Francesco T. Mangano, DO, FACS, FAAP, FACOS

A photo of Francesco Mangano.

Mary Jane and Bob Tritsch Chair, Division of Pediatric Neurosurgery

Division Chief, Division of Pediatric Neurosurgery 

Director of the Pediatric Epilepsy Surgery Program, Division of Pediatric Neurosurgery

Professor, UC Department of Neurosurgery

513-636-4726

513-636-2808

Board Certified

My Biography & Research

Biography

Dr. Francesco Mangano is currently the Mary Jane and Bob Tritsch Chair and professor of Neurological Surgery and Pediatrics. He joined the Division of Pediatric Neurosurgery at Cincinnati Children's in July 2005, with an appointment as assistant professor of neurosurgery in the College of Medicine at the University of Cincinnati.

A graduate of the Philadelphia College of Osteopathic Medicine, Dr. Mangano completed his neurosurgical residency at Long Island Jewish Medical Center in 2004 followed by a fellowship in pediatric neurosurgery at St. Louis Children's Hospital in St. Louis, Missouri. Since joining the faculty of the division of pediatric neurosurgery at Cincinnati Children's Hospital Medical Center, he has been instrumental in developing our nationally renowned Pediatric Epilepsy Program and is Director of the Pediatric Epilepsy Surgery Program.

In addition, he has been a co-principal investigator for an NIH-funded multi-institutional research study investigating advanced MRI imaging techniques in children with congenital hydrocephalus. This study established DTI as a non-invasive biomarker for white matter injury in this condition. Additionally, he currently heads a basic science lab primarily focused on studying new models of hydrocephalus in combination to advanced MR imaging.

His academic endeavors have accounted for 111 publications as well as numerous book chapters. He has presented his work nationally and internationally and continues to teach locally as the site PI for pediatric neurosurgery residencies of the University of Cincinnati and the Henry Ford Medical Center.

He is also fellowship director for the Cincinnati Children’s pediatric neurosurgery fellowship program which has graduated 15 fellows and continues to recruit nationally every year. Dr. Mangano is a member of the American Society of Pediatric Neurosurgeons, the AANS/CNS Section of Pediatric Neurosurgery, and the International Society of Pediatric Neurosurgery. He was board certified in 2008 in Neurological Surgery by the American Osteopathic Board of Surgery.

Additional Languages

Italian

Clinical Interests

Pediatric Epilepsy Program; Pediatric Epilepsy Surgery Program; imaging and monitoring of seizures; surgical intervention; vagal nerve stimulator implantation; brain resection; brain and spinal cord tumors; chiari malformations; tethered cord syndromes in patients with anorectal malformations.

Research Interests

Advanced MRI imaging techniques in children with congenital hydrocephalus.

Academic Affiliation

Professor, UC Department of Neurosurgery

Clinical Divisions

Colorectal Disorders, Neurosurgery, Epilepsy, Brain Tumor

Research Divisions

Neurosurgery

My Locations

My Education

DO: Philadelphia College of Osteopathic Medicine, Philadelphia, PA.

Residency: Neurosurgery, NYCOM-Long Island Jewish Medical Center/North Shore University Hospital Health System, New Hyde Park, NY.

Fellowship: Pediatric Neurosurgery, Washington University School of Medicine-St. Louis Children's Hospital, St. Louis, MO.

Board Certification: Neurological Surgery, American Osteopathic Board of Surgery, 2008.

My Publications

Early identification of epilepsy surgery candidates: A multicenter, machine learning study. Wissel, BD; Greiner, HM; Glauser, TA; Pestian, JP; Kemme, AJ; Santel, D; Ficker, DM; Mangano, FT; Szczesniak, RD; Dexheimer, JW. Acta Neurologica Scandinavica. 2021.

Occipital-Cervical Fusion and Ventral Decompression in the Surgical Management of Chiari-1 Malformation and Syringomyelia: Analysis of Data From the Park-Reeves Syringomyelia Research Consortium. Crevecoeur, TS; Yahanda, AT; Maher, CO; Johnson, GW; Ackerman, LL; David Adelson, PD; Ahmed, R; Albert, GW; Aldana, PR; Alden, TD; et al. Neurosurgery. 2021; 88:332-341.

High-gamma modulation language mapping with stereo-EEG: A novel analytic approach and diagnostic validation. Ervin, B; Buroker, J; Rozhkov, L; Holloway, T; Horn, PS; Scholle, C; Byars, AW; Mangano, FT; Leach, JL; Greiner, HM; et al. Electromyography and Clinical Neurophysiology. 2020; 131:2851-2860.

Generator replacement with cardiac-based VNS device in children with drug-resistant epilepsy: An observational study. Hadjinicolaou, A; Jain, P; Arya, R; Roth, C; Whitney, R; Yau, I; Greiner, HM; Mangano, FT; Rutka, JT; Go, C. Epilepsy Research. 2020; 167.

Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalus. Jin, SC; Dong, W; Kundishora, AJ; Panchagnula, S; Moreno-De-Luca, A; Furey, CG; Allocco, AA; Walker, RL; Nelson-Williams, C; Smith, H; et al. Nature Medicine. 2020; 26:1754-1765.

Reading in children with drug-resistant epilepsy was related to functional connectivity in cognitive control regions. Kraus, D; Vannest, J; Arya, R; Hutton, JS; Leach, JL; Mangano, FT; Tenney, JR; Byars, AW; DeWitt, TG; Horowitz-Kraus, T. Acta Paediatrica, International Journal of Paediatrics. 2020; 109:2105-2111.

Not all ventriculomegaly is created equal: diagnostic overview of fetal, neonatal and pediatric ventriculomegaly. Patel, SK; Zamorano-Fernandez, J; Nagaraj, U; Bierbrauer, KS; Mangano, FT. Child's Nervous System. 2020; 36:1681-1696.

Electrical stimulation sensorimotor mapping with stereo-EEG. Arya, R; Ervin, B; Holloway, T; Dudley, J; Horn, PS; Buroker, J; Rozhkov, L; Scholle, C; Byars, AW; Leach, JL; et al. Electromyography and Clinical Neurophysiology. 2020; 131:1691-1701.

Neuropsychological outcomes after pediatric epilepsy surgery: Role of electrical stimulation language mapping. Sakpichaisakul, K; Byars, AW; Horn, PS; Aungaroon, G; Greiner, HM; Mangano, FT; Holland, KD; Arya, R. Seizure : the journal of the British Epilepsy Association. 2020; 80:183-191.

Magnetic resonance-guided stereotactic laser ablation therapy for the treatment of pediatric brain tumors: a multiinstitutional retrospective study. Arocho-Quinones, EV; Lew, SM; Handler, MH; Tovar-Spinoza, Z; Smyth, M; Bollo, R; Donahue, D; Perry, MS; Levy, ML; Gonda, D; et al. Journal of Neurosurgery: Pediatrics. 2020; 1-9.