About

Biography

As a pediatric rheumatologist and researcher, I specialize in treating autoinflammatory disorders, juvenile idiopathic arthritis (JIA), systemic JIA, and complications of systemic JIA such as macrophage activation syndrome and lung disease.

I've always enjoyed working with children and families. I find the passion of parents inspiring and love the energy, humor and honesty of kids. I was drawn to rheumatology because we are asked hard questions, such as how to solve disease puzzles and how to find the best treatments. I also enjoy the long-term relationships with families and patients.

My interest in how the immune system works and how it fails led me to my research. My graduate work was in microbiology and how highly virulent microbes subvert the host immune system. In rheumatic diseases the immune system has become dysregulated to overreact or attack the body itself.

Broadly, I am interested in autoinflammation — how the body’s first line of defense becomes dysregulated in inflammatory diseases. More specifically, my principle interest is in the complications of systemic JIA such as macrophage activation syndrome and systemic JIA-associated lung disease.

My colleagues and I are trying to determine what causes severe complications of autoinflammatory disorders such as systemic JIA, how do we best treat and control hyperinflammation and how can we use novel biomarkers and genomics to direct our treatments.

I was extremely honored in 2018 to receive the Gold Medal Suzanne Dehoche Prize from the Kourir Association, a French organization for families of children with JIA. They present this prize to researchers whose work is most likely to lead to new treatments for juvenile arthritis. This was an amazing recognition of what we hope to do: Use genomics techniques to accelerate treatments.

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Publications

Lung Ultrasound in Children with Systemic Juvenile Idiopathic Arthritis Associated Interstitial Lung Disease. Vega-Fernandez, P; Ting, TV; Mar, DA; Schapiro, AH; Deluna, MD; Saper, VE; Grom, AA; Schulert, GS; Fairchild, RM. Arthritis Care and Research. 2022.

OA37 Secukinumab treatment in children and adolescents with enthesitis-related arthritis and juvenile psoriatic arthritis: efficacy and safety results from a Phase 3 study. Ramanan, AV; Brunner, HI; Foeldvari, I; Alexeeva, E; Ayaz, NA; Calvo, I; Kasapcopur, O; Chasnyk, VG; Hufnagel, M; Zuber, Z; et al. Rheumatology. 2022; 61.

American College of Rheumatology Clinical Guidance for Multisystem Inflammatory Syndrome in Children Associated With SARS-CoV-2 and Hyperinflammation in Pediatric COVID-19: Version 3. Henderson, LA; Canna, SW; Friedman, KG; Gorelik, M; Lapidus, SK; Bassiri, H; Behrens, EM; Kernan, KF; Schulert, GS; Seo, P; et al. Arthritis and Rheumatology. 2022; 74:e1-e20.

Interfering with interferons: targeting the JAK-STAT pathway in complications of systemic juvenile idiopathic arthritis (SJIA). Verweyen, EL; Schulert, GS. Rheumatology. 2022; 61:926-935.

Serum proteome analysis of systemic JIA and related lung disease identifies distinct inflammatory programs and biomarkers. Chen, G; Deutsch, GH; Schulert, G; Zheng, H; Jang, S; Trapnell, B; Lee, P; Macaubas, C; Ho, K; Schneider, C; et al. Arthritis and Rheumatology. 2022.

Host genetics of pediatric SARS-CoV-2 COVID-19 and multisystem inflammatory syndrome in children. Schulert, GS; Blum, SA; Cron, RQ. Current Opinion in Pediatrics. 2021; 33:549-555.

S100 proteins, cytokines, and chemokines as tear biomarkers in children with juvenile idiopathic arthritis-associated uveitis. Angeles-Han, ST; Miraldi Utz, V; Thornton, S; Schulert, G; Rodriguez-Smith, J; Kauffman, A; Sproles, A; Mwase, N; Hennard, T; Grom, A; et al. Ocular Immunology and Inflammation. 2021; 29:1616-1620.

Pathogenesis and Treatment of Refractory Disease Courses in Systemic Juvenile Idiopathic Arthritis: Refractory Arthritis, Recurrent Macrophage Activation Syndrome and Chronic Lung Disease. Erkens, R; Esteban, Y; Towe, C; Schulert, G; Vastert, S. Rheumatic Disease Clinics of North America. 2021; 47:585-606.

IFN-γ is essential for alveolar macrophage-driven pulmonary inflammation in macrophage activation syndrome. Gao, DK; Salomonis, N; Henderlight, M; Woods, C; Thakkar, K; Grom, AA; Thornton, S; Jordan, MB; Wikenheiser-Brokamp, KA; Schulert, GS. JCI insight. 2021; 6.

miR-181a Mediates Inflammatory Gene Expression After Intracerebral Hemorrhage: An Integrated Analysis of miRNA-seq and mRNA-seq in a Swine ICH Model. Walsh, KB; Zimmerman, KD; Zhang, X; Demel, SL; Luo, Y; Langefeld, CD; Wohleb, E; Schulert, G; Woo, D; Adeoye, O. Journal of Molecular Neuroscience. 2021; 71:1802-1814.

From the Blog


Aggressive Screening Needed to Detect sJIA Lung Complication
Autoimmune Disorders

Aggressive Screening Needed to Detect sJIA Lung Complication

Grant Schulert, MD, PhD, Alexei A. Grom, MD10/29/2019

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