Publications

Du, Y; Guo, M; Wu, Y; Wagner, A; Perl, AK; Wikenheiser-Brokamp, K; Yu, J; Gupta, N; Kopras, E; Krymskaya, V; et al. Lymphangioleiomyomatosis (LAM) Cell Atlas. Thorax. 2022.

Riccetti, MR; Ushakumary, MG; Waltamath, M; Green, J; Snowball, J; Dautel, SE; Endale, M; Lami, B; Woods, J; Ahlfeld, SK; et al. Maladaptive functional changes in alveolar fibroblasts due to perinatal hyperoxia impair epithelial differentiation. JCI insight. 2022; 7.

Teitz-Tennenbaum, S; Viglianti, SP; Jomma, A; Palone, Q; Andrews, H; Selbmann, KN; Lahiri, S; Subbotina, N; Walker, N; Perl, AK T; et al. Sustained Club Cell Injury in Mice Induces Histopathologic Features of Deployment-Related Constrictive Bronchiolitis. American Journal of Pathology. 2022; 192:410-425.

Sun, X; Perl, AK; Li, R; Bell, SM; Sajti, E; Kalinichenko, VV; Kalin, TV; Misra, RS; Deshmukh, H; Clair, G; et al. A census of the lung: CellCards from LungMAP. Developmental Cell. 2022; 57:112-145.e2.

Sitaraman, S; Martin, EP; Na, CL; Zhao, S; Green, J; Deshmukh, H; Perl, AK T; Bridges, JP; Xu, Y; Weaver, TE. Surfactant protein C mutation links postnatal type 2 cell dysfunction to adult disease. JCI insight. 2021; 6.

Ushakumary, MG; Riccetti, M; Perl, AK T. Resident interstitial lung fibroblasts and their role in alveolar stem cell niche development, homeostasis, injury, and regeneration. Stem cells translational medicine. 2021; 10:1021-1032.

Gokey, JJ; Snowball, J; Green, J; Waltamath, M; Spinney, JJ; Black, KE; Hariri, LP; Xu, Y; Perl, AK. Pretreatment of aged mice with retinoic acid supports alveolar regeneration via upregulation of reciprocal PDGFA signalling. Thorax. 2021; 76:456-467.

Guo, M; Yu, JJ; Perl, AK; Wikenheiser-Brokamp, KA; Riccetti, M; Zhang, EY; Sudha, P; Adam, M; Potter, A; Kopras, EJ; et al. Single-Cell Transcriptomic Analysis Identifies a Unique Pulmonary Lymphangioleiomyomatosis Cell. American Journal of Respiratory and Critical Care Medicine. 2020; 202:1373-1387.

Riccetti, M; Gokey, JJ; Aronow, B; Perl, AT. The elephant in the lung: Integrating lineage-tracing, molecular markers, and single cell sequencing data to identify distinct fibroblast populations during lung development and regeneration. Matrix Biology. 2020; 91-92:51-74.

Guo, M; Du, Y; Gokey, JJ; Ray, S; Bell, SM; Adam, M; Sudha, P; Perl, AK; Deshmukh, H; Potter, SS; et al. Single cell RNA analysis identifies cellular heterogeneity and adaptive responses of the lung at birth. Nature Communications. 2019; 10.

Liu, Z; Liao, F; Scozzi, D; Furuya, Y; Pugh, KN; Hachem, R; Chen, DL; Cano, M; Green, JM; Krupnick, AS; et al. An obligatory role for club cells in preventing obliterative bronchiolitis in lung transplants. JCI insight. 2019; 5.

Gokey, JJ; Snowball, J; Sridharan, A; Speth, JP; Black, KE; Hariri, LP; Perl, AT; Xu, Y; Whitsett, JA. MEG3 is increased in idiopathic pulmonary fibrosis and regulates epithelial cell differentiation. JCI insight. 2018; 3.

Gokey, JJ; Sridharan, A; Xu, Y; Green, J; Carraro, G; Stripp, BR; Perl, AT; Whitsett, JA. Active epithelial Hippo signaling in idiopathic pulmonary fibrosis. JCI insight. 2018; 3.

Grants

ARC_Biomarkers for BPD (Woods)

Processing human bronchiolar lavage and tracheal aspirates for long term biorepository storage and perform molecular assays to phenotype cells in these samples.

 

ARC_Translational fibrosis research (Heart Institute)

Processing human fibrosis tissue for the biobank and investigating a drug in our murine Bronchiolitis obliterans model.

 

LAM Foundation Patient Benefit Grant

09/01/2018-08/31/2020

Identification and validation of new biomarkers based on single cell RNAseq.

 

LAM Foundation Established Investigator Grant

03/01/2019-02/28/2021

LAM cells reprogram the epithelial-mesenchymal crosstalk in the alveolar niche.

 

R01 HL 131661-01A1 (Perl)

09/01/2016-08/31/2021

Interstitial resident fibroblasts direct alveolar epithelial differentiation

 

U01 HL 122642 (Whitsett/Potter)

06/15/2014 – 04/30/2019

LungMAP

 

U01 HL 134745 (Whitsett/Kotton/Morrisey)

09/23/16 – 9/22/23

Editing alveolar progenitor cells for correction of monogenic disease