Grant Schulert, MD, PhD

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-636-4676

Email grant.schulert@cchmc.org

Clinical

Pediatric rheumatology; juvenile idiopathic arthritis; macrophage activation syndrome; autoinflammatory syndromes; periodic fevers

Research

Systemic JIA; macrophage activation syndrome; innate immunity; monocyte and macrophage functions; whole exome sequencing
Visit the Schulert Lab

MD: University of Iowa College of Medicine, Iowa City, IA, 2009.

PhD: University of Iowa Department of Microbiology, Iowa City, IA, 2009.

Residency: Pediatrics, Vanderbilt University Medical Center, Nashville, TN.

Fellowship: Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Certification: Pediatrics, 2012; Pediatric Rheumatology, 2017.

View PubMed Publications

Thornton S, Tan R, Sproles A, Do T, Schick J, Grom AA, DeLay M, Schulert GS. A multi-parameter flow cytometry analysis panel to asses CD163 mRNA and protein in monocyte and macrophages populations in hyperinflammatory diseases. J Immunol. 2019 Mar 1;202(5):1635-1643.

Brown RA, Henderlight M, Do T, Yasin S, Grom AA, DeLay M, Thornton S, Schulert GS. Neutrophils from children with systemic juvenile idiopathic arthritis exhibit persistent proinflammatory activation despite long-standing clinically inactive disease. Front Immunol. 2018 Dec 18;9:2995.

Ter Haar NM, van Delft ALJ, Annink KV, van Stel H, Al-Mayouf SM, Amaryan G, Anton J, Barron KS, Benseler S, Brogan PA, Cantarini L, Cattalini M, Cochino AV, de Benedetti F, Dedeoglu F, de Jesus AA, Demirkaya E, Dolezalova P, Durrant KL, Fabio G, Gallizzi R, Goldbach-Mansky R, Hachulla E, Hentgen V, Herlin T, Hofer M, Hoffman HM, Insalaco A, Jansson AF, Kallinich T, Kone-Paut I, Kozlova A, Kuemmerle-Deschner JB, Lachmann HJ, Laxer RM, Martini A, Nielsen S, Nikishina I, Ombrello AK, Özen S, Papadopoulou-Alataki E, Quartier P, Rigante D, Russo R, Simon A, Trachana M, Uziel Y, Ravelli A, Schulert G, Gattorno M, Frenkel J. In silico validation of the Autoinflammatory disease damage index. Ann Rheum Dis. 2018 Nov;77(11):1599-1605.

DeSena AD, Do T, Schulert GS. Systemic autoinflammation with intractable epilepsy managed with interleukin-1 blockade. J Neuroinflammation. 2018 Feb 9;15(1):38.

Schulert GS, Zhang M, Husami A, Fall N, Brunner H, Zhang K, Cron RQ, Grom AA. Novel UNC13D intronic variant disrupting a NFB enhancer in a patient with recurrent macrophage activation syndrome and systemic juvenile idiopathic arthritis. Arthritis Rheum. 2018;70:963-970.

Do T, Tan R, Bennett M, Medvedovic M, Grom AA, Shen N, Thornton S, Schulert GS. MicroRNA networks associated with active systemic juvenile idiopathic arthritis regulate CD163 expression and anti-inflammatory functions in polarized macrophages through two distinct mechanisms. J Leukoc Biol. 2018;103:71-85.

Schulert GS, Minoia F, Bohnsack J, Cron RQ, Hashad S, KonÉ-Paut I, Kostik M, Lovell D, Maritsi D, Nigrovic PA, Pal P, Ravelli A, Shimizu M, Stanevicha V, Vastert S, Woerner A, de Benedetti F, Grom AA. Effect of biologic therapy on clinical and laboratory features of macrophage activation syndrome associated with systemic juvenile idiopathic arthritis. Arthritis Care Res. 2018;70:409-419.Bracaglia C, de Graaf K, Marafon DP, D’Ario G, Guilhot F, Ferlin W, Prencipe G, Caiello I, Davi S, Schulert G, Ravelli A, Grom A, De Min C, De Benedetti F. Elevated circulating levels of interferon-gamma and interferon-gamma related chemokines characterize patients with macrophage activation syndrome complicating systemic JIA. Ann Rheum Dis. 2016;76:166-172.

Schulert GS, Fall N, Harley J, Shen N, Lovell DJ, Thornton S, Grom AA. Monocyte microRNA expression in active systemic juvenile idiopathic arthritis reveals key role of miR-125a-5p in polarized monocyte phenotypes. Arthritis Rheumatol. 2016;68:2300-2313.

Schulert GS, Zhang M, Fall N, Husami A, Kissell D, Hanosh A, Zhang K, Davis K, Jentzen JM, Napolitano L, Siddiqui J, Smith LB, Harms PW, Grom AA, Cron RQ. Whole-Exome Sequencing Reveals Mutations in Genes Linked to Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome in Fatal Cases of H1N1 Influenza. J Infect Dis. 2015 Nov 23;213:1180-88.

Monocyte and Macrophage polarization in systemic juvenile idiopathic arthritis and macrophage activation syndrome. Principal Investigator. National Institutes of Arthritis, Musculoskeletal and Skin Disorders (NIAMS), National Institutes of Health. Aug 2017-Jul 2022. K08-AR072075.

Cincinnati Autoinflammatory Disease Treatment and Research Center. Co-Principal Investigator. Cincinnati Children's Research Foundation Academic Research and Teaching (ARC) Grant. Sep 2018-Aug 2021.