Neonatology

Cystic fibrosis research; lung morphogenesis; control of gene expression in the respiratory epithelium; gene delivery and therapy

Visit the Whitsett Lab.

Biography

Dr. Whitsett's laboratory discovered surfactant proteins B and C, cloned the genes encoding the surfactant proteins A, B, C, and D, Scgb1a1, TTF-1 and others and utilized transgenic mouse models to delete and mutate these genes in transgenic mice. They identified transcriptional networks regulating lung morphogenesis and perinatal lung maturation contributing to the understanding of the roles of TTF-1, CEBPα, SOX2, SOX17, FOXA1, FOXA2, FOXA3, SPDEF, KLF5, CDC42 and others using both in vitro and in vivo methods. They identified multiple transcription factors regulating goblet cell differentiation airway epithelial cells including critical role of SPDEF, FOXA3 and airway goblet cells controlling innate immunity. They produced transgenic mouse models for conditional deletion and expression of genes involved in lung development, disease, and repair. They have generated transgenic models of pulmonary adenocarcinoma and explored the role of transcription factors mediating pulmonary adenocarcinoma in vivo and in vitro. They utilized RNA-Seq, microarray, Chip-Seq in the application of Nex-Gen sequencing and bioinformatics to identify and understand networks involved in the regulation of lung development and disease using clinical sample, as well as in vitro and in vivo models.

Dr. Whitsett has a long interest in training both in the clinical setting in “Neonatology” and in “Pulmonary Biology” and has contributed to the direct training of more than 80 graduate or post-graduate students in his laboratory. The scope of his work is represented in several recent reviews. Initial discoveries from his laboratory provided early insights into the genes and proteins critical for surfactant function including ABCA3, SFTPC, SFTPB, SFTPA, SFTPD.

MD: Columbia University, New York, NY, 1973.

Residency: Pediatrics, Mt. Sinai Hospital, New York City, 1974 to 1976.

Fellowship: Neonatology, Children's Hospital Medical Center, University of Cincinnati College of Medicine, 1976 to 1977.

Davies ER, Kelly JFC, Howarth PH, Wilson DI, Holgate ST, Davies DE, Whitsett JA, Haitchi HM. Soluble ADAM33 initiates airway remodeling to promote susceptibility for allergic asthma in early life. JCI Insight. 2016;1:e87632.

Ustiyan V, Zhang Y, Perl A-KT, Whitsett JA, Kalin TV, Kalinichenko VV. ß-Catenin and Kras/Foxm1 Signaling Pathway are Critical to Restrict Sox9 in Basal Cells During Pulmonary Branching Morphogenesis. Dev Dyn. 2016;245:590-604.

Guo M, Wang H, Potter SS, Whitsett JA, Xu Y. SINCERA: A pipeline for single-cell RNA-Seq profiling analysis. PLoS Comput Biol. 2015;11:e1004575.

Kamath-Rayne BD, Du Y, Hughes M, Wagner EA, Muglia LJ, DeFranco EA, Whitsett JA, Salomonis N, Xu Y. Systems biology evaluation of cell-free amniotic fluid transcriptome of term and preterm infants to detect fetal maturity. BMC Med Genomics. 2015;8:67.

Du Y, Guo M, Whitsett JA, Xu Y. ‘LungGENS’: a web-based tool for mapping single-cell gene expression in the developing lung. Thorax. 2015;70:1092-1094.

Snowball J, Ambalavanan M, Whitsett J, Sinner D. Endodermal Wnt signaling is required for tracheal cartilage formation. Dev Biol. 2015;405:56-70.

Wakata K, Tsuchiya T, Tomoshige K, Takagi K, Yamasaki N, Matsumoto K, Miyazaki T, Nanashima A, Whitsett JA, Maeda Y, Nagayasu T. A favorable prognostic marker for EGFR mutant non-small cell lung cancer: immunohistochemical analysis of MUC5B. BMJ Open. 2015;5:e008366.

Ishida N, Fukazawa T, Maeda Y, Yamatsuji T, Kato K, Matsumoto K, Shimo T, Takigawa N, Whitsett JA, Naomoto Y. A novel P13K inhibitor iMDK suppresses non-small cell lung Cancer cooperatively with a MEK inhibitor. Exp Cell Res. 2015;335:197-206.

Rajavelu P, Chen G, Xu Y, Kitzmiller JA, Korfhagen TR, Whitsett JA. Airway epithelial SPDEF integrates goblet cell differentiation and pulmonary Th2 inflammation. J Clin Invest. 2015;125:2021-2031.

Snowball J, Ambalavanan M, Cornett B, Lang R, Whitsett J, Sinner D. Mesenchymal Wnt signaling promotes formation of sternum and thoracic body wall. Dev Biol. 2015;401:264-275.

Grants

Airway Progenitor Cell Proliferation and Differentiation During Lung Repair. Principal Investigator. National Institutes Health/National Heart, Lung, and Blood Institute. Jan 2012-Dec 2016. U01HL110964.

Transcriptional Programming of Asthma Related Pathology in Respiratory Epithelia. Principal Investigator. National Institutes Health/National Heart, Lung, and Blood Institute. Apr 2013-Mar 2018. 2 R01HL095580.

Omics of Lung Diseases. Principal Investigator. National Institutes Health/National Heart, Lung, and Blood Institute. Sep 2013-May 2018. K12 HL119686.

“Lung Map” Atlas Research Center. Multiple Principal Investigators. National Institutes Health/National Heart, Lung, and Blood Institute. Jun 2014-Apr 2019. U01 HL122642.

Editing Alveolar Progenitor Cells for Correction of Monogenic Disease. Program Director/Principal Investigator. National Institutes Health/National Heart, Lung, and Blood Institute. Sep 2016-Aug 2023. U01 HL134745.

Role of EMC3/TMEM111 in Alveolar Epithelial Cell Function. Program Director/Principal Investigator. National Institutes Health/National Heart, Lung, and Blood Institute. Apr 2017-Mar 2022. R01 HL136722.

Division Director

James M. Greenberg, MD Co-Director, Perinatal Institute

James M. Greenberg, MD, investigates the developmental biology of pulmonary vascular development, including how vascular endothelial growth factor (VEGF) mediates pulmonary vascular, lymphatic and airway development. He studies how VEGF mediates organization of pulmonary vasculature during late fetal life as well as how certain proteins implicated in axonal guidance during central nervous system development also direct developmental processes in the lung.

513-636-3149 james.greenberg@cchmc.org

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James M. Greenberg, MD

Co-Director, Perinatal Institute

Director, Division of Neonatology

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-3149

Fax 513-803-0968

Email james.greenberg@cchmc.org

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Neonatal chronic lung disease; late preterm infant

Biography

Dr. Greenberg is a nationally recognized leader in neonatal-perinatal medicine. He serves as director of the Division of Neonatology for Cincinnati Children's Hospital Medical Center leading one of the largest comprehensive clinical and academic programs for newborn care in the United States. Dr. Greenberg has been division director since 2003, and has been an active clinician, researcher and teacher at Cincinnati Children's Hospital Medical Center for more than 22 years. In 2009, he was appointed associate director of the Perinatal Institute at Cincinnati Children’s and became co-director in 2011.

His research activities include developmental biology of the lung, neonatal chronic lung disease, neonatal epidemiology, and prevention of preterm birth. Dr. Greenberg partners with Cincinnati Children's faculty and regional leaders to lead community health initiatives to reduce preterm birth and eliminate infant mortality. He has authored more than 30 original research articles; and six book chapters in the textbook of Pediatrics, Maternal-Fetal Medicine, and Pulmonology.

As medical director for Regional Newborn Services and division director, Dr. Greenberg led the dramatic growth of the neonatology clinical program from 12 faculty physicians providing care at two neonatal intensive care units (NICUs) to more than 50 physicians providing newborn care at 13 regional hospitals including the five NICUs. The Division of Neonatology now has over 120,000 patient encounters per year. In addition to caring for all of the Level III and Level II intensive care nursery patients in the region, division physicians also see more than 18,000 normal newborns every year. The Newborn Intensive Care at Cincinnati Children’s represents the hub of the neonatology clinical program. This NICU has over 750 admissions per year and focuses its activities on caring for infants with complex medical and surgical problems. All patients requiring surgery, surgical subspecialty care, complex radiographic imaging, or comprehensive diagnostic services are managed at the Cincinnati Children's Hospital Medical Center NICU.

In addition to the clinical program, the Division of Neonatology has an active research program. The division is one of the 22 NICHD Neonatal Research Network Centers. Extramural grant funding for the division in fiscal year 2015 was in excess of $10 million. Division research programs span basic, translational, and clinical endeavors.

The division also has an active quality improvement program focusing on outcomes in varied clinical settings ranging from improving reliability of delivery room thermal stability to reduction of central-line-associated blood stream infections in the NICU.

MD: University of Illinois College of Medicine, Chicago, IL, 1977-1981.

Pediatric Internship and Residency: University of Minnesota Hospital and Clinic, Minneapolis, MN, 1981-1984. Chief Resident, Department of Pediatrics, University of Minnesota Hospital and Clinic, Minneapolis, MN, 1984.

Fellowship: Immunology/Neonatology, University of Minnesota Hospital and Clinic, Minneapolis, MN, 1985-1987; 1988-1989; visiting scientist, Medical Research Council Laboratory of Molecular Biology, Division of Protein and Nucleic Acid Chemistry, Cambridge, England.

Certification: American Board of Pediatrics, 1988; subspecialty board, Neonatal/Perinatal Medicine, 1989.

Binder S, Hill K, Meinzen-Derr J, Greenberg JM, Narendran V. Increasing VLBW Deliveries at Subspecialty Perinatal Centers via Perinatal Outreach. Pediatrics. 2011 Mar;127(3):487-93.

Kulkarni RM, Herman A, Ikegami M, Greenberg JM, Akeson AL. Lymphatic ontogeny and effect of hypoplasia in developing lung. Mech Dev. 2011 Jan-Feb;128(1-2):29-40.

Kulkarni RM, Greenberg JM, Akeson AL. NFATc1 regulates lymphatic endothelial development. Mech Dev. 2009 May-Jun;126(5-6):350-65.

Mallory BP, Mead TJ, Wiginton DA, Kulkarni RM, Greenberg JM, Akeson AL. Lymphangiogenesis in the developing lung promoted by VEGF-A. Microvasc Res. 2006 Jul-Sep;72(1-2):62-73.

Preciado DA, Rutter MJ, Greenberg JM, Bahado-Singh R, Lambers D, Willging JP. Intrapartum management of severe fetal airway obstruction. J Otolaryngol. 2004 Oct;33(5):283-8.

Akeson AL, Cameron JE, Le Cras TD, Whitsett JA, Greenberg JM. Vascular endothelial growth factor-A induces prenatal neovascularization and alters bronchial development in mice. Pediatr Res. 2005 Jan;57(1):82-8.

Greenberg JM, Thompson FY, Brooks SK, Shannon JM, Akeson AL. Slit and robo expression in the developing mouse lung. Dev Dyn. 2004 Jun;230(2):350-60.

Le Cras TD, Spitzmiller RE, Albertine KH, Greenberg JM, Whitsett JA, Akeson AL. VEGF causes pulmonary hemorrhage, hemosiderosis, and air space enlargement in neonatal mice. Am J Physiol Lung Cell Mol Physiol. 2004 Jul;287(1):L134-42.

Akeson AL, Greenberg JM, Cameron JE, Thompson FY, Brooks SK, Wiginton D, Whitsett JA. Temporal and spatial regulation of VEGF-A controls vascular patterning in the embryonic lung. Dev Biol. 2003 Dec 15;264(2):443-55.

Greenberg JM, Thompson FY, Brooks SK, Shannon JM, McCormick-Shannon K, Cameron JE, Mallory BP, Akeson AL. Mesenchymal expression of vascular endothelial growth factors D and A defines vascular patterning in developing lung. Dev Dyn. 2002 Jun;224(2):144-53.

Louis J. Muglia, MD, PhD Co-Director, Perinatal Institute

Louis J. Muglia, MD, PhD, is a pediatric endocrinologist whose research efforts seek to define the mechanisms controlling the timing for birth in humans to prevent or better treat human preterm labor. Recent efforts analyze the contribution of genetic determinants to preterm birth. A second area of investigation is elucidation of the molecular pathways involved in the behavioral and neuroendocrine responses to stress.
Visit the Muglia Lab.

513-803-7902 louis.muglia@cchmc.org

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Louis J. Muglia, MD, PhD

Co-Director, Perinatal Institute

Director, Center for Prevention of Preterm Birth

Director, Division of Human Genetics

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-803-7902

Email louis.muglia@cchmc.org

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Specialties

Pediatric endocrinology

Visit the Muglia Lab.

Biography

Dr. Muglia has pioneered the in vivo analyses of regulation of the endocrine stress response and the molecular pathways leading to birth using novel genetically altered mutant mice. These studies have elucidated the importance of corticotropin-releasing hormone, glucocorticoids, and prostaglandins in neuroendocrine modulation, behavior, and perinatal adaptation. These studies have evolved over the last decade to specifically focus on the mechanisms controlling the timing for birth in humans using genetics and comparative genomics. The composition of the biological clock metering the duration of human gestation remains a central question in reproductive biology. The goal of the Muglia Laboratory is to understand the molecular timing machinery comprising this biological clock to prevent or better treat human preterm labor and delivery.

Among Dr. Muglia’s achievements are more than 180 publications and many awards, including a Burroughs Wellcome Fund Career Development Award in the biomedical sciences, the Society of Pediatric Research Young Investigator Award, and election to the American Society for Clinical Investigation and Association of American Physicians. In 2010, Dr. Muglia was elected to fellow in the American Association for the Advancement of Science. He is an active member of the Society for Pediatric Research, Society for Neuroscience, and the Lawson Wilkins Pediatric Endocrine Society. Dr. Muglia currently serves as chair of the Board of Scientific Counselors for the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health. In 2013, Dr. Muglia was elected to membership in the Institute of Medicine of the National Academies.

BS: University of Michigan, Ann Arbor, MI, 1981.

PhD: University of Chicago, Chicago, IL, 1986.

MD: University of Chicago, Chicago, IL, 1988.

Plunkett J, Doniger S, Orabona G, Morgan T, Haataja R, Hallman M, Puttonen H, Menon R, Kuczynski E, Norwitz E, Victoria Snegovskikh V, Palotie A, Peltonen L, Fellman V, DeFranco EA, Chaudhari BP, McGregor TL, McElroy JJ, Oetjens MT, Teramo K, Boreck I, Fay J, Muglia L. An evolutionary genomic approach to identify genes involved in human birth timing. PLoS Genetics. 2011; 7: e1001365.

Muglia LJ, Katz M. The enigma of spontaneous preterm birth. N Engl J Med. 2010; 362: 529-535.

Kolber BJ, Boyle MP, Wieczorek L, Kelley CL, Kelley CL, Onwuzurike CC, Nettles SA, Vogt SK, Muglia LJ. Transient early-life forebrain corticotropin-releasing hormone elevation causes long-lasting anxiogenic and despair-like changes in mice. J Neurosci. 2010; 30: 2571-2581.

Plunkett J, Feitosa MF, Trusgnich M, Wangler MF, Palomar L, Kistka ZA-F, DeFranco EA, Shen TT, Stormo EAD, Puttonen H, Hallman M, Haataja R, Luukkonen A, Fellman V, Peltonen L, Palotie A, Daw EW, An P, Teramo K, Borecki I, Muglia LJ. Mother’s genome or maternally-inherited genes acting in the fetus influence gestational age in familial preterm birth. Human Heredity. 2009; 68: 209-219.

Kolber BJ, Roberts MS, Howell MP, Wozniak DF, Sands MS, Muglia LJ. Central amygdala glucocorticoid receptor action promotes fear-associated CRH activation and conditioning. Proc Natl Acad Sci USA. 2008; 105: 12004 - 12009.

Roizen J, Asada M, Tong M, Tai H-H, Muglia LJ. Preterm birth without progesterone withdrawal in 15-hydroxyprostaglandin dehydrogenase hypomorphic mice. Mol Endocrinol. 2008; 22: 105-112.

Kistka Z A-F, Palomar P, Lee KA, Boslaugh SE, Wangler MF, Cole FS, DeBaun MR, Muglia LJ. Racial disparity in the frequency of recurrence of preterm birth. Am J Obstet Gynecol. 2007; 196: 131.e1-131.e6.

