Pulmonary Biology

Kalin Lab

Goda, C; Balli, D; Black, M; Milewski, D; Le, T; Ustiyan, V; Ren, X; Kalinichenko, VV; Kalin, TV. Loss of FOXM1 in macrophages promotes pulmonary fibrosis by activating p38 MAPK signaling pathway. Editor, Barsh GS. PLoS Genetics. 2020; 16:e1008692.

Shukla, S; Milewski, D; Pradhan, A; Rama, N; Rice, K; Le, T; Flick, MJ; Vaz, S; Zhao, X; Setchell, KD; et al. The FOXM1 Inhibitor RCM-1 Decreases Carcinogenesis and Nuclear β-Catenin. Molecular Cancer Therapeutics. 2019; 18:1217-1229.

Black, M; Milewski, D; Le, T; Ren, X; Xu, Y; Kalinichenko, VV; Kalin, TV. FOXF1 Inhibits Pulmonary Fibrosis by Preventing CDH2-CDH11 Cadherin Switch in Myofibroblasts. Cell Reports. 2018; 23:442-458.

Milewski, D; Balli, D; Ustiyan, V; Le, T; Dienemann, H; Warth, A; Breuhahn, K; Whitsett, JA; Kalinichenko, VV; Kalin, TV. FOXM1 activates AGR2 and causes progression of lung adenomas into invasive mucinous adenocarcinomas. Editor, Hunter KW. PLoS Genetics. 2017; 13:e1007097.

Milewski, D; Pradhan, A; Wang, X; Cai, Y; Le, T; Turpin, B; Kalinichenko, VV; Kalin, TV. FoxF1 and FoxF2 transcription factors synergistically promote rhabdomyosarcoma carcinogenesis by repressing transcription of p21Cip1 CDK inhibitor. Oncogene: Including Oncogene Reviews. 2017; 36:850-862.

Cheng, X; Black, M; Ustiyan, V; Le, T; Fulford, L; Sridharan, A; Medvedovic, M; Kalinichenko, VV; Whitsett, JA; Kalin, TV. SPDEF inhibits prostate carcinogenesis by disrupting a positive feedback loop in regulation of the Foxm1 oncogene. Editor, Horwitz MS. PLoS Genetics. 2014; 10:e1004656.

Cai, Y; Balli, D; Ustiyan, V; Fulford, L; Hiller, A; Misetic, V; Zhang, Y; Paluch, AM; Waltz, SE; Kasper, S; et al. Foxm1 expression in prostate epithelial cells is essential for prostate carcinogenesis. The Journal of biological chemistry. 2013; 288:22527-22541.

Balli, D; Ustiyan, V; Zhang, Y; Wang, I; Masino, AJ; Ren, X; Whitsett, JA; Kalinichenko, VV; Kalin, TV. Foxm1 transcription factor is required for lung fibrosis and epithelial-to-mesenchymal transition. The EMBO Journal. 2013; 32:231-244.

Balli, D; Ren, X; Chou, F; Cross, E; Zhang, Y; Kalinichenko, VV; Kalin, TV. Foxm1 transcription factor is required for macrophage migration during lung inflammation and tumor formation. Oncogene: Including Oncogene Reviews. 2012; 31:3875-3888.

Balli, D; Zhang, Y; Snyder, J; Kalinichenko, VV; Kalin, TV. Endothelial cell-specific deletion of transcription factor FoxM1 increases urethane-induced lung carcinogenesis. Cancer Research. 2011; 71:40-50.

Shukla, S; Saha, T; Rama, N; Acharya, A; Le, T; Bian, F; Donovan, J; Tan, LA; Vatner, R; Kalinichenko, V; et al. Ultra-high dose-rate proton FLASH improves tumor control. Radiotherapy and Oncology. 2023; 186:109741.

Kolesnichenko, OA; Flood, HM; Zhang, Y; Ustiyan, V; Cuervo Jimenez, HK; Kalin, TV; Kalinichenko, VV. Endothelial progenitor cells derived from embryonic stem cells prevent alveolar simplification in a murine model of bronchopulmonary dysplasia. Frontiers in Cell and Developmental Biology. 2023; 11:1209518.

Pradhan, A; Che, L; Ustiyan, V; Reza, AA; Pek, NM; Zhang, Y; Alber, AB; Kalin, TR; Wambach, JA; Gu, M; et al. Novel FOXF1-Stabilizing Compound TanFe Stimulates Lung Angiogenesis in Alveolar Capillary Dysplasia. American Journal of Respiratory and Critical Care Medicine. 2023; 207:1042-1054.

