Divanovic Lab

Grants

R01DK099222; Divanovic (PI); 08/2013-07/2018; “Immunopathogenesis of Non-alcoholic Fatty Liver Disease”
R01DK099222-02S1; NIDDK Research Supplement to Promote Diversity in Health Related Research; Divanovic (PI), Moreno-Fernandez (Research Fellow); 08/2014-07/2016; “Immunopathogenesis of Non-alcoholic Fatty Liver Disease”
Academic and Research Committee - Cincinnati Children's; Divanovic (Co-PI), Inge (Co-PI), Nakamura (Co-PI); 07/2015-06/2018; “Pediatric Diabetes and Obesity Center”
Burroughs Wellcome Fund (1015032); Divanovic (PI); 07/2015-06/2019; “Role of type I IFNs/IFNAR axis in inflammation-induced preterm birth”
Markham Family Award - Cincinnati Children's Hospital Medical Center Division of Gastroenterology, Hepatology and Nutrition; Divanovic (PI); 01/2016-12/2016; “Pathogenic potential of Th17 axis in NAFLD severity”
Department of Defense (W81XWH-51-1-0370); Gandhi (PI); Divanovic (Co-I); 07/2015-06/2018; “Mechanisms of non-alcoholic steatohepatitis”
New Investigator Scholar (NIS) awards; University of Cincinnati; Divanovic (PI), Giles (Student PI); 06/2014-05/2015; “Environmental regulation of transcriptional networks in inflammation”
R21HL113907; Divanovic (PI); 04/2012-03/2015; “Better mouse models of disease: Humanizing experimental atherosclerosis”
March of Dimes, Prematurity Research Initiative Grant; Dey (PI), Divanovic (Co-PI); 03/2012-02/2015; “Endocannabinoid signaling via CB2 protects against preterm birth by modulating immune responses”

Publications

2021

Moreno-Fernandez, ME; Damen, MS M A; Divanovic, S. A protocol for isolation of primary human immune cells from the liver and mesenteric white adipose tissue biopsies. STAR Protocols. 2021; 2.

Chan, CC; Harley, IT W; Pfluger, PT; Trompette, A; Stankiewicz, TE; Allen, JL; Moreno-Fernandez, ME; Damen, MS M A; Oates, JR; Alarcon, PC; et al. A BAFF/APRIL axis regulates obesogenic diet-driven weight gain. Nature Communications. 2021; 12.

Alarcon, PC; Damen, MS M A; Madan, R; Deepe, GS; Spearman, P; Way, SS; Divanovic, S. Adipocyte inflammation and pathogenesis of viral pneumonias: an overlooked contribution. Mucosal Immunology. 2021; 14:1224-1234.

Damen, MS M A; Stankiewicz, TE; Park, SH; Helsley, RN; Chan, CC; Moreno-Fernandez, ME; Doll, JR; Szabo, S; Herbert, DB R; Softic, S; et al. Non-hematopoietic IL-4Rα expression contributes to fructose-driven obesity and metabolic sequelae. International Journal of Obesity. 2021; 45:2377-2387.

Thomas, AL; Alarcon, PC; Divanovic, S; Chougnet, CA; Hildeman, DA; Moreno-Fernandez, ME. Implications of Inflammatory States on Dysfunctional Immune Responses in Aging and Obesity. 2021; 2.

Cappelletti, M; Presicce, P; Feiyang, M; Senthamaraikannan, P; Miller, LA; Pellegrini, M; Sim, MS; Jobe, AH; Divanovic, S; Way, SS; et al. The induction of preterm labor in rhesus macaques is determined by the strength of immune response to intrauterine infection. PLoS Biology. 2021; 19.

McNelis, K; Yodoshi, T; Divanovic, S; Gandhi, C; Kim, JH; Anton, CG; Trout, AT; Mouzaki, M. Hepatic Steatosis in Infancy: The Beginning of Pediatric Nonalcoholic Fatty Liver Disease?. 2021; 2.

Uddin, J; Tomar, S; Sharma, A; Waggoner, L; Ganesan, V; Marella, S; Yang, Y; Noah, T; Vanoni, S; Patterson, A; et al. PIR-B Regulates CD4+ IL17a+ T-Cell Survival and Restricts T-Cell-Dependent Intestinal Inflammatory Responses. CMGH Cellular and Molecular Gastroenterology and Hepatology. 2021; 12:1479-1502.

