A photo of Lara Danziger-Isakov.

Director, Immunocompromised Host Infectious Disease

Professor, UC Department of Pediatrics

513-636-9101

Board Certified

My Biography & Research

Biography

Children are remarkably resilient, and I find it gratifying to help them live to their full potential despite life-threatening illness. The unanswered questions these patients present drive my research interests — and, as a result, my research is constantly evolving.

I focus on better understanding the infection risk in immunocompromised patients. My research includes discovering new methods to quickly diagnose infection and evaluating the most appropriate treatment options specific to a pathogen. I also study the noninfectious complications and the consequences of infections related to a patient’s underlying illness.

I specialize in treating infections for a variety of patient populations, including those who have received solid organ transplants and hematopoietic stem cell transplants (HSCT), immunocompromised patients and patients undergoing treatment for various cancers. Many of the infections I study are viral or fungal in nature.

My research focuses on understanding the impact of host-pathogen interactions. I have been the protocol chair for three clinical trials supported by the National Institute of Allergy and Infectious Diseases (NIAID). These trials evaluated how the immune system responds to infection and, later, how that impacts graft survival in pediatric transplantation. They also examined the impact of B-cell induction and the barriers to treatment adherence. In the Studies in Pediatric Liver Transplantation (SPLIT) study, I act as principle investigator for the evaluation of cytomegalovirus (CMV) prophylaxis.

I also research infectious disease epidemiology and risk factors, as well as immunization safety and efficacy in immunocompromised pediatric patients. This includes my role as principle investigator for an ongoing multicenter study of live viral vaccination after solid organ transplantation.

As a result of my work, I received the 2012 American Society of Transplantation Clinical Science Career Development Award. I have served as a board member, secretary, annual meeting program chair and, most recently, president-elect for the International Society of Heart and Lung Transplantation.

I am the past chair for the Infectious Disease Community of Practice (IDCOP) for the American Society of Transplantation. And from 2018-2020, I worked as the deputy editor of the American Journal of Transplantation.

Clinical Interests

Pediatric infectious disease; infections in transplantation; infections in immunocompromised hosts

Research Interests

Infections in transplantation; infections in immunocompromised hosts

Academic Affiliation

Professor, UC Department of Pediatrics

Clinical Divisions

Infectious Diseases, Lung Transplant

Research Divisions

Infectious Diseases



Blog Posts

The COVID-19 Vaccine and Immunocompromised Kids

BlogVaccines

The COVID-19 Vaccine and Immunocompromised Kids

By Lara Danziger-Isakov, MD11/22/2021

My Locations

My Education

MD: Case Western Reserve University, Cleveland, OH, 1997.

MPH: Saint Louis University, St. Louis, MO, 2004.

Residency: Pediatrics, Cleveland Clinic Foundation, Cleveland, OH, 1997-2000.

Fellowship: Pediatric Infectious Diseases, St. Louis Children’s Hospital, Washington Univeristy, St. Louis, MO, 2000-2003.

Certification: Pediatrics, 2000; Pediatric Infectious Diseases, 2003.

My Publications

Antibody response to 2-dose SARS-CoV-2 mRNA vaccination in pediatric solid organ transplant recipients. Qin, CX; Auerbach, SR; Charnaya, O; Danziger-Isakov, LA; Ebel, NH; Feldman, AG; Hsu, EK; McAteer, J; Mohammad, S; Perito, ER; et al. American Journal of Transplantation. 2021.

Unpacking the COVID-19 vaccine responses: Do we have what we need for a successful trip?. Danziger-Isakov, L; Sester, M. American Journal of Transplantation. 2021.

The evolution of the ISHLT transplant registry. Preparing for the future. Stehlik, J; Christie, JD; Goldstein, DR; Amarelli, C; Bertolotti, A; Chambers, DC; Dorent, R; Gonzalez-Vilchez, F; Parameshwar, J; Perch, M; et al. Journal of Heart Transplantation. 2021.

Remote intervention engagement and outcomes in the Clinical Trials in Organ Transplantation in Children consortium multisite trial. Duncan-Park, S; Dunphy, C; Becker, J; D’Urso, C; Annunziato, R; Blatter, J; Conrad, C; Goldfarb, SB; Hayes, D; Melicoff, E; et al. American Journal of Transplantation. 2021; 21:3112-3122.

COVID-19 vaccination in pediatric solid organ transplant recipients-Current state and future directions. L’Huillier, AG; Ardura, MI; Chaudhuri, A; Danziger-Isakov, L; Dulek, D; Green, M; Michaels, MG; Posfay-Barbe, KM; Vàsquez, L; Benden, C. Pediatric Transplantation. 2021; 25.

American Society for Transplantation and Cellular Therapy Series: #3-Prevention of Cytomegalovirus Infection and Disease After Hematopoietic Cell Transplantation. Hakki, M; Aitken, SL; Danziger-Isakov, L; Michaels, MG; Carpenter, PA; Chemaly, RF; Papanicolaou, GA; Boeckh, M; Marty, FM. Transplantation and cellular therapy. 2021; 27:707-719.

Comparative Effectiveness of Echinocandins vs Triazoles or Amphotericin B Formulations as Initial Directed Therapy for Invasive Candidiasis in Children and Adolescents. Fisher, BT; Zaoutis, TE; Xiao, R; Wattier, RL; Castagnola, E; Pana, ZD; Fullenkamp, A; Boge, CL K; Ross, RK; Yildirim, I; et al. Journal of the Pediatric Infectious Diseases Society. 2021.

Maintaining Hepatitis B Protection in Immunocompromised Pediatric Rheumatology and Inflammatory Bowel Disease Patients. Aljaberi, N; Ghulam, E; Smitherman, EA; Favier, L; Dykes, DM H; Danziger-Isakov, LA; Brady, RC; Huggins, J. Journal of Rheumatology. 2021; 48:1314-1321.

The limits of refusal: An ethical review of solid organ transplantation and vaccine hesitancy. Kates, OS; Stohs, EJ; Pergam, SA; Rakita, RM; Michaels, MG; Wolfe, CR; Danziger-Isakov, L; Ison, MG; Blumberg, EA; Razonable, RR; et al. American Journal of Transplantation. 2021; 21:2637-2645.

COVID-19 in pediatric kidney transplantation: The Improving Renal Outcomes Collaborative. Varnell, C; Harshman, LA; Smith, L; Liu, C; Chen, S; Al-Akash, S; Barletta, GM; Belsha, C; Brakeman, P; Chaudhuri, A; et al. American Journal of Transplantation. 2021; 21:2740-2748.