People with primary immune deficiencies
have a reduced ability to resist or rid themselves of infectious diseases because their immune system is either absent or only partially functional due to a hereditary or genetic defect. This deficiency can be in one or more of the parts of the body’s immune system such as in primary T cell deficiency (combined immune deficiency, DiGeorge syndrome, severe combined immune deficiency (SCID), Wiskott-Aldrich syndrome), B cell deficiency (common variable immunodeficiency, hyper IgM syndrome, IgA deficiency, specific antibody deficiency, X-linked agammaglobulinemia), or granulocyte deficiency (Chediak Higashi syndrome, chronic granulomatous disease (CGD), hyper IgE syndrome
, leukocyte adhesion defect (LAD), urticaria
). Our division offers treatment and immunologic evaluation of suspected immunodeficiency, including detailed evaluation of cellular immunity (lymphocyte phenotyping, enumeration and activation markers; T cell mitogen and antigen responses; cytotoxic T lymphocyte function; natural killer cell function), antibody function (antibody levels − IgG, IgA, IgM, IgE, IgG subclasses; specific antibody responses to vaccines or pathogens; complement levels and function) and granulocyte morphology and function (adhesion, phagocytosis, killing; respiratory burst).