Research in Adherence to Pediatric Medical Regimens

Avani Modi, PHD, is an associate professor for the Division of Behavioral Medicine and Clinical Psychology and director of the Center for Adherence and Self-Management at Cincinnati Children's within the University of Cincinnati College of Medicine. Her research lab focuses on adherence to pediatric medical regimens, including the measurement of adherence and identifying barriers to effective disease management, especially within pediatric epilepsy. She also has an interest in the development  of health-related quality-of-life outcome measures. Modi completed a K23 Career Development Award from the NIH (K23 HDO57333) and has two active NIH studies

  • R01HD073115 - Supporting Treatment Adherence Regimens in Pediatric Epilepsy
  • R21HD083335-01. Web-based Intervention to Improve Executive Functioning in Teens with Epilepsy  

Through her K23 award, Modi documented patterns of adherence in children with new-onset epilepsy (ages 2-12 years) and identified predictors of adherence (ABC study). She then developed a problem-solving and education intervention to improve adherence for children with epilepsy that is currently being tested through her large-scale randomized controlled clinical trial of 200 participants to improve antiepileptic drug adherence. Participants will be randomized to the problem-solving/education or education only intervention (STAR study).

Modi also conducted a study to examine adherence and risk-taking behaviors in adolescents with epilepsy (AAA study) and then pilot tested an application and text-messaging intervention for adolescents (TAPS study). She is also interested in improving executive functioning skills in adolescents with epilepsy, as this may play a role in adherence. 

Modi and her colleagues are currently developing a web-based intervention to improve executive functioning skills in adolescents with epilepsy (EFI-E study), as well as identifying biomarkers of executive functioning (fMRI study). Finally, Modi and colleagues have developed the PedsQL-Epilepsy Module, which is currently being validated (DAILY study). 

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