Whitlock Lab

Whitlock Research Lab

Large osteo-chondral defects of the femoral head result in significant disability in pediatric, adolescent and young-adult patients. Often, patients must either undergo total hip arthroplasty at a young age with associated activity limitations and increased need for future prosthesis revision or modify their activity significantly until they undergo arthroplasty at a later age with prolonged limitations in activity, productivity and quality of life. Recapitulation of normal developmental mechanisms in a sustainable, tissue-engineered construct may eliminate these shortcomings and lead to better functional and clinical outcomes, particularly in the adolescent and young-adult populations. However, the formation of a stable bone – peri-articular cartilage interface able to support prolonged maintenance of healthy, normal articular cartilage and withstand physiologic joint forces in-vivo currently represents a significant hurdle to the development of such a construct. 

Our lab, led by Patrick W. Whitlock, MD, PhD, focuses on the growth, signaling and development of the interface between physeal and peri-articular cartilage in the developing epiphysis. Our goal is to develop optimized tissue-engineered solutions to treat osteo-articular cartilage defects of the femoral head in pediatric patients by first understanding, and eventually recapitulating, the normal growth and development of the bone – peri-articular cartilage interface.

Contact Us

A photo of Patrick W. Whitlock.

Patrick W. Whitlock, MD, PhD

Orthopaedic Surgeon, Division of Pediatric Orthopaedic Surgery, Cincinnati Children's Hospital Medical Center

Associate Professor, UC Department of Orthopedic Surgery


R1509, Location / Building R
3333 Burnet Avenue
Cincinnati, OH 45229