Bethin KE, Nagai Y, Sladek R, Asada M, Sadovsky Y, Hudson TJ, Muglia LJ. Microarray analysis of uterine gene expression in mouse and human pregnancy. Mol Endocrinol. 2003; 17: 1454-1469.

Gross G, Imamura T, Luedke C, Vogt SK, Olson LM, Nelson DM, Sadovsky Y, Muglia LJ. Opposing actions of prostaglandins and oxytocin determine the onset of murine labor. Proc. Natl. Acad. Sci. USA. 1998; 95: 11871-11875.

Muglia LJ, Jacobson L, Dikkes P, Majzoub JA. Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need. Nature. 1995; 373:427-432.

Grants

Maternal Temperament, Stress, Inflammation and Preterm Birth. Multi-PI. NIH/NICHD. Sep 2013-Aug 2017.

March of Dimes Prematurity Research Center Ohio Collaborative. Coordinating PI. March of Dimes. Jul 2013-Jun 2018.

Faculty

Shawn K. Ahlfeld, MD Attending Neonatologist, Perinatal Institute

Shawn K. Ahlfeld, MD, investigates the effects of neonatal lung injury on alveolar repair and development. Using developmentally-relevant genetic and physiologic approaches, he is identifying the role of interstitial fibroblasts in mechanisms behind alveolar simplification characteristic of bronchopulmonary dysplasia, with the long-term goal of developing novel therapies that promote normal alveolar lung development and function.

513-803-7723 shawn.ahlfeld@cchmc.org

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Shawn K. Ahlfeld, MD

Attending Neonatologist, Perinatal Institute

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-803-7723

Email shawn.ahlfeld@cchmc.org

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Clinical

Neonatal-perinatal medicine; bronchopulmonary dysplasia

Research

Neonatal lung injury, development, and repair; neonatal lung mesenchymal development; biomarkers of neonatal lung injury; animal models of bronchopulmonary dysplasia

Biography

As a neonatal fellow and junior faculty, Dr. Ahlfeld has evaluated the role of matricellular proteins in saccular and early alveolar lung development. He and his team has determined that hyperoxia exposure resulted in the mis-expression of the Transforming Growth Factor Beta (TGFβ)-responsive extracellular matrix protein, periostin, during critical periods of saccular-alveolar lung development. Periostin proved to be a novel marker for both normal myofibroblastic activity during alveolarization and abnormal myofibroblastic persistence during late fibrotic stages of lung injury.

Under a scholar grant through the Prematurity and Respiratory Outcomes Program (PROP), they have demonstrated, for the first time, that plasma periostin levels in extremely premature infants during the first weeks of age correlate with the development and severity of BPD. Their investigations into TGFβ superfamily signaling during saccular and alveolar lung development, as well as its role in BPD pathogenesis, are ongoing.

Contrary to the prevailing notion of up-regulation, TGFβ extracellular signaling ligands, intracellular signaling messengers, and down-stream signaling targets are all down-regulated during early hyperoxic lung injury. They have determined that TGFβ down-regulation coincides with a period of saccular-alveolar lung development that is critical for development of distal lung complexity and function. The down-regulation of TGFβ signaling during this critical window of lung development occurs well before the up-regulation of TGFβ signaling associated with chronic hyperoxic lung injury that they and others have described.

Additionally, his team has identified that a second matricellular protein, TGFβ-induced protein (TGFBI), is a novel extracellular matrix protein mis-expressed by neonatal hyperoxia and vital for normal alveolar development.

Their findings have provided new mechanistic targets in BPD pathogenesis and have challenged the paradigm related to the role of TGFβ up-regulation in neonatal lung injury.

MD: Indiana University School of Medicine, Indianapolis, IN, 2005.

Residency: Pediatrics, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN.

Fellowship: Neonatal-Perinatal Medicine, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN.

Certification: General Pediatrics, 2008; Neonatal and Perinatal Medicine, 2012.

Ahlfeld SK, Wang J, Gao Y, Snider P, Conway SJ. Initial suppression of transforming growth factor-β signaling and loss of TGFBI causes early alveolar structural defects resulting in bronchopulmonary dysplasia. Am J Pathol. 2016.

Goss KN, Tepper RS, Lahm T, Ahlfeld SK. Increased Cardiac Output and Preserved Gas Exchange Despite Decreased Alveolar Surface Area in Rats Exposed to Neonatal Hyperoxia and Adult Hypoxia. Am J Respir Cell Mol Biol. 2015;53(6):902-6.

Goss KN, Cucci AR, Fisher AJ, Albrecht M, Frump A, Tursunova R, Gao Y, Brown MB, Petrache I, Tepper RS, *Ahlfeld SK, *Lahm T. Neonatal hyperoxic lung injury favorably alters adult right ventricular remodeling response to chronic hypoxia exposure. Am J Physiol Lung Cell Mol Physiol. 2015 Apr 15;308(8):L797-806. (* co-senior authorship).

Assaf SJ, Chang DV, Tiller CJ, Kisling JA, Case J, Mund JA, Slaven JE, Yu Z, Ahlfeld SK, Poindexter B, Haneline LS, Ingram DA, Tepper RS. Lung Parenchymal Development in Premature Infants without Bronchopulmonary Dysplasia. Pediatr Pulmonol. 2015;50(12):1313-9.

Beam K, Aliaga S, Ahlfeld S, Cohen-Wolkowiez M, Smith P, Laughon M. A systematic review of randomized controlled trials for the prevention of bronchopulmonary dysplasia in infants. J Perinatol. 2014;34(9):705-10.

Ahlfeld SK, Gao Y, Conway SJ, Tepper RS. Relationship of Structural to Functional Impairment during Alveolar-Capillary Membrane Development. Am J Pathol. 2015;185(4):913-9.

Ahlfeld SK, Conway SJ. Assessment of Inhibited Alveolar-Capillary Membrane Structural Development and Function in Bronchopulmonary Dysplasia. Birth Defects Res A Clin Mol Teratol. 2014;100(3):168-79.

Ahlfeld SK, Gao Y, Wang J, Horgusluoglu E, Bolanis E, Clapp DW, Conway SJ. Periostin down-regulation is an early marker of inhibited neonatal murine lung alveolar septation. Birth Defects Res A Clin Mol Teratol. 2013;97(6):373-85.

Ahlfeld SK, Conway SJ. Aberrant signaling pathways of the lung mesenchyme and their contributions to the pathogenesis of bronchopulmonary dysplasia. Birth Defects Res A Clin Mol Teratol. 2012;94(1):3-15.

Sehra S, Yao W, Nguyen ET, Ahyi AN, Barbé Tuana FM, Ahlfeld SK, Snider P, Tepper RS, Petrache I, Conway SJ, Kaplan MH. Periostin regulates goblet cell metaplasia in a model of allergic airway inflammation. J Immunol. 2011;186(8):4959-66.

Henry T. Akinbi, MD Attending Neonatologist, Neonatology and Pulmonary Biology

Henry T. Akinbi, MD, studies host defense proteins in innate defense of the lungs using gene-targeted mice. The role of lysozyme in: 1) lung infection; 2) inflammation and 3) anti-oxidant defense is a major focus of his research program.

513-636-8915 henry.akinbi@cchmc.org

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Henry T. Akinbi, MD

Attending Neonatologist, Neonatology and Pulmonary Biology

Member, Perinatal Institute

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-8915

Fax 513-636-7868

Email henry.akinbi@cchmc.org

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Clinical

Neonatal infections; blood transfusions

Research

Pharmacokinetis/pharmacodynamics of psychotropic medications in neonates; role of lysozyme in airway host defense

MD: University of Ife, Ile-Ife, Nigera, Africa, 1980.

Residency: Pediatrics, University of North Carolina at Chapel Hill, 1988-1991.

Neonatology Fellowship: Children's Hospital of Philadelphia, Philadelphia, PA, 1991-1994.

Certification: General Pediatrics, 1991; Recertification, 1998; Newborn Medicine, 1995; Recertification, 2002.

Danilov SM, Lünsdorf H, Nesterovitch AB, Epshtein Y, Letsiou E, Akinbi HT, Kryukova OV, Piegeler T, Golukhova EZ, Schwartz DE, Dull RO, Minshall RD, Kost OA, Garcia JGN. Lysozyme and bilirubin bind to ACE and regulate its conformation and shedding. Scientific Reports. 2016.

Isemann B, Mueller E, Narendran V, Akinbi H. Impact of early sodium supplementation on hyponatremia and growth in premature infants: a randomized controlled trial. Journal of Parenteral and Enteral Nutrition. 2016;40(3):342-9.

Hall ES, Isemann BT, Wexelblatt SL, Meinzen-Derr J, Wiles JR, Harvey S, Akinbi HT. A cohort comparison of buprenorphine versus methadone treatment for neonatal abstinence syndrome. J Pediatr. 2016 Mar;170:39-44.e1.

Wiles JR, Isemann B, Mizuno T, Tabangin ME, Ward LP, Akinbi H, Vinks AA. Pharmacokinetics of Oral Methadone in the Treatment of Neonatal Abstinence Syndrome: A Pilot Study. J Pediatr. 2015 Dec;167(6):1214-20.e3.

Coya JM, Akinbi HT, Sáenz A, Yang L, Weaver TE, Casals C. Natural anti-infective pulmonary proteins: In vivo cooperative action of surfactant protein SP-A and the lung antimicrobial peptide SP-BN. J Immunol. 2015 Aug 15;195(4):1628-36.

Wiles JR, Isemann B, Ward LP, Vinks AA, Akinbi H. Current management of neonatal abstinence syndrome. J Pediatr. 2014 Sep;165(3):440-6.

Wiles JR, Leslie N, Knilans TK, Akinbi H. Prolonged QTc Interval in Association with Medium-chain Acyl-coenzyme A Dehydrogenase Deficiency. Pediatrics. 2014;133(6):e1-e6.

Monangi N, Slaughter J, Smith C, Dawodu A, Akinbi HT. Vitamin D status of early preterm infants and the effects of vitamin D intake during hospital stay. Arch Dis Child Fetal Neonatal Ed. 2014;99(2):F166-8.

Glasser SW, Maxfield MD, Ruetschilling TL, Akinbi HT, Baatz JE, Kitzmiller JA, Page K, Xu Y, Bao EL, Korfhagen TR. Persistence of LPS induced lung inflammation in surfactant protein C deficient mice. Am J Respir Cell Mol Biol. 2013;49(5):845-54.

Dawodu A, Akinbi HT. Vitamin D nutrition in pregnancy: Current opinion. Int J Womens Health. 2013;24;5:333-43.

Tanya E. Cahill, MD Clinical Neonatologist, Division of Neonatology

Tanya E. Cahill, MD, is interested in high risk infant follow-up and neonatal abstinence syndrome.

513-636-3882 tanya.cahill@cchmc.org

Hitesh Deshmukh, MD, PhD Attending Neonatologist, Perinatal Institute

Hitesh Deshmukh, MD, PhD, and his laboratory focuses on the role of intestinal commensal bacteria in development of appropriate innate immune responses to pathogens in neonates. The ultimate goal of this research is to develop novel therapeutic approaches to decrease mortality in premature babies, one of the most vulnerable groups.

513-803-7448 hitesh.deshmukh@cchmc.org

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Hitesh Deshmukh, MD, PhD

Attending Neonatologist, Perinatal Institute

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-803-7448

Email hitesh.deshmukh@cchmc.org

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MB; BS: University of Mumbai, Mumbai, India, 2001.

PhD: University of Cincinnati, Cincinnati, OH, 2006.

Residency: Pediatrics, State University of New York at Buffalo, Buffalo, NY, 2011.

Fellowship: Neonatology, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, 2014.

Certification: American Board of Pediatrics, 2012.

Deshmukh HS, Liu Y, Menkiti OR, Mei J, Dai N, O'Leary CE, et al. The microbiota regulates neutrophil homeostasis and host resistance to Escherichia coli K1 sepsis in neonatal mice. Nature Medicine. 2014 Apr 20.

Yan QS, Sharma-Kuinkel BK, Deshmukh HS, Tsalik EL, Cr DD, Lucas JA et al. Dusp3 and Psme3 Are Associated with Murine Susceptibility to Staphylococcus aureus Infection and Human Sepsis. Plos Pathogens. 2014 Jun 5;10(6).

Deshmukh HS, Lioy J. The use of early lung biopsy in detection of fatal pulmonary disease in the neonate. The Journal of Pediatrics. 2014 Apr;164(4):934-6.

Deshmukh HS, Caty MG, Ryan RM, Lakshminrusimha S. Intermittent 'bulge' in the umbilical cord. Journal of Perinatology. 2010 Jul;30(7):500-2.

Ahn SH, Deshmukh HS8, Johnson N, Cowell LG, Rude TH, Scott WK, et al. Two genes on A/J chromosome 18 are associated with susceptibility to Staphylococcus aureus infection by combined microarray and QTL analyses. PLoS Pathogens. 2010;6(9):e1001088. *co-first author.

Deshmukh HS, McLachlan A, Atkinson JJ, Hardie WD, Korfhagen TR, Dietsch M, et al. Matrix metalloproteinase-14 mediates a phenotypic shift in the airways to increase mucin production. American Journal of Respiratory and Critical Care Medicine. 2009 Nov 1;180(9):834-45.

Deshmukh HS, Hamburger JB, Ahn SH, McCafferty DG, Yang SR, Fowler VG, Jr. Critical role of NOD2 in regulating the immune response to Staphylococcus aureus. Infection and immunity. 2009 Apr;77(4):1376-82.

Deshmukh HS, Shaver C, Case LM, Dietsch M, Wesselkamper SC, Hardie WD, et al. Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production. American Journal of Respiratory Cell and Molecular Biology. 2008 Apr;38(4):446-54.

Campbell SJ, Deshmukh HS*, Nelson CL, Bae IG, Stryjewski ME, Federspiel JJ, et al. Genotypic characteristics of Staphylococcus aureus isolates from a multinational trial of complicated skin and skin structure infections. Journal of Clinical Microbiology. 2008 Feb;46(2):678-84. *co-first author.

Deshmukh HS, Case LM, Wesselkamper SC, Borchers MT, Martin LD, Shertzer HG, et al. Metalloproteinases mediate mucin 5AC expression by epidermal growth factor receptor activation. American Journal of Respiratory and Critical Care Medicine. 2005 Feb 15;171(4):305-14.

Elizabeth M. Enlow, MD, MS Attending Neonatologist, Perinatal Institute

Elizabeth M. Enlow, MD, MS, is interested in the non-medical determinants of health in the high-risk infant population. Specifically, she studies the transition from the NICU to home and how socioeconomic disparities influence outcomes after discharge. She views health care through a social justice lens and seeks to partner with the community to generate solutions.

513-636-5470 elizabeth.enlow@cchmc.org

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Elizabeth M. Enlow, MD, MS

Attending Neonatologist, Perinatal Institute

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-636-5470

Email elizabeth.enlow@cchmc.org

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Clinical

Neonatology; health care justice; access to care; family centered care

Research

Neonatology; social determinants of health; health disparities; health literacy; community engaged research; mixed methods research; perinatal outcomes; medical home

Biography

Dr. Enlow seeks to understanding the intersection of health and society throughout her medical training and career. At the University of Arizona, where she graduated in the top two of her medical school class, she was active in many organizations seeking equity in health care. As a pediatric resident at Stanford University, she participated in the Stanford Advocacy Track and led a research study examining the experiences of low-income, mostly Latino, families as they transitioned from the NICU to home.

She continued in this line of research as a neonatology fellow at The Children's Hospital of Philadelphia. She lead research exploring the effect of continuity of care in infancy on early childhood outcomes as well as the impact of health literacy of parents of premature infants on health care utilization after NICU discharge. She was awarded a nationally competitive NSRA Ruth L Kirschstein T32 training grant. This award allowed her to complete a Masters of Health Policy Research at the University of Pennsylvania where she completed additional training in health policy research methodology and biostatistics. Her thesis project explored the experiences of low-income mothers in the first 30 days after NICU discharge. As a faculty member at CCHMC within the UC Department of Pediatrics, she is interested in further elucidating the barriers parents face after NICU discharge, including the role of health literacy, and understanding the complex mechanism by which social determinants influence perinatal outcomes.

MD: University of Arizona, Tucson, AZ, 2009.

Residency: Pediatrics, Stanford University, Palo Alto, CA, 2012.

Fellowship: Neonatology, The Children's Hospital of Philadelphia, Philadelphia, PA, 2015.

MS: Masters of Science in Health Policy Research, Philadelphia, PA, 2016.

