Divanovic Lab

Grants

R01DK099222; Divanovic (PI); 08/2013-07/2018; “Immunopathogenesis of Non-alcoholic Fatty Liver Disease”
R01DK099222-02S1; NIDDK Research Supplement to Promote Diversity in Health Related Research; Divanovic (PI), Moreno-Fernandez (Research Fellow); 08/2014-07/2016; “Immunopathogenesis of Non-alcoholic Fatty Liver Disease”
Academic and Research Committee - Cincinnati Children's; Divanovic (Co-PI), Inge (Co-PI), Nakamura (Co-PI); 07/2015-06/2018; “Pediatric Diabetes and Obesity Center”
Burroughs Wellcome Fund (1015032); Divanovic (PI); 07/2015-06/2019; “Role of type I IFNs/IFNAR axis in inflammation-induced preterm birth”
Markham Family Award - Cincinnati Children's Hospital Medical Center Division of Gastroenterology, Hepatology and Nutrition; Divanovic (PI); 01/2016-12/2016; “Pathogenic potential of Th17 axis in NAFLD severity”
Department of Defense (W81XWH-51-1-0370); Gandhi (PI); Divanovic (Co-I); 07/2015-06/2018; “Mechanisms of non-alcoholic steatohepatitis”
New Investigator Scholar (NIS) awards; University of Cincinnati; Divanovic (PI), Giles (Student PI); 06/2014-05/2015; “Environmental regulation of transcriptional networks in inflammation”
R21HL113907; Divanovic (PI); 04/2012-03/2015; “Better mouse models of disease: Humanizing experimental atherosclerosis”
March of Dimes, Prematurity Research Initiative Grant; Dey (PI), Divanovic (Co-PI); 03/2012-02/2015; “Endocannabinoid signaling via CB2 protects against preterm birth by modulating immune responses”

Publications

2019

Oates, JR; McKell, MC; Moreno-Fernandez, ME; Damen, MS M A; Deepe, GS; Qualls, JE; Divanovic, S. Macrophage Function in the Pathogenesis of Non-alcoholic Fatty Liver Disease: The Mac Attack. Frontiers in Immunology. 2019; 10.

Namjou, B; Lingren, T; Huang, Y; Parameswaran, S; Cobb, BL; Stanaway, IB; Connolly, JJ; Mentch, FD; Benoit, B; Niu, X; et al. GWAS and enrichment analyses of non-alcoholic fatty liver disease identify new trait-associated genes and pathways across eMERGE Network. BMC Medicine. 2019; 17.

Schroeder, T; Wiese, AV; Ender, F; Quell, KM; Vollbrandt, T; Duhn, J; Suenderhauf, A; Kuenstner, A; Moreno-Fernandez, ME; Derer, S; et al. Short-term high-fat diet feeding protects from the development of experimental allergic asthma in mice. Clinical and Experimental Allergy. 2019; 49:1245-1257.

Chan, CC; Damen, MS M A; Alarcon, PC; Sanchez-Gurmaches, J; Divanovic, S. Inflammation and Immunity: From an Adipocyte's Perspective. Journal of Interferon and Cytokine Research. 2019; 39:459-471.

Chowdhury, D; Alrefai, H; Figueroa, JA L; Candor, K; Porollo, A; Fecher, R; Divanovic, S; Jr, DG S; Vignesh, KS. Metallothionein 3 Controls the Phenotype and Metabolic Programming of Alternatively Activated Macrophages. Cell Reports. 2019; 27:3873-3886.e7.

2018

Zhang, C; Seo, J; Murakami, K; Salem, ES B; Bernhard, E; Borra, VJ; Choi, K; Yuan, CL; Chan, CC; Chen, X; et al. Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology. Nature Communications. 2018; 9.

Mukherjee, R; Moreno-Fernandez, ME; Giles, DA; Cappelletti, M; Stankiewicz, TE; Chan, CC; Divanovic, S. Nicotinamide Adenine Dinucleotide Phosphate (Reduced) Oxidase 2 Modulates Inflammatory Vigor During Nonalcoholic Fatty Liver Disease Progression in Mice. Hepatology Communications. 2018; 2:546-560.

Moreno-Fernandez, ME; Giles, DA; Stankiewicz, TE; Sheridan, R; Karns, R; Cappelletti, M; Lampe, K; Mukherjee, R; Sina, C; Sallese, A; et al. Peroxisomal beta-oxidation regulates whole body metabolism, inflammatory vigor, and pathogenesis of nonalcoholic fatty liver disease. JCI insight. 2018; 3.

Cappelletti, M; Lawson, MJ; Chan, CC; Wilburn, AN; Divanovic, S. Differential outcomes of TLR2 engagement in inflammation-induced preterm birth. Journal of Leukocyte Biology. 2018; 103:535-543.

