Millay Lab
Publications

Publications

Hindi, SM; Petrany, MJ; Greenfeld, E; Focke, LC; Cramer, AAW; Whitt, MA; Khairallah, RJ; Ward, CW; Chamberlain, JS; Podbilewicz, B; Prasad, V; Millay, DP. Enveloped viruses pseudotyped with mammalian myogenic cell fusogens target skeletal muscle for gene delivery. Cell. 2023; 186(10):2062-2077.e17.

Gamage, DG; Melikov, K; Munoz-Tello, P; Wherley, TJ; Focke, LC; Leikina, E; Huffman, E; Diao, J; Kojetin, DJ; Prasad, V; Chernomordik, LV; Millay, DP. Phosphatidylserine orchestrates Myomerger membrane insertions to drive myoblast fusion. Proceedings of the National Academy of Sciences of the United States of America. 2022; 119(38):e2202490119.

Eigler, T; Zarfati, G; Amzallag, E; Sinha, S; Segev, N; Zabary, Y; Zaritsky, A; Shakked, A; Umansky, K-B; Schejter, ED; Millay, DP; Tzahor, E; Avinoam, O. ERK1/2 inhibition promotes robust myotube growth via CaMKII activation resulting in myoblast-to-myotube fusion. Developmental Cell. 2021; 56(24):3349-3363.e6.

Prasad, V; Millay, DP. Skeletal muscle fibers count on nuclear numbers for growth. Seminars in Cell and Developmental Biology. 2021; 119:3-10.

Petrany, MJ; Swoboda, CO; Sun, C; Chetal, K; Chen, X; Weirauch, MT; Salomonis, N; Millay, DP. Single-nucleus RNA-seq identifies transcriptional heterogeneity in multinucleated skeletal myofibers. Nature Communications. 2020; 11(1):6374.

Cramer, AAW; Prasad, V; Eftestøl, E; Song, T; Hansson, K-A; Dugdale, HF; Sadayappan, S; Ochala, J; Gundersen, K; Millay, DP. Nuclear numbers in syncytial muscle fibers promote size but limit the development of larger myonuclear domains. Nature Communications. 2020; 11(1):6287.

Petrany, MJ; Song, T; Sadayappan, S; Millay, DP. Myocyte-derived Myomaker expression is required for regenerative fusion but exacerbates membrane instability in dystrophic myofibers. JCI Insight. 2020; 5(9).

Petrany, MJ; Swoboda, CO; Sun, C; Chetal, K; Chen, X; Weirauch, MT; Salomonis, N; Millay, DP. Single-nucleus RNA-seq identifies transcriptional heterogeneity in multinucleated skeletal myofibers. bioRxiv. 2020; 2020.04.14.041400.

Goh, Q; Song, T; Petrany, MJ; Cramer, AA; Sun, C; Sadayappan, S; Lee, S-J; Millay, DP. Myonuclear accretion is a determinant of exercise-induced remodeling in skeletal muscle. eLife. 2019; 8.

Quinn, ME; Goh, Q; Kurosaka, M; Gamage, DG; Petrany, MJ; Prasad, V; Millay, DP. Myomerger induces fusion of non-fusogenic cells and is required for skeletal muscle development. Nature Communications. 2017; 8:15665.

Tripathi, GM; Dourson, AJ; Montecino-Morales, F; Wayland, JL; Khanna, S; Hofmann, MC; Durumutla, HB; Govindarajan, T; Queme, LF; Millay, DP; Jankowski, MP. Synaptic-like coupling of macrophages to myofibers regulates muscle repair. Current Biology. 2025; 35(24):6010-6023.e5.

Calvo, C; Swoboda, CO; Montecino-Morales, F; Nagar, S; Petrany, MJ; Sun, C; Bindu Durumutla, H; Quattrocelli, M; Millay, DP. The multimodal transcriptional response of denervated skeletal muscle involves regulation of Gramd1 genes impacting muscle size. Proceedings of the National Academy of Sciences of the United States of America. 2025; 122(39):e2424246122.

Millay, D; Hindi, S; Wong, A. 11INVLeveraging the muscle fusogens for gene delivery. Neuromuscular Disorders. 2025; 53:105832.

