Francesco T. Mangano, DO, FACS, FAAP, FACOS

Chief, Division of Pediatric Neurosurgery

Director, Pediatric Epilepsy Surgery Program

Academic Affiliations

Professor, UC Department of Neurosurgery

Phone 513-636-4726

Fax 513-636-2808



Pediatric Epilepsy Program; Pediatric Epilepsy Surgery Program; imaging and monitoring of seizures; surgical intervention; vagal nerve stimulator implantation; brain resection; brain and spinal cord tumors; chiari malformations; tethered cord syndromes in patients with anorectal malformations.


Advanced MRI imaging techniques in children with congenital hydrocephalus.

Visit the Mangano Lab.

Francesco Mangano joined the Division of Pediatric Neurosurgery at Cincinnati Children's in July 2005, as an assistant professor of neurosurgery within the UC Department of Neurosurgery.

A graduate of the Philadelphia College of Osteopathic Medicine, Dr. Mangano completed his neurosurgical residency at Long Island Jewish Medical Center in 2004 followed by a fellowship in pediatric neurosurgery at St. Louis Children's Hospital in St. Louis, MO.

Since joining the faculty of the Division of Pediatric Neurosurgery at this Cincinnati Children's Hospital Medical Center, he has been instrumental in developing our nationally renowned Pediatric Epilepsy Program and is director of the Pediatric Epilepsy Surgery Program. This program has already given many children a chance to experience a whole new life with marked reduction in the frequency of their debilitating seizures. After extensive evaluation and state of the art imaging and monitoring of the seizures, surgical intervention in many cases can then be exactly targeted to the source of the seizures. An extensive array of surgical techniques may be offered these patients, which ranges from implantation of a vagal nerve stimulator to resection of one whole side of the brain.

His other clinical interests include tumors of the brain and spinal cord, chiari malformations, and tethered cord symptoms in patients with anorectal malformations.

In addition, he is a co-principal investigator for an NIH-funded multi-institutional research study investigating advanced MRI imaging techniques in children with congenital hydrocephalus. This is only one of his numerous active research projects which have resulted in numerous publications, book chapters and national and international presentations in the field.

Dr. Mangano is a member of the American Society of Pediatric Neurosurgeons and the Congress of Neurological Surgeons. He was board certified in 2008 in neurological surgery by the American Osteopathic Board of Surgery and currently serves as the vice chair of the Residency Evaluation and Standards Committee and the Secretary Treasurer of the Neurological Surgery Discipline of the ACOS.

DO: Philadelphia College of Osteopathic Medicine (PCOM), Philadelphia, PA.

Residency: NYCOM-Long Island, Jewish Medical Center / North Shore University Health System, New Hyde Park, NY.

Fellowship: Washington University School of Medicine-St. Louis Children's Hospital, St. Louis, MO.

Board Certification: Neurological Surgery, American Osteopathic Board of Surgery, 2008.

View PubMed Publications

Yuan W, Holland SK, Shimony JS, Altaye M, Mangano FT, Limbrick DD, Jones BV, Nash T, Rajagopal A, Simpson S, Ragan D, McKinstry RC. Abnormal structural connectivity in the brain networks of children with hydrocephalus. Neuroimage Clin. 2015 Apr 29;8:483-92.

Kosnik-Infinger L, Carroll C, Greiner H, Leach J, Mangano FT. Management of cerebral cavernous malformations in the pediatric population: a literature review and case illustrations. J Neurosurg Sci. 2015 Sep;59(3):283-94.

Miles L, Greiner HM, Mangano FT, Horn PS, Leach JL, Miles MV. Cytochrome c oxidase deficit is associated with the seizure onset zone in young patients with focal cortical dysplasia Type II. Metab Brain Dis. 2015 Oct;30(5):1151-60.

Akbari SH, Limbrick DD Jr, McKinstry RC, Altaye M, Ragan DK, Yuan W, Mangano FT, Holland SK, Shimony JS. Periventricular hyperintensity in children with hydrocephalus. Pediatr Radiol. 2015 Jul;45(8):1189-97.

Ragan DK, Cerqua J, Nash T, McKinstry RC, Shimony JS, Jones BV, Mangano FT, Holland SK, Yuan W, Limbrick DD Jr. The accuracy of linear indices of ventricular volume in pediatric hydrocephalus: technical note. J Neurosurg Pediatr. 2015 Jun;15(6):547-51.

Arya R, Wilson JA, Vannest J, Byars AW, Greiner HM, Buroker J, Fujiwara H, Mangano FT, Holland KD, Horn PS, Crone NE, Rose DF. Electrocorticographic language mapping in children by high-gamma synchronization during spontaneous conversation: comparison with conventional electrical cortical stimulation. Epilepsy Res. 2015 Feb;110:78-87.

Arya R, Greiner HM, Horn PS, Turner M, Holland KD, Mangano FT. Corpus callosotomy for childhood-onset drug-resistant epilepsy unresponsive to vagus nerve stimulation. Pediatr Neurol. 2014 Dec;51(6):800-5.

Arya R, Tenney JR, Horn PS, Greiner HM, Holland KD, Leach JL, Gelfand MJ, Rozhkov L, Fujiwara H, Rose DF, Franz DN, Mangano FT. Long-term outcomes of resective epilepsy surgery after invasive presurgical evaluation in children with tuberous sclerosis complex and bilateral multiple lesions. J Neurosurg Pediatr. 2015 Jan;15(1):26-33.

Leach JL, Miles L, Henkel DM, Greiner HM, Kukreja MK, Holland KD, Rose DF, Zhang B, Mangano FT. Magnetic resonance imaging abnormalities in the resection region correlate with histopathological type, gliosis extent, and postoperative outcome in pediatric cortical dysplasia. J Neurosurg Pediatr. 2014 Jul;14(1):68-80.

Brahimaj B, Greiner HM, Leach JL, Horn PS, Stevenson CB, Miles L, Byars A, Holland K, Sutton M,Mangano FT. The surgical management of pediatric brain tumors causing epilepsy: consideration of the epileptogenic zone. Childs Nerv Syst. 2014 Aug;30(8):1383-91.