Genetic Mutations and Patient Outcomes
Our goal is to determine the link between different genetic mutations causing PFIC (genotypes) and patient outcomes. To do this, we are investigating the mechanisms by which the known genetic mutations cause cholestasis. By following up with our patients year-over-year, we are able to assess their prognosis with and without liver transplantation.
In addition to this, we study the risk of developing liver cancer and extrahepatic manifestations in patients with different genetic mutations.
Associated Research Labs