Prabakaran, AD; Montecino-Morales, F; Mcfarland, K; Govindarajan, T; Durumutla, HB; Latimer, H; Akinborewa, O; Villa, C; Millay, DP; Quattrocelli, M. The human genetic variant rs6190 unveils Foxc1 and Arid5a as novel prometabolic targets of the glucocorticoid receptor in muscle. Science Advances. 2025; 11(28):eadw2593.

Calvo, C; Smith, C; Song, T; Montecino-Morales, F; Sadayappan, S; Millay, DP; Kim, M. Loss of Ufsp1 does not cause major changes at the neuromuscular junction. PLoS ONE. 2025; 20(8):e0328690.

Sun, C; Swoboda, CO; Morales, FM; Calvo, C; Petrany, MJ; Parameswaran, S; Vonhandorf, A; Weirauch, MT; Lepper, C; Millay, DP. Lineage tracing of nuclei in skeletal myofibers uncovers distinct transcripts and interplay between myonuclear populations. Nature Communications. 2024; 15(1):9372.

Franco-Romero, A; Morbidoni, V; Milan, G; Sartori, R; Wulff, J; Romanello, V; Armani, A; Salviati, L; Conte, M; Salvioli, S; Millay, DP; Tooze, SA; Trevisson, E; Sandri, M. C16ORF70/MYTHO promotes healthy aging in C.elegans and prevents cellular senescence in mammals. Journal of Clinical Investigation. 2024; 134(15).

Prabakaran, AD; Mcfarland, K; Miz, K; Durumutla, HB; Piczer, K; El Abdellaoui Soussi, F; Latimer, H; Werbrich, C; Chung, H-J; Blair, NS; Millay, DP; Morris, AJ; Prideaux, B; Finck, BN; Quattrocelli, M. Intermittent glucocorticoid treatment improves muscle metabolism via the PGC1α/Lipin1 axis in an aging-related sarcopenia model. Journal of Clinical Investigation. 2024; 134(11).

Wherley, TJ; Thomas, S; Millay, DP; Saunders, T; Roy, S. Molecular regulation of myocyte fusion. Current Topics in Developmental Biology. 2024; 158:53-82.

Grimes, KM; Maillet, M; Swoboda, CO; Bowers, SLK; Millay, DP; Molkentin, JD. MEK1-ERK1/2 signaling regulates the cardiomyocyte non-sarcomeric actin cytoskeletal network. American Journal of Physiology. Heart and Circulatory Physiology. 2024; 326(1):H180-H189.

Grimes, KM; Bowers, SL; Swoboda, CO; Millay, DP; Molkentin, JD. Abstract P2023: Mitogen-activated Protein Kinase-directed Modulation Of The Non-sarcomeric Actin Cytoskeleton In Cardiomyocytes. Circulation Research. 2023; 133(Suppl_1).

O'donnell, A; Gonzalez, BA; Mukherjee, S; Wilson, R; Alfieri, CM; Swoboda, CO; Millay, DP; Zorn, AM; Yutzey, KE. Localized Prox1 Regulates Aortic Valve Endothelial Cell Diversity and Extracellular Matrix Stratification in Mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 2023; 43(8):1478-1493.

Hindi, SM; Petrany, MJ; Greenfeld, E; Focke, LC; Cramer, AAW; Whitt, MA; Khairallah, RJ; Ward, CW; Chamberlain, JS; Podbilewicz, B; Prasad, V; Millay, DP. Enveloped viruses pseudotyped with mammalian myogenic cell fusogens target skeletal muscle for gene delivery. Cell. 2023; 186(10):2062-2077.e17.

Witcher, PC; Sun, C; Millay, DP. Expression of Myomaker and Myomerger in myofibers causes muscle pathology. Skeletal Muscle. 2023; 13(1):8.

Gamage, DG; Melikov, K; Munoz-Tello, P; Wherley, TJ; Focke, LC; Leikina, E; Huffman, E; Diao, J; Kojetin, DJ; Prasad, V; Chernomordik, LV; Millay, DP. Phosphatidylserine orchestrates Myomerger membrane insertions to drive myoblast fusion. Proceedings of the National Academy of Sciences of the United States of America. 2022; 119(38):e2202490119.

Hindi, SM; Millay, DP. All for One and One for All: Regenerating Skeletal Muscle. Cold Spring Harbor perspectives in biology. 2022; 14(8).

Millay, DP. Regulation of the myoblast fusion reaction for muscle development, regeneration, and adaptations. Experimental Cell Research. 2022; 415(2):113134.

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