Projects
Lab Projects (4)
Fibroblast Thursday
Fibroblasts: it’s complicated. These shape-shifting, matrix-meddling cells are central to development, disease, and everything in between—and they’re not giving up their secrets easily. As a fibroblast expert, I host Fibroblast Thursday—a monthly deep-dive (every third Thursday) where we untangle the messy truths of fibroblast biology.
Alveolar Regeneration
We study restoration of lunch architecture in neonatal and adult lung injury. Our goal is to understand a reverse alveolar simplification in newer forms of Bronchopulmonary dysplasia (BPD), a central challenge in neonatal lung disease.
Pioneering Tet-Inducible Gene Control and Lineage Tracing in the Lung
Our early work on embryonic lung development laid the groundwork for the use of tetracycline-inducible systems to manipulate gene activation, deletion, and lineage tracing specifically in the lung epithelium.
Bronchiolar Injury Repair
We investigate mechanisms of airway remodeling in chronic lung disease. Airway wall thickening and epithelial injury are key features of small airway diseases. Given limited effectiveness of current treatments for COPD and BOS, we look to better understand the mechanisms driving epithelial loss and peribronchiolar fibrosis.
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