Research in Adherence to Pediatric Medical Regimens

Avani Modi, PHD, is an associate professor for the Division of Behavioral Medicine and Clinical Psychology and director of the Center for Adherence and Self-Management at Cincinnati Children's within the University of Cincinnati College of Medicine.

Her research lab focuses on adherence to pediatric medical regimens, including the measurement of adherence, identification of adherence barriers, and the development and testing of adherence interventions, especially within pediatric epilepsy. She also has an interest in the development of health-related quality-of-life outcome measures. Modi completed a K23 Career Development Award from the NIH (K23 HDO57333) and has two new NIH studies.

Through her K23 award, Modi documented patterns of adherence in children with new-onset epilepsy (ages 2-12 years) and identified predictors of adherence. She then developed and tested a problem-solving and education intervention to improve adherence in 200 young children with epilepsy and their caregivers via a large-scale randomized controlled clinical to improve antiepileptic drug adherence.

Modi also conducted a study examining adherence and risk-taking behaviors in adolescents with epilepsy and then pilot tested an application and text-messaging intervention for adolescents. She is also interested in improving executive functioning skills in adolescents with epilepsy, as this may play a role in adherence.

Modi and her colleagues developed a web-based intervention to improve executive functioning skills in adolescents with epilepsy, as well as identifying biomarkers of executive functioning. Finally, Modi and colleagues developed the PedsQL-Epilepsy Module, an epilepsy-specific health-related quality of life measure with parent-proxy and self-reported versions that range the developmental span from 2-25 years.