Physicians and researchers at Cincinnati Children’s participate in numerous clinical research projects in hopes of improving the prognosis and quality of life for patients with brain tumors.

Some studies are sponsored by Cincinnati Children’s, and many others are offered at our site through national institutions such as the Children’s Oncology Group, Pediatric Brain Research Consortium, Neurofibromatosis Clinical Consortium and the National Cancer Institute’s Pediatric Phase I Consortium. Participation in these groups provides patients with early access to the latest anticancer drug development clinical research studies, some of them pioneered at Cincinnati Children’s. Many of our physicians serve in leadership roles for these research organizations, further strengthening our connection to the latest advances in clinical research and care.

Current Research

Current clinical research projects at Cincinnati Children’s focus on:

  • Novel chemotherapy combinations for patients with relapsed or refractory (treatment-resistant) tumors 
  • Targeted small-molecule anticancer drugs 
  • High-dose therapy regimens with blood and marrow transplantation
  • Viral therapy 
  • Quality-of-life issues during and after treatment, and “late effects,” which are health problems that occur months or years after cancer is diagnosed and treated
  • Quantitative, noninvasive imaging techniques that provide information on a patient’s tumor and its effect on the brain

In addition, investigators are conducting research at the Proton Therapy Center at Cincinnati Children’s, home of the world’s only proton therapy gantry dedicated to research.