Publications & Presentations
Publications
. Uncovering the Lipid Web: Discovering the Multifaceted Roles of Lipids in Human Diseases and Therapeutic Opportunities. International Journal of Molecular Sciences. 2023; 24:13223.
. Complement Turning Violent in Ultra-Rare Genetic Disorder. Journal of immunology (Baltimore, Md. : 1950). 2023; 210:153.04.
. Exploring Pro-Inflammatory Immunological Mediators: Unraveling the Mechanisms of Neuroinflammation in Lysosomal Storage Diseases. Biomedicines. 2023; 11:1067.
. Targeting the Complement-Sphingolipid System in COVID-19 and Gaucher Diseases: Evidence for a New Treatment Strategy. International Journal of Molecular Sciences. 2022; 23:14340.
. Pre-existing humoral immune comebacks control the development of the severe form of coronavirus disease 2019 in Gaucher patients. Clinical and Translational Discovery. 2022; 2:e96.
. The Role of Alpha-Synuclein Autoantibodies in the Induction of Brain Inflammation and Neurodegeneration in Aged Humans. Frontiers in Aging Neuroscience. 2022; 14:902191.
. Genetic Defects and Pro-inflammatory Cytokines in Parkinson's Disease. Frontiers in Neurology. 2021; 12:636139.
. An unexpected player in Gaucher disease: The multiple roles of complement in disease development. Seminars in Immunology. 2018; 37:30-42.
. Complement drives glucosylceramide accumulation and tissue inflammation in Gaucher disease. Nature. 2017; 543:108-112.
. Neuronopathic Gaucher disease: dysregulated mRNAs and miRNAs in brain pathogenesis and effects of pharmacologic chaperone treatment in a mouse model. Human Molecular Genetics. 2015; 24:7031-7048.
. Molecular basis for downregulation of C5a-mediated inflammation by IgG1 immune complexes in allergy and asthma. Current Allergy and Asthma Reports. 2013; 13:596-606.
. Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcγRIIB and dectin-1. Nature Medicine. 2012; 18:1401-1406.
. Staphylococcal complement evasion by various convertase-blocking molecules. The Journal of Experimental Medicine. 2007; 204:2461-2471.
. A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma. The Journal of Clinical Investigation. 2006; 116:783-796.
. Embracing the Science of Motherhood: Pregnancy's Transformative Effects on the Central Nervous System and the Radiance of Maternal Hormones and Immune Responses. Discovery medicine. 2023; 35:673-696.
. Uncovering the Lipid Web: Discovering the Multifaceted Roles of Lipids in Human Diseases and Therapeutic Opportunities. International Journal of Molecular Sciences. 2023; 24:13223.
. Complement Turning Violent in Ultra-Rare Genetic Disorder. Journal of immunology (Baltimore, Md. : 1950). 2023; 210:153.04.
. Exploring Pro-Inflammatory Immunological Mediators: Unraveling the Mechanisms of Neuroinflammation in Lysosomal Storage Diseases. Biomedicines. 2023; 11:1067.
. Targeting the Complement-Sphingolipid System in COVID-19 and Gaucher Diseases: Evidence for a New Treatment Strategy. International Journal of Molecular Sciences. 2022; 23:14340.
. Defibrillator Delivered Energy Measurement Study with a Calibration Set Up at Different Trans-Thoracic Impedance. Mapan - Journal of Metrology Society of India. 2022; 37:477-481.
. Pre-existing humoral immune comebacks control the development of the severe form of coronavirus disease 2019 in Gaucher patients. Clinical and Translational Discovery. 2022; 2:e96.
. The Role of Alpha-Synuclein Autoantibodies in the Induction of Brain Inflammation and Neurodegeneration in Aged Humans. Frontiers in Aging Neuroscience. 2022; 14:902191.
. Acid β-glucosidase insufficiency activates the C-X-C Motif Chemokine Ligand 9/CXCR3 axis leading to T cell mediated inflammation in Gaucher disease. Journal of immunology (Baltimore, Md. : 1950). 2022; 208:166.01.