Certification: Pediatrics 2012, Neonatology, 2016.

Lorch SA, Enlow E. The Role of Social Determinants in Explaining Racial/Ethnic Disparities in Perinatal Outcomes. Pediatr Res. 2016 Jan;79(1-2):141-7.

Enlow E, Herbert SL, Jovel IJ, Lorch SA, Anderson C, Chamberlain LJ. Neonatal intensive care unit to home: the transition from parent and pediatrician perspectives, a prospective cohort study. J Perinatol. 2014;34(10):761-766.

Gray M, Kovatis KZ, Stuart T, Enlow E, Itkin M, Keller MS, French HM. Treatment of congenital pulmonary lymphangiectasia using ethiodized oil lymphangiography. J Perinatol. 2014;34(9):720-2.

Beth E. Haberman, MD Senior Medical Director, Neonatal Services

Beth E. Haberman, MD, has special interests in the care of infants with congenital diaphragmatic hernia and follow-up care of premature and term infants with complex medical needs.

513-636-5465 beth.haberman@cchmc.org

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Beth E. Haberman, MD

Senior Medical Director, Neonatal Services

Medical Director, Newborn Intensive Care Unit (NICU)

Medical Director, Neonatal Transport Program

Associate Director, High-Risk Infant Follow-Up Program

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-636-5465

Fax 513-636-5846

Email beth.haberman@cchmc.org

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CDH and infant follow-up; care of infants with congenital diaphragmatic hernia; follow-up care of premature and term infants with complex medical needs

Biography

Dr. Haberman currently serves as senior medical director for the level IV Newborn Intensive Care Unit at Cincinnati Children's. Her focus is on operations of the NICU, quality improvement and patient safety. She is also the neonatal medical director for the Transport Team. Dr. Haberman’s clinical interests focus on care of babies born with congenital diaphragmatic hernia and post-discharge NICU follow up of neonates and infants with complex medical needs. She attends clinically in the NICU at Cincinnati Children's and in the Cincinnati regional community nurseries.

Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 1996-1999.

Residency: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1993-1996.

MD: University of Louisville, Louisville, KY, 1993.

Vuletin JF, Lim FY, Cnota J, Kline-Fath B, Salisbury S, Haberman B, Kingma P, Frischer J, Crombleholme T. Prenatal pulmonary hypertension index: novel prenatal predictor of severe postnatal pulmonary artery hypertension in antenatally diagnosed congenital diaphragmatic hernia. J Pediatr Surg. 2010 Apr;45(4):703-8.

Greenberg JM, Donovan EF, Warner BB, Haberman BE, Narendran V, Schibler KR. Neonatal Morbidities of Prenatal and Perinatal Origin. Creasy and Resnik”s Maternal-Fetal Medicine: Principles and Practice. 2008 6th ed. Chapter 58. Elsevier Ltd., Philadelphia, PA.

Castro L, Yolton K, Haberman B, Roberto N, Hansen NI, Ambalavanan N, Vohr BR, Donovan EF. Bias in reported neurodevelopmental outcomes among extremely low birth weight survivors. Pediatrics. 2004 Aug;114(2):404-10.

Eric S. Hall, PhD

Eric S. Hall, PhD, participates in a number of interdisciplinary teams investigating prematurity and neonatal disease. Along with coordinating data collection and exchange efforts, his work involves the application of knowledge discovery techniques to clinical data sets, as well as the development of software tools to assist in the summarization of clinical data and the modeling of clinical processes.

513-803-2083 eric.hall@cchmc.org

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Eric S. Hall, PhD

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-803-2083

Fax 513-803-0968

Email eric.hall@cchmc.org

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Biomedical informatics; clinical informatics; data linkage; infant mortality; maternal child health; neonatal abstinence syndrome; preterm birth; public health informatics

Biography

Dr. Hall leads data management and integration supporting research and quality improvement within the Cincinnati Children's Hospital Medical Center Perinatal Institute. His research expertise includes geospatial and cost analyses, integration of maternal and child data sets enabling population-based research, and the development of risk models to identify perinatal patients at highest risk for adverse outcomes.

PhD: University of Utah, Salt Lake City, UT, 2008.

MS: Brigham Young University, Provo, UT, 2003.

BS: Brigham Young University, Provo, UT, 2001.

View Publications on Google Scholar

Hall ES, Greenberg JM. Estimating community-level costs of preterm birth. Public Health. 2016 Dec;141(12):222-8.

Hall ES, Wexelblatt SL, Greenberg JM. Self-reported and laboratory evaluation of late pregnancy nicotine exposure and drugs of abuse. J Perinatol. 2016 Jul 7.

Hall ES, Meinzen-Derr J, Wexelblatt SL. Cohort analysis of a pharmacokinetic-modeled methadone weaning optimization for neonatal abstinence syndrome. J Pediatr. 2015 Dec;167(6):1221-1225.e1.

Hall ES, Wexelblatt SL, Crowley M, Grow JL, Jasin LR, Klebanoff MA, McClead RE, Meinzen-Derr J, Mohan VK, Stein H, Walsh MC. A multicenter cohort study of treatments and hospital outcomes in neonatal abstinence syndrome. Pediatrics. 2014 Aug;134(2):e527-34.

Hall ES, Goyal NK, Ammerman RT, Miller M, Jones DE, Short JA, Van Ginkel JB. Development of a linked perinatal data resource from state administrative and community-based program data. Matern Child Health J. 2014 Jan;18(1):316-25.

Steven B. Hoath, MD

Steven B. Hoath, MD, has varied research interests including epidermal barrier development (in utero and postnatal), fetal and neonatal skin adaptation (skin/environment interactions), tissue engineering of human skin (in vitro systems), innate immune function (biology of vernix and skin proteomics), development of non-invasive skin-based sensors for brain monitoring and the role of the skin as a critical interface for health care delivery.

513-803-0960 steven.hoath@cchmc.org

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Steven B. Hoath, MD

Academic Affiliations

Emeritus, UC Department of Pediatrics

Phone 513-803-0960

Fax 513-803-0969

Email steven.hoath@cchmc.org

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Clinical

Human skin development; multiple roles of the skin in neonatal care; new perspectives on the skin as a sensory interface; role of the skin as an accessible environmental interface which complements ‘internal’ medicine; evidence-based organizational change in healthcare delivery to newborns; interface between medicine and nursing; focus on the bedside for the development of a truly “personalized” or “individualized” medicine in the future.

Research

Epidermal barrier development (in utero and postnatal); fetal and neonatal skin adaptation (skin/environment interactions); tissue engineering of human skin (in vitro systems); innate immune function (biology of vernix and skin proteomics); development of non-invasive skin-based sensors for brain monitoring; role of the skin as a critical interface for health care delivery.

Biography

Dr. Hoath graduated from Stanford University and the University of Hamburg, Germany with majors in biology and German studies. He received his MD from the University of California, Los Angeles and completed his pediatric residency and fellowship in neonatology at UCLA before joining Cincinnati Children’s Hospital Medical Center in 1984.

He has a longstanding interest in the development of fetal and newborn skin and the multiple roles of the skin as a critical interface for healthcare delivery in the NICU. In 1994, he was one of seven international investigators participating in the first joint effort by NASA and the National Institutes of Health to study the effect of spaceflight and zero gravity on mammalian pregnancy and fetal development. This work grounds the idea of the skin as the ‘biological spacesuit’ for the human body.

He has authored multiple papers, chapters, and a book on neonatal skin development. He is an inventor on five patents awarded to Cincinnati Children’s Hospital Medical Center based on the biology of the multifunctional fetal skin ‘cream’, vernix caseosa. Recent work has focused on the logico-mathematical organization of human epidermis and the close embryological connection of the skin and the brain.

Certification: American Board of Pediatrics, June 1983; Neonatal-Perinatal Medicine, November, 1983.

Adjunct Assistant Professor: Harbor UCLA Medical Center, Los Angeles, 1983.

Residency: University of California, Los Angeles, 1977-79.

Internship: Harbor-UCLA Medical Center, 1976-1977.

MD: University of California, Los Angeles, CA, 1976.

Fellowship: Neonatology, Harbor-UCLA, Los Angeles Medical Center, 1980-1982; Pathology, UCLA School of Medicine, 1973-1974.

Baccalaureate: Stanford University, Biology & German Studies, 1972.

Visscher MO, Robinson M, Fugit B, Rosenberg RJ, Hoath SB, Randall Wickett R. Amputee skin condition: occlusion, stratum corneum hydration and free amino acid levels. Arch Dermatol Res. 2010 Dec 16.

Davis JA, Visscher MO, Wickett RR, Hoath SB. Influence of tumour necrosis factor-α polymorphism-308 and atopy on irritant contact dermatitis in healthcare workers. Contact Dermatitis. 2010 Dec;63(6):320-32.

Davis JA, Visscher MO, Wickett RR, Hoath SB. Role of TNF-α polymorphism -308 in neurosensory irritation. Int J Cosmet Sci. 2010 Jul 15.

Narendran V, Visscher MO, Abril I, Hendrix SW, Hoath SB. Biomarkers of epidermal innate immunity in premature and full-term infants. Pediatr Res. 2010 Apr;67(4):382-6.

Barai ND, Boyce ST, Hoath SB, Visscher MO, Kasting GB. Improved barrier function observed in cultured skin substitutes developed under anchored conditions. Skin Res Technol. 2008 Nov;14(4):418-24.

Walker VP, Akinbi HT, Meinzen-Derr J, Narendran V, Visscher M, Hoath SB. Host defense proteins on the surface of neonatal skin: implications for innate immunity. J Pediatr. 2008 Jun;152(6):777-81.

Hoath SB, Pickens WL, Visscher MO. The biology of vernix caseosa. Int J Cosmet Sci. 2006 Oct;28(5):319-33.

Spitzmiller RE, Phillips T, Meinzen-Derr J, Hoath SB. Amplitude-integrated EEG is useful in predicting neurodevelopmental outcome in full-term infants with hypoxic-ischemic encephalopathy: a meta-analysis. J Child Neurol. 2007 Sep;22(9):1069-78.

Tansirikongkol A, Hoath SB, Pickens WL, Visscher MO, Wickett RR. Equilibrium water content in native vernix and its cellular component. J Pharm Sci. 2008 Feb;97(2):985-94.

Tansirikongkol A, Wickett RR, Visscher MO, Hoath SB. Effect of vernix caseosa on the penetration of chymotryptic enzyme: potential role in epidermal barrier development. Pediatr Res. 2007 Jul;62(1):49-53.

Alan H. Jobe, MD, PhD Director, Division of Perinatal Biology

Alan H. Jobe, MD, PhD, has a special research focus on surfactant physiology. Dr. Jobe is also interested in lung maturation and lung injury in the fetus and newborn, the use of antenatal corticosteroids, and lung injury with ventilation of the preterm infant.

513-636-8563 alan.jobe@cchmc.org

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Alan H. Jobe, MD, PhD

Director, Division of Perinatal Biology

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-8563

Fax 513-636-8691

Email alan.jobe@cchmc.org

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Clinical Interests

Clinical trials in neonatology; bronchopulmonary dysplasia

Research Interests

Lung maturation and lung injury in the fetus and newborn; use of antenatal corticosteroids; lung injury with ventilation of the preterm

Biography

Dr. Jobe is a neonatologist and professor of pediatrics at Cincinnati Children’s. His research contributions include studies of surfactant metabolism, the hormonal regulation of lung maturation, mechanisms of lung injury with mechanical ventilation, and neonatal resuscitation. He has been chair of the NICHD Neonatal Research Network Steering Committee and chair of the NICHD Global Research Network Steering Committee. He has a 26-year collaborative research project on fetal development with Professor John Newnham at the University of Western Australia. He remains actively involved with clinical and translational research to improve outcomes for infants. He was an associate editor for Journal of Pediatrics for 18 years. He presently is a consultant for the Bill and Melinda Gates Foundation for infant mortality. Noteworthy recognitions are the E. Mead Johnson Award for Pediatric Research, the Virginia Apgar Award from the AAP, and election to The US National Institute of Medicine.

MD: University of California, San Diego, CA, 1973.

PhD: University of California, San Diego, CA, 1973.

Residency: University Hospital, University of California, San Diego, CA, 1974 to 1975.

Fellowship: University of California, San Diego, CA, 1975 to 1977.

Board Certified: Pediatrics and Neonatal-Perinatal Medicine.

Moss TJM, Nitsos I, Knox CL, Polglase GR, Kallapur SG, Ikegami M, Jobe AH, Newnham JP. Ureaplasma colonization of amniotic fluid and efficacy of antenatal corticosteroids for preterm lung maturation in sheep. AJOG. 2009;200(1):96.e1-6.

Polglase GR, Hillman NH, Ball MK, Kramer BW, Kallapur SG, Jobe AH, Pillow JJ. Lung and systemic inflammation in preterm lambs on CPAP or conventional ventilation. Pediatr Res. 2009;65(1):67-71.

Cheah F-C, Pillow JJ, Kramer BW, Polglase GR, Nitsos I, Newnham JP, Jobe AH, Kallapur SG. Airway inflammatory cell responses to intra-amniotic lipopolysaccharide in a sheep model of chorioamnionitis. Am J Physiol Lung Cell Mol Physiol. 2008;296:L384-93.

Ball MK, Jobe AH, Polglase GR, Kallapur SG, Choe-Cheah F, Hillman NH, Pillow JJ. High and low body temperature during the initiation of ventilation for near-term lambs. Resuscitation. 2008;80:133-7.

Kramer BW, Albertine KH, Moss TJM, Nitsos I, Speer CP, Newnham JP, Jobe AH. All-trans retinoic acid does not modulate intra-amniotic endotoxin mediated effects on the fetal sheep lung. The Anatomical Record. 2008;291:1271-7.

Polglase GR, Hillman NH, Pillow JJ, Cheah F-C, Nitsos I, Moss TJ, Kramer BW, Ikegami M, Kallapur SG, Jobe AH. Positive end-expiratory pressure and tidal volume during initial ventilation of preterm lambs. Pediatr Res. 2008;64:517.

Hillman N, Moss TJM, Nitsos I, Kramer BW, Bachurski C, Ikegami M, Jobe AH, Kallapur SG. Toll-like receptors and agonist responses in the developing fetal sheep lung. Pediatr Res. 2008;63:388-93.

Sweet DG, Huggett MT, Warner JA, Moss TJM, Halliday HL, Newnham JP, Kallapur SG, Jobe AH, Kramer BW. Maternal betamethasone and chorioamnionitis induce different collagenases and lung maturation in fetal sheep lungs. Neonatology. 2008;94:79-86.

Jobe AH, Moss TJM, Nitsos Il, Ikegami M, Kallapur SG, Newnham JP. Betamethasone for lung maturation: testing dose and formulation in fetal sheep. AJOG. 2007;197:523.

Moss TJM, Knox CL, Kallapur SG, Nitsos I, Theodoropoulos C, Ikegami M, Newnham JP, Jobe AH. Experimental amniotic fluid infection in sheep: effects of Ureaplasma parvum serovars 3 and 6 on preterm or term fetal sheep. Am J Ob Gyn. 2008;198:122e18.

Beth Ann Johnson, MD, MA Attending Neonatologist, Neonatology and Pulmonary Biology

Beth Ann Johnson, MD, MA, has a research focus in perinatal cardiology, premature infants with congenital heart disease, fetal diagnosis, and simulation.

513-636-3291 beth_ann.johnson@cchmc.org

Beena D. Kamath-Rayne, MD, MPH Attending Neonatologist, Neonatology and Pulmonary Biology

Beena D. Kamath-Rayne, MD, MPH, investigates the discovery of biomarkers for fetal maturity and fetal development in order to date pregnancy. She also does research on neonatal resuscitation training and skills acquisition in both domestic and global health settings.

513-803-1606 beena.kamath-rayne@cchmc.org

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Beena D. Kamath-Rayne, MD, MPH

Attending Neonatologist, Neonatology and Pulmonary Biology

Global Health Center

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-803-1606

Fax 513-636-0171

Email beena.kamath-rayne@cchmc.org

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Perinatal epidemiology and public health; global health

Biography

Dr. Kamath-Rayne is doing collaborative research with maternal-fetal medicine on preterm birth, fetal maturity, and biomarker discovery in amniotic fluid, with the hopes of developing less invasive tests of fetal maturity. She has a provisional patent for this work. She has received a BIRCWH K12, OMICS K12, and Perinatal Institute Pilot and Feasibility awards to fund this research. She has published on neonatal outcomes after elective Cesarean section, and after documented fetal lung maturity. Her work was required reading for the Maintenance for Certification for the American Board of Obstetrics and Gynecology in 2010.

