The Satish Madala Research Laboratory works to identify the cellular and molecular mechanisms involved the initiation, maintenance, and progression of pulmonary fibrosis. Pulmonary inflammation and fibrosis disrupts gas exchange in the tiny air sacs of the lungs and is the leading cause of morbidity and mortality for many respiratory diseases. Nevertheless, despite its enormous impact on human health, there currently are no approved treatments that directly target the mechanism(s) of fibrosis.
We study hematopoietic and non-hematopoietic stromal cell interactions using molecular, biochemical and immunology tools to identify novel therapeutic targets in chronic lung diseases such as idiopathic pulmonary fibrosis (IPF) and systemic sclerosis (SSc), and cystic fibrosis (CF). We use both in vitro and in vivo models to test the mechanisms involved in pulmonary inflammation and fibrosis.
Our recent studies have helped to define unique functions of fibrocytes and their heterogeneous interactions with other lung stromal cells in causing the expansion of adventitial and pleural fibrotic lesions in the lung. Research trainees of my lab will have opportunity to use several advanced methods in biochemistry and immunology to investigate the mechanisms of pulmonary inflammation and fibrosis.