. Acid β-glucosidase insufficiency activates the C-X-C Motif Chemokine Ligand 9/CXCR3 axis leading to T cell mediated inflammation in Gaucher disease. 2022; 208:166.01.
. Fat and Protein Combat Triggers Immunological Weapons of Innate and Adaptive Immune Systems to Launch Neuroinflammation in Parkinson's Disease. International Journal of Molecular Sciences. 2022; 23:1089.
. C-X-C Motif Chemokine Ligand 9 and Its CXCR3 Receptor Are the Salt and Pepper for T Cells Trafficking in a Mouse Model of Gaucher Disease. International Journal of Molecular Sciences. 2021; 22:12712.
. Genetic Defects and Pro-inflammatory Cytokines in Parkinson's Disease. Frontiers in Neurology. 2021; 12:636139.
. Genetic parkinsonisms and cancer: a systematic review and meta-analysis. Reviews in the Neurosciences. 2021; 32:159-167.
. Complement activation causes oncogene expression in Gaucher disease. Journal of immunology (Baltimore, Md. : 1950). 2019; 202:181.9.
National & International Presentations
March 30, 2021: Clinically proven complement 5 targeting strategies: A path to develop effective therapy for Gaucher’s disease patients. Manoj Pandey, Alexion Pharmaceuticals (Boston, MA, USA).
May 10-15, 2021: The link between Complement System and Anemia in Gaucher disease. Pandey MK, Magnusen AF, McKay MA, Hatton SL, Magnusen DN, Rapien J , Nyamajenjere TC, DiPasquale BA, and Christopher Woods. Poster presentation in Poster sessions (Molecular and Metabolic Control of Innate Immunity; May 13, 2021) of The Annual Meeting of the American Association of Immunology (Virtual Immunology 2021).
October 19th, 2021: Twist and turn of complement in induction of brain inflammation in GBA1– linked Parkinson’s disease. Manoj Pandey, GBA consortium, Michael J. Fox Foundation (New YORK, NY, USA).
May 9-13, 2019: Complement activation causes oncogene expression in Gaucher disease. Pandey MK, Magnusen AF, McKay MA, Nyamajenjere TC, DiPasquale BA, Magnusen DN, Rani R, Witte D, Grabowski GA, Köhl J. Poster presentation in The Annual Meeting of the American Association of Immunology at San Diego Convention Center, San Diego, California.
November 19th, 2019: GBA1 defects cause C5a-C5aR1-induced neurodegeneration in Parkinson’s disease. Manoj Pandey, GBA consortium, Michael J. Fox Foundation (New YORK, NY, USA).
April, 21-27, 2018: Dendritic cells, CD4+ T cells, and a synuclein triangle fuels neuroinflammation in Parkinson’s disease. Magnusen D, Nyamajenjere T, Rapien J, Mckay M, Magnusen A, Pandey M. Poster presentation at 70th American Academy of Neurology Annual Meeting, Los Angeles, CA.
May 4-8, 2018: Complement 5a galvanizes immune inflammation in Hunter syndrome. Pandey MK, Prada CE, Nyamajenjere TC, McKay MA, Magnusen AF, Rapien J, and Köhl J. Poster presentation at American Association of Immunology meeting at Austin Convention Center, Austin, TX.
February 13- 17, 2017: Glucosylceramide partnership with immunological villain in Gaucher disease. Pandey MK, Burrow TA, Rani R, Martin LJ, Magnusen AF, McKay, M, Magnusen D, Witte DP, Zhang, W, Setchell, KD, Kohl, J, Grabowski, GA Platform presentation in 13th annual World Symposium organized by Lysosomal Disease Network at Manchester Grand Hyatt, San Diego, CA.
May 12-16, 2017: Complement drives neurodegeneration in Gaucher disease. Pandey MK, Magnusen DN, Mckay MA, Magnusen AF, Rani R, Caballero M, Zhang W, Setchell KD, Grabowski GA, Köhl J. Poster presentation in American Association of Immunology meeting at Walter E. Washington Convention Center, Washington, D.C.