Dr. Kamath-Rayne is jointly appointed in Global Health and serves on the American Academy of Pediatrics Helping Babies Survive Planning Group. She is the associate editor for the 2nd Edition of Helping Babies Breathe (HBB), a global curriculum in neonatal resuscitation, and contributing editor to Essential Care for Small Babies and the Helping Mothers and Babies Survive Quality Improvement Workbook. She is collaborating on several research studies of HBB around the world. With Dr. Alan Jobe, she has served as a neonatal consultant for MANDATE (Maternal and Neonatal Directed Assessment of Technology), a project funded by the Bill and Melinda Gates Foundation to RTI International to inform the development of technologies to decrease maternal and neonatal mortality worldwide. Finally, she does research on educational outcomes of teaching neonatal resuscitation to pediatric residents.

MD: Georgetown University, Washington, DC, 2000.

Residency: Children's Hospital Colorado/University of Colorado Health Sciences, Denver, CO, 2003.

Fellowship: Children's Hospital Colorado/University of Colorado Health Sciences, Denver, CO, 2008.

MPH: Colorado School of Public Health, Aurora, CO, 2008.

Berkelhamer SK, Kamath-Rayne BD, Niermeyer S. Neonatal Resuscitation in Low-Resource Settings. Clin Perinatol. 2016;43(3):573-591.

Kamath-Rayne BD, Rozance PJ, Goldenberg RL, Jobe AH. Antenatal corticosteroids beyond 34 weeks: What do we do now? Am J Obstet Gynecol. 2016.

Kamath-Rayne BD, Du Y, Hughes M, Wagner E, Muglia LJ, DeFranco EA, Whitsett JA, Salomonis N, Xu Y. Systems biology evaluation of cell-free amniotic fluid transcriptome of term and preterm infants to detect fetal maturity. BMC Med Genomics. 2015;8(1):67.

Seto TL, Tabangin ME, Josyula S, Taylor KK, Vasquez JC, Kamath-Rayne BD. Educational outcomes of Helping Babies Breathe training at a community hospital in Honduras. Perspect Med Educ. 2015;4(5):225-32.

Kamath-Rayne BD, Griffin JB, Moran K, Jones B, Downs A, McClure EM, Goldenberg RL, Rouse D, Jobe AH. Resuscitation and obstetrical care to reduce intrapartum-related neonatal death: A MANDATE study. Matern Child Health J. 2015;12(Suppl 2):S13.

Hall ES, Folger AT, Kelly E, Kamath-Rayne BD. Impact of gestational age estimate method on the calculation of preterm birth rates. Matern Child Health J. 2014;18(3):755-62.

Kamath BD, Marcotte, MP, DeFranco, EA. Neonatal morbidity after documented fetal lung maturity in late preterm and early term infants. Am J Obstet Gynecol. 2011; 204: 518.e1-e8.

Kamath BD, MacGuire ER, McClure EM, Goldenberg RL, Jobe AH. Neonatal mortality from respiratory distress syndrome: a historical review with lessons for low-resource countries. Pediatrics. 2011; 127(6):1139-46.

Kamath BD, Todd JK, Glazner JE, Lezotte D, Lynch AM. Neonatal outcomes after elective Cesarean section. Obstetr Gynecol. 2009; 113(6): 1231-1238. *Required reading for Maintenance of Certification for American Board of Obstetrics and Gynecology, 2010.

Kamath BD, Box TL, Simpson M, Hernández J. Infants born at the threshold of viability in relation to neonatal mortality: Colorado, 1991 to 2003. J Perinatol. 2008; 28(5): 354-360.

Grants

Prediction of Fetal Maturity Using Novel Biomarkers from Cell Free Amniotic Fluid Transcriptome. Principal Investigator. National Institutes of Health OMICS K12. Nov 2014-Oct 2016.

Development of improved methods for predicting fetal maturity. Principal Investigator. Cincinnati Children’s Hospital Medical Center Shared Facilities Discovery Award. Dec 2015-Dec 2016.

Prediction of Fetal Maturity Using Novel Biomarkers from Cell- Free Amniotic Fluid Transcriptome. Principal Investigator. Cincinnati Children’s Hospital Medical Center--Center for Pediatric Genomics Pilot Grant. Jul 2016-Jun 2017.

Retention of neonatal resuscitation skills in pediatric residents. Principal Investigator. Perinatal Institute Pilot and Feasibility Grant. Jul 2015-Jun 2017.

Heather C. Kaplan, MD, MSCE Attending Neonatologist, Neonatology and Pulmonary Biology

Heather C. Kaplan, MD, MSCE, focuses on understanding variations in evidence-based care practices across hospitals and identifying strategies for increasing the implementation of evidence and other innovations into practice. She recently began a line of investigation aimed at building the evidence base for quality improvement so that QI can be used more effectively as a strategy for improving quality and patient outcomes.

513-803-0478 heather.kaplan@cchmc.org

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Heather C. Kaplan, MD, MSCE

Attending Neonatologist, Neonatology and Pulmonary Biology

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-803-0478

Fax 513-636-0171

Email heather.kaplan@cchmc.org

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Understanding variations in evidence-based care practices across hospitals; examining strategies for increasing the implementation of evidence into practice in perinatal care; using a systems lens to understand and ultimately change behavior at the individual, group, organizational, and environmental levels of the health care system.

Biography

Heather C. Kaplan, MD, MSCE, is passionate about improving the quality and safety of perinatal care and has a solid foundation in epidemiology and research fundamentals. Through her role in the Ohio Perinatal Quality Collaborative, she gained practical experience in the use of quality improvement methods to reduce preterm births and improve outcomes of preterm newborns in Ohio and has formed collaborative relationships with obstetrical and neonatal care providers across the state.

Additionally she has an understanding care delivery in a complex system requires taking a multidisciplinary, multilevel approach. Her career includes didactic coursework in multidisciplinary theories and methods.

BA: Washington University, St. Louis, MO.

MD: Northwestern University, Chicago, IL.

Residency: Children's National Medical Center, Washington, DC.

Fellowship: The Children's Hospital of Philadelphia, Philadelphia, PA.

MSCE: University of Pennsylvania, Philadelphia, PA.

Kaplan HC, Lannon C, Walsh MC, Donovan EF; Ohio Perinatal Quality Collaborative. Ohio statewide quality-improvement collaborative to reduce late-onset sepsis in preterm infants. Pediatrics. 2011 Mar;127(3):427-35.

Kaplan HC, Lorch SA, Pinto-Martin J, Putt M, Silber JH. Assessment of surfactant use in preterm infants as a marker of neonatal intensive care unit quality. BMC Health Serv Res. 2011 Jan 31;11:22.

Kaplan HC, Brady PW, Dritz MC, Hooper DK, Linam WM, Froehle CM, Margolis P. The influence of context on quality improvement success in health care: a systematic review of the literature. Milbank Q. 2010 Dec;88(4):500-59.

Kaplan, HC, Tabangin ME, McClendon D, Meinzen-Derr J, Margolis PA, Donovan EF. Understanding Variation in Vitamin A Supplementation Among NICUs. Pediatrics. 2010 Aug;126(2):e367-73.

Alan P. Kenny, MD, PhD

Alan P. Kenny, MD, PhD, studies the molecular mechanisms controlling the earliest stages of respiratory and digestive organ development, including the role of a pool of foregut progenitor cells in the ventral endoderm which are induced by FGF and BMP signals emanating from the cardiogenic mesenchyme.

513-803-2224 alan.kenny@cchmc.org

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Alan P. Kenny, MD, PhD

Attending Neonatologist, Perinatal Institute
Member, Division of Neonatology
Member, Division of Pulmonary Biology

Academic Affiliations

Instructor, UC Department of Pediatrics

Phone 513-803-2224

Fax 513-636-7868

Email alan.kenny@cchmc.org

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Clinical

Neonatal care; neonatal lung disease; neonatal malformations and anomalies

Research

Lung progenitor development; stem cell differentiation; fetal malformations

Biography

Alan P. Kenny, MD, PhD, focuses his research on elucidating the molecular mechanisms controlling the earliest stages of respiratory and digestive organ development. Available evidence suggests that early lung, liver, and pancreas lineages develop from a pool of foregut progenitor cells in the ventral endoderm. They are induced by FGF and BMP signals emanating from the cardiogenic mesenchyme during early somite stages of development through a mechanism that is highly conserved among vertebrates. Despite significant gains in our understanding of this process, fundamentally important questions remain unanswered. First, how are the common foregut organ progenitors specified? Second, how are FGF and BMP pathways spatiotemporally coordinated such that different organs are induced from the common foregut progenitor? A third and most intriguing question is - what are the endoderm genetic programs activated in response to induction from mesoderm that ultimately direct specific foregut organ development?

These questions remain unanswered mostly due to experimental limitations inherent in mouse embryos, which are small and difficult to dissect at such an early stage. Dr. Kenny uses the experimental advantages of the large, externally developing, abundant Xenopus embryos to address these critical, unresolved issues. Specifically, Dr. Kenny is testing his hypothesis that cardiogenic FGF and BMP signaling of different durations induce different organs. Dr. Kenny’s microarray experiment to identify the endodermal genes induced very early in response to mesodermal signaling. Surprisingly, several negative regulators of BMP signaling were induced early by mesoderm signaling. My preliminary work suggests the hypothesis that BMP inhibitory feedback is a critical component induced during early foregut organ progenitor development. This work should ultimately increase our understanding of normal and abnormal early fetal organ development, lending further insight into foregut malformations such as tracheoesophageal fistula and congenital diaphragmatic hernia. Additionally, this work aims to offer better means to direct human embryonic stem cells toward more foregut organ-specific cell fates for therapeutic purposes.

MD: University of Rochester School of Medicine and Dentistry, Rochester, NY, 2002.

PhD: Biology.

Residency: Golisano Children’s Hospital at Strong, University of Rochester, Rochester, NY, 2002-2005.

Fellowship: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2005-2008.

Certifications: In Pediatrics, 2007 American Board of Pediatrics; American Board of Pediatrics, Board Eligible in Neonatal-Perinatal Medicine, 2008.

Agricola ZN, Jagpal AK, Allbee AW, Prewitt AR, Shifley ET, Rankin SA, Zorn AM, Kenny AP. Identification of Genes Specific to Migrating Primitive Myeloid Lineage in Xenopus laevis. Developmental Dynamics. 2016;245(1):47-55.

Nolan K, Kattamuri C, Luedeke DM, Deng X, Jagpal A, Zhang F, Linhardt RJ, Kenny AP, Zorn AM, Thompson TB. Structure of Protein Related to DAN and Cerberus (PRDC): Insights into the Mechanism of BMP Antagonism. Structure. 2013 Aug 6;21(8):1417-29.

Kenny AP, Tabangin M, Hall E, Woodrooffe K, Lai W, Meinzen-Derr J, Hopkin RJ, Greenberg JM. Cincinnati Regional Incidence, Morbidity, and Mortality of Neonatal Foregut Defects and High Coincidence with Cardiovascular Malformations. Journal of Neonatal Biology. 2013;2:1-7.

Shifley ET, Kenny AP, Rankin SA, Zorn AM. Prolonged FGF signaling is necessary for lung and liver induction in Xenopus. BMC Developmental Biology. 2012;12(27).

Kenny AP, Rankin SA, Allbee AW, Prewitt AR, Zhang Z, Shifley ET, Louza MP, Zorn AM. Sizzled-tolloid interactions maintain foregut progenitors by regulating fibronectin-dependent BMP signaling. Developmental Cell. 2012;23(2):292-304.

Paul S. Kingma, MD, PhD Neonatal Director, Cincinnati Fetal Center

Paul S. Kingma, MD, PhD, investigates the role of the innate immune system in neonatal infection. Specific projects currently focus on the role of surfactant protein D in neonatal sepsis and acute respiratory distress syndrome and on neutrophil function in cystic fibrosis patients.

513-636-2995 paul.kingma@cchmc.org

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Paul S. Kingma, MD, PhD

Neonatal Director, Cincinnati Fetal Center

Member, Perinatal Institute
Member, Division of Neonatology
Member, Division of Pulmonary Biology

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-636-2995

Fax 513-636-7868

Email paul.kingma@cchmc.org

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Clinical

Neonatology; fetal care; neonatal care of infants with congenital malformations including congenital diaphragmatic hernia, tracheal-esophageal defects and gastroschisis

Research

Innate immune systems; surfactant protein D; Neonatal lung growth; genetic basis of congenital malformations

Biography

Paul S. Kingma, MD, PhD, serves as an attending physician in the Cincinnati Children’s NICU and as neonatal director of the Cincinnati Fetal Center. Dr Kingma leads several basic science and translation research projects that focus on four primary goals.

The first goal is to improve our understanding of pathogenesis of congenital diaphragmatic hernia (CDH). To this end, Dr. Kingma’s laboratory is developing novel methods for measuring lung injury in CHD infants and he has advanced the use of airway pressure release ventilation as a method of reducing lung injury in infants with CDH. In addition, as part of a collaboration with Dr. Jason Woods, Dr. Kingma is using novel MRI-based methods to measure lung growth and function in CDH infants.

The second goal is to improve our understanding of the formation, repair and prognosis of tracheal esophageal (TE) defects. Dr. Kingma is using novel MRI techniques for evaluating tracheal and esophageal morphology in infants with TE defects. In addition, Dr. Kingma is leading an effort to gather detailed anatomic, genetic and clinical outcome data on a large cohort of patients with TE defects in order enhance diagnosis, predict patients at risk for complications, and ultimately improve treatment.

The third goal is to develop effective clinical management strategies to prevent and treat intestinal dysfunction and feeding intolerance in infants with gastroschisis. Dr. Kingma is currently leading a Gerber Foundation funded study that is using MRI to quantify intestinal factors that lead to enteral feeding intolerance.

The final goal of is to improve our understanding of the molecular pathogenesis of neonatal lung injury. Specifically, Dr. Kingma is evaluating the role of the Surfactant Protein D (SP-D) and the pulmonary innate immune system. In addition, Dr. Kingma is part of a Cincinnati Children's collaboration that is developing SP-D as a therapeutic agent designed to improve surfactant function and reduce lung injury in premature infants.

BS: Calvin College, MI, 1992.

MD: Vanderbilt University, TN, 2000.

PhD: Vanderbilt University, TN, 2000.

Residency: Cincinnati Children's Hospital Medical Center, 2003.

Fellowship: Cincinnati Children's Hospital Medical Center, 2005.

Fu T, Kingma PS. Diagnosing Infection in a Neonate Using Whole-Body Screening Magnetic Resonance Imaging. Pediatrics. 2016.

Higano N, Hahn A, Tkach J, Cao X, Walkup L, Thomen R, Merhar S, Kingma P, Fain S, Woods J. Retrospective Respiratory self-gating and removal of bulk motion in pulmonary UTE MRI of neonates and adults. Magnetic Resonance in Medicine. 2016.

Coleman A, Phithakwatchara N, Shaaban A, Keswani S, Kline-Fath B, Kingma P, Haberman B, Lim FY. Fetal lung growth represented by longitudinal changes in MRI-derived fetal lung volume parameters predicts survival in isolated left-sided congenital diaphragmatic hernia. Prenat Diagn. 2015;35(2):160-6.

Lynema S, Marmer D, Hall E, Meinzen-Derr, J, Kingma PS. Neutrophil CD64 as a diagnostic marker of sepsis: impact on neonatal care. Am J Perinatology. 2015;32(4):331-6.

Landis MW, Butler D, Lim FY, Keswani SG, Frischer JS, Haberman BE, Kingma PS. Octreotide for chylous effusions in congenital diaphragmatic hernia. J Pediatr Surg. 2013;48(11):2226-9.

Wetzel EA, Kingma PS. Subgaleal hemorrhage in a neonate with Factor X deficiency following a non-traumatic cesarean section. J Perinatol. 2012;32(4):304-5.

Le LD, Keswani SG, Biesiada J, Lim FY, Kingma PS, Haberman BE, Frischer J, Habli M, Crombleholme TM. The congenital diaphragmatic hernia composite prognostic index correlates with survival in left-sided congenital diaphragmatic hernia. J Pediatr Surg. 2012;47(1):57-62.

King BA, Boyd JT, Kingma PS. Pulmonary maturational arrest and death in a patient with pulmonary interstitial glycogenosis. Pediatr Pulmonol. 2011;46(11):1142-5.

