At Cincinnati Children’s, researchers in the lab collaborate with physicians and clinical researchers to improve treatments for patients with blood diseases. We are intent on bringing findings from the lab into the clinic to improve the outcome for current and future patients.
Our team is working together to find new ways to answer the following research questions and many others:
- Can we improve gene transfer technologies to develop cures for dangerous and debilitating blood diseases?
- How can we rehydrate red blood cells in patients so that they will not experience the most deadly and painful symptoms of sickle cell anemia?
- How do white blood cells move to the site of infection? And how can knowing this improve therapies for immune disorders and blood diseases?
- What can we learn by studying Fanconi anemia genes, and how can we use that knowledge to develop better treatments?
- How do blood stem cells move through the blood to the marrow, and vice versa? Can we use this knowledge to improve outcomes from stem cell transplant procedures?
- Can we deliver a corrective gene to patients’ bone marrow cells to eliminate sickle cell disease?
- Which proteins can make red blood cells sturdier and healthier in patients with red blood cell diseases?
- Do factors in the blood that are responsible for blood clotting also direct inflammatory reactions? How can this knowledge be used to treat arthritis, multiple sclerosis, bacterial infection and blood diseases?