Kalin Lab

Goda, C; Balli, D; Black, M; Milewski, D; Le, T; Ustiyan, V; Ren, X; Kalinichenko, VV; Kalin, TV. Loss of FOXM1 in macrophages promotes pulmonary fibrosis by activating p38 MAPK signaling pathway. PLoS Genetics. 2020; 16:e1008692-e1008692.

Shukla, S; Milewski, D; Pradhan, A; Rama, N; Rice, K; Le, T; Flick, MJ; Vaz, S; Zhao, X; Setchell, KD; et al. The FOXM1 Inhibitor RCM-1 Decreases Carcinogenesis and Nuclear beta-Catenin. Molecular Cancer Therapeutics. 2019; 18:1217-1229.

Black, M; Milewski, D; Le, T; Ren, X; Xu, Y; Kalinichenko, VV; Kalin, TV. FOXF1 Inhibits Pulmonary Fibrosis by Preventing CDH2-CDH11 Cadherin Switch in Myofibroblasts. Cell Reports. 2018; 23:442-458.

Milewski, D; Balli, D; Ustiyan, V; Le, T; Dienemann, H; Warth, A; Breuhahn, K; Whitsett, JA; Kalinichenko, VV; Kalin, TV. FOXM1 activates AGR2 and causes progression of lung adenomas into invasive mucinous adenocarcinomas. PLoS Genetics. 2017; 13:e1007097-e1007097.

Milewski, D; Pradhan, A; Wang, X; Cai, Y; Le, T; Turpin, B; Kalinichenko, VV; Kalin, TV. FoxF1 and FoxF2 transcription factors synergistically promote rhabdomyosarcoma carcinogenesis by repressing transcription of p21(Cip1) CDK inhibitor. Oncogene: Including Oncogene Reviews. 2017; 36:850-862.

Cheng, X; Black, M; Ustiyan, V; Le, T; Fulford, L; Sridharan, A; Medvedovic, M; Kalinichenko, VV; Whitsett, JA; Kalin, TV. SPDEF Inhibits Prostate Carcinogenesis by Disrupting a Positive Feedback Loop in Regulation of the Foxm1 Oncogene. PLoS Genetics. 2014; 10:e1004656-e1004656.

Cai, Y; Balli, D; Ustiyan, V; Fulford, L; Hiller, A; Misetic, V; Zhang, Y; Paluch, AM; Waltz, SE; Kasper, S; et al. Foxm1 Expression in Prostate Epithelial Cells Is Essential for Prostate Carcinogenesis. The Journal of biological chemistry. 2013; 288:22527-22541.

Balli, D; Ustiyan, V; Zhang, Y; Wang, I; Masino, AJ; Ren, X; Whitsett, JA; Kalinichenko, VV; Kalin, TV. Foxm1 transcription factor is required for lung fibrosis and epithelial-to-mesenchymal transition. The EMBO Journal. 2013; 32:231-244.

Balli, D; Ren, X; Chou, F; Cross, E; Zhang, Y; Kalinichenko, VV; Kalin, TV. Foxm1 transcription factor is required for macrophage migration during lung inflammation and tumor formation. Oncogene: Including Oncogene Reviews. 2012; 31:3875-3888.

Balli, D; Zhang, Y; Snyder, J; Kalinichenko, VV; Kalin, TV. Endothelial Cell-Specific Deletion of Transcription Factor FoxM1 Increases Urethane-Induced Lung Carcinogenesis. Cancer Research. 2011; 71:40-50.

Pradhan, A; Kalin, TV; Kalinichenko, VV. Genome Editing for Rare Diseases. Current stem cell reports. 2020; 6:41-51.

Bolte, C; Ustiyan, V; Ren, X; Dunn, AW; Pradhan, A; Wang, G; Kolesnichenko, OA; Deng, Z; Zhang, Y; Shi, D; et al. Nanoparticle delivery of proangiogenic transcription factors into the neonatal circulation inhibits alveolar simplification caused by hyperoxia. American Journal of Respiratory and Critical Care Medicine. 2020; 202:100-111.

Black, M; Arumugam, P; Shukla, S; Pradhan, A; Ustiyan, V; Milewski, D; Kalinichenko, VV; Kalin, TV. FOXM1 nuclear transcription factor translocates into mitochondria and inhibits oxidative phosphorylation. Molecular Biology of the Cell. 2020; 31:1411-1424.

Goda, C; Balli, D; Black, M; Milewski, D; Le, T; Ustiyan, V; Ren, X; Kalinichenko, VV; Kalin, TV. Loss of FOXM1 in macrophages promotes pulmonary fibrosis by activating p38 MAPK signaling pathway. PLoS Genetics. 2020; 16:e1008692-e1008692.

Bolte, C; Kalin, TV; Kalinichenko, VV. Molecular, cellular, and bioengineering approaches to stimulate lung regeneration after injury. Seminars in Cell and Developmental Biology. 2020; 100:101-108.

Gasilina, A; Premnauth, G; Gurjar, P; Biesiada, J; Hegde, S; Milewski, D; Ma, G; Kalin, TV; Merino, E; Meller, J; et al. IODVA1, a guanidinobenzimidazole derivative, targets Rac activity and Ras-driven cancer models. PLoS ONE. 2020; 15:e0229801-e0229801.

Ren, X; Ustiyan, V; Guo, M; Wang, G; Bolte, C; Zhang, Y; Xu, Y; Whitsett, JA; Kalin, TV; Kalinichenko, VV. Postnatal alveologenesis depends on FOXF1 signaling in c-KIT1 endothelial progenitor cells. American Journal of Respiratory and Critical Care Medicine. 2019; 200:1164-1176.

