Perl Lab

Perl Lab

Riccetti, MR; Green, J; Taylor, TJ; Perl, AK T. Prenatal FGFR2 Signaling via PI3K/AKT Specifies the PDGFRA+ Myofibroblast. American Journal of Respiratory Cell and Molecular Biology. 2024; 70:63-77.

Riccetti, MR; Ushakumary, MG; Waltamath, M; Green, J; Snowball, J; Dautel, SE; Endale, M; Lami, B; Woods, J; Ahlfeld, SK; Perl, AK T. Maladaptive functional changes in alveolar fibroblasts due to perinatal hyperoxia impair epithelial differentiation. JCI insight. 2022; 7:e152404.

Sun, X; Perl, AK; Li, R; Bell, SM; Sajti, E; Kalinichenko, VV; Kalin, TV; Misra, RS; Deshmukh, H; Clair, G; Xu, Y; Pryhuber, G; Whitsett, J; Morrisey, EE. A census of the lung: CellCards from LungMAP. Developmental Cell. 2022; 57:112-145.e2.

Ushakumary, MG; Riccetti, M; Perl, AK T. Resident interstitial lung fibroblasts and their role in alveolar stem cell niche development, homeostasis, injury, and regeneration. Stem cells translational medicine. 2021; 10:1021-1032.

Gokey, JJ; Snowball, J; Green, J; Waltamath, M; Spinney, JJ; Black, KE; Hariri, LP; Xu, Y; Perl, AK. Pretreatment of aged mice with retinoic acid supports alveolar regeneration via upregulation of reciprocal PDGFA signalling. Thorax. 2021; 76:456-467.

Riccetti, M; Gokey, JJ; Aronow, B; Perl, AT. The elephant in the lung: Integrating lineage-tracing, molecular markers, and single cell sequencing data to identify distinct fibroblast populations during lung development and regeneration. Matrix Biology. 2020; 91-92:51-74.

Guo, M; Du, Y; Gokey, JJ; Ray, S; Bell, SM; Adam, M; Sudha, P; Perl, AK; Deshmukh, H; Potter, SS; Whitsett, JA; Xu, Y. Single cell RNA analysis identifies cellular heterogeneity and adaptive responses of the lung at birth. Nature Communications. 2019; 10:37.

Endale, M; Ahlfeld, S; Bao, E; Chen, X; Green, J; Bess, Z; Weirauch, MT; Xu, Y; Perl, AK. Temporal, spatial, and phenotypical changes of PDGFRα expressing fibroblasts during late lung development. Developmental Biology. 2017; 425:161-175.

Xu, Y; Mizuno, T; Sridharan, A; Du, Y; Guo, M; Tang, J; Wikenheiser-Brokamp, KA; Perl, AT; Funari, VA; Gokey, JJ; Stripp, BR; Whitsett, JA. Single-cell RNA sequencing identifies diverse roles of epithelial cells in idiopathic pulmonary fibrosis. JCI insight. 2016; 1:e90558.

Green, J; Endale, M; Auer, H; Perl, AK T. Diversity of Interstitial Lung Fibroblasts Is Regulated by Platelet-Derived Growth Factor Receptor α Kinase Activity. American Journal of Respiratory Cell and Molecular Biology. 2016; 54:532-545.

Chen, L; Acciani, T; Le Cras, T; Lutzko, C; Perl, AT. Dynamic regulation of platelet-derived growth factor receptor α expression in alveolar fibroblasts during realveolarization. American Journal of Respiratory Cell and Molecular Biology. 2012; 47:517-527.

Rawlins, EL; Perl, A. The a "MAZE "ing world of lung-specific transgenic mice. American Journal of Respiratory Cell and Molecular Biology. 2012; 46:269-282.

Perl, AK T; Gale, E. FGF signaling is required for myofibroblast differentiation during alveolar regeneration. American Journal of Physiology: Lung Cellular and Molecular Physiology. 2009; 297:L299-L308.

Perl, AK T; Wert, SE; Loudy, DE; Shan, Z; Blair, PA; Whitsett, JA. Conditional recombination reveals distinct subsets of epithelial cells in trachea, bronchi, and alveoli. American Journal of Respiratory Cell and Molecular Biology. 2005; 33:455-462.

Hokuto, I; Perl, AK T; Whitsett, JA. Prenatal, but not postnatal, inhibition of fibroblast growth factor receptor signaling causes emphysema. The Journal of biological chemistry. 2003; 278:415-421.

Perl, AK T; Wert, SE; Nagy, A; Lobe, CG; Whitsett, JA. Early restriction of peripheral and proximal cell lineages during formation of the lung. Proceedings of the National Academy of Sciences of USA. 2002; 99:10482-10487.

Perl, AK; Dahl, U; Wilgenbus, P; Cremer, H; Semb, H; Christofori, G. Reduced expression of neural cell adhesion molecule induces metastatic dissemination of pancreatic beta tumor cells. Nature Medicine. 1999; 5:286-291.