February 29-March 3, 2016: Immune cells attack and neurodegeneration in Gaucher disease. Pandey MK, Caballero M, Tinch SL, Schroeder LM, Gross C, Vorhees C, Burrow TA, Grabowski GA. Platform presentation in 12th annual World Symposium organized by Lysosomal Disease Network at Manchester Grand Hyatt, San Diego, CA, USA.
May 13-17, 2016: Immune cells encounter with α-synuclein fuels neurodegeneration in Parkinson’s disease. Pandey MK, Gross C, Caballero M, Mckay MA, Tiwari D, Schroeder LM, Burrow TA. Poster presentation in American Association of Immunology meeting at the Washington State Convention Center, Seattle, WA.
September 4-8th, 2016: C5a drives glucosylceramide accumulation and tissue inflammation in Gaucher disease. Pandey MK, Burrow TA, Gross, C, Witte, D. Zhang, W, Setchell, KD, Leslie, ND, Grabowski, GA, Kohl J. Platform presentation in XXVI International Complement Workshop at Kanazawa, Japan.
September 9-10, 2016: α-synuclein collaboration with immunological villains. McKay MA, Magnusen D, Caballero M, Tiwari D, Schroeder LM, Gross C, Burrow TA, and Pandey MK. Annual Immunology Retreat at Deer Creek Lodge and Conference Center, Columbus, OH, USA.
October 24-25, 2014: Glucosylceramide-induced C5a triggers immunological twist in Gaucher Disease. Pandey MK. Speaker in Session-IV of Annual Immunology Retreat at Shawnee Lodge and Conference Center, West Portsmouth, OH, USA.
February 10-13, 2014: Gaucher disease: Glucosylceramide - mediated TLR4 - MyD88 induction cause enhanced CXCL13 secretion and increased B cell trafficking in a mouse model. Pandey MK, Tinch SL, Jabre NA, Grabowski GA. 10th annual World Symposium organized by Lysosmal Disease Network at The Manchester Grand Hyatt, One Market Place, San Diego, CA, USA.
February 12-15, 2013: C5a mediated increases of CD40 and CD40L molecules on dendritic and T cells are critical to Th1-Th17 mediated inflammation in Gaucher disease model. Pandey MK, Tinch SL, Grabowski GA. 9th annual World Symposium organized by Lysosmal Disease Network at Hilton Orlando, Orlando FL, USA.
November 6 -10, 2012: Chemotactic factors critical for increased immunological cell invasion in Gaucher disease mice Pandey MK, Jabre NA, Grabowski GA. American Society of Human Genetics at Moscone Center, San Francisco, CA, USA.
April 19-21, 2012: Elevated inflammatory cytokines in a mouse model of Gaucher Disease. Jabre NA, Pandey MK, Grabowski G. American College of Physicians Internal Medicine meeting at New Orleans, LA, USA.
August 21-24, 2011: Synergistic roles for C5aR and C5L2 in the development of anti-GBM nephritis. Figge J, Pandey MK, Karsten CM, Westermann J, Madaio M, Köhl J. XIII European Meeting on Complement in Human Disease at Leiden, The Netherlands.
August 21-24, 2011: Galactosylated IgG1 links FcRIIB and dectin 1 to suppress C5aR-mediated inflammation. Karsten CM, Pandey MK, Figge J, Taylor PR, McDonald JU, Strait RT, Harris NL, Koehl G, Brown GD, Finkelman FD, Koehl J. XIII European Meeting on Complement in Human Disease at Leiden, The Netherlands.
January 27- 29, 2011: Enhanced leukocyte chemotaxis into serum from a mouse model of Gaucher Disease. Jabre NA, Pandey MK, Grabowski G. Western Student Medical Research Forum at Carmel, CA, USA.
August 1-5,2010: Imbalance of complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for age related macular degeneration (AMD). Lauer N, Fritsche LG, Weber BHF, Hartmann A, Keilhauer CN, Hälbich S, Oppermann M, Pandey MK, Köhl J, Zipfel PF, Skerka C. XXIII International Complement Workshop at Grand Hyatt New York 109 East 42nd Street at Grand Central Terminal, New York, New York, USA 10017.
