Perl Lab

Perl Lab

Riccetti, MR; Green, J; Taylor, TJ; Perl, A-KT. Prenatal FGFR2 Signaling via PI3K/AKT Specifies the PDGFRA+ Myofibroblast. American Journal of Respiratory Cell and Molecular Biology. 2024; 70(1):63-77.

Riccetti, MR; Ushakumary, MG; Waltamath, M; Green, J; Snowball, J; Dautel, SE; Endale, M; Lami, B; Woods, J; Ahlfeld, SK; Perl, A-KT. Maladaptive functional changes in alveolar fibroblasts due to perinatal hyperoxia impair epithelial differentiation. JCI Insight. 2022; 7(5).

Sun, X; Perl, A-K; Li, R; Bell, SM; Sajti, E; Kalinichenko, VV; Kalin, TV; Misra, RS; Deshmukh, H; Clair, G; Xu, Y; Pryhuber, G; Whitsett, J; Morrisey, EE. A census of the lung: CellCards from LungMAP. Developmental Cell. 2022; 57(1):112-145.e2.

Ushakumary, MG; Riccetti, M; Perl, A-KT. Resident interstitial lung fibroblasts and their role in alveolar stem cell niche development, homeostasis, injury, and regeneration. Stem Cells Translational Medicine. 2021; 10(7):1021-1032.

Gokey, JJ; Snowball, J; Green, J; Waltamath, M; Spinney, JJ; Black, KE; Hariri, LP; Xu, Y; Perl, AK. Pretreatment of aged mice with retinoic acid supports alveolar regeneration via upregulation of reciprocal PDGFA signalling. Thorax. 2021; 76(5):456-467.

Riccetti, M; Gokey, JJ; Aronow, B; Perl, A-KT. The elephant in the lung: Integrating lineage-tracing, molecular markers, and single cell sequencing data to identify distinct fibroblast populations during lung development and regeneration. Matrix Biology. 2020; 91-92:51-74.

Guo, M; Du, Y; Gokey, JJ; Ray, S; Bell, SM; Adam, M; Sudha, P; Perl, AK; Deshmukh, H; Potter, SS; Whitsett, JA; Xu, Y. Single cell RNA analysis identifies cellular heterogeneity and adaptive responses of the lung at birth. Nature Communications. 2019; 10(1):37.

Endale, M; Ahlfeld, S; Bao, E; Chen, X; Green, J; Bess, Z; Weirauch, MT; Xu, Y; Perl, AK. Temporal, spatial, and phenotypical changes of PDGFRα expressing fibroblasts during late lung development. Developmental Biology. 2017; 425(2):161-175.

Xu, Y; Mizuno, T; Sridharan, A; Du, Y; Guo, M; Tang, J; Wikenheiser-Brokamp, KA; Perl, A-KT; Funari, VA; Gokey, JJ; Stripp, BR; Whitsett, JA. Single-cell RNA sequencing identifies diverse roles of epithelial cells in idiopathic pulmonary fibrosis. JCI Insight. 2016; 1(20):e90558.

Green, J; Endale, M; Auer, H; Perl, A-KT. Diversity of Interstitial Lung Fibroblasts Is Regulated by Platelet-Derived Growth Factor Receptor α Kinase Activity. American Journal of Respiratory Cell and Molecular Biology. 2016; 54(4):532-545.

Chen, L; Acciani, T; Le Cras, T; Lutzko, C; Perl, A-KT. Dynamic regulation of platelet-derived growth factor receptor α expression in alveolar fibroblasts during realveolarization. American Journal of Respiratory Cell and Molecular Biology. 2012; 47(4):517-527.

Rawlins, EL; Perl, A-K. The a"MAZE"ing world of lung-specific transgenic mice. American Journal of Respiratory Cell and Molecular Biology. 2012; 46(3):269-282.

Perl, A-KT; Gale, E. FGF signaling is required for myofibroblast differentiation during alveolar regeneration. American Journal of Physiology - Lung Cellular and Molecular Physiology. 2009; 297(2):L299-L308.

Perl, A-KT; Wert, SE; Loudy, DE; Shan, Z; Blair, PA; Whitsett, JA. Conditional recombination reveals distinct subsets of epithelial cells in trachea, bronchi, and alveoli. American Journal of Respiratory Cell and Molecular Biology. 2005; 33(5):455-462.

Hokuto, I; Perl, A-KT; Whitsett, JA. Prenatal, but not postnatal, inhibition of fibroblast growth factor receptor signaling causes emphysema. Journal of Biological Chemistry. 2003; 278(1):415-421.

Perl, A-KT; Wert, SE; Nagy, A; Lobe, CG; Whitsett, JA. Early restriction of peripheral and proximal cell lineages during formation of the lung. Proceedings of the National Academy of Sciences of the United States of America. 2002; 99(16):10482-10487.

Perl, AK; Dahl, U; Wilgenbus, P; Cremer, H; Semb, H; Christofori, G. Reduced expression of neural cell adhesion molecule induces metastatic dissemination of pancreatic beta tumor cells. Nature Medicine. 1999; 5(3):286-291.

Perl, AK; Wilgenbus, P; Dahl, U; Semb, H; Christofori, G. A causal role for E-cadherin in the transition from adenoma to carcinoma. Nature. 1998; 392(6672):190-193.