Amy T. Nathan, MD

Medical Director, Neonatology and Pulmonary Biology

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-803-0909



Necrotizing enterocolitis; quality improvement; neonatal immune responses; family-centered care


Immune modulation of lung injury and inflammation 

Innate immune responses at the epithelial boundaries in preterm infants (lung, intestine) can be protective, but inflammatory responses may also cause significant damage. Necrotizing enterocolitis is a devastating, multi-factorial disease marked by intense inflammation, which may be related to changes in the intestinal microbiome combined with compromised perfusion. Dr. Nathan focuses on antecedent factors leading to necrotizing enterocolitis and is interested in applying quality improvement methods to reduce the incidence of this major morbidity in preterm infants.

MD: Yale University School of Medicine, New Haven, CT, 1998.

Residency: University of North Carolina, Chapel Hill, NC, 1998-2002.

Fellowship: University of North Carolina, Chapel Hill, NC, 2002-2005.

Certification: Pediatrics 2001; Neonatology, 2008.

View PubMed Publications

Wills-Karp M, Nathan A, Page K, Karp CL. New insights into innate immune mechanisms underlying allergenicity. Mucosal Immunol. 2010 Mar;3(2):104-10.

Nathan AT, Peterson EA, Chakir J, Wills-Karp M. Innate immune responses of airway epithelium to house dust mite are mediated through beta-glucan-dependent pathways. J Allergy Clin Immunol. 2009 Mar;123(3):612-8.

Chavez-Valdez R, Ahlawat R, Wills-Karp M, Nathan AT, Ezell T, and Gauda EB. Correlation between serum caffeine levels and changes in cytokine profile in a cohort of preterm infants. J Peds. Aug 5 2010.

Wexelblatt, SL, Greenberg, JM, and Nathan AT. Regional care model enables rapid response to adverse drug events. J Perintatol. 2010 30: 300-2.

Chavez-Valdez R, Wills-Karp M, Ahlawat R, Cristofalo EA, Nathan AT, and Gauda EB. Caffeine modulates TNF- production by cord blood monocytes; the role of adenosine receptors. Ped Research. 2009 65(2):203-8.

Wendel KR, Nathan AT. Inhaled nitric oxide. Newborn and Infant Nursing Reviews. 2006 6(2):100-105.