Perl, AK; Wilgenbus, P; Dahl, U; Semb, H; Christofori, G. A causal role for E-cadherin in the transition from adenoma to carcinoma. Nature. 1998; 392:190-193.

Rudman-Melnick, V; Vanhoutte, D; Stowers, K; Sargent, M; Adam, M; Ma, Q; Perl, AK T; Miethke, AG; Burg, A; Shi, T; Hildeman, DA; Woodle, ES S; Kofron, JM; Devarajan, P. Gucy1α1 specifically marks kidney, heart, lung and liver fibroblasts. Scientific Reports. 2024; 14:29307.

Riccetti, MR; Green, J; Taylor, TJ; Perl, AK T. Prenatal FGFR2 Signaling via PI3K/AKT Specifies the PDGFRA+ Myofibroblast. American Journal of Respiratory Cell and Molecular Biology. 2024; 70:63-77.

Trempus, CS; Papas, BN; Sifre, MI; Bortner, CD; Scappini, E; Tucker, CJ; Xu, X; Johnson, KL; Deterding, LJ; Williams, JG; Pommerolle, L; Cinar, R; Perl, AK; Garantziotis, S. Functional Pdgfra fibroblast heterogeneity in normal and fibrotic mouse lung. JCI insight. 2023; 8:e164380.

Du, Y; Guo, M; Wu, Y; Wagner, A; Perl, AK; Wikenheiser-Brokamp, K; Yu, J; Gupta, N; Kopras, E; Krymskaya, V; Kwiatkowski, D; Henske, EP; McCormack, F; Xu, Y. Lymphangioleiomyomatosis (LAM) Cell Atlas. Thorax. 2023; 78:85-87.

Riccetti, MR; Ushakumary, MG; Waltamath, M; Green, J; Snowball, J; Dautel, SE; Endale, M; Lami, B; Woods, J; Ahlfeld, SK; Perl, AK T. Maladaptive functional changes in alveolar fibroblasts due to perinatal hyperoxia impair epithelial differentiation. JCI insight. 2022; 7:e152404.

Teitz-Tennenbaum, S; Viglianti, SP; Jomma, A; Palone, Q; Andrews, H; Selbmann, KN; Lahiri, S; Subbotina, N; Walker, N; Perl, AK T; Lama, VN; Sisson, TH; Osterholzer, JJ. Sustained Club Cell Injury in Mice Induces Histopathologic Features of Deployment-Related Constrictive Bronchiolitis. The American journal of pathology. 2022; 192:410-425.

Sun, X; Perl, AK; Li, R; Bell, SM; Sajti, E; Kalinichenko, VV; Kalin, TV; Misra, RS; Deshmukh, H; Clair, G; Xu, Y; Pryhuber, G; Whitsett, J; Morrisey, EE. A census of the lung: CellCards from LungMAP. Developmental Cell. 2022; 57:112-145.e2.

Tisdale-Macioce, N; Green, J; Perl, AK T; Ashbaugh, A; Wiederhold, NP; Patterson, TF; Cushion, MT. The Promise of Lung Organoids for Growth and Investigation of Pneumocystis Species. Frontiers in Fungal Biology. 2021; 2:740845.

Sitaraman, S; Martin, EP; Na, CL; Zhao, S; Green, J; Deshmukh, H; Perl, AK T; Bridges, JP; Xu, Y; Weaver, TE. Surfactant protein C mutation links postnatal type 2 cell dysfunction to adult disease. JCI insight. 2021; 6:e142501.

Ushakumary, MG; Riccetti, M; Perl, AK T. Resident interstitial lung fibroblasts and their role in alveolar stem cell niche development, homeostasis, injury, and regeneration. Stem cells translational medicine. 2021; 10:1021-1032.

Gokey, JJ; Snowball, J; Green, J; Waltamath, M; Spinney, JJ; Black, KE; Hariri, LP; Xu, Y; Perl, AK. Pretreatment of aged mice with retinoic acid supports alveolar regeneration via upregulation of reciprocal PDGFA signalling. Thorax. 2021; 76:456-467.

Guo, M; Yu, JJ; Perl, AK; Wikenheiser-Brokamp, KA; Riccetti, M; Zhang, EY; Sudha, P; Adam, M; Potter, A; Kopras, EJ; Kwiatkowski, DJ; Whitsett, JA; McCormack, FX; Xu, Y. Single-Cell Transcriptomic Analysis Identifies a Unique Pulmonary Lymphangioleiomyomatosis Cell. American Journal of Respiratory and Critical Care Medicine. 2020; 202:1373-1387.

Riccetti, M; Gokey, JJ; Aronow, B; Perl, AT. The elephant in the lung: Integrating lineage-tracing, molecular markers, and single cell sequencing data to identify distinct fibroblast populations during lung development and regeneration. Matrix Biology. 2020; 91-92:51-74.