A photo of William D. Hardie.

Member, Division of Pulmonary Medicine

Professor, UC Department of Pediatrics



Board Certified

My Biography & Research


When I started college, I planned to be a social worker, but I always liked science. One night after watching an episode of MASH on television, it occurred to me that I could combine my aptitude for math and science with caring for people as a physician.

Going into pediatrics was a natural choice, as working with children is its own reward. As a student, I remember a pediatrician telling me he liked pediatrics because he felt it made him younger — and as I get older, I agree. I was drawn to pulmonary medicine during medical school and enjoyed the respiratory system physiology and research challenges.

As a pediatric pulmonologist, I treat general pediatric issues as well as patients who have shortness of breath with exercise. I also care for patients with a primary spontaneous pneumothorax, an abnormal accumulation of air in the space between the lungs and the chest cavity (the pleural space).

I have broad experience in many facets of pediatric pulmonary medicine, but not one primary focus. My understanding of exercise physiology is somewhat unique since I have played or coached several sports, including four years as a college swimmer and two years playing water polo while in medical school. This experience helps me relate well to many of the patients who are active in sports and have limitations related to breathing. As one of my mentors said, “The secret to caring for the patient is to care for the patient.”

I have maintained a basic science laboratory for now more than 20 years focused on pulmonary fibrosis. My colleagues and I seek to identify the proteins and cellular pathways associated with this disorder and explore potential novel treatments. My clinical research interests include cardiopulmonary exercise testing in patients with shortness of breath with exercise. While not a research activity, I am very involved with national and state organizations advocating for improving air quality.

At my small farm, located between Mason and Lebanon, Ohio, I make maple and walnut syrup. This year I published a study demonstrating that walnut syrup is not allergenic in a small group of patients with a walnut tree nut allergy. I also have an orchard with apple and paw paw trees and have sold some paw paws to a produce market in Cincinnati. My daughters and I grow and sell sunflowers as a charitable fundraiser.

I grew up near Wilmington College in Ohio and worked for the Cincinnati Bengals during their summer training camps. My first year at Cincinnati Children’s as an intern in 1990 was the last year the Bengals won a playoff game. I vow not to leave Cincinnati Children’s until this happens again!

Clinical Interests

General pediatric pulmonary with additional expertise in managing children with recurrent pneumonia, pneumothorax, pectus excavatum and shortness of breath with exercise

Research Interests

Pulmonary fibrosis

Academic Affiliation

Professor, UC Department of Pediatrics


Pulmonary Medicine, Home Ventilator, Pulmonary Function, Pulmonary Medicine

My Locations

My Education

MD: Vanderbilt University, Nashville, TN, 1990.

Residency: Children's Hospital Medical Center, Cincinnati, OH.

Fellowship: Children's Hospital Medical Center, Cincinnati, OH.

Certification: Pediatrics, 1993; Pulmonary Medicine, 1999.

My Publications

Respiratory Medications in Infants < 29 Weeks during the First Year Postdischarge: The Prematurity and Respiratory Outcomes Program (PROP) Consortium. Ryan, RM; Keller, RL; Poindexter, BB; D'Angio, CT; Shaw, PA; Bellamy, SL; Moore, PE; McPherson, C; Greenberg, JM; Chougnet, C; et al. The Journal of Pediatrics. 2019; 208:148-155.e3.

Black Race Is Associated with a Lower Risk of Bronchopulmonary Dysplasia. Ryan, RM; Feng, R; Bazacliu, C; Ferkol, TW; Ren, CL; Mariani, TJ; Poindexter, BB; Wang, F; Moore, PE; Chougnet, C; et al. The Journal of Pediatrics. 2019; 207:130-135.e2.

Longitudinal free-breathing MRI measurement of murine lung physiology in a progressive model of lung fibrosis. Guo, J; Hardie, WD; Cleveland, ZI; Davidson, C; Xu, X; Madala, SK; Woods, JC. Journal of applied physiology (Bethesda, Md. : 1985). 2019; 126:1138-1149.

Exome sequencing identifies gene variants and networks associated with extreme respiratory outcomes following preterm birth. Hamvas, A; Feng, R; Bi, Y; Wang, F; Bhattacharya, S; Mereness, J; Kaushal, M; Cotten, CM; Ballard, PL; Mariani, TJ; et al. BMC Genetics. 2018; 19.

Subacute TGF beta expression drives inflammation, goblet cell hyperplasia, and pulmonary function abnormalities in mice with effects dependent on CFTR function. Kramer, EL; Hardie, WD; Madala, SK; Davidson, C; Clancy, JP. American Journal of Physiology: Lung Cellular and Molecular Physiology. 2018; 315:L456-L465.

Acute Responses to Diuretic Therapy in Extremely Low Gestational Age Newborns: Results from the Prematurity and Respiratory Outcomes Program Cohort Study. Blaisdell, CJ; Troendle, J; Zajicek, A; Chougnet, C; Greenberg, JM; Hardie, W; Jobe, AH; McDowell, K; Ferkol, T; Holland, MR; et al. The Journal of Pediatrics. 2018; 197:42-47.e1.

Bronchopulmonary Dysplasia and Perinatal Characteristics Predict 1-Year Respiratory Outcomes in Newborns Born at Extremely Low Gestational Age: A Prospective Cohort Study. Keller, RL; Feng, R; DeMauro, SB; Ferkol, T; Hardie, W; Rogers, EE; Stevens, TP; Voynow, JA; Bellamy, SL; Shaw, PA; et al. The Journal of Pediatrics. 2017; 187:89-97.e3.

Magnetic resonance imaging of disease progression and resolution in a transgenic mouse model of pulmonary fibrosis. Cleveland, ZI; Zhou, YM; Akinyi, TG; Dunn, RS; Davidson, CR; Guo, J; Woods, JC; Hardie, WD. American Journal of Physiology: Lung Cellular and Molecular Physiology. 2017; 312:L488-L499.

Results of a Prospective Study Evaluating a Noninvasive Method of Hemoglobin Adjustment for Determining the Diffusing Capacity of the Lung. Foster, KE; Sahay, RD; Zhang, N; Hardie, WD. Annals of the American Thoracic Society. 2017; 14:41-48.

Unique and Redundant Functions of p70 Ribosomal S6 Kinase Isoforms Regulate Mesenchymal Cell Proliferation and Migration in Pulmonary Fibrosis. Madala, SK; Sontake, V; Edukulla, R; Davidson, CR; Schmidt, S; Hardie, WD. American Journal of Respiratory Cell and Molecular Biology. 2016; 55:792-803.