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Assistant Professor, UC Department of Pediatrics

513-636-4676

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My Biography & Research

Biography

As a pediatric rheumatologist and researcher, I specialize in treating autoinflammatory disorders, juvenile idiopathic arthritis (JIA), systemic JIA, and complications of systemic JIA such as macrophage activation syndrome and lung disease.

I've always enjoyed working with children and families. I find the passion of parents inspiring and love the energy, humor and honesty of kids. I was drawn to rheumatology because we are asked hard questions, such as how to solve disease puzzles and how to find the best treatments. I also enjoy the long-term relationships with families and patients.

My interest in how the immune system works and how it fails led me to my research. My graduate work was in microbiology and how highly virulent microbes subvert the host immune system. In rheumatic diseases the immune system has become dysregulated to overreact or attack the body itself.

Broadly, I am interested in autoinflammation — how the body’s first line of defense becomes dysregulated in inflammatory diseases. More specifically, my principle interest is in the complications of systemic JIA such as macrophage activation syndrome and systemic JIA-associated lung disease.

My colleagues and I are trying to determine what causes severe complications of autoinflammatory disorders such as systemic JIA, how do we best treat and control hyperinflammation and how can we use novel biomarkers and genomics to direct our treatments.

I was extremely honored in 2018 to receive the Gold Medal Suzanne Dehoche Prize from the Kourir Association, a French organization for families of children with JIA. They present this prize to researchers whose work is most likely to lead to new treatments for juvenile arthritis. This was an amazing recognition of what we hope to do: Use genomics techniques to accelerate treatments.

Clinical Interests

Pediatric rheumatology; juvenile idiopathic arthritis; macrophage activation syndrome; autoinflammatory syndromes; periodic fevers

Research Interests

Systemic JIA; macrophage activation syndrome; innate immunity; monocyte and macrophage functions; whole exome sequencing

Academic Affiliation

Assistant Professor, UC Department of Pediatrics

Clinical Divisions

Rheumatology, Lupus

Research Divisions

Rheumatology



Blog Posts

Aggressive Screening Needed to Detect sJIA Lung Complication

Autoimmune Disorders

Aggressive Screening Needed to Detect sJIA Lung Complication

Grant Schulert, MD, PhD, Alexei A. Grom, MD10/29/2019

My Education

MD: University of Iowa College of Medicine, Iowa City, IA, 2009.

PhD: University of Iowa Department of Microbiology, Iowa City, IA, 2009.

Residency: Pediatrics, Vanderbilt University Medical Center, Nashville, TN.

Fellowship: Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Certification: Pediatrics, 2012; Pediatric Rheumatology, 2017.

My Publications

The use of S100 proteins testing in juvenile idiopathic arthritis and autoinflammatory diseases in a pediatric clinical setting: A retrospective analysis. Aljaberi, N; Tronconi, E; Schulert, G; Grom, AA; Lovell, DJ; Huggins, JL; Henrickson, M; Brunner, HI. Pediatric Rheumatology Online Journal. 2020; 18.

Defining the scourge of COVID-19 hyperinflammatory syndrome. Cron, RQ; Schulert, GS; Tattersall, RS. 2020; 2:e727-e729.

A novel STING1 variant causes a recessive form of STING-associated vasculopathy with onset in infancy (SAVI). Lin, B; Berard, R; Al Rasheed, A; Aladba, B; Kranzusch, PJ; Henderlight, M; Grom, A; Kahle, D; Torreggiani, S; Aue, AG; et al. Journal of Allergy and Clinical Immunology. 2020; 146:1204-1208.e6.

American College of Rheumatology Clinical Guidance for Multisystem Inflammatory Syndrome in Children Associated With SARS–CoV-2 and Hyperinflammation in Pediatric COVID-19: Version 1. Henderson, LA; Canna, SW; Friedman, KG; Gorelik, M; Lapidus, SK; Bassiri, H; Behrens, EM; Ferris, A; Kernan, KF; Schulert, GS; et al. Arthritis and Rheumatology. 2020; 72:1791-1805.

The storm beneath the storm: MAS-HLH in inflammatory myopathies. Schulert, GS. The Journal of rheumatology. 2020; 47:1461-1463.

Can tocilizumab calm the cytokine storm of COVID-19?. Schulert, GS. 2020; 2:e449-e451.

Proceedings from the 2ndNext Gen Therapies for Systemic Juvenile Idiopathic Arthritis and Macrophage Activation Syndrome symposium held on October 3-4, 2019. Canna, SW; Schulert, GS; de Jesus, A; Pickering, A; Brunner, H; Gadina, M; Levine, S; Goldbach-Mansky, R; Boutelle, J; Sinha, R; et al. Pediatric Rheumatology Online Journal. 2020; 18.

On the Alert for Cytokine Storm: Immunopathology in COVID-19. Henderson, LA; Canna, SW; Schulert, GS; Volpi, S; Lee, PY; Kernan, KF; Caricchio, R; Mahmud, S; Hazen, MM; Halyabar, O; et al. Arthritis and Rheumatology. 2020; 72:1059-1063.

The genetics of macrophage activation syndrome. Schulert, GS; Cron, RQ. Genes and Immunity. 2020; 21:169-181.

Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases. de Jesus, AA; Hou, Y; Brooks, S; Malle, L; Biancotto, A; Huang, Y; Calvo, KR; Marrero, B; Moir, S; Oler, AJ; et al. Journal of Clinical Investigation. 2020; 130:1669-1682.