Francesco T. Mangano, DO, FACS, FAAP, FACOS

A photo of Francesco Mangano.

Mary Jane and Bob Tritsch Chair, Division of Pediatric Neurosurgery

Division Chief, Division of Pediatric Neurosurgery 

Director of the Pediatric Epilepsy Surgery Program, Division of Pediatric Neurosurgery

Professor, UC Department of Neurosurgery

513-636-4726

513-636-2808

Board Certified

My Biography & Research

Biography

Dr. Francesco Mangano is currently the Mary Jane and Bob Tritsch Chair and professor of Neurological Surgery and Pediatrics. He joined the Division of Pediatric Neurosurgery at Cincinnati Children's in July 2005, with an appointment as assistant professor of neurosurgery in the College of Medicine at the University of Cincinnati.

A graduate of the Philadelphia College of Osteopathic Medicine, Dr. Mangano completed his neurosurgical residency at Long Island Jewish Medical Center in 2004 followed by a fellowship in pediatric neurosurgery at St. Louis Children's Hospital in St. Louis, Missouri. Since joining the faculty of the division of pediatric neurosurgery at Cincinnati Children's Hospital Medical Center, he has been instrumental in developing our nationally renowned Pediatric Epilepsy Program and is Director of the Pediatric Epilepsy Surgery Program.

In addition, he has been a co-principal investigator for an NIH-funded multi-institutional research study investigating advanced MRI imaging techniques in children with congenital hydrocephalus. This study established DTI as a non-invasive biomarker for white matter injury in this condition. Additionally, he currently heads a basic science lab primarily focused on studying new models of hydrocephalus in combination to advanced MR imaging.

His academic endeavors have accounted for 111 publications as well as numerous book chapters. He has presented his work nationally and internationally and continues to teach locally as the site PI for pediatric neurosurgery residencies of the University of Cincinnati and the Henry Ford Medical Center.

He is also fellowship director for the Cincinnati Children’s pediatric neurosurgery fellowship program which has graduated 15 fellows and continues to recruit nationally every year. Dr. Mangano is a member of the American Society of Pediatric Neurosurgeons, the AANS/CNS Section of Pediatric Neurosurgery, and the International Society of Pediatric Neurosurgery. He was board certified in 2008 in Neurological Surgery by the American Osteopathic Board of Surgery.

Additional Languages

Italian

Clinical Interests

Pediatric Epilepsy Program; Pediatric Epilepsy Surgery Program; imaging and monitoring of seizures; surgical intervention; vagal nerve stimulator implantation; brain resection; brain and spinal cord tumors; chiari malformations; tethered cord syndromes in patients with anorectal malformations.

Research Interests

Advanced MRI imaging techniques in children with congenital hydrocephalus.

Academic Affiliation

Professor, UC Department of Neurosurgery

Clinical Divisions

Colorectal Disorders, Neurosurgery, Epilepsy, Brain Tumor

Research Divisions

Neurosurgery

My Locations

My Education

DO: Philadelphia College of Osteopathic Medicine, Philadelphia, PA.

Residency: Neurosurgery, NYCOM-Long Island Jewish Medical Center/North Shore University Hospital Health System, New Hyde Park, NY.

Fellowship: Pediatric Neurosurgery, Washington University School of Medicine-St. Louis Children's Hospital, St. Louis, MO.

Board Certification: Neurological Surgery, American Osteopathic Board of Surgery, 2008.

My Publications

Factors associated with syrinx size in pediatric patients treated for Chiari malformation type I and syringomyelia: A study from the Park-Reeves Syringomyelia research consortium. Hale, AT; David Adelson, P; Albert, GW; Aldana, PR; Alden, TD; Anderson, RC E; Bauer, DF; Bonfield, CM; Brockmeyer, DL; Chern, JJ; et al. Journal of Neurosurgery: Pediatrics. 2020; 25:629-639.

Neonatal hydrocephalus leads to white matter neuroinflammation and injury in the corpus callosum of Ccdc39 hydrocephalic mice. Goulding, DS; Vogel, RC; Pandya, CD; Shula, C; Gensel, JC; Mangano, FT; Goto, J; Miller, BA. Journal of Neurosurgery: Pediatrics. 2020; 25:476-8.

Treatment Options for Hydrocephalus Following Foramen Magnum Decompression for Chiari I Malformation: A Multicenter Study. Bartoli, A; Soleman, J; Berger, A; Wisoff, JH; Hidalgo, ET; Mangano, FT; Keating, RF; Thomale, UW; Boop, F; Roth, J; et al. Neurosurgery. 2020; 86:500-508.

Abnormal anisotropic diffusion properties in pediatric myelomeningocele patients treated with fetal surgery: an initial DTI study. Mangano, FT; Stevenson, CB; Nagaraj, U; Conley, A; Yuan, W. Child's Nervous System. 2020; 36:827-833.

Functional MRI in Children: Current Clinical Applications. Guerin, JB; Greiner, HM; Mangano, FT; Leach, JL. Seminars in Pediatric Neurology. 2020; 33:100800-100800.

Characterization of a novel rat model of X-linked hydrocephalus by CRISPR-mediated mutation in L1cam. Emmert, AS; Vuong, SM; Shula, C; Lindquist, D; Yuan, W; Hu, Y; Mangano, FT; Goto, J. Journal of Neurosurgery. 2020; 132:945-958.

Complications in Children with Ehlers-Danlos Syndrome Following Spine Surgery: Analysis of the Pediatric National Surgery Quality Improvement Program Database. Matur, AV; Nouri, A; Huang, S; Elson, NC; Jeong, W; Bierbrauer, KS; Mangano, FT; Cheng, JS. World Neurosurgery. 2020; 133:e473-e478.

Prospective validation of a machine learning model that uses provider notes to identify candidates for resective epilepsy surgery. Wissel, BD; Greiner, HM; Glauser, TA; Holland-Bouley, KD; Mangano, FT; Santel, D; Faist, R; Zhang, N; Pestian, JP; Szczesniak, RD; et al. Epilepsia. 2020; 61:39-48.

Kurtosis and skewness of high-frequency brain signals are altered in paediatric epilepsy. Xiang, J; Maue, E; Fan, Y; Qi, L; Mangano, FT; Greiner, H; Tenney, J. 2020; 2.

Impaired neural differentiation and glymphatic CSF flow in the Ccdc39 rat model of neonatal hydrocephalus: Genetic interaction with L1cam. Emmert, AS; Iwasawa, E; Shula, C; Schultz, P; Lindquist, D; Dunn, RS; Fugate, EM; Hu, Y; Mangano, FT; Goto, J. DMM Disease Models and Mechanisms. 2019; 12:dmm040972-dmm040972.