A photo of Francesco Mangano.

Francesco T. Mangano, DO, FACS, FAAP, FACOS

  • Mary Jane and Bob Tritsch Chair, Division of Pediatric Neurosurgery
  • Division Chief, Division of Pediatric Neurosurgery 
  • Director of the Pediatric Epilepsy Surgery Program, Division of Pediatric Neurosurgery
  • Professor, UC Department of Neurosurgery
  • Board Certified



Dr. Francesco Mangano is currently the Mary Jane and Bob Tritsch Chair and professor of Neurological Surgery and Pediatrics. He joined the Division of Pediatric Neurosurgery at Cincinnati Children's in July 2005, with an appointment as assistant professor of neurosurgery in the College of Medicine at the University of Cincinnati.

A graduate of the Philadelphia College of Osteopathic Medicine, Dr. Mangano completed his neurosurgical residency at Long Island Jewish Medical Center in 2004 followed by a fellowship in pediatric neurosurgery at St. Louis Children's Hospital in St. Louis, Missouri. Since joining the faculty of the division of pediatric neurosurgery at Cincinnati Children's Hospital Medical Center, he has been instrumental in developing our nationally renowned Pediatric Epilepsy Program and is Director of the Pediatric Epilepsy Surgery Program.

In addition, he has been a co-principal investigator for an NIH-funded multi-institutional research study investigating advanced MRI imaging techniques in children with congenital hydrocephalus. This study established DTI as a non-invasive biomarker for white matter injury in this condition. Additionally, he currently heads a basic science lab primarily focused on studying new models of hydrocephalus in combination to advanced MR imaging.

His academic endeavors have accounted for 111 publications as well as numerous book chapters. He has presented his work nationally and internationally and continues to teach locally as the site PI for pediatric neurosurgery residencies of the University of Cincinnati and the Henry Ford Medical Center.

He is also fellowship director for the Cincinnati Children’s pediatric neurosurgery fellowship program which has graduated 15 fellows and continues to recruit nationally every year. Dr. Mangano is a member of the American Society of Pediatric Neurosurgeons, the AANS/CNS Section of Pediatric Neurosurgery, and the International Society of Pediatric Neurosurgery. He was board certified in 2008 in Neurological Surgery by the American Osteopathic Board of Surgery.

DO: Philadelphia College of Osteopathic Medicine, Philadelphia, PA.

Residency: Neurosurgery, NYCOM-Long Island Jewish Medical Center/North Shore University Hospital Health System, New Hyde Park, NY.

Fellowship: Pediatric Neurosurgery, Washington University School of Medicine-St. Louis Children's Hospital, St. Louis, MO.

Board Certification: Neurological Surgery, American Osteopathic Board of Surgery, 2008.


Pediatric Epilepsy Program; Pediatric Epilepsy Surgery Program; imaging and monitoring of seizures; surgical intervention; vagal nerve stimulator implantation; brain resection; brain and spinal cord tumors; chiari malformations; tethered cord syndromes in patients with anorectal malformations.

Services and Specialties

Colorectal Disorders, Neurosurgery, Epilepsy, Brain Tumor


Advanced MRI imaging techniques in children with congenital hydrocephalus.

Research Areas


Additional Languages


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MRI and pathology comparisons in Rasmussen's encephalitis: a multi-institutional examination of hemispherotomy outcomes relative to imaging and histological severity. Doherty, A; Knudson, K; Fuller, C; Leach, JL; Wang, AC; Marupudi, N; Han, RH; Tomko, S; Ojemann, J; Smyth, MD; Mangano, F; Skoch, J. Child's Nervous System. 2024; 40:1799-1806.

Utilization trends in cerebrospinal fluid shunt infection prevention techniques in the United States from 2007 to 2015. Podkovik, S; Zhou, C; Coffin, SE; Hall, M; Hauptman, JS; Kronman, MP; Mangano, FT; Pollack, IF; Sedano, S; Schaffzin, JK; Thorell, E; Warf, BC; Whitlock, KB; Simon, TD. Journal of Neurosurgery: Pediatrics. 2024; 33:349-358.

Early Identification of Candidates for Epilepsy Surgery: A Multicenter, Machine Learning, Prospective Validation Study. Wissel, BD; Greiner, HM; Glauser, TA; Pestian, JP; Ficker, DM; Cavitt, JL; Estofan, L; Holland-Bouley, KD; Mangano, FT; Szczesniak, RD; Dexheimer, JW; Maurer, M; Cohn, D. Neurology. 2024; 102:e208048.

Added value of corpus callosotomy following vagus nerve stimulation in children with Lennox-Gastaut syndrome: A multicenter, multinational study. Roth, J; Bergman, L; Weil, AG; Brunette-Clement, T; Weiner, HL; Treiber, JM; Shofty, B; Cukiert, A; Cukiert, CM; Tripathi, M; Alsowat, D; Alotaibi, F; Ragheb, J; Uliel-Sibony, S. Epilepsia. 2023; 64:3205-3212.

Early postnatal microglial ablation in the Ccdc39 mouse model reveals adverse effects on brain development and in neonatal hydrocephalus. Brown, FN; Iwasawa, E; Shula, C; Fugate, EM; Lindquist, DM; Mangano, FT; Goto, J. Fluids and Barriers of the CNS. 2023; 20:42.

Utility of the material community deprivation index as a metric to identify at-risk children for severe traumatic brain injury. Gaulden, AL; Trinidad, S; Moody, S; Kotagal, M; Mangano, FT; Patel, SK. Neurosurgical Focus. 2023; 55:E8.

Neuropsychological outcomes after epilepsy surgery: A comparison of stereo electroencephalography and subdural electrodes. Arya, R; Frink, C; Kargol, C; Byars, AW; Huddleston, D; Diedenhofer, DB; Aungaroon, G; Ervin, B; Horn, PS; Ihnen, SK Z; Mangano, FT; Glauser, TA; Greiner, HM; Holland, KD. European Journal of Neurology. 2023; 30:2986-2998.

Associations of Standard Care, Intrathecal Antibiotics, and Antibiotic-Impregnated Catheters With Cerebrospinal Fluid Shunt Infection Organisms and Resistance. Sedano, S; Kronman, MP; Whitlock, KB; Zhou, C; Coffin, SE; Hauptman, JS; Heller, E; Mangano, FT; Pollack, IF; Schaffzin, JK; Thorell, E; Warf, BC; Simon, TD. Journal of the Pediatric Infectious Diseases Society. 2023; 12:504-512.

Preoperative left shoulder elevation > 1 cm is predictive of severe postoperative shoulder imbalance in early onset idiopathic scoliosis patients treated with growth-friendly instrumentation. Li, Y; Yang, D; Bergman, R; Jha, S; Casden, M; Smith, JT; Vitale, M; Heffernan, M; Abdullah, AS A; Ahn, E; Lavelle, W; Lenke, L; Lew, S; Li, Y. Spine Deformity. 2023; 11:1157-1167.

DTI of Opioid-Exposed Fetuses Using ComBat Harmonization: A Bi-Institutional Study. Dudley, JA; Nagaraj, UD; Merhar, S; Mangano, FT; Kline-Fath, BM; Ou, X; Acheson, A; Yuan, W. American Journal of Neuroradiology. 2023; 44:1084-1089.

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