August 1-5, 2010: A novel role for C5a in B-cell regulation driving the pathology in immune complex nephritis. Pandey MK, Figge J, Karsten CM, Madaio M, Gerard C, Köhl J. XXIII International Complement Workshop at Grand Hyatt New York 109 East 42nd Street at Grand Central Terminal, New York, New York, USA 10017.
September 10-12, 2009: Cross-talk between IgG Fc and C5a receptors regulates neutrophilic inflammation in immune complex diseases. Pandey MK, Köhl J. Neutrophil Granulocytes Revisited International Symposium of Novel Functions of Neutrophil Granulocytes at Lübeck, Germany.
September 5 - 8, 2009: Factor H related human plasma proteins CFHR1, CFHR2 and CFHR3 regulate complement activation and exert anti-inflammatory activities. Eberhardt H, Lauer N, Pandey MK, Köhl J, Hartmann A, Ludwig M, Zipfel PF , Skerka K. 12th European Meeting on Complement in Human Disease at Thermal Hotel Visegrád, Hungary.
September 5 - 8, 2009: Synergistic roles for C5aR and C5L2 in Goodpasture's disease. Pandey MK, Köhl J. 12th European Meeting on Complement in Human Disease at Thermal Hotel Visegrád, Hungary.
November 19-24, 2008: A critical role for C5L2 in a murine model of Goodpasture’s Disease. Pandey MK, Madaio M, Koehl J. 37th Annual Autumn Immunology Conference at Chicago Marriott Downtown 540 North Michigan Avenue Chicago, IL 60611, USA.
May 3– 6, 2008: Lack of C5a Receptor Signaling Impacts T Cell Phenotype by Impairing Dendritic Cell Function. Weaver DJ, Reis E, Koehl G, Magnussen A, Pandey MK, Koehl J. Pediatric Academic Societies’ Annual Meeting, Honolulu, Hawaii, USA.
September 8-11, 2007: Aggregation of FcgRIIB by IgG1 immune complexes inhibits chemoattractant receptor mediated inflammation. Pandey MK, Harris NL, Köhl G, Magnusen AF, Köhl J. 11th European meeting “Complement in human disease” at Cardiff.
June 11–15, 2007: IgG1-specific aggregation of FcgRIIB inhibits chemoattractant receptor mediated inflammation. Pandey MK, Köhl J. 4th International Workshop on “Complement Associated Diseases, Animal Models, and Therapeutics” at the AKS Porto Heli Hotel Athens, Greece.
November 17-20, 2006: C5a receptor and toll-like receptor cross talk regulates the B1 B cell compartment. Magnusen AF, Pandey MK, Köhl J. 35th Annual Autumn Immunology Conference at Chicago Marriott Downtown 540 North Michigan Avenue Chicago, IL 60611, USA.
November 17-20, 2006: The inhibitory FcγR receptor blocks chemoattractant receptor signaling as a novel pathway to regulate immune complex-mediated inflammation. Pandey MK, Harris NL, Magnusen AF, Köhl G, Köhl J. 35th Annual Autumn Immunology Conference at Chicago Marriott Downtown 540 North Michigan Avenue Chicago, IL 60611, USA.
October 22-26, 2006: Inhibitory FcγR receptors negatively regulate C5aR-mediated effector functions in immune complex diseases. Pandey MK, Köhl G, Köhl J. XXI International Complement Workshop at Beijing, China.
May 20-25, 2005: Murine alveolar epithelial cells type II in culture and osmotic challenge. Bauer PR, Pandey MK, Hubmayr RD. American Thoracic Society meeting at San Diego Convention Center, 111 W. Harbor Drive, San Diego, CA 92101, USA.
May 20-25, 2005: Effects of stretch and transdifferentiation on caveolin-1 expression in alveolar epithelial cells. Pandey MK, Rasmussen DL, Hubmayr RD. American Thoracic Society meeting at San Diego Convention Center, 111 W. Harbor Drive, San Diego, CA 92101, USA.
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