Moreno-Fernandez, ME; Sharma, V; Stankiewicz, TE; Oates, JR; Doll, JR; Damen, MS M A; Almanan, MA T A; Chougnet, CA; Hildeman, DA; Divanovic, S. Aging mitigates the severity of obesity-associated metabolic sequelae in a gender independent manner. Nutrition and Diabetes. 2021; 11.

Moreno-Fernandez, ME; Giles, DA; Oates, JR; Chan, CC; Damen, MS M A; Doll, JR; Stankiewicz, TE; Chen, X; Chetal, K; Karns, R; et al. PKM2-dependent metabolic skewing of hepatic Th17 cells regulates pathogenesis of non-alcoholic fatty liver disease. Cell Metabolism. 2021; 33:1187-1204.e9.

Noah, TK; Lee, JB; Brown, CA; Yamani, A; Tomar, S; Ganesan, V; Newberry, RD; Huffnagle, GB; Divanovic, S; Hogan, SP. Thermoneutrality Alters Gastrointestinal Antigen Passage Patterning and Predisposes to Oral Antigen Sensitization in Mice. Frontiers in Immunology. 2021; 12.

Jose, S; Mukherjee, A; Horrigan, O; Setchell, KD R; Zhang, W; Moreno-Fernandez, ME; Andersen, H; Sharma, D; Haslam, DB; Divanovic, S; et al. Obeticholic acid ameliorates severity of Clostridioides difficile infection in high fat diet-induced obese mice. Mucosal Immunology. 2021; 14:500-510.

2020

Thiel, AL; Ragab, M; Wagner, AE; Divanovic, S; Derer, S; Sina, C. Purification and Functional Characterization of the Chloroform/Methanol-Soluble Protein 3 (CM3) From Triticum aestivum in Drosophila melanogaster. Frontiers in Nutrition. 2020; 7.

Chan, CC; Damen, MS M A; Moreno-Fernandez, ME; Stankiewicz, TE; Cappelletti, M; Alarcon, PC; Oates, JR; Doll, JR; Mukherjee, R; Chen, X; et al. Type I interferon sensing unlocks dormant adipocyte inflammatory potential. Nature Communications. 2020; 11.

Cappelletti, M; Doll, JR; Stankiewicz, TE; Lawson, MJ; Sauer, V; Wen, B; Kalinichenko, VV; Sun, X; Tilburgs, T; Divanovic, S. Maternal regulation of inflammatory cues is required for induction of preterm birth. JCI insight. 2020; 5.

Moreno-Fernandez, ME; Miraldi, ER; Divanovic, S. Not Chopped Liver-A Careful, Fate-Mapping Study of Macrophages in NASH. Cell Metabolism. 2020; 32:328-330.

Softic, S; Stanhope, KL; Boucher, J; Divanovic, S; Lanaspa, MA; Johnson, RJ; Kahn, CR. Fructose and hepatic insulin resistance. Critical Reviews in Clinical Laboratory Sciences. 2020; 57:308-322.

Almanan, M; Raynor, J; Ogunsulire, I; Malyshkina, A; Mukherjee, S; Hummel, SA; Ingram, JT; Saini, A; Xie, MM; Alenghat, T; et al. IL-10-producing Tfh cells accumulate with age and link inflammation with age-related immune suppression. Science advances. 2020; 6.

2019

Oates, JR; McKell, MC; Moreno-Fernandez, ME; Damen, MS M A; Deepe, GS; Qualls, JE; Divanovic, S. Macrophage Function in the Pathogenesis of Non-alcoholic Fatty Liver Disease: The Mac Attack. Frontiers in Immunology. 2019; 10.

Namjou, B; Lingren, T; Huang, Y; Parameswaran, S; Cobb, BL; Stanaway, IB; Connolly, JJ; Mentch, FD; Benoit, B; Niu, X; et al. GWAS and enrichment analyses of non-alcoholic fatty liver disease identify new trait-associated genes and pathways across eMERGE Network. BMC Medicine. 2019; 17.