2017

Wang, N; McKell, M; Dang, A; Yamani, A; Waggoner, L; Vanoni, S; Noah, T; Wu, D; Kordowski, A; Koehl, J; et al. Lipopolysaccharide suppresses IgE-mast cell-mediated reactions. Clinical and Experimental Allergy. 2017; 47:1574-1585.

Pagel, R; Baer, F; Schroeder, T; Suenderhauf, A; Kuenstner, A; Ibrahim, SM; Autenrieth, SE; Kalies, K; Koenig, P; Tsang, AH; et al. Circadian rhythm disruption impairs tissue homeostasis and exacerbates chronic inflammation in the intestine. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2017; 31:4707-4719.

Kopec, AK; Abrahams, SR; Thornton, S; Palumbo, JS; Mullins, ES; Divanovic, S; Weiler, H; III, OA P; Mackman, N; Goss, A; et al. Thrombin promotes diet-induced obesity through fibrin-driven inflammation. Journal of Clinical Investigation. 2017; 127:3152-3166.

Giles, DA; Moreno-Fernandez, ME; Stankiewicz, TE; Graspeuntner, S; Cappelletti, M; Wu, D; Mukherjee, R; Chan, CC; Lawson, MJ; Klarquist, J; et al. Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling. Nature Medicine. 2017; 23:829-838.

Fischer, K; Ruiz, HH; Jhun, K; Finan, B; Oberlin, DJ; van der Heide, V; Kalinovich, AV; Petrovic, N; Wolf, Y; Clemmensen, C; et al. Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis. Nature Medicine. 2017; 23:623-630.

Cappelletti, M; Presicce, P; Lawson, MJ; Chaturvedi, V; Stankiewicz, TE; Vanoni, S; Harley, IT W; McAlees, JW; Giles, DA; Moreno-Fernandez, ME; et al. Type I interferons regulate susceptibility to inflammation-induced preterm birth. JCI insight. 2017; 2.

Vanoni, S; Tsai, Y; Waddell, A; Waggoner, L; Klarquist, J; Divanovic, S; Hoebe, K; Steinbrecher, KA; Hogan, SP. Myeloid-derived NF-kappa B negative regulation of PU.1 and c/EBP-beta-driven pro-inflammatory cytokine production restrains LPS-induced shock. Innate Immunity. 2017; 23:175-187.

2016

Giles, DA; Ramkhelawon, B; Donelan, EM; Stankiewicz, TE; Hutchison, SB; Mukherjee, R; Cappelletti, M; Karns, R; Karp, CL; Moore, KJ; et al. Modulation of ambient temperature promotes inflammation and initiates atherosclerosis in wild type C57BL/6 mice. Molecular Metabolism. 2016; 5:1121-1130.

Vignesh, KS; Figueroa, JA L; Porollo, A; Divanovic, S; Caruso, JA; Jr, DG S. IL-4 Induces Metallothionein 3-and SLC30A4-Dependent Increase in Intracellular Zn2+ that Promotes Pathogen Persistence in Macrophages. Cell Reports. 2016; 16:3232-3246.

Schroeder, T; Kucharczyk, D; Baer, F; Pagel, R; Derer, S; Jendrek, ST; Suenderhauf, A; Brethack, A; Hirose, M; Moeller, S; et al. Mitochondrial gene polymorphisms alter hepatic cellular energy metabolism and aggravate diet-induced non-alcoholic steatohepatitis. Molecular Metabolism. 2016; 5:283-295.

Giles, DA; Moreno-Fernandez, ME; Stankiewicz, TE; Cappelletti, M; Huppert, SS; Iwakura, Y; Dong, C; Shanmukhappa, SK; Divanovic, S. Regulation of Inflammation by IL-17A and IL-17F Modulates Non-Alcoholic Fatty Liver Disease Pathogenesis. PLoS ONE. 2016; 11:e0149783-e0149783.

Cappelletti, M; Della Bella, S; Ferrazzi, E; Mavilio, D; Divanovic, S. Inflammation and preterm birth. Journal of Leukocyte Biology. 2016; 99:67-78.

2015

Giles, DA; Moreno-Fernandez, ME; Divanovic, S. IL-17 Axis Driven Inflammation in Non-Alcoholic Fatty Liver Disease Progression. Current Drug Targets. 2015; 16:1315-1323.

Raynor, J; Karns, R; Almanan, M; Li, K; Divanovic, S; Chougnet, CA; Hildeman, DA. IL-6 and ICOS Antagonize Bim and Promote Regulatory T Cell Accrual with Age. Journal of immunology (Baltimore, Md. : 1950). 2015; 195:944-952.

McAlees, JW; Whitehead, GS; Harley, IT W; Cappelletti, M; Rewerts, CL; Holdcroft, AM; Divanovic, S; Wills-Karp, M; Finkelman, FD; Karp, CL; et al. Distinct Tlr4-expressing cell compartments control neutrophilic and eosinophilic airway inflammation. Mucosal Immunology. 2015; 8:863-873.

Divanovic Lab

Grants

Publications

Connect With Us