Pradhan, A; Dunn, A; Ustiyan, V; Bolte, C; Wang, G; Whitsett, JA; Zhang, Y; Porollo, A; Hu, Y; Xiao, R; et al. The S52F FOXF1 mutation inhibits STAT3 signaling and causes alveolar capillary dysplasia. American Journal of Respiratory and Critical Care Medicine. 2019; 200:1045-1056.

Ramkissoon, A; Chaney, KE; Milewski, D; Williams, KB; Williams, RL; Choi, K; Miller, A; Kalin, TV; Pressey, JG; Szabo, S; et al. Targeted Inhibition of the Dual Specificity Phosphatases DUSP1 and DUSP6 Suppress MPNST Growth via JNK. Clinical Cancer Research. 2019; 25:clincanres.3224.2018-clincanres.3224.2018.

Shukla, S; Milewski, D; Pradhan, A; Rama, N; Rice, K; Le, T; Flick, MJ; Vaz, S; Zhao, X; Setchell, KD; et al. The FOXM1 Inhibitor RCM-1 Decreases Carcinogenesis and Nuclear beta-Catenin. Molecular Cancer Therapeutics. 2019; 18:1217-1229.

Flood, HM; Bolte, C; Dasgupta, N; Sharma, A; Zhang, Y; Gandhi, CR; Kalin, TV; Kalinichenko, VV. The Forkhead box F1 transcription factor inhibits collagen deposition and accumulation of myofibroblasts during liver fibrosis. Biology Open. 2019; 8:bio039800-bio039800.

Whitsett, JA; Kalin, TV; Xu, Y; Kalinichenko, VV. BUILDING AND REGENERATING THE LUNG CELL BY CELL. Physiological Reviews. 2019; 99:513-554.

Ustiyan, V; Bolte, C; Zhang, Y; Han, L; Xu, Y; Yutzey, KE; Zorn, AM; Kalin, TV; Shannon, JM; Kalinichenko, VV. FOXF1 transcription factor promotes lung morphogenesis by inducing cellular proliferation in fetal lung mesenchyme. Developmental Biology. 2018; 443:50-63.

Black, M; Milewski, D; Le, T; Ren, X; Xu, Y; Kalinichenko, VV; Kalin, TV. FOXF1 Inhibits Pulmonary Fibrosis by Preventing CDH2-CDH11 Cadherin Switch in Myofibroblasts. Cell Reports. 2018; 23:442-458.

Bolte, C; Whitsett, JA; Kalin, TV; Kalinichenko, VV. Transcription Factors Regulating Embryonic Development of Pulmonary Vasculature. In: Parthasarathi K, Ed. MOLECULAR AND FUNCTIONAL INSIGHTS INTO THE PULMONARY VASCULATURE. : SPRINGER INTERNATIONAL PUBLISHING AG; SPRINGER INTERNATIONAL PUBLISHING AG; 2018.

Milewski, D; Balli, D; Ustiyan, V; Le, T; Dienemann, H; Warth, A; Breuhahn, K; Whitsett, JA; Kalinichenko, VV; Kalin, TV. FOXM1 activates AGR2 and causes progression of lung adenomas into invasive mucinous adenocarcinomas. PLoS Genetics. 2017; 13:e1007097-e1007097.

Bolte, C; Flood, HM; Ren, X; Jagannathan, S; Barski, A; Kalin, TV; Kalinichenko, VV. FOXF1 transcription factor promotes lung regeneration after partial pneumonectomy. Scientific Reports. 2017; 7.

Weiler, SM E; Pinna, F; Wolf, T; Lutz, T; Geldiyev, A; Sticht, C; Knaub, M; Thomann, S; Bissinger, M; Wan, S; et al. Induction of Chromosome Instability by Activation of Yes-Associated Protein and Forkhead Box M1 in Liver Cancer. Gastroenterology. 2017; 152:2037-2051.e22.

Sun, L; Ren, X; Wang, I; Pradhan, A; Zhang, Y; Flood, HM; Han, B; Whitsett, JA; Kalin, TV; Kalinichenko, VV. The FOXM1 inhibitor RCM-1 suppresses goblet cell metaplasia and prevents IL-13 and STAT6 signaling in allergen-exposed mice. Science Signaling. 2017; 10:eaai8583-eaai8583.

Milewski, D; Pradhan, A; Wang, X; Cai, Y; Le, T; Turpin, B; Kalinichenko, VV; Kalin, TV. FoxF1 and FoxF2 transcription factors synergistically promote rhabdomyosarcoma carcinogenesis by repressing transcription of p21(Cip1) CDK inhibitor. Oncogene: Including Oncogene Reviews. 2017; 36:850-862.

Fulford, L; Milewski, D; Ustiyan, V; Ravishankar, N; Cai, Y; Le, T; Masineni, S; Kasper, S; Aronow, B; Kalinichenko, VV; et al. The transcription factor FOXF1 promotes prostate cancer by stimulating the mitogen-activated protein kinase ERK5. Science Signaling. 2016; 9:ra48-ra48.

Ustiyan, V; Zhang, Y; Perl, AT; Whitsett, JA; Kalin, TV; Kalinichenko, VV. beta-Catenin and Kras/Foxm1 Signaling Pathway Are Critical to Restrict Sox9 in Basal Cells During Pulmonary Branching Morphogenesis. Developmental Dynamics. 2016; 245:590-604.

Cai, Y; Bolte, C; Le, T; Goda, C; Xu, Y; Kalin, TV; Kalinichenko, VV. FOXF1 maintains endothelial barrier function and prevents edema after lung injury. Science Signaling. 2016; 9:ra40-ra40.