A photo of David Neal Franz.

David Neal Franz, MD

  • Founding Director, Tuberous Sclerosis Clinic
  • Associate Director of Clinical Affairs, Division of Neurology
  • Professor, UC Department of Pediatrics
I believe in providing the best care and treatment for my patients and families, whatever that may be.
David Neal Franz, MD



As a brain doctor, I care for children with general neurologic conditions. I specialize in neurocutaneous disorders and neuropharmacology. I’m the founding director of the Tuberous Sclerosis Clinic at Children’s Hospital Medical Center.

I believe in providing the best care and treatment for my patients and families, whatever that may be.

At Cincinnati Children’s we try our sincere best to help patients and families living with a complex neurological and medical diagnosis. Many of these conditions do not have established or approved therapies.

My research focuses on targeted therapies for epilepsy and genetic brain disorders.

MD: Ohio State University College of Medicine, Columbus, OH, 1985.

Residency: Wright State University Affiliated Hospitals, Dayton, OH.

Fellowship: Children's Hospital Medical Center, Cincinnati, OH.

Certification: Pediatrics, 1990, 2016; Neurology with special competence in child neurology, 1992.


Tuberous sclerosis (adults and children); neuropharmacology; neurocutaneous disorders; general pediatric neurology

Services and Specialties

Neurology, Tuberous Sclerosis, Sturge-Weber Syndrome

Research Areas


Additional Languages


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Stiripentol for Drug-Resistant Epilepsy Treatment in Tuberous Sclerosis Complex. Aungaroon, G; Mehta, A; Horn, PS; Franz, DN. Pediatric Neurology. 2023; 139:86-92.

Prevalence of thoracoabdominal imaging findings in tuberous sclerosis complex. Ritter, DM; Fessler, BK; Ebrahimi-Fakhari, D; Wei, J; Franz, DN; Krueger, DA; Trout, AT; Towbin, AJ. Orphanet Journal of Rare Diseases. 2022; 17:124.

Cellular and molecular characterization of two novel asparagine synthetase gene mutations linked to asparagine synthetase deficiency. Staklinski, SJ; Chang, MC; Yu, F; Collins Ruff, K; Franz, DN; Qian, Z; Bloom, LB; Merritt, ME; McKenna, R; Kilberg, MS. The Journal of biological chemistry. 2022; 298:102385.

Symptom rates and profile clustering in tuberous sclerosis complex-associated neuropsychiatric disorders (TAND). Alperin, S; Krueger, DA; Franz, DN; Agricola, KD; Stires, G; Horn, PS; Capal, JK. Journal of Neurodevelopmental Disorders. 2021; 13:60.

Prenatal Sirolimus Treatment for Rhabdomyomas in Tuberous Sclerosis. Ebrahimi-Fakhari, D; Stires, G; Hahn, E; Krueger, D; Franz, DN. Pediatric Neurology. 2021; 125:26-31.

RHOA signaling defects result in impaired axon guidance in iPSC-derived neurons from patients with tuberous sclerosis complex. Catlett, TS; Onesto, MM; McCann, AJ; Rempel, SK; Glass, J; Franz, DN; Gómez, TM. Nature Communications. 2021; 12:2589.

Updated International Tuberous Sclerosis Complex Diagnostic Criteria and Surveillance and Management Recommendations. Northrup, H; Aronow, ME; Bebin, EM; Bissler, J; Darling, TN; de Vries, PJ; Frost, MD; Fuchs, Z; Gosnell, ES; Gupta, N; et al. Pediatric Neurology. 2021; 123:50-66.

Diabetes in Individuals With Tuberous Sclerosis Complex Treated With mTOR Inhibitors. Agricola, K; Stires, G; Krueger, DA; Capal, JK; Franz, DN; Ritter, DM. Pediatric Neurology. 2021; 120:7-10.

Lymphangioleiomyomatosis Association with Underlying Genotype in Patients with Tuberous Sclerosis Complex. Tian, X; Glass, JE; Kwiatkowski, DJ; Towbin, AJ; Li, Y; Sund, KL; Krueger, DA; Franz, DN; McCormack, FX; Gupta, N. Annals of the American Thoracic Society. 2021; 18:815-819.

Frequency, Progression, and Current Management: Report of 16 New Cases of Nonfunctional Pancreatic Neuroendocrine Tumors in Tuberous Sclerosis Complex and Comparison With Previous Reports. Mowrey, K; Northrup, H; Rougeau, P; Hashmi, SS; Krueger, DA; Ebrahimi-Fakhari, D; Towbin, AJ; Trout, AT; Capal, JK; Franz, DN; et al. Frontiers in Neurology. 2021; 12:627672.

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