Lee TC, Lim FY, Keswani SG, Frischer JS, Haberman B, Kingma PS, Habli M, Jaekle RK, Sharp G, Kline-Fath B, Rubio EI, Calvo M, Guimaraes C, Crombleholme TM. Late gestation fetal magnetic resonance imaging-derived total lung volume predicts postnatal survival and need for extracorporeal membrane oxygenation support in isolated congenital diaphragmatic hernia. J Pediatr Surg. 2011;46(6):1165-71.

King BA, Kingma PS. Surfactant Protein D deficiency increases lung injury during endotoxemia. Am J Respir Cell Mol Bio. 2011;44(5):709-15.

Tom R. Korfhagen, MD, PhD Attending Physician, Perinatal Institute, Neonatology and Pulmonary Biology

Tom R. Korfhagen, MD, PhD, is interested in mechanisms protecting the lung from injury and as a physician in the NICU Follow up Clinic, to determine processes improving growth and development of newborns discharged from NICU care.

513-636-8920 tom.korfhagen@cchmc.org

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Tom R. Korfhagen, MD, PhD

Attending Physician, Perinatal Institute, Neonatology and Pulmonary Biology

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-8920

Fax 513-636-7868

Email tom.korfhagen@cchmc.org

Show All

Clinical

Newborn Care Associates; NICU Follow up Clinic

Research

Lung protection from injury

BA: University of Cincinnati, Cincinnati, OH, 1972.

PhD: University of Cincinnati, Cincinnati, OH, 1977.

MD: University of Cincinnati, Cincinnati, OH, 1981.

Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1981-1984.

Fellowship: Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 1984-1987 (Peter Dignan, Director); Infectious Diseases, Massachusetts General Hospital, Boston, MA.

Certifications: National Board of Medical Examiners, 7/1982; American Board of Pediatrics, 5/1986; American Board of Medical Genetics, 6/1987.

Hassett DJ, Korfhagen TR, Irvin RT, Schurr MJ, Sauer K, Lau GW, Sutton MD, Yu H, Hoiby N. Pseudomonas aeruginosa biofilm infections in cystic fibrosis: insights into pathogenic processes and treatment strategies. Expert Opin Ther Targets. 2010 Feb;14(2):117-30. Review.

Le Cras TD, Korfhagen TR, Davidson C, Schmidt S, Fenchel M, Ikegami M, Whitsett JA, Hardie WD. Inhibition of PI3K by PX-866 prevents transforming growth factor-alpha-induced pulmonary fibrosis. Am J Pathol. 2010 Feb;176(2):679-86.

Chen G, Korfhagen TR, Xu Y, Kitzmiller J, Wert SE, Maeda Y, Gregorieff A, Clevers H, Whitsett JA. SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production. J Clin Invest. 2009 Oct;119(10):2914-24.

Deshmukh HS, McLachlan A, Atkinson JJ, Hardie WD, Korfhagen TR, Dietsch M, Liu Y, Di PY, Wesselkamper SC, Borchers MT, Leikauf GD. Matrix metalloproteinase-14 mediates a phenotypic shift in the airways to increase mucin production. Am J Respir Crit Care Med. 2009 Nov 1;180(9):834-45.

Glasser SW, Witt TL, Senft AP, Baatz JE, Folger D, Maxfield MD, Akinbi HT, Newton DA, Prows DR, Korfhagen TR. Surfactant protein C-deficient mice are susceptible to respiratory syncytial virus infection. Am J Physiol Lung Cell Mol Physiol. 2009 Jul;297(1):L64-72.

Korfhagen TR, Le Cras TD, Davidson CR, Schmidt SM, Ikegami M, Whitsett JA, Hardie WD. Rapamycin prevents transforming growth factor-alpha-induced pulmonary fibrosis. Am J Respir Cell Mol Biol. 2009 Nov;41(5):562-72.

Kramer EL, Mushaben EM, Pastura PA, Acciani TH, Deutsch GH, Khurana Hershey GK, Korfhagen TR, Hardie WD, Whitsett JA, Le Cras TD. Early growth response-1 suppresses epidermal growth factor receptor-mediated airway hyperresponsiveness and lung remodeling in mice. Am J Respir Cell Mol Biol. 2009 Oct;41(4):415-25.

Glasser SW, Senft AP, Whitsett JA, Maxfield MD, Ross GF, Richardson TR, Prows DR, Xu Y, Korfhagen TR. Macrophage dysfunction and susceptibility to pulmonary Pseudomonas aeruginosa infection in surfactant protein C-deficient mice. J Immunol. 2008 Jul 1;181(1):621-8.

Hardie WD, Davidson C, Ikegami M, Leikauf GD, Le Cras TD, Prestridge A, Whitsett JA, Korfhagen TR. EGF receptor tyrosine kinase inhibitors diminish transforming growth factor-alpha-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2008 Jun;294(6):L1217-25.

Deshmukh HS, Shaver C, Case LM, Dietsch M, Wesselkamper SC, Hardie WD, Korfhagen TR, Corradi M, Nadel JA, Borchers MT, Leikauf GD. Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production. Am J Respir Cell Mol Biol. 2008 Apr;38(4):446-54.

Jennifer McAllister, MD, CLC Medical Director, West Chester Hopsital Special Care Nursery

Jennifer McAllister, MD, CLC, has research interests that include Neonatal Abstinence Syndrome with a focus on follow up of these infants after discharge.

513-517-0601 jennifer.mcallister@cchmc.org

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Jennifer McAllister, MD, CLC

Medical Director, West Chester Hopsital Special Care Nursery

Medical Director, NICU Follow Up Clinic-NAS Clinic

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-517-0601

Email jennifer.mcallister@cchmc.org

Show All

Clinical

Neonatal Abstinence Syndrome; newborn care; breastfeeding

Research

Follow up care of infants treated for Neonatal Abstinence Syndrome

Biography

Dr. McAllister is a pediatrician who has been with the Perinatal Institute since 2013. She is the co-medical director of the Neonatal Abstinence Clinic (NAS), and her research investigates the short and long term outcomes of babies diagnosed with NAS. She is interested in standardizing and optimizing care for newborns with NAS both inpatient and upon discharge from the hospital.

Additionally she is involved in resident education and has helped develop the newborn resident education curriculum.

MD: University of Toledo College of Medicine, Toledo, OH, 2007.

Residency: Pediatrics, University of Michigan Mott Children's Hospital, Ann Arbor, MI, 2010.

Certification: Pediatrics, 2010.

Patrick SW, Schumacher RE, Benneyworth BD, Krans EE, McAllister JM, Davis MM. Neonatal abstinence syndrome and associated health care expenditures: United States, 2000-2009. JAMA. 2012 May 9;307(18)1934-40.

Iyer MS, Santen SA, Nypaver M, Warrier K, Bradin S, Chapman R, McAllister J, Vredeveld J, House JB. Assessing the validity evidence of an objective structured assessment tool of technical skills for neonatal lumbar punctures. Acad Emerg Med. 2013 Mar;20(3):321-4.

Boon W, McAllister J, Attar MA, Chapman RL, Mullan PB, Haftel HM. Evaluation of Heart Rate Assessment Timing, Communication, Accuracy, and Clinical Decision-Making during High Fidelity Simulation of Neonatal Resuscitation. Int J Pediatr. 2014;2014;927430.

Kristin R. Melton, MD Associate Program Director, Neonatal-Perinatal Medicine Fellowship

Kristin R. Melton, MD, is interested in early craniofacial development and focuses on the tissue interactions that direct the formation, migration and differentiation of neural crest cells. The Melton Lab focuses on understanding the influence of the endothelium and the cranial mesoderm on neural crest development.

513-803-0022

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Kristin R. Melton, MD

Associate Program Director, Neonatal-Perinatal Medicine Fellowship

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-803-0022

Fax 513-636-7868

Show All

Clinical

Congenital malformations

Research

Craniofacial malformations; somitogenesis

Biography

Craniofacial defects are an important cause of morbidity for children worldwide, with craniofacial defects making up one third of all congenital anomalies and occurring in association with over 100 different genetic syndromes. Cranial neural crest cells are multipotent, migratory cells that form most of the bone, cartilage, connective tissue and peripheral nervous system of the head and face. Craniofacial defects are largely attributed to abnormalities in the formation, migration or differentiation of the neural crest. The cranial neural crest is responsive to the tissues that surround it, however, so craniofacial defects may result from a primary defect in neural crest cells, or from a defect in the tissues that signal to neural crest.

Kristin Melton, MD, has an interest in studying the tissues that signal to the neural crest, such as the endothelium and cranial mesoderm, and the signaling pathways utilized by these tissues. Using embryo culture techniques, cell culture and transgenic mouse models, Dr. Melton is investigating the interaction between the endothelium and the neural crest. Microarray has also been used to identify a number of mesoderm-specific genes that may play key roles in craniofacial development.

Dr. Melton is a practicing neonatologist and attends at the RCNIC in Cincinnati Children’s Hospital Medical Center. Her clinical interests include newborns with complex congenital anomalies and genetic defects, as well as a focus on family-centered care.

BA: Washington University, St. Louis, MO, 1991.

MD: University of Nebraska, Omaha, NE, 1995.

Residency: Children's Mercy Hospital, Kansas City, MO, 1998.

Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2001.

Gibb S, Zagorska A, Melton K, Tenin G, Vacca I, Trainor P, Maroto M, Dale JK. Interfering with Wnt signalling alters the periodicity of the segmentation clock. Dev Biol. 2009 Jun 1;330(1):21-31.

Nesslein LL, Melton KR, Ikegami M, Na CL, Wert SE, Rice WR, Whitsett JA, Weaver TE. Partial SP-B deficiency perturbs lung function and causes air space abnormalities. Am J Physiol Lung Cell Mol Physiol. 2005 Jun;288(6):L1154-61.

Melton KR, Nesslein LL, Ikegami M, Tichelaar JW, Clark JC, Whitsett JA, Weaver TE. SP-B deficiency causes respiratory failure in adult mice. Am J Physiol Lung Cell Mol Physiol. 2003 Sep;285(3):L543-9.

Melton K, Akinbi HT. Neonatal jaundice. Strategies to reduce bilirubin-induced complications. Postgrad Med. 1999 Nov;106(6):167-8, 171-4, 177-8.

Stephanie L. Merhar, MD, MS Attending Neonatologist, Neonatology and Pulmonary Biology

Stephanie L. Merhar, MD, MS, is interested in optimizing neuroimaging in preterm and term infants at risk for brain injury, neonatal seizure treatment and neurodevelopmental outcomes of infants in the NICU.

513-803-5180 stephanie.merhar@cchmc.org

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Stephanie L. Merhar, MD, MS

Attending Neonatologist, Neonatology and Pulmonary Biology

Research Director, NICU Follow Up Clinic
Follow Up Principal Investigator, Cincinnati site, NICHD Neonatal Research Network

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-803-5180

Email stephanie.merhar@cchmc.org

Show All

Clinical

Infants with perinatal brain injury; neonatal follow up.

Research

Follow-up outcomes; advanced neuroimaging to predict outcomes in infants with brain injury.

Biography

Stephanie L. Merhar, MD, MS, is a neonatologist with a research focus in the field of neuroimaging, developing ways to use advanced imaging techniques to predict and improve the outcomes of term and preterm babies with brain injury.

MD: University of Pennsylvania, Philadelphia, PA, 2005.

Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, 2005-2008.

Fellowship: Neonatology, Cincinnati Children's Hospital Medical Center, 2008-2011.

Certification: Pediatrics, 2008.

Merhar S. Biomarkers in neonatal posthemorrhagic hydrocephalus. Neonatology. 2011 Jul;101(1):1-7.

Merhar SL, Schibler KR, Sherwin CM, Meinzen-Derr J, Shi J, Balmakund T, Vinks AA. Pharmacokinetics of levetiracetam in neonates with seizures. J Pediatrics. 2011 Jul;159(1):152-154.

Merhar SL, Manning-Courtney P. Two boys with 47 XXY and autism. J Autism Devl Disord. 2007 May;37(5):840-6.

Merhar SL, Gilbert DL. Clinical (video) findings and cerebrospinal fluid neurotransmitters in 2 children with severe chronic bilirubin encephalopathy, including a former preterm infant without marked hyperbilirubinemia. Pediatrics. 2005 Nov;116(5):1226-30.

Levy SE, Mandell DS, Merhar SL, Ittenbach RF, Pinto-Martin JA. Use of complementary and alternative medicine among children recently diagnosed with autistic spectrum disorder. J Dev Behav Ped. 2003 Dec;24(6):418-423.

Nagendra K. Monangi, MD Attending Neonatologist, Neonatology and Pulmonary Biology

513-803-3982 nagendra.monangi@cchmc.org

Ardythe L. Morrow, PhD Director, Center for Interdisciplinary Research in Human Milk and Lactation

513-636-7584 ardythe.morrow@cchmc.org

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Ardythe L. Morrow, PhD

Director, Center for Interdisciplinary Research in Human Milk and Lactation

Global Health Center

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-7584

Fax 513-636-7509

Email ardythe.morrow@cchmc.org

Show All

Human milk; child health and nutrition

Biography

Dr. Morrow received her MSc in nutrition from the University of the West Indies, Kingston, Jamaica (1980) and PhD in epidemiology from the University of Texas at Houston (1991). Since 1987 she has worked with colleagues in Mexico, Boston, and Houston on an NIH-funded program project on human milk immune protection against infectious disease.

She is currently professor of pediatrics at Cincinnati Children's Hospital Medical Center within the University of Cincinnati College of Medicine. She founded and directs the Center for Epidemiology and Biostatistics that has 35 faculty and staff and a multi-disciplinary Human Milk Research Program that includes clinical and basic science investigators in eight divisions.

She has published extensively on breastfeeding promotion and human milk protection against infectious diseases. Her primary focus is on protection by human milk glycans and protection against infectious disease, but she has expanded her research to understanding the relationship between breastfeeding and chronic diseases. She has been an ad hoc reviewer for NIH on breastfeeding research and a technical advisor for international breastfeeding policy and programs for Gates Foundation, UNICEF, and WHO, is on the editorial board of the Journal of Human Lactation and the journal of the Academy of Breastfeeding Medicine. She is an elected member of the American Pediatric Society. She has over 100 publications, and is the primary author of the WHO monograph, Community-based Strategies for Breastfeeding Promotion and Support in Developing Countries (2004).

She has served as chair of the Milk Club of the (American) Society for Pediatric Research for the past four years. In 1997, she received a Young Investigator award from ISRHML for her randomized trial of breastfeeding support (Lancet, 1999). She was co-organizer of the 2002 ISRHML international meeting in Mexico and is co-editor of the book "Protecting Infants through Human Milk: Advancing the Scientific Evidence."

BA: Rice University, Houston, TX.

MSc: University of the West Indies, Kingston, Jamaica.

PhD: The University of Texas School of Public Health, Houston, TX, 1991.

South AP, Wessel JJ, Sberna A, Patel M, Morrow AL. Hospital readmission among infants with gastroschisis. J Perinatol. 2011 Feb 10.

Morrow AL, Meinzen-Derr J, Huang P, Schibler KR, Cahill T, Keddache M, Kallapur SG, Newburg DS, Tabangin M, Warner BB, Jiang X. Fucosyltransferase 2 Non-Secretor and Low Secretor Status Predicts Severe Outcomes in Premature Infants. J Pediatr. 2011 May;158(5):745-51.

Farkas T, Cross RW, Hargitt E 3rd, Lerche NW, Morrow AL, Sestak K. Genetic diversity and histo-blood group antigen interactions of rhesus enteric caliciviruses. J Virol. 2010 Sep;84(17):8617-25.

Woo JG, Guerrero ML, Altaye M, Ruiz-Palacios GM, Martin LJ, Dubert-Ferrandon A, Newburg DS, Morrow AL. Human milk adiponectin is associated with infant growth in two independent cohorts. Breastfeed Med. 2009 Jun;4(2):101-9.

Huang P, Morrow AL, Jiang X. The carbohydrate moiety and high molecular weight carrier of histo-blood group antigens are both required for norovirus-receptor recognition. Glycoconj J. 2009 Nov;26(8):1085-96.

Meinzen-Derr J, Morrow AL, Hornung RW, Donovan EF, Dietrich KN, Succop PA. Epidemiology of necrotizing enterocolitis temporal clustering in two neonatology practices. J Pediatr. 2009 May;154(5):656-61.

Geraghty SR, Khoury JC, Morrow AL, Lanphear BP. Reporting individual test results of environmental chemicals in breast milk: potential for premature weaning. Breastfeed Med. 2008 Dec;3(4):207-13.

