Publications

D’souza, AM; Gnanamony, M; Thomas, M; Hanley, P; Kanabar, D; de Alarcon, P; Muth, A; Timchenko, N. Second Generation Small Molecule Inhibitors of Gankyrin for the Treatment of Pediatric Liver Cancer. Cancers. 2022; 14.

Johnston, ME; Timchenko, N. Molecular signatures of aggressive pediatric liver cancer. 2021; 2:1-4.

Johnston, ME; Rivas, MP; Nicolle, D; Gorse, A; Gulati, R; Kumbaji, M; Weirauch, MT; Bondoc, A; Cairo, S; Geller, J; et al. Olaparib Inhibits Tumor Growth of Hepatoblastoma in Patient-Derived Xenograft Models. Hepatology. 2021; 74:2201-2215.

Rivas, M; Johnston, ME; Gulati, R; Kumbaji, M; Margues Aguiar, TF; Timchenko, L; Krepischi, A; Shin, S; Bondoc, A; Tiao, G; et al. HDAC1-Dependent Repression of Markers of Hepatocytes and P21 Is Involved in Development of Pediatric Liver Cancer. CMGH Cellular and Molecular Gastroenterology and Hepatology. 2021; 12:1669-1682.

Timchenko, NA. Help for Sick Kids: New Insights Into Hepatoblastoma. CMGH Cellular and Molecular Gastroenterology and Hepatology. 2021; 12:350-351.

D’Souza, AM; Cast, A; Kumbaji, M; Rivas, M; Gulati, R; Johnston, M; Smithrud, D; Geller, J; Timchenko, N. Small Molecule Cjoc42 Improves Chemo-Sensitivity and Increases Levels of Tumor Suppressor Proteins in Hepatoblastoma Cells and in Mice by Inhibiting Oncogene Gankyrin. Frontiers in Pharmacology. 2021; 12.

Rivas, MP; Aguiar, TF M; Maschietto, M; Lemes, RB; Caires-Júnior, LC; Goulart, E; Telles-Silva, KA; Novak, E; Cristofani, LM; Odone, V; et al. Hepatoblastomas exhibit marked NNMT downregulation driven by promoter DNA hypermethylation. Tumor Biology. 2020; 42.

Wang, M; Weng, W; Stock, L; Lindquist, D; Martinez, A; Gourdon, G; Timchenko, N; Snape, M; Timchenko, L. Correction of Glycogen Synthase Kinase 3β in Myotonic Dystrophy 1 Reduces the Mutant RNA and Improves Postnatal Survival of DMSXL Mice. Molecular and Cellular Biology. 2019; 39.

Cast, A; Kumbaji, M; D'Souza, A; Rodriguez, K; Gupta, A; Karns, R; Timchenko, L; Timchenko, N. Liver Proliferation Is an Essential Driver of Fibrosis in Mouse Models of Nonalcoholic Fatty Liver Disease. Hepatology Communications. 2019; 3:1036-1049.

Khanal, T; Leung, Y; Jiang, W; Timchenko, N; Ho, S; Kim, K. NR2E3 is a key component in p53 activation by regulating a long noncoding RNA DINO in acute liver injuries. FASEB Journal. 2019; 33:8335-8348.

Valanejad, L; Cast, A; Wright, M; Bissig, K; Karns, R; Weirauch, MT; Timchenko, N. PARP1 activation increases expression of modified tumor suppressors and pathways underlying development of aggressive hepatoblastoma. Communications Biology. 2018; 1.

Rodriguez, K; Cast, A; Timchenko, NA. Correction of aging phenotype in the liver. Aging. 2018; 10:1795-1796.

Nguyen, P; Valanejad, L; Cast, A; Wright, M; Garcia, JM; El-Serag, HB; Karns, R; Timchenko, NA. Elimination of Age-Associated Hepatic Steatosis and Correction of Aging Phenotype by Inhibition of cdk4-C/EBPα-p300 Axis. Cell Reports. 2018; 24:1597-1609.

Wei, C; Stock, L; Schneider-Gold, C; Sommer, C; Timchenko, NA; Timchenko, L. Reduction of Cellular Nucleic Acid Binding Protein Encoded by a Myotonic Dystrophy Type 2 Gene Causes Muscle Atrophy. Molecular and Cellular Biology. 2018; 38.

D'Souza, AM; Jiang, Y; Cast, A; Valanejad, L; Wright, M; Lewis, K; Kumbaji, M; Shah, S; Smithrud, D; Karns, R; et al. Gankyrin Promotes Tumor-Suppressor Protein Degradation to Drive Hepatocyte Proliferation. CMGH Cellular and Molecular Gastroenterology and Hepatology. 2018; 6:239-255.

Cast, A; Valanejad, L; Wright, M; Nguyen, P; Gupta, A; Zhu, L; Shin, S; Timchenko, N. C/EBPα-dependent preneoplastic tumor foci are the origin of hepatocellular carcinoma and aggressive pediatric liver cancer. Hepatology. 2018; 67:1857-1871.

Wei, C; Stock, L; Valanejad, L; Zalewski, ZA; Karns, R; Puymirat, J; Nelson, D; Witte, D; Woodgett, J; Timchenko, NA; et al. Correction of GSK3β at young age prevents muscle pathology in mice with myotonic dystrophy type 1. FASEB Journal. 2018; 32:2073-2085.

Timchenko, NA. Mitochondrial and anabolic pathways in hepatocellular carcinoma. Hepatology. 2018; 67:823-825.

Guillory, B; Jawanmardi, N; Iakova, P; Anderson, B; Zang, P; Timchenko, NA; Garcia, JM. Ghrelin deletion protects against age-associated hepatic steatosis by downregulating the C/EBPα-p300/DGAT1 pathway. Aging Cell. 2018; 17.

Current Projects

Learn more about the projects underway in the lab.

Current Projects