The long-term goal of the Digestive Health Center (DHC) is to improve child health through better diagnosis, treatments and outcomes for our three (3) key targeted focus areas, including:

  1. Mechanisms of Liver Disease
    -- Biliary atresia, cholestatic syndromes, and immune -mediated diseases
    -- Fatty liver disease and metabolic syndrome in children
    -- Treatment of viral hepatitis in adults and children

  2. Digestive Disease and Immunity
    -- Inflammatory bowel disease: mucosal immunology, microbial sensing
    -- GI epithelium: cellular ecosystem, crosstalk, and function; mucosal permeability
    -- Eosinophilic gastrointestinal disorders

  3. Stem Cell and Organoid Modeling of Digestive Disease
    -- Molecular basis of organogenesis
    -- Organoids to model physiological domains: esophagus, stomach, intestine, colon, liver, bile duct
    -- iPSC- and patient-derived organoids to model GI and liver diseases