Donovan, J; Deng, Z; Bian, F; Shukla, S; Gomez-Arroyo, J; Shi, D; Kalinichenko, VV; Kalin, TV. Improving anti-tumor efficacy of low-dose Vincristine in rhabdomyosarcoma via the combination therapy with FOXM1 inhibitor RCM1. Frontiers in Oncology. 2023; 13:1112859.

Wang, G; Wen, B; Deng, Z; Zhang, Y; Kolesnichenko, OA; Ustiyan, V; Pradhan, A; Kalin, TV; Kalinichenko, VV. Endothelial progenitor cells stimulate neonatal lung angiogenesis through FOXF1-mediated activation of BMP9/ACVRL1 signaling. Nature Communications. 2022; 13:2080.

Wen, B; Wang, G; Li, E; Kolesnichenko, OA; Tu, Z; Divanovic, S; Kalin, TV; Kalinichenko, VV. In vivo generation of bone marrow from embryonic stem cells in interspecies chimeras. eLife. 2022; 11:e74018.

Ribeiro, R; Macedo, JC; Costa, M; Ustiyan, V; Shindyapina, AV; Tyshkovskiy, A; Gomes, RN; Castro, JP; Kalin, TV; Vasques-Nóvoa, F; et al. In vivo cyclic induction of the FOXM1 transcription factor delays natural and progeroid aging phenotypes and extends healthspan. 2022; 2:397-411.

Sun, X; Perl, AK; Li, R; Bell, SM; Sajti, E; Kalinichenko, VV; Kalin, TV; Misra, RS; Deshmukh, H; Clair, G; et al. A census of the lung: CellCards from LungMAP. Developmental Cell. 2022; 57:112-145.e2.

Kalinichenko, VV; Bolte, CS; Kalin, TV. Transcription Factors: Forkhead Box (FOX) ☆. Encyclopedia of Respiratory Medicine. : Elsevier; Elsevier; 2022.

Kolesnichenko, OA; Whitsett, JA; Kalin, TV; Kalinichenko, VV. Therapeutic Potential of Endothelial Progenitor Cells in Pulmonary Diseases. American Journal of Respiratory Cell and Molecular Biology. 2021; 65:473-488.

Deng, Z; Lin, J; Bud’ko, SL; Webster, B; Kalin, TV; Kalinichenko, VV; Shi, D. Dual Targeting with Cell Surface Electrical Charge and Folic Acid via Superparamagnetic Fe3O4@Cu2-xS for Photothermal Cancer Cell Killing. Cancers. 2021; 13:5275.

Sun, F; Wang, G; Pradhan, A; Xu, K; Gomez-Arroyo, J; Zhang, Y; Kalin, GT; Deng, Z; Vagnozzi, RJ; He, H; et al. Nanoparticle Delivery of STAT3 Alleviates Pulmonary Hypertension in a Mouse Model of Alveolar Capillary Dysplasia. Circulation. 2021; 144:539-555.

Wang, G; Wen, B; Ren, X; Li, E; Zhang, Y; Guo, M; Xu, Y; Whitsett, JA; Kalin, TV; Kalinichenko, VV. Generation of Pulmonary Endothelial Progenitor Cells for Cell-based Therapy Using Interspecies Mouse-Rat Chimeras. American Journal of Respiratory and Critical Care Medicine. 2021; 204:326-338.

Li, E; Ustiyan, V; Wen, B; Kalin, GT; Whitsett, JA; Kalin, TV; Kalinichenko, VV. Blastocyst complementation reveals that NKX2-1 establishes the proximal-peripheral boundary of the airway epithelium. Developmental Dynamics. 2021; 250:1001-1020.

Wang, Y; Pandey, RN; Roychoudhury, K; Milewski, D; Kalin, TV; Szabo, S; Pressey, JG; Hegde, RS. Targeting EYA3 in Ewing Sarcoma Retards Tumor Growth and Angiogenesis. Molecular Cancer Therapeutics. 2021; 20:803-815.

Milewski, D; Shukla, S; Gryder, BE; Pradhan, A; Donovan, J; Sudha, P; Vallabh, S; Pyros, A; Xu, Y; Barski, A; et al. FOXF1 is required for the oncogenic properties of PAX3-FOXO1 in rhabdomyosarcoma. Oncogene: Including Oncogene Reviews. 2021; 40:2182-2199.

