A photo of Natasha Pillay-Smiley.

Pediatric Neuro-Oncologist, Cancer and Blood Diseases Institute

Assistant Professor, UC Department of Pediatrics


Board Certified

About Me


Dr. Pillay Smiley completed her medical training at Chicago College of Osteopathic Medicine and Pediatrics Residency at Advocate Children's Lutheran General Hospital in the Chicago area. She went on to the Pediatric Hematology/Oncology/Stem Cell Transplant Fellowship at Nationwide Children's Hospital in Columbus, OH before returning to Chicago for a Pediatric Neuro-Oncology Fellowship and the start of her career at Northwestern University/Ann & Robert H. Lurie Children's Hospital.

Clinical Interests

Pediatric CNS disease; CNS specific survivorship; CNS specific cancer predisposition including NF-1 and NF-2

Academic Affiliation

Assistant Professor, UC Department of Pediatrics

Clinical Divisions

Brain Tumor

My Locations

My Publications

Characterizing temporal genomic heterogeneity in pediatric low-grade gliomas. Lazow, MA; Hoffman, L; Schafer, A; Osorio, DS; Boué, DR; Rush, S; Wright, E; Lane, A; DeWire-Schottmiller, MD; Smolarek, T; et al. Acta Neuropathologica Communications. 2020; 8.

Trametinib-associated Hyponatremia in a Child With Low-grade Glioma is Not Seen Following Treatment With Alternative MEK Inhibitor. Lazow, MA; Lawson, SA; Salloum, R; Hummel, TR; Pillay Smiley, N; DeWire-Schottmiller, MD; Fouladi, M; de Blank, P. Journal of Pediatric Hematology/Oncology. 2020; Publish Ahead of Print.

Variation in Platelet Delta Granules Over Time in Young Women Undergoing Evaluation for Heavy Menstrual Bleeding. Woods, GM; Pillay Smiley, N; Stanek, J; Kahwash, S; Kerlin, BA; O’Brien, SH. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. 2019; 22:123-127.

Introduction to the Special Issue on Pediatric Neuro-Oncology. Pillay Smiley, N; Khatua, S. Bioengineering. 2018; 5:109-109.

Primary Central Nervous System Malignant Melanoma in Children: A Case Series and Review of the Literature. Choi, DK; Pillay-Smiley, N; Marzec, S; Wadhwani, NR; DiPatri, AJ; Tomita, T; Lulla, RR. Journal of Pediatric Hematology/Oncology. 2018; 40:616-619.

Neurocognitive and Psychosocial Outcomes in Pediatric Brain Tumor Survivors. Stavinoha, PL; Askins, MA; Powell, SK; Pillay Smiley, N; Robert, RS. Bioengineering. 2018; 5:73-73.

Blood-brain barrier-adapted precision medicine therapy for pediatric brain tumors. Marini, BL; Benitez, LL; Zureick, AH; Salloum, R; Gauthier, AC; Brown, J; Wu, Y; Robinson, DR; Kumar, C; Lonigro, R; et al. Translational Research: the journal of laboratory and clinical medicine. 2017; 188:27.e1-39.

Hypoxia-induced proliferation of HeLa cells depends on epidermal growth factor receptor-mediated arginase II induction. Setty, BA; Pillay Smiley, N; Pool, CM; Jin, Y; Liu, Y; Nelin, LD. Physiological Reports. 2017; 5:e13175-e13175.

Severe Radiation Necrosis Successfully Treated With Bevacizumab in an Infant with Low-Grade Glioma and Tumor-Associated Intractable Trigeminal Neuralgia. Pillay Smiley, N; Alden, T; Hartsell, W; Fangusaro, J. Pediatric Blood and Cancer. 2016; 63:1671-1673.