genetic Counseling. 2021; 30:533-543.

Overcoming barriers to establishing autopsy procurement programs in pediatric patients with central nervous system tumors: a call to develop regional centers. DeWire, M; Erker, C; Hummel, TR; Chow, LM L; de Blank, P; Salloum, R; Pillay-Smiley, N; Hoffman, L; Gilger, E; Gallagher, M; et al. Journal of Neuro-Oncology. 2021; 152:107-114.

Characterizing temporal genomic heterogeneity in pediatric low-grade gliomas. Lazow, MA; Hoffman, L; Schafer, A; Osorio, DS; Boué, DR; Rush, S; Wright, E; Lane, A; DeWire-Schottmiller, MD; Smolarek, T; et al. Acta neuropathologica communications. 2020; 8.

Variation in Platelet Delta Granules Over Time in Young Women Undergoing Evaluation for Heavy Menstrual Bleeding. Woods, GM; Pillay Smiley, N; Stanek, J; Kahwash, S; Kerlin, BA; O’Brien, SH. Pediatric and Developmental Pathology. 2019; 22:123-127.

Introduction to the Special Issue on Pediatric Neuro-Oncology. Pillay Smiley, N; Khatua, S. Bioengineering. 2018; 5.

Primary Central Nervous System Malignant Melanoma in Children: A Case Series and Review of the Literature. Choi, DK; Pillay-Smiley, N; Marzec, S; Wadhwani, NR; DiPatri, AJ; Tomita, T; Lulla, RR. Journal of Pediatric Hematology/Oncology. 2018; 40:616-619.

Neurocognitive and Psychosocial Outcomes in Pediatric Brain Tumor Survivors. Stavinoha, PL; Askins, MA; Powell, SK; Pillay Smiley, N; Robert, RS. Bioengineering. 2018; 5.

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