Our research focuses on alveolar fibroblasts during septation and bronchiolar fibrosis after epithelial injury. Our projects strive to understand the cellular and molecular mechanisms related to the pathology of lung diseases, like bronchopulmonary dysplasia (BPD), emphysema, chronic obstructive pulmonary disease (COPD) and bronchiolitis obliterans (BOS). We use state of the art transgenic mouse models to provide novel and innovative tools to enable studies of complex molecular pathways and lineage relationships, in lung development and diseases. Jenna Green established immunofluorescence staining protocols for adult mouse lung that allow 3d high resolution confocal imaging. Our histological approach is complemented by sophisticated flow cytometry to identify subpopulations of pulmonary fibroblasts, which was established by Leiling Chen, PhD. We have two major focuses in the lab:
Read about our work to find out what cellular and molecular mechanisms are important to regrow lung.