A photo of Alexander Miethke.

Medical Director, Liver Transplant Program

Assistant Professor, UC Department of Pediatrics

513-636-8948

Board Certified

My Biography & Research

Biography

Alexander G. Miethke, MD, joined the Division of Gastroenterology, Hepatology and Nutrition as a fellow in 2005, after completing his Pediatric Residency Training at Cincinnati Children's Hospital Medical Center. Following the completion of his fellowship, he pursued an additional year of training in pediatric transplant hepatology under the mentorship of Dr. William Balistreri and the physicians and surgeons of the Pediatric Liver Care Center.

In 2009, Dr. Miethke was appointed assistant professor of pediatrics in the Division of Gastroenterology, Hepatology and Nutrition and the Pediatric Liver Care Center at Cincinnati Children's within the UC Department of Pediatrics. His basic science research interests include the role of regulatory T cells in biliary atresia and other immune mediated liver diseases and the genetic basis of chronic cholestasis syndromes.

Additional Languages

German

Clinical Interests

Pediatric liver disease including biliary atresia, inherited liver diseases, autoimmune hepatitis, and primary sclerosing cholangitis; gastrointestinal problems in children with bone marrow failure syndromes

Research Interests

Immune mediated liver injury, specifically the role of regulatory T cells in biliary atresia and primary sclerosing cholangitis; genetic basis for intrahepatic cholestasis in children; acute liver failure in infants with mitochondrial disorders

Academic Affiliation

Assistant Professor, UC Department of Pediatrics

Departments

Gastroenterology GI, Liver Care, Liver Transplant, Autoimmune Liver Disease, Liver Tumor, Gastroenterology, Fibrosis

My Locations

My Education

MD: Humboldt-University, Berlin, Germany, 2000.

Residency: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2002-2004.

Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2005-2007.

Advanced Fellowship: Pediatric Transplant Hepatology, University of Cincinnati and Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2009.

Certification: Pediatrics, 2005; Pediatric Gastroenterology, 2009; Pediatric Transplant Hepatology, 2010.

My Publications

Expanding and Underscoring the Hepato-Encephalopathic Phenotype of QIL1/MIC13. Russell, BE; Whaley, KG; Bove, KE; Labilloy, A; Lombardo, RC; Hopkin, RJ; Leslie, ND; Prada, C; Assouline, Z; Barcia, G; et al. Hepatology. 2019; 70:1066-1070.

Ursodeoxycholic Acid Therapy in Pediatric Primary Sclerosing Cholangitis: Predictors of Gamma Glutamyltransferase Normalization and Favorable Clinical Course. Deneau, M; Perito, E; Ricciuto, A; Gupta, N; Kamath, BM; Palle, S; Vitola, B; Smolka, V; Ferrari, F; Amir, AZ; et al. The Journal of Pediatrics. 2019; 209:92-96.e1.

Interleukin 2 Promotes Hepatic Regulatory T Cell Responses and Protects From Biliary Fibrosis in Murine Sclerosing Cholangitis. Taylor, AE; Carey, AN; Kudira, R; Lages, CS; Shi, T; Lam, S; Karns, R; Simmons, J; Shanmukhappa, K; Almanan, M; et al. Hepatology. 2018; 68:1905-1921.

Placebo-Controlled Randomized Trial of an Intestinal Bile Salt Transport Inhibitor for Pruritus in Alagille Syndrome. Shneider, BL; Spino, C; Kamath, BM; Magee, JC; Bass, LM; Setchell, KD; Miethke, A; Molleston, JP; Mack, CL; Squires, RH; et al. Hepatology Communications. 2018; 2:1184-1198.

Putting it all together: established and emerging MRI techniques for detecting and measuring liver fibrosis. Serai, SD; Trout, AT; Miethke, A; Diaz, E; Xanthakos, SA; Dillman, JR. Pediatric Radiology: roentgenology, nuclear medicine, ultrasonics, CT, MRI. 2018; 48:1256-1272.

Neurodevelopmental Outcome of Young Children with Biliary Atresia and Native Liver: Results from the ChiLDReN Study. Ng, VL; Sorensen, LG; Alonso, EM; Fredericks, EM; Ye, W; Moore, J; Karpen, SJ; Shneider, BL; Molleston, JP; Bezerra, JA; et al. The Journal of Pediatrics. 2018; 196:139-147.e3.

Zebrafish abcb11b mutant reveals strategies to restore bile excretion impaired by bile salt export pump deficiency. Ellis, JL; Bove, KE; Schuetz, EG; Leino, D; Valencia, CA; Schuetz, JD; Miethke, A; Yin, C. Hepatology. 2018; 67:1531-1545.

Hepatic MDR3 expression impacts lipid homeostasis and susceptibility to inflammatory bile duct obstruction in neonates. Carey, AN; Zhang, W; Setchell, KD R; Simmons, JR; Shil, T; Lages, CS; Mullen, M; Carroll, K; Karns, R; Bessho, K; et al. Pediatric Research. 2017; 82:122-132.

Analysis of Surgical Interruption of the Enterohepatic Circulation as a Treatment for Pediatric Cholestasis. Wang, KS; Tiao, G; Bass, LM; Hertel, PM; Mogul, D; Kerkar, N; Clifton, M; Azen, C; Bull, L; Rosenthal, P; et al. Hepatology. 2017; 65:1645-1654.

The Dendritic Cell-T Helper 17-Macrophage Axis Controls Cholangiocyte Injury and Disease Progression in Murine and Human Biliary Atresia. Lages, CS; Simmons, J; Maddox, A; Jones, K; Karns, R; Sheridan, R; Shanmukhappa, SK; Mohanty, S; Kofron, M; Russo, P; et al. Hepatology. 2017; 65:174-188.