Understanding the Role of Fibroblasts in Lung Development, Injury, and Regeneration
Bronchopulmonary dysplasia (BPD) is a common and serious complication of preterm birth that disrupts normal lung development and repair. Our lab is dedicated to understanding the role of fibroblasts in lung development, injury, and regeneration. We investigate how signaling pathways guide fibroblast interactions with epithelial and endothelial cells, as well as the extracellular matrix, to shape tissue architecture and function.
Recently, we have focused on the transcriptional regulation of fibroblast specification and identity. To dissect these complex cellular networks, we integrate high-resolution imaging, transcriptomic and proteomic profiling, and advanced data analysis to build a systems-level understanding of fibroblast behavior in both health and disease.
