A photo of William D. Hardie.

Professor, UC Department of Pediatrics

513-636-6771

513-636-4615

Board Certified

My Biography & Research

Clinical Interests

Pulmonary function tests; pneumonia; empyema

Research Interests

Growth factors in lung remodeling

Academic Affiliation

Professor, UC Department of Pediatrics

Departments

Pulmonary Medicine, Pediatric Home Ventilator Program, Pulmonary Medicine, Pulmonary Function Lab

My Locations

My Education

MD: Vanderbilt University, Nashville, TN, 1990.

Residency: Children's Hospital Medical Center, Cincinnati, OH.

Fellowship: Children's Hospital Medical Center, Cincinnati, OH.

Certification: Pediatrics, 1993; Pulmonary Medicine, 1999.

My Publications

Le Cras TD, Korfhagen TR, Davidson C, Schmidt S, Fenchel M, Ikegami M, Whitsett JA, Hardie WD. Inhibition of PI3K by PX-866 prevents transforming growth factor-alpha-induced pulmonary fibrosis. Am J Pathol. 2010 Feb;176(2):679-86

Deshmukh HS, McLachlan A, Atkinson JJ, Hardie WD, Korfhagen TR, Dietsch M, Liu Y, Di PY, Wesselkamper SC, Borchers MT, Leikauf GD.  Matrix metalloproteinase-14 mediates a phenotypic shift in the airways to increase mucin production. Am J Respir Crit Care Med. 2009 Nov 1;180(9):834-45.

Hardie WD, Glasser SW, Hagood JS. Emerging concepts in the pathogenesis of lung fibrosis. Am J Pathol. 2009 Jul;175(1):3-16.

Korfhagen TR, Le Cras TD, Davidson CR, Schmidt SM, Ikegami M, Whitsett JA, Hardie WD. Rapamycin prevents transforming growth factor-alpha-induced pulmonary fibrosis. Am J Respir Cell Mol Biol. 2009 Nov;41(5):562-72.

Kramer EL, Mushaben EM, Pastura PA, Acciani TH, Deutsch GH, Khurana Hershey GK, Korfhagen TR, Hardie WD, Whitsett JA, Le Cras TD. Early growth response-1 suppresses epidermal growth factor receptor-mediated airway hyperresponsiveness and lung remodeling in mice. Am J Respir Cell Mol Biol. 2009 Oct;41(4):415-25.

Hardie WD. 50 Years Ago in The Journal of Pediatrics Pediatric Empyema: A Second Look at its Incidence and Importance. Kiesewetter, WB, Rusnock JR, Girdany BR. J Pediatr 1959;54:81-6. J Pediatr. 2009 Jan 1;154(1):131.

Loeb JS, Blower WC, Feldstein JF, Koch BA, Munlin AL, Hardie WD. Acceptability and repeatability of spirometry in children using updated ATS/ERS criteria. Pediatr Pulmonol. 2008 Oct;43(10):1020-4.

Hardie WD, Davidson C, Ikegami M, Leikauf GD, Le Cras TD, Prestridge A, Whitsett JA, Korfhagen TR. EGF receptor tyrosine kinase inhibitors diminish transforming growth factor-alpha-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2008 Jun;294(6):L1217-25.

Deshmukh HS, Shaver C, Case LM, Dietsch M, Wesselkamper SC, Hardie WD, Korfhagen TR, Corradi M, Nadel JA, Borchers MT, Leikauf GD. Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production. Am J Respir Cell Mol Biol. 2008 Apr;38(4):446-54.

McPhail GL, Hardie WD. Cavitary lung lesions in a 2-year-old child. Respiration. 2008;76(1):117-8.