Early Pregnancy Events (Implantation, Decidualization, and Placentation)
Regulated cellular changes occur in the uterus during early pregnancy to facilitate the development of embryos.
Using genetically modified mouse models and uterine cell lines in vitro, the Dey and Sun labs investigate signaling pathways critical to establish a receptive uterine environment to accommodate implanting embryos and facilitate normal placentation.
Three-dimensional (3D) visualization of the whole uterus during early pregnancy helps us to reveal the fetal-maternal interaction in an unprecedented way. Using established normal and engineered trophoblast stem cells, we study molecular mechanisms that underlie processes ranging from trophoblast differentiation to invasion. These models are utilized to better understand human pregnancy.