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Assistant Professor, UC Department of Pediatrics


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My Biography & Research


As a pediatric rheumatologist and researcher, I specialize in treating autoinflammatory disorders, juvenile idiopathic arthritis (JIA), systemic JIA, and complications of systemic JIA such as macrophage activation syndrome and lung disease.

I've always enjoyed working with children and families. I find the passion of parents inspiring and love the energy, humor and honesty of kids. I was drawn to rheumatology because we are asked hard questions, such as how to solve disease puzzles and how to find the best treatments. I also enjoy the long-term relationships with families and patients.

My interest in how the immune system works and how it fails led me to my research. My graduate work was in microbiology and how highly virulent microbes subvert the host immune system. In rheumatic diseases the immune system has become dysregulated to overreact or attack the body itself.

Broadly, I am interested in autoinflammation — how the body’s first line of defense becomes dysregulated in inflammatory diseases. More specifically, my principle interest is in the complications of systemic JIA such as macrophage activation syndrome and systemic JIA-associated lung disease.

My colleagues and I are trying to determine what causes severe complications of autoinflammatory disorders such as systemic JIA, how do we best treat and control hyperinflammation and how can we use novel biomarkers and genomics to direct our treatments.

I was extremely honored in 2018 to receive the Gold Medal Suzanne Dehoche Prize from the Kourir Association, a French organization for families of children with JIA. They present this prize to researchers whose work is most likely to lead to new treatments for juvenile arthritis. This was an amazing recognition of what we hope to do: Use genomics techniques to accelerate treatments.

Clinical Interests

Pediatric rheumatology; juvenile idiopathic arthritis; macrophage activation syndrome; autoinflammatory syndromes; periodic fevers

Research Interests

Systemic JIA; macrophage activation syndrome; innate immunity; monocyte and macrophage functions; whole exome sequencing

Academic Affiliation

Assistant Professor, UC Department of Pediatrics

Clinical Divisions

Rheumatology, Lupus, Rare Lung Diseases

Research Divisions


Blog Posts

Aggressive Screening Needed to Detect sJIA Lung Complication

Autoimmune Disorders

Aggressive Screening Needed to Detect sJIA Lung Complication

Grant Schulert, MD, PhD, Alexei A. Grom, MD10/29/2019

My Locations

My Education

MD: University of Iowa College of Medicine, Iowa City, IA, 2009.

PhD: University of Iowa Department of Microbiology, Iowa City, IA, 2009.

Residency: Pediatrics, Vanderbilt University Medical Center, Nashville, TN.

Fellowship: Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Certification: Pediatrics, 2012; Pediatric Rheumatology, 2017.

My Publications

Host genetics of pediatric SARS-CoV-2 COVID-19 and multisystem inflammatory syndrome in children. Schulert, GS; Blum, SA; Cron, RQ. Current Opinion in Pediatrics. 2021.

IFN-γ is essential for alveolar macrophage-driven pulmonary inflammation in macrophage activation syndrome. Gao, DK; Salomonis, N; Henderlight, M; Woods, C; Thakkar, K; Grom, AA; Thornton, S; Jordan, MB; Wikenheiser-Brokamp, KA; Schulert, GS. JCI insight. 2021; 6.

miR-181a Mediates Inflammatory Gene Expression After Intracerebral Hemorrhage: An Integrated Analysis of miRNA-seq and mRNA-seq in a Swine ICH Model. Walsh, KB; Zimmerman, KD; Zhang, X; Demel, SL; Luo, Y; Langefeld, CD; Wohleb, E; Schulert, G; Woo, D; Adeoye, O. Journal of Molecular Neuroscience. 2021; 71:1802-1814.

Interfering with Interferons: targeting the JAK-STAT pathway in complications of systemic juvenile idiopathic arthritis (SJIA). Verweyen, EL; Schulert, GS. Rheumatology. 2021.

Inflammatory biomarkers in COVID-19-associated multisystem inflammatory syndrome in children, Kawasaki disease, and macrophage activation syndrome: a cohort study. Rodriguez-Smith, JJ; Verweyen, EL; Clay, GM; Esteban, YM; de Loizaga, SR; Baker, EJ; Do, T; Dhakal, S; Lang, SM; Grom, AA; et al. The Lancet. Rheumatology. 2021; 3:e574-e584.

Distinct Gene Expression Signatures Characterize Strong Clinical Responders Versus Nonresponders to Canakinumab in Children With Systemic Juvenile Idiopathic Arthritis. Verweyen, EL; Pickering, A; Grom, AA; Schulert, GS. Arthritis and Rheumatology. 2021; 73:1334-1340.

The IL-18/IFNγ axis in systemic JIA and MAS-new answers, more questions. Schulert, GS. Rheumatology. 2021; 60:3045-3047.

COVID-19 and cytokine storm syndrome: are there lessons from macrophage activation syndrome?. Ombrello, MJ; Schulert, GS. Translational Research. 2021; 232:1-12.

Novel Treatment of Infant With COVID-19 With the Sialidase Fusion Protein, DAS181. Danziger-Isakov, L; Khalil, N; Divanovic, A; Frenck, R; Grimley, M; Iliopoulos, I; Marsh, R; Paulsen, G; Phillips, CL; Schulert, G; et al. Pediatric Infectious Disease Journal. 2021; 40:e234-e235.

Repression of CTSG, ELANE and PRTN3-mediated histone H3 proteolytic cleavage promotes monocyte-to-macrophage differentiation. Cheung, P; Schaffert, S; Chang, SE; Dvorak, M; Donato, M; Macaubas, C; Foecke, MH; Li, TM; Zhang, L; Coan, JP; et al. Nature Immunology. 2021; 22:711-722.