Olsen IE, Lawson ML, Meinzen-Derr J, Sapsford AL, Schibler KR, Donovan EF, Morrow AL. Use of a body proportionality index for growth assessment of preterm infants. J Pediatr. 2009 Apr;154(4):486-91.

Meinzen-Derr J, Poindexter B, Wrage L, Morrow AL, Stoll B, Donovan EF. Role of human milk in extremely low birth weight infants' risk of necrotizing enterocolitis or death. J Perinatol. 2009 Jan;29(1):57-62.

Woo JG, Dolan LM, Morrow AL, Geraghty SR, Goodman E. Breastfeeding helps explain racial and socioeconomic status disparities in adolescent adiposity. Pediatrics. 2008 Mar;121(3):e458-65.

Vivek Narendran, MD, MRCP, MBA Medical Director, University of Cincinnati Medical Center NICU

Vivek Narendran, MD, MRCP, MBA, is interested in innate immunity of the skin with a particular focus on epidermal biomarkers and antimicrobial peptides on the skin surface.

513-803-0961 vivek.narendran@cchmc.org

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Vivek Narendran, MD, MRCP, MBA

Medical Director, University of Cincinnati Medical Center NICU

Medical Director, Cincinnati Perinatal Outreach Project

Director, Neonatal Intensive Care Unit and Newborn Services, Christ Hospital

Member, Perinatal Institute

Member, Division of Neonatology

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-803-0961

Fax 513-803-0969

Email vivek.narendran@cchmc.org

Show All

Clinical

Non-invasive ventilation of the preterm infant; surfactant trials; business case for quality improvements

Research

Innate immunity of the skin with a particular focus on epidermal biomarkers and antimicrobial peptides on the skin surface

MBBS: Bangalore Medical College, Bangalore, India, 1985.

MD/DNB: JN Medical College, Belgaum, India, 1990.

Fellowship: Neonatology, Westmead Hospital, Sydney, Australia, 1992-94.

Residency: Pediatrics, Leicester Royal Infirmary, Leicester, United Kingdom, 1994-1996.

Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1997-1998.

Fellowship: Neonatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1996, 1998-2000.

Credentials: Pediatrics, 1998 & 2008; Pediatrics, Royal College of Physicians (MRCP), United Kingdom, 1996; Neonatal-Perinatal Medicine 2001 & 2008.

Seto TL, Tabangin ME, Dawodu A, Steinhoff M, Narendran V. Racial disparities in cord blood vitamin D levels and its association with small for gestational age infants. J Perinatol. 2016 Aug;36(8):623-8.

Isemann B, Mueller EW, Narendran V, Akinbi H. Impact of Early Sodium Supplementation on Hyponatremia and Growth in Premature Infants: A Randomized Controlled Trial. JPEN J Parenter Enteral Nutr. 2016 Mar;40(3):342-9.

Hall ES, Lang MD, Levin L, Narendran V. Variation in Neonatal Inpatient Charges at the State and Local Level. Hospital Topics. 2015;93(2):27-35.

Visscher M, Narendran V. Ontogeny of skin. Advances in Wound Care Review (New Rochelle). 2014 Apr 1;3(4):291-303.

Chinta R, Rao MB, Narendran V, Malla G, Joshi M. Economic recession and headache related hospital admissions. Hospital Topics. 2013 Apr-Jun;91(2):37-42.

Donovan EF, Sparling K, Lake MR, Narendran V, Rose B et al. The investment case for preventing NICU associated infections. Am J Perinatol. 2013 Mar;30(3):179-84.

Downes K, Meinzen-Derr J, Narendran V, Akinbi H. The lost art of intubation: Assessing opportunities for residents to perform neonatal intubation. J Perinatol. 2012 Dec;32(12):927-32.

Visscher M, Taylor T, Narendran V. Neonatal intensive care practices and the influence on skin condition. J Eur Acad Dermatol Venereol. 2013 Apr;27(4):486-93.

Thomas C, Hoath SB, Narendran V. Neurodevelopmental outcomes of ELBW infants ventilated with continuous positive airway pressure vs mechanical ventilation. Indian Journal of Pediatrics. 2012;79(2):218-223.

Shah TA, Meinzen-Derr J, Steichen J, Yolton K, Narendran V, Schibler KR. Hospital and neurodevelopmental outcomes of extremely low-birth weight infants with necrotizing enterocolitis and spontaneous intestinal perforation. J Perinatol. 2012 Jul;32(7):552-8.

Amy T. Nathan, MD Medical Director, Neonatology and Pulmonary Biology

Amy T. Nathan, MD, focuses on antecedent factors leading to necrotizing enterocolitis and is interested in applying quality improvement methods to reduce the incidence of this major morbidity in preterm infants.

513-803-0909 amy.nathan@cchmc.org

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Amy T. Nathan, MD

Medical Director, Neonatology and Pulmonary Biology

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-803-0909

Email amy.nathan@cchmc.org

Show All

Clinical

Necrotizing enterocolitis; quality improvement; neonatal immune responses; family-centered care

Research

Immune modulation of lung injury and inflammation

Biography

Innate immune responses at the epithelial boundaries in preterm infants (lung, intestine) can be protective, but inflammatory responses may also cause significant damage. Necrotizing enterocolitis is a devastating, multi-factorial disease marked by intense inflammation, which may be related to changes in the intestinal microbiome combined with compromised perfusion. Dr. Nathan focuses on antecedent factors leading to necrotizing enterocolitis and is interested in applying quality improvement methods to reduce the incidence of this major morbidity in preterm infants.

MD: Yale University School of Medicine, New Haven, CT, 1998.

Residency: University of North Carolina, Chapel Hill, NC, 1998-2002.

Fellowship: University of North Carolina, Chapel Hill, NC, 2002-2005.

Certification: Pediatrics 2001; Neonatology, 2008.

Wills-Karp M, Nathan A, Page K, Karp CL. New insights into innate immune mechanisms underlying allergenicity. Mucosal Immunol. 2010 Mar;3(2):104-10.

Nathan AT, Peterson EA, Chakir J, Wills-Karp M. Innate immune responses of airway epithelium to house dust mite are mediated through beta-glucan-dependent pathways. J Allergy Clin Immunol. 2009 Mar;123(3):612-8.

Chavez-Valdez R, Ahlawat R, Wills-Karp M, Nathan AT, Ezell T, and Gauda EB. Correlation between serum caffeine levels and changes in cytokine profile in a cohort of preterm infants. J Peds. Aug 5 2010.

Wexelblatt, SL, Greenberg, JM, and Nathan AT. Regional care model enables rapid response to adverse drug events. J Perintatol. 2010 30: 300-2.

Chavez-Valdez R, Wills-Karp M, Ahlawat R, Cristofalo EA, Nathan AT, and Gauda EB. Caffeine modulates TNF- production by cord blood monocytes; the role of adenosine receptors. Ped Research. 2009 65(2):203-8.

Wendel KR, Nathan AT. Inhaled nitric oxide. Newborn and Infant Nursing Reviews. 2006 6(2):100-105.

Nehal A. Parikh, DO, MS Attending Neonatologist, Perinatal Institute

Nehal A. Parikh, DO, MS, investigates the etiology and development of perinatal brain injury/delayed brain development in high-risk newborns and early identification of prognostic biomarkers of neurodevelopmental disabilities. The goal of his research is to provide insight into abnormal brain development/injury and prevent disabilities through early risk stratification and rigorous clinical trials of neuroprotective interventions.

513-636-7584 nehal.parikh@cchmc.org

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Nehal A. Parikh, DO, MS

Attending Neonatologist, Perinatal Institute

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-7584

Email nehal.parikh@cchmc.org

Show All

Clinical

Evidence-based and family-centered care of very premature infants and term infants with asphyxia/neonatal encephalopathy; critically-ill newborns

Research

Early diagnosis of perinatal brain injury/delayed brain development; prediction and prevention of neurodevelopmental disabilities

Biography

Dr. Nehal Parikh’s singular goal is to prevent neurodevelopmental disabilities. Following rigorous training in translational research and clinical trials, he embarked on studies of etiology, prediction and prevention of neurodevelopmental disabilities in high-risk newborns. He has led or co-led several cohort studies of advanced brain MRI in very preterm infants, clinical trials of neuroprotective therapies in high-risk newborns, and the development of the NICHD NRN Extremely Preterm Birth Outcomes prognostic calculator and website. Increased survival of extremely preterm infants has contributed to a higher prevalence of survivors with motor, cognitive, and behavioral/psychiatric abnormalities. Accurate diagnosis of these abnormalities takes 2 to 3 years. These early years are when the brain is most active in building its wiring system and optimally receptive to change and healing. Thus, when the diagnosis is delayed by up to 3 years, we are losing precious time. Newer approaches to diagnosis, prediction and prevention of developmental disabilities are urgently needed to improve the long-term quality of life of high-risk newborns.

The Parikh lab employs advanced brain MRI tools such as volumetric, diffusion, and functional MRI for early identification of biomarkers of brain injury/delayed development that are predictive of disabilities in individual high-risk neonates/infants. The lab’s current focus is to understand the nature of the commonly encountered diffuse white matter abnormalities and to develop early prognostic models of motor, cognitive, and behavioral abnormalities in a geographic cohort of 500 very preterm infants. This important step will facilitate risk stratification, soon after birth, to design clinical trials of targeted neuroprotective interventions during the critical window of the first 3 years after birth when brain plasticity is at its peak.

DO: NY College of Osteopathic Medicine of NY Institute of Technology, Long Island, NY, 1996.

Residency: Pediatrics, Winthrop University Hospital of SUNY Stony Brook, Long Island, NY, 1999.

Fellowship: Neonatology, Thomas Jefferson University of Jefferson Medical College, Philadelphia, PA, 2002.

MS: Translational/Clinical Research, University of Texas Medical School at Houston, Houston, TX, 2007.

Certification: Pediatrics, 1996.

Certification: Neonatology, 2003, 2010.

Parikh, NA. Advanced Neuroimaging and its Role in Predicting Neurodevelopmental Outcomes in Very Preterm Infants. Seminars in Perinatology. 2016.

He L, Parikh NA. Brain Functional Network Connectivity Development in Very Preterm Infants: The First Six Months. Early Human Development. 2016;98:29-35.

Pogribna U, Burson K, Lasky RE, Narayana PA, Evans PW, Parikh NA. Role of Diffusion Tensor Imaging (DTI) as an Independent Predictor of Cognitive and Language Development in Extremely Preterm Infants. Am J of Neuroradiol. 2014;35(4):790-796.

Kaur S, Powell S, He L, Pierson C, Parikh NA. Reliability and repeatability of quantitative tractography methods for mapping structural white matter connectivity in preterm and term infants at term-equivalent age. PLoS One. 2014;9(1):e85807.

Parikh NA, He L, Bonfante-Mejia E, Hochhauser L, Evans P, Burson K, Kaur S. Automatically Quantified Diffuse Excessive High Signal Intensity on MRI Predicts Cognitive Development in Preterm Infants. Pediatr Neurol. 2013;49(6):424-30.

Parikh NA, Lasky RE, Kennedy KA, McDavid G, Tyson JE. Perinatal factors and regional brain volume abnormalities at term in a cohort of extremely low birth weight infants. PLoS ONE. 2013;8(5):e62804.

Parikh NA, Kennedy KA, Lasky RE, McDavid G, Tyson JE. Pilot Randomized Trial of Hydrocortisone in Ventilator-Dependent Extremely Preterm Infants: Effects on Regional Brain Volumes. J Pediatr. 2012;162(4):685-690.

Yu X, Zhang Y, Lasky RE, Datta S, Parikh NA, Narayana PA. Comprehensive Brain MRI Segmentation in High Risk Preterm Newborns. PLoS One. 2010;5(11):e13874.

Tyson JE, Parikh NA, Langer J, Green C, Higgins R, for the NICHD Neonatal Research Network. Intensive Care for Extreme Prematurity – Moving Beyond Gestational Age. N Engl J Med. 2008;358(16):1672-81.

Parikh NA, Lasky RE, Kennedy KA, Moya FR, Hochhauser L, Romo S, Tyson JE. Postnatal Dexamethasone Therapy and Cerebral Tissue Volumes in Extremely Low Birth Weight Infants. Pediatrics. 2007;119(2):265-272.

Grants

A New Model to Identify Preterm Neonates at High-Risk for Cognitive Deficits. Principal Investigator. National Institutes of Health / National Institute of Neurological Disorders and Stroke. Apr 2016-Jan 2021.

Early Prediction of Cerebral Palsy in Premature Infants using Advanced MRI Biomarkers. Principal Investigator. National Institutes of Health/ National Institute of Neurological Disorders and Stroke. Oct 2016-Sep 2021.

Mihaela Pavlicev, PhD

Mihaela Pavlicev, PhD, is an evolutionary geneticist working on the structure of genetic variation of complex traits, with a special focus on epistasis and pleiotropy. Understanding how past evolution shaped this structure can help identify the genetic basis of complex traits, including complex disease. The lab uses computational, theoretical and experimental methods in two systems: vertebrate limbs and birth timing.
Visit the Pavlicev Lab.

mihaela.pavlicev@cchmc.org

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Mihaela Pavlicev, PhD

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Email mihaela.pavlicev@cchmc.org

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The structure of genotype-phenotype map; evolutionary history of female reproductive biology

Visit the Pavlicev Lab.

Biography

Dr. Pavlicev received a PhD in ecology from the University of Vienna in 2003. After PhD she trained in molecular phylogenetics at the Natural History Museum in Vienna, primarily working on phylogenetics of lizards and birds. During subsequent postdoctoral training in quantitative genetics, she worked on the structure and evolution of the genotype-to-phenotype map, first at Washington University in St. Louis, and later at the Center for Ecological and Evolutionary Synthesis at the University of Oslo, Norway. She subsequently spent a year at Konrad Lorenz Institute for Evolution and Cognition in Altenberg near Vienna and combined writing with teaching at the Department of Theoretical Biology, University of Vienna. She joined faculty at Cincinnati Children’s in the summer of 2013.

Dr. Pavlicev`s work focuses on understanding the patterns of phenotypic variation and its underlying genetics in the context of past evolution (see Publications). These approaches have fairly recently become used to understand human detrimental variation, i.e., disease, in a field commonly referred to as evolutionary medicine. Dr. Pavlicev`s lab focuses on the evolution of female reproduction and specifically pregnancy, in order to address the causes for the prevalence of premature births in human population.

PhD: University of Vienna, Austria, 2003.

Postdoc: Washington University St. Louis (with Jim Cheverud), University of Oslo (with Thomas Hansen).

Arendt D, Musser JM, Baker CVH, Bergman A, Cepko C, Erwin DH, Pavličev M, Schlosser G, Widder S, Laubichler MD, Wagner GP. Evolution of sister cell types by individuation. Nature Reviews Genetics. 2016.

Kin K, Maziarz J, Chavan AR, Kamat M, Vasudevan S, Emera D, Lynch V, Ott T, Pavličev M, Wagner GP. The transcriptomic evolution of mammalian pregnancy: gene expression innovations in endometrial stromal fibroblasts. Genome biology and evolution. 2016.

Pavličev M, Wagner GP. The evolutionary origin of female orgasm. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution. 2016.

Eidem HR, Rinker DC, Ackerman WE, Buhimschi IA, Buhimschi CS, Dunn-Fletcher C, Kallapur SG, Pavličev M, Muglia LJ, Abbot P, Rokas A. Comparing human and macaque placental transcriptomes to disentangle preterm birth pathology from gestational age effects. Placenta. 2016;41:74-82.

Mitteroecker P, Cheverud JM, Pavličev M. Multivariate Analysis of Genotype–Phenotype Association. Genetics. 2016;202(4):1345-1363.

Pavličev M, Cheverud JM. Constraints Evolve: Context-Dependency of Gene Effects Allows Evolution of Pleiotropy. Annual Review of Ecology, Evolution, and Systematics. 2015;46(1).

Pavličev M, Widder S. Wiring for independence: Positive feedback motifs facilitate individuation of traits in development and evolution. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution. 2015;324(2): 104-113.

Pavličev M, Hiratsuka K, Swaggart KA, Dunn C, Muglia LJ. Detecting endogenous retrovirus-driven tissue-specific gene transcription. Genome biology and evolution. 2015;7(4):1082-1097.

