A photo of Lara Danziger-Isakov.

Lara A. Danziger-Isakov, MD, MPH


  • Director, Immunocompromised Host Infectious Disease
  • Professor, UC Department of Pediatrics

About

Biography

Children are remarkably resilient, and I find it gratifying to help them live to their full potential despite life-threatening illness. The unanswered questions these patients present drive my research interests — and, as a result, my research is constantly evolving.

I focus on better understanding the infection risk in immunocompromised patients. My research includes discovering new methods to quickly diagnose infection and evaluating the most appropriate treatment options specific to a pathogen. I also study the noninfectious complications and the consequences of infections related to a patient’s underlying illness.

I specialize in treating infections for a variety of patient populations, including those who have received solid organ transplants and hematopoietic stem cell transplants (HSCT), immunocompromised patients and patients undergoing treatment for various cancers. Many of the infections I study are viral or fungal in nature.

My research focuses on understanding the impact of host-pathogen interactions. I have been the protocol chair for three clinical trials supported by the National Institute of Allergy and Infectious Diseases (NIAID). These trials evaluated how the immune system responds to infection and, later, how that impacts graft survival in pediatric transplantation. They also examined the impact of B-cell induction and the barriers to treatment adherence. In the Studies in Pediatric Liver Transplantation (SPLIT) study, I act as principle investigator for the evaluation of cytomegalovirus (CMV) prophylaxis.

I also research infectious disease epidemiology and risk factors, as well as immunization safety and efficacy in immunocompromised pediatric patients. This includes my role as principle investigator for an ongoing multicenter study of live viral vaccination after solid organ transplantation.

As a result of my work, I received the 2012 American Society of Transplantation Clinical Science Career Development Award. I have served as a board member, secretary, annual meeting program chair and, most recently, president-elect for the International Society of Heart and Lung Transplantation.

I am the past chair for the Infectious Disease Community of Practice (IDCOP) for the American Society of Transplantation. And from 2018-2020, I worked as the deputy editor of the American Journal of Transplantation.

Location

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Publications

Posttraumatic stress and medication adherence in pediatric transplant recipients. Duncan-Park, S; Danziger-Isakov, L; Armstrong, B; Williams, N; Odim, J; Shemesh, E; Sweet, S; Annunziato, R. American Journal of Transplantation. 2021.

476. A Global Survey of Countermeasures Against the COVID-19 Pandemic Among Solid Organ Transplant Centers. Villavicencio, A; Raja, M; Kumar, D; Danziger-Isakov, L; Theodoropoulos, N; Morris, MI; Guerra, G; Abbo, LM; Natori, Y. Open Forum Infectious Diseases. 2021; 8:s339-s340.

64. Absolute Monocyte Count (AMC) as Early and Safe Marker for Discharge in Low-risk Pediatric Febrile Neutropenia with Cancer. Alali, M; Bartlett, A; Danziger-Isakov, L. Open Forum Infectious Diseases. 2021; 8:s150-s151.

Unpacking the COVID-19 vaccine responses: Do we have what we need for a successful trip?. Danziger-Isakov, L; Sester, M. American Journal of Transplantation. 2021; 21:3827-3828.

The evolution of the ISHLT transplant registry. Preparing for the future. Stehlik, J; Christie, JD; Goldstein, DR; Amarelli, C; Bertolotti, A; Chambers, DC; Dorent, R; Gonzalez-Vilchez, F; Parameshwar, J; Perch, M; et al. Journal of Heart Transplantation. 2021; 40:1670-1681.

The Risk of Resurgence in Vaccine-Preventable Infections Due to Coronavirus Disease 2019-Related Gaps in Immunization. Feldman, AG; O'Leary, ST; Danziger-Isakov, L. Clinical Infectious Diseases. 2021; 73:1920-1923.

Return to School and COVID-19 Vaccination for Pediatric Solid Organ Transplant Recipients in the United States: Expert Opinion for 2021-2022. Downes, KJ; Statler, VA; Orscheln, RC; Cousino, MK; Green, M; Michaels, MG; Muller, WJ; Sharma, TS; Danziger-Isakov, LA; Ardura, MI. Journal of the Pediatric Infectious Diseases Society. 2021.

Febrile Neutropenia Syndromes in Children: Risk Factors and Outcomes of Primary, Prolonged, and Recurrent Fever. Alali, M; David, MZ; Ham, SA; Danziger-Isakov, L; Pisano, J. Journal of Pediatric Hematology/Oncology. 2021; 43:e962-e971.

Antibody response to 2-dose SARS-CoV-2 mRNA vaccination in pediatric solid organ transplant recipients. Qin, CX; Auerbach, SR; Charnaya, O; Danziger-Isakov, LA; Ebel, NH; Feldman, AG; Hsu, EK; McAteer, J; Mohammad, S; Perito, ER; et al. American Journal of Transplantation. 2021.

Remote intervention engagement and outcomes in the Clinical Trials in Organ Transplantation in Children consortium multisite trial. Duncan-Park, S; Dunphy, C; Becker, J; D’Urso, C; Annunziato, R; Blatter, J; Conrad, C; Goldfarb, SB; Hayes, D; Melicoff, E; et al. American Journal of Transplantation. 2021; 21:3112-3122.

From the Blog


The COVID-19 Vaccine and Immunocompromised Kids
BlogVaccines

The COVID-19 Vaccine and Immunocompromised Kids

By Lara Danziger-Isakov, MD11/22/2021

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