A photo of Lara Danziger-Isakov.

Director, Immunocompromised Host Infectious Disease

Professor, UC Department of Pediatrics

513-636-9101

Board Certified

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My Biography & Research

Biography

Children are remarkably resilient, and I find it gratifying to help them live to their full potential despite life-threatening illness. The unanswered questions these patients present drive my research interests — and, as a result, my research is constantly evolving.

I focus on better understanding the infection risk in immunocompromised patients. My research includes discovering new methods to quickly diagnose infection and evaluating the most appropriate treatment options specific to a pathogen. I also study the noninfectious complications and the consequences of infections related to a patient’s underlying illness.

I specialize in treating infections for a variety of patient populations, including those who have received solid organ transplants and hematopoietic stem cell transplants (HSCT), immunocompromised patients and patients undergoing treatment for various cancers. Many of the infections I study are viral or fungal in nature.

My research focuses on understanding the impact of host-pathogen interactions. I have been the protocol chair for three clinical trials supported by the National Institute of Allergy and Infectious Diseases (NIAID). These trials evaluated how the immune system responds to infection and, later, how that impacts graft survival in pediatric transplantation. They also examined the impact of B-cell induction and the barriers to treatment adherence. In the Studies in Pediatric Liver Transplantation (SPLIT) study, I act as principle investigator for the evaluation of cytomegalovirus (CMV) prophylaxis.

I also research infectious disease epidemiology and risk factors, as well as immunization safety and efficacy in immunocompromised pediatric patients. This includes my role as principle investigator for an ongoing multicenter study of live viral vaccination after solid organ transplantation.

As a result of my work, I received the 2012 American Society of Transplantation Clinical Science Career Development Award. I have served as a board member, secretary, annual meeting program chair and, most recently, president-elect for the International Society of Heart and Lung Transplantation.

I am the past chair for the Infectious Disease Community of Practice (IDCOP) for the American Society of Transplantation. And from 2018-2020, I worked as the deputy editor of the American Journal of Transplantation.

Clinical Interests

Pediatric infectious disease; infections in transplantation; infections in immunocompromised hosts

Research Interests

Infections in transplantation; infections in immunocompromised hosts

Academic Affiliation

Professor, UC Department of Pediatrics

Clinical Divisions

Infectious Diseases, Lung Transplant

Research Divisions

Infectious Diseases

My Locations

My Education

MD: Case Western Reserve University, Cleveland, OH, 1997.

MPH: Saint Louis University, St. Louis, MO, 2004.

Residency: Pediatrics, Cleveland Clinic Foundation, Cleveland, OH, 1997-2000.

Fellowship: Pediatric Infectious Diseases, St. Louis Children’s Hospital, Washington Univeristy, St. Louis, MO, 2000-2003.

Certification: Pediatrics, 2000; Pediatric Infectious Diseases, 2003.

My Publications

Febrile Neutropenia Syndromes in Children: Risk Factors and Outcomes of Primary, Prolonged, and Recurrent Fever. Alali, M; David, MZ; Ham, SA; Danziger-Isakov, L; Pisano, J. Journal of Pediatric Hematology/Oncology. 2021.

COVID-19 vaccination in pediatric solid organ transplant recipients-Current state and future directions. L’Huillier, AG; Ardura, MI; Chaudhuri, A; Danziger-Isakov, L; Dulek, D; Green, M; Michaels, MG; Posfay-Barbe, KM; Vàsquez, L; Benden, C. Pediatric Transplantation. 2021.

Active and Protected: Developing a "Safer Sex " Handout for Adolescents and Young Adults with Cancer. McGrady, ME; Bredenberg, DL; Danziger-Isakov, L; Rios, J; Frias, O; West, MY; Fisher, P; Salloum, R; Pressey, JG; Norris, RE. Journal of Adolescent and Young Adult Oncology. 2021; 10:351-354.

Novel Treatment of Infant With COVID-19 With the Sialidase Fusion Protein, DAS181. Danziger-Isakov, L; Khalil, N; Divanovic, A; Frenck, R; Grimley, M; Iliopoulos, I; Marsh, R; Paulsen, G; Phillips, CL; Schulert, G; et al. Pediatric Infectious Disease Journal. 2021; 40:e234-e235.

ISHLT consensus statement for the selection and management of pediatric and congenital heart disease patients on ventricular assist devices Endorsed by the American Heart Association. Lorts, A; Conway, J; Schweiger, M; Adachi, I; Amdani, S; Auerbach, SR; Barr, C; Bleiweis, MS; Blume, ED; Burstein, DS; et al. Journal of Heart Transplantation. 2021.

Cryptococcus transmission through solid organ transplantation in the United States: A report from the Ad Hoc Disease Transmission Advisory Committee. Penumarthi, LR; La Hoz, RM; Wolfe, CR; Jackson, BR; Mehta, AK; Malinis, M; Danziger-Isakov, L; Strasfeld, L; Florescu, DF; Vece, G; et al. American Journal of Transplantation. 2021; 21:1911-1923.

C4 article: Implications of COVID-19 in transplantation. Aaron, JG; Abbo, LM; Alconchel, F; Amarelli, C; Anjan, S; Ardura, MI; Azar, MM; Azzi, J; Baddley, JW; Balliet, W; et al. American Journal of Transplantation. 2021; 21:1801-1815.

Immunity to varicella, measles, and mumps in patients evaluated for lung transplantation. Hostetler, HP; Neely, ML; Lydon, E; Danziger-Isakov, LA; Todd, JL; Palmer, SM. American Journal of Transplantation. 2021.

Long-Term Infectious Complications of Kidney Transplantation. Agrawal, A; Ison, MG; Danziger-Isakov, L. Clinical journal of the American Society of Nephrology : CJASN. 2021.

Remote intervention engagement and outcomes in the Clinical Trials in Organ Transplantation in Children consortium multisite trial. Duncan-Park, S; Dunphy, C; Becker, J; D’Urso, C; Annunziato, R; Blatter, J; Conrad, C; Goldfarb, SB; Hayes, D; Melicoff, E; et al. American Journal of Transplantation. 2021.