How We're Keeping You Safe | What Patients & Families Need to Know

Our Leadership

John B. Harley, MD, PhD Director, Center for Autoimmune Genomics and Etiology (CAGE)

John B. Harley, MD, PhD, is a rheumatologist and biochemist with special clinical and research interests in the genetic etiology of inflammatory diseases. His experimental focus is the many genetic effects and environmental causes of systemic lupus erythematosus (SLE) and related inflammatory diseases. Through this work, nearly 50 genes are known and Epstein Barr virus has been identified to trigger the systemic autoimmunity of lupus. Dr. Harley also builds infrastructure with which to do high throughput genotyping, expression analysis, and epigenetics, which he makes available to his colleagues from around the world. In recent experiments, Dr. Harley organized the logistics of managing >18,000 subjects at >30,000 genetic markers, 3200 subjects at 1.2 million markers, and 10,000 subjects at 196,000 markers. Dr. Harley is committed to all of the steps between association detection through replication and toward identifying the possible functional genetic variants and to pursuing their biology.

Louis J. Muglia, MD, PhD Co-Director, Perinatal Institute

Louis J. Muglia, MD, PhD, is a pediatric endocrinologist whose research efforts seek to define the mechanisms controlling the timing for birth in humans to prevent or better treat human preterm labor. Recent efforts analyze the contribution of genetic determinants to preterm birth. A second area of investigation is elucidation of the molecular pathways involved in the behavioral and neuroendocrine responses to stress.
Visit the Muglia Lab.

Margaret K. Hostetter, MD BK Rachford Professor and Chair, Department of Pediatrics

Margaret K. Hostetter, MD, studies the pathogenesis of bloodstream infections caused by the yeast Candida albicans. Her work has highlighted the role of C. albicans in biofilms, activation of human T cells, and evasion of innate immune mechanisms. Her clinical research is focused on the medical evaluation of internationally adopted children.

Steering Team

  • Heide Aungst, MA, senior specialist, communication & outreach, Center for Pediatric Genomics
  • John Hogenesch, PhD, professor, Divisions of Human Genetics and Immunobiology, Center for Chronobiology
  • Michelle McGowan, PhD, research associate professor, Ethics Center
  • Melanie Myers, PhD, director, Genetic Counseling Graduate Programs*
  • Steve Potter, PhD, professor, Developmental Biology*
  • Carlos Prada, MD, co-director, RASopathy Program*
  • Laura Ramsey, PhD, assistant professor, Genetic Pharmacology Service*
  • Matthew Weirauch, PhD, assistant professor, Center for Autoimmune Genomics and Etiology*
  • Aaron Zorn, PhD, associate director, Digestive Health Center

*Indicates CpG awardee

> Meet the rest of the CpG team