Swaggart K, Pavličev M, Muglia LJ. Genomics of Preterm Birth. In: Perspective on Human Reproductive and Newborn Medicine, ed: Norwitz E, Bianchi D. Cold Spring Harbor Perspective. 2015.

Wagner GP, Kin K, Muglia L, Pavličev M. Evolution of mammalian pregnancy and the origin of the decidual stromal cell. International Journal of Developmental Biology. 2013;58(2-3-4):117-126.

Brenda Poindexter, MD, MS Director of Clinical and Translational Research, Perinatal Institute

513-803-9029 brenda.poindexter@cchmc.org

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Brenda Poindexter, MD, MS

Director of Clinical and Translational Research, Perinatal Institute

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-803-9029

Email brenda.poindexter@cchmc.org

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Clinical

Neonatology; clinical and translational research

Research

Nutrition in neonates

Biography

Dr. Brenda Poindexter is the director of Clinical and Translational Research for the Perinatal Institute. She has been a PI for the Eunice Kennedy Shriver NICHD Neonatal Research Network for more than 10 years and has devoted her career to the conduct of both observational and interventional trials in newborn infants. Her primary research interests relate to the role of early nutrition on growth and developmental outcomes in premature infants.

Dr. Poindexter completed residency in pediatrics at Cincinnati Children’s and then fellowship training in neonatal-perinatal medicine at Indiana University. Research training during fellowship began in the laboratory of Dr. Scott Denne, where she received the SPR Fellow’s Clinical Research Award and the Midwest SPR Kenny Trainee Investigator Award for her work related to amino acid metabolism. She was also mentored by Dr. James Lemons as her focus expanded to multicenter clinical trials. While at IU, she also earned a master’s degree in clinical research.

Dr. Poindexter is also an experienced clinician and teacher. She currently serves on the AAP Committee on Fetus and Newborn and the American Board of Pediatrics Neonatal Subboard. She was co-editor of the recently updated Nutritional Care of Preterm Infants, a textbook that is a practical resource for practicing neonatologists, dietitians, and nurses in neonatal intensive care units all over the world.

Dr. Poindexter has served as president of the Midwest Society for Pediatric Research and currently serves on the SPR Council representing Neonatology.

MD: Medical College of Ohio, Toledo, OH, 1990.

MS: Indiana University, Indianapolis, IN, 2004.

Residency: Cincinnati Children's Medical Hospital Center, Cincinnati, OH, 1993.

Fellowship: Indiana University School of Medicine, Indianapolis, IN, 1997.

Certification: General Pediatrics 1993; Neonatal and Perinatal Medicine, 1997.

Ahlfeld SK, Davis SD, Kelley KJ, Poindexter BB. Early Elevation of Plasma Periostin Is Associated with Chronic Ventilator-Dependent Bronchopulmonary Dysplasia. Am J Respir Crit Care Med. 2016 Dec 1;194(11):1430-1433.

Navarrete CT, Wrage LA, Carlo WA, Walsh MC, Rich W, Gantz MG, Das A, Schibler K, Newman NS, Piazza AJ, Poindexter BB, Shankaran S, Sánchez PJ, Morris BH, Frantz ID 3rd, Van Meurs KP, Cotten CM, Ehrenkranz RA, Bell EF, Watterberg KL, Higgins RD, Duara S; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Growth Outcomes of Preterm Infants Exposed to Different Oxygen Saturation Target Ranges from Birth. J Pediatr. 2016 Sep;176:62-68.e4.

Phelps DL, Ward RM, Williams RL, Nolen TL, Watterberg KL, Oh W, Goedecke M, Ehrenkranz RA, Fennell T, Poindexter BB, Cotten CM, Hallman M, Frantz ID 3rd, Faix RG, Zaterka-Baxter KM, Das A, Ball MB, Lacy CB, Walsh MC, Carlo WA, Sánchez PJ, Bell EF, Shankaran S, Carlton DP, Chess PR, Higgins RD. Clindamycin Pharmacokinetics and Safety in Preterm and Term Infants. Antimicrob Agents Chemother. 2016 Apr 22;60(5):2888-94.

Gonzalez D, Delmore P, Bloom BT, Cotten CM, Poindexter BB, McGowan E, Shattuck K, Bradford KK, Smith PB, Cohen-Wolkowiez M, Morris M, Yin W, Benjamin DK Jr, Laughon MM. Clindamycin Pharmacokinetics and Safety in Preterm and Term Infants. Antimicrob Agents Chemother. 2016 Apr 22;60(5):2888-94.

Poindexter BB, Martin CR. Impact of Nutrition on Bronchopulmonary Dysplasia. Clin Perinatol. 2015 Dec;42(4):797-806.

John H. Reuter, MD, PhD Attending Neonatologist, Neonatology and Pulmonary Biology

John H. Reuter, MD, PhD, is active in the administration of a 4000 delivery/year community level II service. His academic interests include breast milk and nutrition in the preterm infant.

513-862-2748 john.reuter@cchmc.org

Ward R. Rice, MD, PhD Medical Director, Newborn Services, St. Elizabeth Medical Center

Ward R. Rice, MD, PhD, studies the molecular and cellular mechanisms that regulate processing of surfactant protein C, a protein that is critical for lung function.

513-636-3149 ward.rice@cchmc.org

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Ward R. Rice, MD, PhD

Medical Director, Newborn Services, St. Elizabeth Medical Center

Director, Neonatology Fellowship Training Program

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-3149

Fax 513-636-7868

Email ward.rice@cchmc.org

Show All

Clinical

Hypotension in ELBW infants; EMR

Research

Processing of surfactant protein C

Biography

Ward R. Rice, MD, PhD, is the director of the Neonatology Fellowship Training Program and director of Newborn Services, St. Elizabeth Medical Center.

Dr. Rice received MD and PhD degrees from the University of Chicago and has been on the faculty since 1983. He has been the director of the Neonatology Fellowship Training Program since 1990. During this time, he has supervised the clinical training of more than 100 fellows who currently hold academic appointments across the United States and around the world.

His past NIH supported research accomplishments included identification of novel G-protein coupled receptors on alveolar type II cells and studies of the interaction of the opportunistic pathogen P carinii with alveolar type II cells. He currently works in collaboration with Dr. Timothy Weaver to study biosynthesis of surfactant protein C.

PhD: University of Chicago, Chicago, Illinois, 1972-76.

PhD: Biochemistry, Thesis Advisor: T.L. Steck, MD, Thesis: "Pyruvate Flux Across The Isolated Human Erythrocyte Membrane."

MD: University of Chicago, Chicago, Illinois, 1972-78.

Internship: Duke University Medical Center, Durham, North Carolina, 1978-79.

Residency: Duke University Medical Center, Durham, North Carolina, 1979-81.

Fellowship Neonatology: University of Cincinnati College of Medicine, Children's Hospital Medical Center, 1981-83.

Certification: Pediatrics, 1983; Sub-board Neonatal-Perinatal Medicine, 1983.

Conkright JJ, Apsley KS, Martin EP, Ridsdale R, Rice WR, Na CL, Yang B, Weaver TE. Nedd4-2-mediated ubiquitination facilitates processing of surfactant protein-C. Am J Respir Cell Mol Biol. 2010 Feb;42(2):181-9.

Nesslein LL, Melton KR, Ikegami M, Na CL, Wert SE, Rice WR, Whitsett JA, Weaver TE. Partial SP-B deficiency perturbs lung function and causes air space abnormalities. Am J Physiol Lung Cell Mol Physiol. 2005 Jun;288(6):L1154-61.

Rice WR, Conkright JJ, Na CL, Ikegami M, Shannon JM, Weaver TE. Maintenance of the mouse type II cell phenotype in vitro. Am J Physiol Lung Cell Mol Physiol. 2002 Aug;283(2):L256-64.

Huffman Reed JA, Rice WR, Zsengellér ZK, Wert SE, Dranoff G, Whitsett JA. GM-CSF enhances lung growth and causes alveolar type II epithelial cell hyperplasia in transgenic mice. Am J Physiol. 1997 Oct;273(4 Pt 1):L715-25.

Rice W, Shannon JM, Burton F, Fiedeldey D. Expression of a brain-type cannabinoid receptor (CB1) in alveolar Type II cells in the lung: regulation by hydrocortisone. Eur J Pharmacol. 1997 May 30;327(2-3):227-32.

Linke MJ, Burton FM, Fiedeldey DT, Rice WR. Surfactant phospholipid secretion from rat alveolar type II cells: possible role of PKC isozymes. Am J Physiol. 1997 Feb;272(2 Pt 1):L171-7.

Chroneos ZC, Abdolrasulnia R, Whitsett JA, Rice WR, Shepherd VL. Purification of a cell-surface receptor for surfactant protein A. J Biol Chem. 1996 Jul 5;271(27):16375-83.

Haas M, Rice WR. Respiratory distress syndrome for the practicing pediatrician. Pediatr Ann. 1995 Nov;24(11):572-6, 579-80. Review.

Rice WR, Burton FM, Fiedeldey DT. Cloning and expression of the alveolar type II cell P2u-purinergic receptor. Am J Respir Cell Mol Biol. 1995 Jan;12(1):27-32.

Rice WR, Singleton FM, Linke MJ, Walzer PD. Regulation of surfactant phosphatidylcholine secretion from alveolar type II cells during Pneumocystis carinii pneumonia in the rat. JClin Invest. 1993 Dec;92(6):2778-82.

Stefanie Riddle, MD Attending Neonatologist, Neonatology and Pulmonary Biology

513-636-4830 stefanie.riddle@cchmc.org

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Stefanie Riddle, MD

Attending Neonatologist, Neonatology and Pulmonary Biology

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-636-4830

Email stefanie.riddle@cchmc.org

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Clinical

Neonatology; fetal care; care of infants with congenital anomalies.

Research

Clinical outcomes of infants with congenital anomalies.

Biography

Dr. Riddle completed pediatric residency and neonatology fellowship at Cincinnati Children’s. She has a clinical and research interest in optimizing the post-natal care of neonates with congenital anomalies. As a fellow, she focused on understanding prematurity-related morbidities following fetal myelomeningocele repair. She also performed a cost analysis comparing the fetal repair strategy to traditional post-natal management. Currently, her work focuses on outcomes of patients with renal and genitourinary anomalies that lead to abnormal amniotic fluid volumes who are at high risk of pulmonary hypoplasia. She aims to better describe contemporary care of these patients to inform standard practice, as well as improve prenatal counseling for families.

MD: University of Alabama School of Medicine, Birmingham, AL, 2010.

Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2013.

Fellowship: Neonatal-Perinatal Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2016.

Certification: Pediatrics, 2013.

Kurt R. Schibler, MD Attending Neonatologist, Neonatology and Pulmonary Biology

Kurt R. Schibler, MD, is the principal investigator for the NICHD Neonatal Research Network at Cincinnati Children’s and is also involved in thematic collaborative research investigating the immune mechanisms underlying morbidity and mortality associated with preterm birth. He aims to identify infants at high risk for developing necrotizing enterocolitis and late onset infection and to devise strategies to prevent and to treat these complications.

513-636-3972 kurt.schibler@cchmc.org

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Kurt R. Schibler, MD

Attending Neonatologist, Neonatology and Pulmonary Biology

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-3972

Fax 513-636-7868

Email kurt.schibler@cchmc.org

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Clinical

Clinical trials; neonatal immune development

Research

Immune mechanisms underlying morbidity and mortality associated with preterm birth; necrotizing enterocolitis; complications of prematurity

MD: University of Cincinnati, Cincinnati, Ohio, 1984.

Residency: Pediatrics, Indiana University, Indianapolis, Indiana, 1990.

Fellowship: Neonatology, University of Utah, Salt Lake City, Utah, 1993.

Certification: Pediatrics 1990; Neonatal-Perinatal Medicine 1993, renewed 1999 and 2007.

Johnson RF, Cohen AP, Guo Y, Schibler K, Greinwald JH. Genetic mutations and aminoglycoside-induced ototoxicity in neonates. Otolaryngol Head Neck Surg. 2010 May;142(5):704-7.

Lavery AP, Meinzen-Derr JK, Anderson E, Ma Q, Bennett MR, Devarajan P, Schibler KR. Urinary NGAL in premature infants. Pediatr Res. 2008 Oct;64(4):423-8.

Schibler KR, Georgelas A, Rigaa A. Developmental biology of the dendritic cell system. Acta Paediatr Suppl. 2002;91(438):9-16.

Book Chapters

Schibler KR. Developmental Biology of the Hematopoietic Growth Factors. In Fetal and Neonatal Physiology. Polin RA, Fox WW, eds. Philadelphia: WB Saunders, 2009.

Schibler KR. The Mononuclear Phagocyte System. In Fetal and Neonatal Physiology. Polin RA, Fox WW, eds. Philadelphia: WB Saunders, 2009.

Donovan E, Greenberg J, Habernman B, Narendran V, Schibler K, Warner B. Neonatal Morbidities of Prenatal and Perinatal Origin. In Maternal-Fetal Medicine. Creasy RK, Resnik R and Iams JD., eds Philadelphia : WB Saunders, 2009.

Augusto F. Schmidt, MD, PhD Clinical Fellow, Neonatology and Pulmonary Biology

513-636-4214 augusto.schmidt@cchmc.org

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Augusto F. Schmidt, MD, PhD

Clinical Fellow, Neonatology and Pulmonary Biology

Academic Affiliation

Phone 513-636-4214

Email augusto.schmidt@cchmc.org

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Clinical

Neonatology; neonatal ventilation; antenatal steroids

Research

Fetal maturation induced by antenatal steroids; fetal brain development and injury; congenital diaphragmatic hernia

MD: Universidade Estadual de Campinas, Brazil, 2007.

PhD: Universidade Estadual de Campinas, Brazil, 2010.

Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2013.

Certification: Pediatrics, 2013.

Schmidt AF, Kannan PS, Kemp MW, Kramer BW, Newnham JP, Jobe AH, Kallapur SG. Intra-amniotic LPS modulates expression of antimicrobial peptides in the fetal sheep lung. Pediatr Res. 2014;76(5):441-447.

Schmidt AF, Rojas-Moscoso JA, Goncalves FL, Gallindo RM, Monica FZ, Antunes E, Figueira RL, Sbragia L. Increased contractility and impaired relaxation of the left pulmonar artery in a rabbit model of congenital diaphragmatic hernia. Pediatr Surg Int. 2013;29(5):489-494.

Schmidt AF, Goncalves FL, Regis AC, Gallindo RM, Sbragia L. Prenatal retinoic acid treatment improves lung vascularization and VEGF expression in CDH rat. Am J Obstet Gynecol. 2012;207(1):76.e25-32.

Schmidt AF, Goncalves FL, Nassr AC, Pereira LA, Farmer D, Sbragia L. Antenatal steroid and tracheal occlusion restore vascular endothelial growth factor receptors in congenital diaphragmatic hernia rat model. Am J Obstet Gynecol. 2010;203(2):184.e13-20.

Debora I. Sinner, PhD

Debora I. Sinner, PhD, is interested in understanding the molecular mechanisms underlying foregut formation. Specifically, her lab focuses on the molecular mechanism underlying lung and upper airway development and the paracrine interactions between epithelium and mesenchyme. Ultimately, her goal is to use the embryo as a paradigm to understand diseases affecting upper airway and lung. To this end her lab utilizes knockout mouse models and the frog embryo combined with molecular and cellular approaches using in vitro systems.

513-803-1353 debora.sinner@cchmc.org

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Debora I. Sinner, PhD

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-803-1353

Email debora.sinner@cchmc.org

Show All

Developmental biology; pulmonary biology

Visit the Sinner Lab.

Biography

Debora Sinner, PhD, obtained her doctoral degree from University of Buenos Aires, Argentina. Her dissertation focused on the effects of maternal diabetes during murine embryonic development and role of prostaglandins and reactive species of oxygen in glucose induced abnormal development. As a postdoctoral trainee in the Division of Developmental Biology at Cincinnati Children's, Dr. Sinner focused on the molecular mechanisms underlying endoderm formation, the germ layer that gives rise to the gastrointestinal tract. Under the direction of her mentor, Aaron Zorn, PhD, we identified a mechanism by which Sox proteins regulate the Wnt signaling pathway during frog development. These findings are relevant since Wnt signaling pathway has been linked to development and disease.

After completion of her doctoral training, Dr. Sinner accepted a faculty position in the Division of Neonatology and Pulmonary Biology at Cincinnati Children's within the UC Department of Pediatrics. Her current research focuses on upper airway and lung development. Dr. Sinner's lab is studying how paracrine Wnt signaling controls the differentiation of pulmonary cells lineages, including the microvasculature and airway cartilage.

