Center for Autoimmune Genomics and Etiology (CAGE)
Weirauch Research Lab

Understanding the Mechanisms of Gene Transcriptional Regulation

The control of when and where genes are utilized is a major component driving phenotypic differences between organisms and individuals. In our lab, we use computational methods to study how, when, where, and why genes are “turned on and off.” To this end, we study transcription factors, which interact with the genome by binding to short sequences proximal to the genes they control. Humans have 1500 different transcription factors, each of which recognizes different short sequences, or “motifs,” within the genome. We develop methods for determining transcription factor motifs, integrating these motifs with other information to predict transcription factor binding, and understanding the regulatory mechanisms underlying human diseases.

About the PI

Matthew Weirauch

Matthew Weirauch, PhD

Our lab is highly collaborative; my colleagues and I work on a wide range of biological and disease topics. We also take a general approach of using all available data to generate and ultimately validate new hypotheses.

Learn More and Meet My Team