Pulmonary Medicine
Hardie Lab

Hardie Research Lab

The focus of the Hardie Research Lab is to further understand the biology of lung remodeling, specifically pulmonary fibrosis. Pulmonary fibrosis is a complication found in a number of adult and pediatric diseases and is a significant contributor to morbidity and mortality worldwide. Currently there are no approved medical therapies to inhibit progression or reverse established pulmonary fibrosis emphasizing the important need to develop effective therapeutic approaches.

The long-term goal of the laboratory is to identify molecular and biologic mechanisms mediating pulmonary fibrotic processes that can be pharmacologically or genetically targeted to inhibit progression and reverse ongoing lung fibrosis in human diseases. To accomplish these goals the laboratory utilizes advanced methods in cellular biology including cell culture and preclinical models of progressive lung fibrosis.

About the PI

A photo of William D. Hardie.

William Hardie, MD

My colleagues and I seek to identify the proteins and cellular pathways associated with this disorder and explore potential novel treatments. We are currently focused on a rare lung fibrosis condition called pleuroparenchymal fibroelastosis which can afflict both children and adults.

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