Loss of FOXM1 in macrophages promotes pulmonary fibrosis by activating p38 MAPK signaling pathway. Editor, Barsh GS. PLoS Genetics. 2020; 16:e1008692.
.The FOXM1 Inhibitor RCM-1 Decreases Carcinogenesis and Nuclear β-Catenin. Molecular Cancer Therapeutics. 2019; 18:1217-1229.
.FOXF1 Inhibits Pulmonary Fibrosis by Preventing CDH2-CDH11 Cadherin Switch in Myofibroblasts. Cell Reports. 2018; 23:442-458.
.FOXM1 activates AGR2 and causes progression of lung adenomas into invasive mucinous adenocarcinomas. Editor, Hunter KW. PLoS Genetics. 2017; 13:e1007097.
.FoxF1 and FoxF2 transcription factors synergistically promote rhabdomyosarcoma carcinogenesis by repressing transcription of p21Cip1 CDK inhibitor. Oncogene: Including Oncogene Reviews. 2017; 36:850-862.
.SPDEF inhibits prostate carcinogenesis by disrupting a positive feedback loop in regulation of the Foxm1 oncogene. Editor, Horwitz MS. PLoS Genetics. 2014; 10:e1004656.
.Foxm1 expression in prostate epithelial cells is essential for prostate carcinogenesis. The Journal of biological chemistry. 2013; 288:22527-22541.
.Foxm1 transcription factor is required for lung fibrosis and epithelial-to-mesenchymal transition. The EMBO Journal. 2013; 32:231-244.
.Foxm1 transcription factor is required for macrophage migration during lung inflammation and tumor formation. Oncogene: Including Oncogene Reviews. 2012; 31:3875-3888.
.Endothelial cell-specific deletion of transcription factor FoxM1 increases urethane-induced lung carcinogenesis. Cancer Research. 2011; 71:40-50.
.Ultra-high dose-rate proton FLASH improves tumor control. Radiotherapy and Oncology. 2023; 186:109741.
.Endothelial progenitor cells derived from embryonic stem cells prevent alveolar simplification in a murine model of bronchopulmonary dysplasia. Frontiers in Cell and Developmental Biology. 2023; 11:1209518.
.Novel FOXF1-Stabilizing Compound TanFe Stimulates Lung Angiogenesis in Alveolar Capillary Dysplasia. American Journal of Respiratory and Critical Care Medicine. 2023; 207:1042-1054.
.Improving anti-tumor efficacy of low-dose Vincristine in rhabdomyosarcoma via the combination therapy with FOXM1 inhibitor RCM1. Frontiers in Oncology. 2023; 13:1112859.
.Endothelial progenitor cells stimulate neonatal lung angiogenesis through FOXF1-mediated activation of BMP9/ACVRL1 signaling. Nature Communications. 2022; 13:2080.
.In vivo generation of bone marrow from embryonic stem cells in interspecies chimeras. eLife. 2022; 11:e74018.
.In vivo cyclic induction of the FOXM1 transcription factor delays natural and progeroid aging phenotypes and extends healthspan. 2022; 2:397-411.
.A census of the lung: CellCards from LungMAP. Developmental Cell. 2022; 57:112-145.e2.
.Elsevier; Elsevier; 2022.
. Transcription Factors: Forkhead Box (FOX) ☆. Encyclopedia of Respiratory Medicine. :Therapeutic Potential of Endothelial Progenitor Cells in Pulmonary Diseases. American Journal of Respiratory Cell and Molecular Biology. 2021; 65:473-488.
.Dual Targeting with Cell Surface Electrical Charge and Folic Acid via Superparamagnetic Fe3O4@Cu2-xS for Photothermal Cancer Cell Killing. Cancers. 2021; 13:5275.
.Nanoparticle Delivery of STAT3 Alleviates Pulmonary Hypertension in a Mouse Model of Alveolar Capillary Dysplasia. Circulation. 2021; 144:539-555.
.Generation of Pulmonary Endothelial Progenitor Cells for Cell-based Therapy Using Interspecies Mouse-Rat Chimeras. American Journal of Respiratory and Critical Care Medicine. 2021; 204:326-338.
.Blastocyst complementation reveals that NKX2-1 establishes the proximal-peripheral boundary of the airway epithelium. Developmental Dynamics. 2021; 250:1001-1020.
.Targeting EYA3 in Ewing Sarcoma Retards Tumor Growth and Angiogenesis. Molecular Cancer Therapeutics. 2021; 20:803-815.
.FOXF1 is required for the oncogenic properties of PAX3-FOXO1 in rhabdomyosarcoma. Oncogene: Including Oncogene Reviews. 2021; 40:2182-2199.
.In Vivo Generation of Lung and Thyroid Tissues from Embryonic Stem Cells Using Blastocyst Complementation. American Journal of Respiratory and Critical Care Medicine. 2021; 203:471-483.
.Genome Editing for Rare Diseases. Current stem cell reports. 2020; 6:41-51.
.Nanoparticle Delivery of Proangiogenic Transcription Factors into the Neonatal Circulation Inhibits Alveolar Simplification Caused by Hyperoxia. American Journal of Respiratory and Critical Care Medicine. 2020; 202:100-111.
.FOXM1 nuclear transcription factor translocates into mitochondria and inhibits oxidative phosphorylation. Editor, Fox T. Molecular Biology of the Cell. 2020; 31:1411-1424.
.Loss of FOXM1 in macrophages promotes pulmonary fibrosis by activating p38 MAPK signaling pathway. Editor, Barsh GS. PLoS Genetics. 2020; 16:e1008692.
.Molecular, cellular, and bioengineering approaches to stimulate lung regeneration after injury. Seminars in Cell and Developmental Biology. 2020; 100:101-108.
.IODVA1, a guanidinobenzimidazole derivative, targets Rac activity and Ras-driven cancer models. Editor, Lebedeva IV. PloS one. 2020; 15:e0229801.
.Postnatal Alveologenesis Depends on FOXF1 Signaling in c-KIT+ Endothelial Progenitor Cells. American Journal of Respiratory and Critical Care Medicine. 2019; 200:1164-1176.
.The S52F FOXF1 Mutation Inhibits STAT3 Signaling and Causes Alveolar Capillary Dysplasia. American Journal of Respiratory and Critical Care Medicine. 2019; 200:1045-1056.
.The FOXM1 Inhibitor RCM-1 Decreases Carcinogenesis and Nuclear β-Catenin. Molecular Cancer Therapeutics. 2019; 18:1217-1229.
.Targeted Inhibition of the Dual Specificity Phosphatases DUSP1 and DUSP6 Suppress MPNST Growth via JNK. Clinical Cancer Research. 2019; 25:4117-4127.
.The Forkhead box F1 transcription factor inhibits collagen deposition and accumulation of myofibroblasts during liver fibrosis. Biology Open. 2019; 8:bio039800.
.Building and Regenerating the Lung Cell by Cell. Physiological Reviews. 2019; 99:513-554.
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Tanya Kalin, MD, PhD
Professor
UC Department of Pediatrics
Member, Pulmonary Biology, Cincinnati Children's Hospital Medical Center
Mailing Address:
3333 Burnet Ave.
MLC 7009
Cincinnati, OH 45229
Phone: 513-803-1201
Email: tatiana.kalin@cchmc.org