Perl Lab
Perl Lab


Du, Y; Guo, M; Wu, Y; Wagner, A; Perl, AK; Wikenheiser-Brokamp, K; Yu, J; Gupta, N; Kopras, E; Krymskaya, V; et al. Lymphangioleiomyomatosis (LAM) Cell Atlas. Thorax. 2023; 78:85-87.

Riccetti, MR; Ushakumary, MG; Waltamath, M; Green, J; Snowball, J; Dautel, SE; Endale, M; Lami, B; Woods, J; Ahlfeld, SK; et al. Maladaptive functional changes in alveolar fibroblasts due to perinatal hyperoxia impair epithelial differentiation. JCI insight. 2022; 7:e152404.

Teitz-Tennenbaum, S; Viglianti, SP; Jomma, A; Palone, Q; Andrews, H; Selbmann, KN; Lahiri, S; Subbotina, N; Walker, N; Perl, AK T; et al. Sustained Club Cell Injury in Mice Induces Histopathologic Features of Deployment-Related Constrictive Bronchiolitis. The American journal of pathology. 2022; 192:410-425.

Sun, X; Perl, AK; Li, R; Bell, SM; Sajti, E; Kalinichenko, VV; Kalin, TV; Misra, RS; Deshmukh, H; Clair, G; et al. A census of the lung: CellCards from LungMAP. Developmental Cell. 2022; 57:112-145.e2.

Tisdale-Macioce, N; Green, J; Perl, AK T; Ashbaugh, A; Wiederhold, NP; Patterson, TF; Cushion, MT. The Promise of Lung Organoids for Growth and Investigation of Pneumocystis Species. Frontiers in Fungal Biology. 2021; 2:740845.

Sitaraman, S; Martin, EP; Na, CL; Zhao, S; Green, J; Deshmukh, H; Perl, AK T; Bridges, JP; Xu, Y; Weaver, TE. Surfactant protein C mutation links postnatal type 2 cell dysfunction to adult disease. JCI insight. 2021; 6:e142501.

Ushakumary, MG; Riccetti, M; Perl, AK T. Resident interstitial lung fibroblasts and their role in alveolar stem cell niche development, homeostasis, injury, and regeneration. Stem cells translational medicine. 2021; 10:1021-1032.

Gokey, JJ; Snowball, J; Green, J; Waltamath, M; Spinney, JJ; Black, KE; Hariri, LP; Xu, Y; Perl, AK. Pretreatment of aged mice with retinoic acid supports alveolar regeneration via upregulation of reciprocal PDGFA signalling. Thorax. 2021; 76:456-467.

Guo, M; Yu, JJ; Perl, AK; Wikenheiser-Brokamp, KA; Riccetti, M; Zhang, EY; Sudha, P; Adam, M; Potter, A; Kopras, EJ; et al. Single-Cell Transcriptomic Analysis Identifies a Unique Pulmonary Lymphangioleiomyomatosis Cell. American Journal of Respiratory and Critical Care Medicine. 2020; 202:1373-1387.

Riccetti, M; Gokey, JJ; Aronow, B; Perl, AT. The elephant in the lung: Integrating lineage-tracing, molecular markers, and single cell sequencing data to identify distinct fibroblast populations during lung development and regeneration. Matrix Biology. 2020; 91-92:51-74.

Guo, M; Du, Y; Gokey, JJ; Ray, S; Bell, SM; Adam, M; Sudha, P; Perl, AK; Deshmukh, H; Potter, SS; et al. Single cell RNA analysis identifies cellular heterogeneity and adaptive responses of the lung at birth. Nature Communications. 2019; 10:37.

Liu, Z; Liao, F; Scozzi, D; Furuya, Y; Pugh, KN; Hachem, R; Chen, DL; Cano, M; Green, JM; Krupnick, AS; et al. An obligatory role for club cells in preventing obliterative bronchiolitis in lung transplants. JCI insight. 2019; 5:124732.


ARC_Biomarkers for BPD (Woods)

Processing human bronchiolar lavage and tracheal aspirates for long term biorepository storage and perform molecular assays to phenotype cells in these samples.


ARC_Translational fibrosis research (Heart Institute)

Processing human fibrosis tissue for the biobank and investigating a drug in our murine Bronchiolitis obliterans model.


LAM Foundation Patient Benefit Grant


Identification and validation of new biomarkers based on single cell RNAseq.


LAM Foundation Established Investigator Grant


LAM cells reprogram the epithelial-mesenchymal crosstalk in the alveolar niche.


R01 HL 131661-01A1 (Perl)


Interstitial resident fibroblasts direct alveolar epithelial differentiation


U01 HL 122642 (Whitsett/Potter)

06/15/2014 – 04/30/2019



U01 HL 134745 (Whitsett/Kotton/Morrisey)

09/23/16 – 9/22/23

Editing alveolar progenitor cells for correction of monogenic disease