The laboratory has made several discoveries pertaining to the identification of mechanisms that cause immune inflammation in Gaucher disease. These include the identification of glucosylceramide (GC) loaded DCs and CD4+T cells, which upon stimulation showed increased production of pro-inflammatory cytokines, C-C, and C-X-C chemokines. These data suggested that DCs and CD4+T cells interaction drive inflammatory responses that lead to Gaucher disease manifestation. We now seek to determine if other APCs such as Mɸs, PMNs, and B cells also interact with certain T cells to trigger innate and adaptive immune responses. The lab is extensively involved in defining the signaling cascades that trigger GC induced immune inflammation in Gaucher disease.