Dr. Khurana Hershey has built and contributed to several innovative longitudinal cohorts over the last 2 decades to study the epidemiology of childhood asthma and allergic disease and conduct outcomes studies in childhood asthma. These cohorts include the Greater Cincinnati Pediatric Clinic Repository (GCPCR), the Ohio Pediatric Asthma Repository (OPAR), the first state-wide repository for asthma, and the Cincinnati Childhood Asthma and Air Pollution Study (CCAAPS) birth cohort. These cohorts have resulted in numerous publications and critical new insights into the epidemiology of disease, phenotypes of childhood asthma, identification of genetic and environmental factors that promote development and persistence of asthma and allergic diseases. The cohorts provide a tremendous and unique infrastructure for translation of findings from epidemiologic studies to the laboratory and back to human patients.
Read some of our related publications.
Extensive 20 year, longitudinal cohort, housed within a customized database with tracking system of all biological and clinical data. Includes clinical and demographic information; environmental exposure and adherence data; bronchial hyperresponsiveness (BHR) and SPT results and biological samples.
Aim 1 of U19AI070235. The first US cohort of 500 children with atopic dermatitis. M-PAACH will track them for 1 to 7 years to determine factors that promote progression to asthma. Children are assessed for allergic disease, symptoms and exposures. Biologic samples are collected, skin barrier assessed, skin prick test (SPT) for aeroallergens and food.
Birth Cohort of 762 children at high risk for developing allergic disease. Tracks allergic, asthma and neurological outcomes, from age 1-12; Allergic and non-allergic controls, asthma and non-asthma.
Inner city asthma initiative, funded by the National Institute of Allergy and Infectious Diseases (NIAID). Nationwide clinical trials network to evaluate new therapies and management strategies, to reduce the burden of asthma in children and adolescents living in the inner city.
A phase II extension study from CCAAPS. It is one of twelve cohorts in CREW across the country looking for the relationship between childhood asthma and early-life environmental factors that cause childhood asthma.
A comprehensive biorepository of children hospitalized for asthma at the 6 major Ohio children’s hospitals. Goals are to compare and understand effectiveness of strategies currently utilized for the treatment of acute asthma, better define and anticipate treatment response, delineate relevant phenotypes and sub-phenotypes and identify best practices.