Schroeder, T; Wiese, AV; Ender, F; Quell, KM; Vollbrandt, T; Duhn, J; Suenderhauf, A; Kuenstner, A; Moreno-Fernandez, ME; Derer, S; et al. Short-term high-fat diet feeding protects from the development of experimental allergic asthma in mice. Clinical and Experimental Allergy. 2019; 49:1245-1257.

Chan, CC; Damen, MS M A; Alarcon, PC; Sanchez-Gurmaches, J; Divanovic, S. Inflammation and Immunity: From an Adipocyte's Perspective. Journal of Interferon and Cytokine Research. 2019; 39:459-471.

Chowdhury, D; Alrefai, H; Figueroa, JA L; Candor, K; Porollo, A; Fecher, R; Divanovic, S; Jr, DG S; Vignesh, KS. Metallothionein 3 Controls the Phenotype and Metabolic Programming of Alternatively Activated Macrophages. Cell Reports. 2019; 27:3873-3886.e7.

2018

Zhang, C; Seo, J; Murakami, K; Salem, ES B; Bernhard, E; Borra, VJ; Choi, K; Yuan, CL; Chan, CC; Chen, X; et al. Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology. Nature Communications. 2018; 9.

Mukherjee, R; Moreno-Fernandez, ME; Giles, DA; Cappelletti, M; Stankiewicz, TE; Chan, CC; Divanovic, S. Nicotinamide adenine dinucleotide phosphate (reduced) oxidase 2 modulates inflammatory vigor during nonalcoholic fatty liver disease progression in mice. Hepatology Communications. 2018; 2:546-560.

Moreno-Fernandez, ME; Giles, DA; Stankiewicz, TE; Sheridan, R; Karns, R; Cappelletti, M; Lampe, K; Mukherjee, R; Sina, C; Sallese, A; et al. Peroxisomal β-oxidation regulates whole body metabolism, inflammatory vigor, and pathogenesis of nonalcoholic fatty liver disease. JCI insight. 2018; 3.

Cappelletti, M; Lawson, MJ; Chan, CC; Wilburn, AN; Divanovic, S. Differential outcomes of TLR2 engagement in inflammation-induced preterm birth. Journal of Leukocyte Biology. 2018; 103:535-543.

2017

Wang, N; McKell, M; Dang, A; Yamani, A; Waggoner, L; Vanoni, S; Noah, T; Wu, D; Kordowski, A; Koehl, J; et al. Lipopolysaccharide suppresses IgE-mast cell-mediated reactions. Clinical and Experimental Allergy. 2017; 47:1574-1585.

Pagel, R; Baer, F; Schroeder, T; Suenderhauf, A; Kuenstner, A; Ibrahim, SM; Autenrieth, SE; Kalies, K; Koenig, P; Tsang, AH; et al. Circadian rhythm disruption impairs tissue homeostasis and exacerbates chronic inflammation in the intestine. FASEB Journal. 2017; 31:4707-4719.

Kopec, AK; Abrahams, SR; Thornton, S; Palumbo, JS; Mullins, ES; Divanovic, S; Weiler, H; III, OA P; Mackman, N; Goss, A; et al. Thrombin promotes diet-induced obesity through fibrin-driven inflammation. Journal of Clinical Investigation. 2017; 127:3152-3166.

Giles, DA; Moreno-Fernandez, ME; Stankiewicz, TE; Graspeuntner, S; Cappelletti, M; Wu, D; Mukherjee, R; Chan, CC; Lawson, MJ; Klarquist, J; et al. Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling. Nature Medicine. 2017; 23:829-838.

Fischer, K; Ruiz, HH; Jhun, K; Finan, B; Oberlin, DJ; van der Heide, V; Kalinovich, AV; Petrovic, N; Wolf, Y; Clemmensen, C; et al. Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis. Nature Medicine. 2017; 23:623-630.

Cappelletti, M; Presicce, P; Lawson, MJ; Chaturvedi, V; Stankiewicz, TE; Vanoni, S; Harley, IT W; McAlees, JW; Giles, DA; Moreno-Fernandez, ME; et al. Type I interferons regulate susceptibility to inflammation-induced preterm birth. JCI insight. 2017; 2.

Divanovic Lab

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