MS: University of Buenos Aires, Argentina, 1999.

PhD: University of Buenos Aires, Argentina, 2003.

Post doctoral training: Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2003-2009.

Snowball J, Ambalavanan M, Whitsett J, Sinner D. Endodermal Wnt signaling is required for tracheal cartilage formation. Developmental Biology. 2015 Jul;379:38-52.

Snowball J, Ambalavanan M, Cornett B, Lang R, Whitsett J, Sinner D. Mesenchymal Wnt Signaling Promotes Formation of Sternum and Thoracic Body Wall. Developmental Biology. 2015;401(2):264-275.

Cornett B, Snowball J, Varisco B, Lang R, Whitsett J, Sinner D. Wntless is required for peripheral lung differentiation and pulmonary vascular development. Developmental Biology. 2013 Jul;379:38-52.

Sinner D, Kim GJ, Henderson GC, Igal RA. StearoylCoA desaturase-5: a novel regulator of neuronal cell proliferation and differentiation. PLoS ONE. 2012;7(6):e39787.

Kormish JD, Sinner D, Zorn AM. Interactions between SOX factors and Wnt/beta-catenin signaling in development and disease. Dev Dyn. 2010 Jan;239(1):56-68.

Li Y, Rankin SA, Sinner D, Kenny AP, Krieg PA, Zorn AM. Sfrp5 coordinates foregut specification and morphogenesis by antagonizing both canonical and noncanonical Wnt11 signaling. Genes Dev. 2008 Nov 1;22(21):3050-63.

Sinner D, Kordich JJ, Opoka R Rankin SA,. Lin S-J, Jonatan D, Zorn AM, Wells JM. Beta-catenin/Tcf activity is repressed by Sox17 and enhanced by Sox4 in colon carcinoma cells. Mol Cell Biol. 2007;27:7802-7815.

Sinner D, Kirilenko P, Rankin S, Wei E, Howard L, Kofron M, Heasman J, Woodland HR, Zorn AM. Global analysis of the transcriptional network controlling Xenopus endoderm formation. Development. 2006 May;133(10):1955-66.

Sinner D, Rankin S, Lee M, Zorn AM. Sox17 and beta-catenin cooperate to regulate the transcription of endodermal genes. Development. 2004 Jul;131(13):3069-80.

Sinner D, Caviglia JM, Jawerbaum A, Igal RA, Gonzalez E. Lipid metabolism in the embryos of diabetic rats during early organogenesis: modulatory effect of prostaglandin E2. Reprod Fertil Dev. 2003;15(1-2):75-80.

Grants

Molecular mechanisms underlying tracheomalacia. Principal Investigator. National Institutes of Health/National Heart, Lung, and Blood Institute. Aug 2012-Jul 2017. 1K01HL115447-01.

Molecular basis of dorsal-ventral patterning of conducting airways. Principal Investigator. National Institutes of Health/National Heart, Lung, and Blood Institute. Sep 2016-Aug 2018. R03.

Kristen Suhrie, MD Neonatologist, Perinatal Institute

Kristen Suhrie, MD, is working on a translational research project to develop a prenatal genetic screening test to identify fetuses affected by genetic disorders using cell free fetal DNA obtained from a maternal blood sample as early as the first trimester of pregnancy. The goal of her research is to identify fetuses affected by genetic disease early in pregnancy to allow for improved prenatal and neonatal care for these patients.

513-803-0274 kristen.suhrie@cchmc.org

Daniel T. Swarr, MD

Daniel T. Swarr, MD, investigates epigenetic regulation of gene expression during early endoderm and lung development, and is particularly interested in the role that long non-coding RNAs (lncRNAs) play during development and disease. The goal of his research is to provide insights into the pathogenesis of congenital malformations and pulmonary disorders.

513-803-8396 daniel.swarr@cchmc.org

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Daniel T. Swarr, MD

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-803-8396

Email daniel.swarr@cchmc.org

Show All

Clinical

Isolated and syndromic birth defects; bronchopulmonary dysplasia; pediatric lung diseases; general neonatology

Research

Early endoderm and lung development; epigenetic regulation of gene expression; long non-coding RNAs; Congenital lung malformations; TEF/EA; VACTERL

Biography

After finishing general pediatrics residency training at Baylor College of Medicine, Dr. Swarr completed a combined fellowship program at The Children’s Hospital of Philadelphia, which lead to Board certification in Neonatal-Perinatal Medicine and Medical Genetics & Genomics. As both a neonatologist and geneticist, Dr. Swarr is particularly interested in both isolated and syndromic birth defects impacting the health of newborn infants.

The goal of Dr. Swarr’s research is to improve our understanding of the etiology and pathogenesis of congenital malformations and pulmonary disease using a wide variety of tools from developmental biology, genetics and epigenetics. His laboratory is particularly interested in understanding epigenetic mechanisms by which gene expression is regulated during early endoderm and lung development, and how disruptions of these processes lead to neonatal disease. Current work seeks to define the role of long non-coding RNAs (lncRNAs) during lung development and lung epithelial repair after injury.

Dr. Swarr’s laboratory is also actively involved in “translating” findings from basic developmental biology to better understanding disorders of the esophagus, trachea, and lungs through a patient registry-biorepository established in collaboration with investigators at CCHMC and The Children’s Hospital of Philadelphia.

MD: Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 2007.

Residency: General Pediatrics, Baylor College of Medicine & Texas Children’s Hospital, Houston, TX, 2007-2010.

Fellowship: Combined Fellowship in Neonatal-Perinatal Medicine and Medical Genetics, The Children’s Hospital of Philadelphia, Philadelphia, PA, 2010-2015.

Board Certifications: General Pediatrics, 2010; Medical Genetics & Genomics, 2015; Neonatal-Perinatal Medicine, 2016.

Swarr DT, Morrisey EE. Lung endoderm morphogenesis: gasping for form and function. Annu Rev Cell Dev Biol. 2015 Nov 13;31:553-73.

Luo M, Mulchandani S, Dubbs HA, Swarr DT, Pyle L, Zackai EH, Spinner NP, Conlin LK. Detection of mutually exclusive mosaicism in a girl with genotype-phenotype discrepancies. Am J Med Genet A. 2015 Dec;167A(12):3091-5.

Kruska P, Li D, Harr MH, Wilson NR, Swarr D, McCormick E, Chiavacci R, Li M, Johnson J, McDonald-McGinn D, Deardorff M, Falk MJ, Allanson J, Saadi I, Hakonarson H, Muenke M, Zackai EH. Mutations in SPECC1L, encoding sperm antigen with calponin homology and coiled-coil domains 1-like, are found in some cases of autosomal dominant Opitz G/BBB syndrome. J Med Genet. 2015 Feb;52(2):104-10.

Herriges M*, Swarr DT*, Morley MP, Peng T, Stewart KM, Morrisey EE. Long non-coding RNAs are preferentially located near transcription factors and regulate lung development. Genes Dev. 2014 Jun 15;28(12):1363-79. *Co-first authors

Wenger TL, Gerdes J, Deardorff MA, Taub K, Swarr DT, Abend N. Telemedicine for genetic and neurologic evaluation of infants in the Neonatal Intensive Care Unit. J Perinatol. 2014 Mar;34(3):234-40.

Swarr DT, Khalek N, Treat J, Horton M, Riviere JB, Dobyns W, Zackai EH. Expanding the differential diagnosis of fetal hydrops: an unusual prenatal presentation of megalencephaly-capillary malformation syndrome. Prenat Diagn. 2013 Oct;33(10):1010-2.

Kalish JM, Conlin LK, Bhatti TR, Feret H, Harris MC, Izumi K, Mostoufi-Moab S, Saitta S, States LJ, Swarr DT, Wilkens AB, Zackai EH, Zelley K, Bartolomei MS, Nichols KE, Palladino AA, Spinner NB, Deardorff MA. Clinical presentation of three subjects with genome-wide paternal uniparental disomy. Am J Med Genet A. 2013 Mar;161(3):473-8.

Sen P, Yang Y, Navarro C, Silva I, Szafranski P, Kolodziejska KE, Dharmadhikari AV, Kozakewich H, Kearney D, Cahill JB, Whitt M, Bilic M, Margraf L, Charles A, Goldblatt J, Gibson K, Lantz P, Garvin J, Petty J, Kiblawi Z, Zuppan C, McConkie-Rosell A, McDonald MT, Peterson-Carmichael SL, Gaede JT, Shivanna B, Schady D, Friedlich PS, Hays SR, Valenzuela Palafoll I, Siebers-Renelt U, Bohring A, Finn LS, Siebert JR, Galambos C, Nguyen L, Riley M, Chassaing N, Vigouroux A, Rocha G, Fernandes S, Brumbaugh J, Roberts K, Homing L, Lo I, Lam S, Gerychova R, Jezova M, Valaskova I, Fellman F, Afshar K, Giannoni E, Muhlethaler V, Liang J, Lioy J, Deshmukh H, Srinivasan L, Swarr DT, Sloman M, Shaw-Smith C, van Loon L, Hagman C, Sznajer Y, Barrea C, Galant C, Detaille T, Wambach J, Cole JS, Hamvas A, Prince L, Langston C, Welty S, Stankiewicz P. Novel FOXF1 mutations in sporadic and familial cases of alveolar capillary dysplasia with misaligned pulmonary veins imply a role for its DNA binding domain. Hum Mutat. 2013 June;34(6):801-11.

Nathanson J, Swarr DT, Singer A, Liu M, Chinn A, Jones W, Hurst J, Khalek N, Zackai E, Slavotinek A. Novel FREM1 mutations expand the phenotypic spectrum associated with Manitoba-Oculo-Tricho-Anal (MOTA) syndrome and Bifid Nose Renal Agenesis Anorectal Malformations (BNAR) syndrome. Am J Med Genet A. 2013 Mar;161(3):473-8.

Swarr DT, Bloom D, Lewis RA, Elenberg E, Friedman EM, Glotzbach C, Wissman SD, Shaffer LG, Potocki L. Potocki-Shaffer syndrome: comprehensive clinical assessment, review of the literature, and proposals for medical management. Am J Med Genet A. 2010 Mar;152A(3):565-72.

Laura P. Ward, MD, IBCLC Medical Director, Mercy Hospital Anderson Nurseries

Laura Placke Ward, MD, IBCLC, focuses on strategies to prevent significant hyperbilirubinemia in term and late preterm infants.

513-803-0963 laura.ward@cchmc.org

High Res

Laura P. Ward, MD, IBCLC

Medical Director, Mercy Hospital Anderson Nurseries

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-803-0963

Fax 513-803-0969

Email laura.ward@cchmc.org

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Clinical

Neonatology; quality improvement; breastfeeding; necrotizing enterocolitis

Research

Neonatal abstinence syndrome; breastfeeding

Biography

Dr. Ward graduated from St. Louis University School of Medicine in 1994. She went on to complete her residency in pediatrics and her fellowship in neonatology at the Children’s National Medical Center in Washington DC from 1994-2000.

Dr. Ward has been a neonatologist in the division since 2002, and attends at The University Hospital.

MD: St. Louis University School of Medicine, St. Louis, MO, 1994.

Residency: Pediatrics, Children’s National Medical Center, Washington DC, 1994-1997.

Fellowship: Neonatology, Children’s National Medical Center, Washington DC, 1997-2000.

Certifications: Pediatrics, 1997; Neonatology, 2003; International Board Certified Lactation Consultant, 2013.

Wiles JR, Isemann B, Tomoyuki M, Tabangin ME, Ward LP, Akinbi H, Vinks AA. Pharmacokinetics of Oral Methadone in the Treatment of Neonatal Abstinence Syndrome: A Pilot Study. J Pediatr. 2015;167(7):1214-1220.

Wexelblatt SL, Ward LP, Torok K, Tisdale E, Meinzen-Derr JK, Greenberg JM. Universal Maternal Drug Testing in a High-Prevalence Region of Prescription Opiate Abuse. J Pediatr. 2015;166(3):582-586.

Wiles JR, Isemann,B, Ward LP, Vinks AA, Akinbi H. Current Management of Neonatal Abstinence Syndrome Secondary to Intrauterine Opioid Exposure. J Pediatr. 2014;165(3):440-446.

Moyer LB, Goyal NK, Meinzen-Derr J, Ward LP, Rust CL, Wexelblatt SL, Greenberg JM. Factors Associated with Readmission in Late Preterm Infants: A Matched Case Control Study. Hosp Pediatr. 2014;4(5):298-304.

Delfosse NM, Ward LP, Lagomarcino AJ, Auer C, Smith C, Meinzen-Derr J, Valentine CV, Schibler KR, Morrow AL. Donor human milk largely replaces formula-feeding of preterm infants in two urban hospitals. J Perinatol. 2013;33(6):446-451.

Ward LP, Auer CA, Smith C, Schoettker PJ, Pruett R, Shah NY, Kotagal UR. The Human Milk Project: A Quality Improvement Initiative to Increase Human Milk Consumption in Very Low Birth Weight Infants. Breastfeed Med. 2012;7(4):234-240.

Kathy E. Wedig-Stevie, MD Medical Director, High Risk Follow-up Clinic at Good Samaritan Hospital

Kathy E. Wedig-Stevie, MD, focuses on neonatal follow-up, including the follow-up of graduates from the NICU and drug exposed neonates with neonatal abstinence syndrome. Her future research plans involve neuroimaging and therapy based on the neurological findings.

513-872-2748 kathy.wedig@cchmc.org

High Res

Kathy E. Wedig-Stevie, MD

Medical Director, High Risk Follow-up Clinic at Good Samaritan Hospital

Neonatologist, Good Samaritan Hospital

Medical Director, Mercy Hospital Fairfield Nurseries

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-872-2748

Fax 513-872-4979

Email kathy.wedig@cchmc.org

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Neonatal high risk infant follow up and developmental follow up; developmental and clinical follow up of preterm infants and children exposed to opioids in utero.

Biography

Dr. Wedig-Stevie was a graduate of the University of Cincinnati Medical School in 1978. She completed her residency in pediatrics at Cincinnati Children's Hospital Medical Center from 1978-1981 and completed her fellowship in neonatology at University Hospitals in Cleveland from 1981-1983.

She continued as a neonatologist at Good Samaritan Hospital in Cincinnati from 1983-1996. In 1996, she came to Cincinnati Children's as a neonatologist and has continued her work here ever since. At the same time, she has also been the associate professor of clinical pediatrics at the University of Cincinnati. Dr. Wedig-Stevie is the director of Cincinnati Children's Neonatal Followup at TriHealth and the co-founder of the Neonatal Abstinence Clinic at Cincinnati Children's.

MD: University of Cincinnati Medical School, Cincinnati, OH, 1978.

Residency: Pediatrics, University of Cincinnati Medical Center, Cincinnati, OH, 1978-1981.

Fellowship: Neonatology, University Hospitals: Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, OH, 1983.

Certifications: Pediatrics, 1983; Neonatology, 1983.

Wedig KE, Whitsett JA. Down the primrose path: petechiae in a neonate exposed to herbal remedy for parturition. J Pediatr. 2008 Jan;152(1):140, 140.e1.

Wedig KE, Kogan J, Schorry EK, Whitsett JA. Skeletal demineralization and fractures caused by fetal magnesium toxicity. J Perinatol. 2006 Jun;26(6):371-4.

Scott L. Wexelblatt, MD Regional Director of Newborn Services, Perinatal Institute

Scott L. Wexelblatt, MD, does clinical research in Neonatal Abstinence Syndrome. The goal in this research is to improve the care of opioid exposed newborns.

513-803-0999 scott.wexelblatt@cchmc.org

High Res

Scott L. Wexelblatt, MD

Regional Director of Newborn Services, Perinatal Institute

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-803-0999

Fax 513-803-2633

Email scott.wexelblatt@cchmc.org

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Neonatal Abstinence Syndrome

Biography

Dr. Scott Wexelblatt is the regional medical director for newborn services for the Cincinnati region. He is an assistant professor in the Division of Neonatology, Perinatal Institute at Cincinnati Children’s Hospital Medical Center, and the University of Cincinnati College of Medicine. He attended medical school at the University of Vermont, and completed his pediatric residency at Cincinnati Children’s Hospital Medical Center. He is a faculty member with the Ohio Perinatal Quality Collaborative (OPQC) on the Neonatal Abstinence Syndrome project.

MD: University of Vermont College of Medicine, Burlington, VT, 1996.

Residency: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH.

Certification: American Board of Pediatrics, 1999.