Timchenko Lab

Publications

Glaser, K; Depasquale, EAK; Berklite, L; Hickner, BT; Rao, P; Patel, RH; Badachhape, AA; Roy, S; Schepers, E; Timchenko, NA; Takebe, T; Woodfield, SE; Vasudevan, SA; Bondoc, AJ. Investigating the oncogenic role of aberrant EZH2 in hepatoblastoma. Scientific Reports. 2026.

Jennings, K; Tian, C; Brown, RL; Horn, PS; Schoser, B; Kushlaf, H; Timchenko, NA; Timchenko, L. Elevated Levels of Active GSK3β in the Blood of Patients with Myotonic Dystrophy Type 1 Correlate with Muscle Weakness. International Journal of Molecular Sciences. 2025; 26(21).

Fleifil, Y; Gulati, R; Jennings, K; Kycia, I; Bondoc, A; Tiao, G; Geller, J; Weirauch, M; Vakili, K; Timchenko, L; Timchenko, N. β-Catenin-Cohesin Ring-CEGRs/ALCDs Axis Activation Contributes to the Development of Hepatoblastoma and Fibrolamellar HCC. Molecular Cancer Research. 2025; 23(11):901-912.

Jennings, K; Lindquist, D; Poonia, A; Schoser, B; Schneider-Gold, C; Timchenko, NA; Timchenko, L. The role of CNBP in brain atrophy and its targeting in myotonic dystrophy type 2. Human Molecular Genetics. 2025; 34(6):512-522.

Fleifil, Y; Gulati, R; Jennings, K; Miethke, A; Bondoc, A; Tiao, G; Geller, JI; Karns, R; Timchenko, L; Timchenko, N. DNAJB1-PKAc Kinase Is Expressed in Young Patients with Pediatric Liver Cancers and Enhances Carcinogenic Pathways. Cancers. 2024; 17(1).

Gulati, R; Fleifil, Y; Jennings, K; Bondoc, A; Tiao, G; Geller, J; Timchenko, L; Timchenko, N. Inhibition of Histone Deacetylase Activity Increases Cisplatin Efficacy to Eliminate Metastatic Cells in Pediatric Liver Cancers. Cancers. 2024; 16(13).

Gulati, R; Timchenko, N. C/EBPα-mediated epigenetic control of liver disorders in young children. Journal of Cancer Biology. 2024; 5(1):23-27.

Glaser, K; Schepers, EJ; Zwolshen, HM; Lake, CM; Timchenko, NA; Karns, RA; Cairo, S; Geller, JI; Tiao, GM; Bondoc, AJ. EZH2 is a key component of hepatoblastoma tumor cell growth. Pediatric Blood and Cancer. 2024; 71(2):e30774.

Gulati, R; Lutz, M; Hanlon, M; Cast, A; Karns, R; Geller, J; Bondoc, A; Tiao, G; Timchenko, L; Timchenko, NA. Cellular origin and molecular mechanisms of lung metastases in patients with aggressive hepatoblastoma. Hepatology Communications. 2024; 8(2).

Xue, M; Dong, L; Zhang, H; Li, Y; Qiu, K; Zhao, Z; Gao, M; Han, L; Chan, AKN; Li, W; Chen, J; Shen, B; Chen, H; Su, R. METTL16 promotes liver cancer stem cell self-renewal via controlling ribosome biogenesis and mRNA translation. Journal of Hematology and Oncology. 2024; 17(1):7.

Hanlon, MA; Gulati, R; Johnston, M; Fleifil, Y; Rivas, M; Timchenko, NA. Genetic Ablation of C/EBPα-p300 Pathway Blocks Development of Obese Pregnancy Associated Liver Disorders in Offspring. Cellular and Molecular Gastroenterology and Hepatology (CMGH). 2024; 17(3):347-360.

Liu, X; Wang, J; Li, F; Timchenko, N; Tsai, RYL. Transcriptional control of a stem cell factor nucleostemin in liver regeneration and aging. PLoS ONE. 2024; 19(9):e0310219.

Lutz, M; Levanti, M; Karns, R; Gourdon, G; Lindquist, D; Timchenko, NA; Timchenko, L. Therapeutic Targeting of the GSK3β-CUGBP1 Pathway in Myotonic Dystrophy. International Journal of Molecular Sciences. 2023; 24(13).

Brown, A; Pan, Q; Fan, L; Indersie, E; Tian, C; Timchenko, N; Li, L; Hansen, BS; Tan, H; Lu, M; Peng, J; Pruett-Miller, SM; Yu, J; Cairo, S; Zhu, L. Ribonucleotide reductase subunit switching in hepatoblastoma drug response and relapse. Communications Biology. 2023; 6(1):249.

Gulati, R; Hanlon, MA; Lutz, M; Quitmeyer, T; Geller, J; Tiao, G; Timchenko, L; Timchenko, N. Phosphorylation-Mediated Activation of β-Catenin-TCF4-CEGRs/ALCDs Pathway Is an Essential Event in Development of Aggressive Hepatoblastoma. Cancers. 2022; 14(24).

Gulati, R; Johnston, M; Rivas, M; Cast, A; Kumbaji, M; Hanlon, MA; Lee, S; Zhou, P; Lake, C; Schepers, E; Geller, J; Tiao, G; Shin, S; Timchenko, N. β-catenin cancer-enhancing genomic regions axis is involved in the development of fibrolamellar hepatocellular carcinoma. Hepatology Communications. 2022; 6(10):2950-2963.

D'souza, AM; Gnanamony, M; Thomas, M; Hanley, P; Kanabar, D; De Alarcon, P; Muth, A; Timchenko, N. Second Generation Small Molecule Inhibitors of Gankyrin for the Treatment of Pediatric Liver Cancer. Cancers. 2022; 14(13).