Wen, B; Li, E; Ustiyan, V; Wang, G; Guo, M; Na, CL; Kalin, GT; Galvan, V; Xu, Y; Weaver, TE; et al. In Vivo Generation of Lung and Thyroid Tissues from Embryonic Stem Cells Using Blastocyst Complementation. American Journal of Respiratory and Critical Care Medicine. 2021; 203:471-483.

Pradhan, A; Kalin, TV; Kalinichenko, VV. Genome Editing for Rare Diseases. Current stem cell reports. 2020; 6:41-51.

Bolte, C; Ustiyan, V; Ren, X; Dunn, AW; Pradhan, A; Wang, G; Kolesnichenko, OA; Deng, Z; Zhang, Y; Shi, D; et al. Nanoparticle Delivery of Proangiogenic Transcription Factors into the Neonatal Circulation Inhibits Alveolar Simplification Caused by Hyperoxia. American Journal of Respiratory and Critical Care Medicine. 2020; 202:100-111.

Black, M; Arumugam, P; Shukla, S; Pradhan, A; Ustiyan, V; Milewski, D; Kalinichenko, VV; Kalin, TV. FOXM1 nuclear transcription factor translocates into mitochondria and inhibits oxidative phosphorylation. Editor, Fox T. Molecular Biology of the Cell. 2020; 31:1411-1424.

Goda, C; Balli, D; Black, M; Milewski, D; Le, T; Ustiyan, V; Ren, X; Kalinichenko, VV; Kalin, TV. Loss of FOXM1 in macrophages promotes pulmonary fibrosis by activating p38 MAPK signaling pathway. Editor, Barsh GS. PLoS Genetics. 2020; 16:e1008692.

Bolte, C; Kalin, TV; Kalinichenko, VV. Molecular, cellular, and bioengineering approaches to stimulate lung regeneration after injury. Seminars in Cell and Developmental Biology. 2020; 100:101-108.

Gasilina, A; Premnauth, G; Gurjar, P; Biesiada, J; Hegde, S; Milewski, D; Ma, G; Kalin, TV; Merino, E; Meller, J; et al. IODVA1, a guanidinobenzimidazole derivative, targets Rac activity and Ras-driven cancer models. Editor, Lebedeva IV. PloS one. 2020; 15:e0229801.

Ren, X; Ustiyan, V; Guo, M; Wang, G; Bolte, C; Zhang, Y; Xu, Y; Whitsett, JA; Kalin, TV; Kalinichenko, VV. Postnatal Alveologenesis Depends on FOXF1 Signaling in c-KIT+ Endothelial Progenitor Cells. American Journal of Respiratory and Critical Care Medicine. 2019; 200:1164-1176.

Pradhan, A; Dunn, A; Ustiyan, V; Bolte, C; Wang, G; Whitsett, JA; Zhang, Y; Porollo, A; Hu, Y; Xiao, R; et al. The S52F FOXF1 Mutation Inhibits STAT3 Signaling and Causes Alveolar Capillary Dysplasia. American Journal of Respiratory and Critical Care Medicine. 2019; 200:1045-1056.

Shukla, S; Milewski, D; Pradhan, A; Rama, N; Rice, K; Le, T; Flick, MJ; Vaz, S; Zhao, X; Setchell, KD; et al. The FOXM1 Inhibitor RCM-1 Decreases Carcinogenesis and Nuclear β-Catenin. Molecular Cancer Therapeutics. 2019; 18:1217-1229.

Ramkissoon, A; Chaney, KE; Milewski, D; Williams, KB; Williams, RL; Choi, K; Miller, A; Kalin, TV; Pressey, JG; Szabo, S; et al. Targeted Inhibition of the Dual Specificity Phosphatases DUSP1 and DUSP6 Suppress MPNST Growth via JNK. Clinical Cancer Research. 2019; 25:4117-4127.

Flood, HM; Bolte, C; Dasgupta, N; Sharma, A; Zhang, Y; Gandhi, CR; Kalin, TV; Kalinichenko, VV. The Forkhead box F1 transcription factor inhibits collagen deposition and accumulation of myofibroblasts during liver fibrosis. Biology Open. 2019; 8:bio039800.

Whitsett, JA; Kalin, TV; Xu, Y; Kalinichenko, VV. Building and Regenerating the Lung Cell by Cell. Physiological Reviews. 2019; 99:513-554.