A photo of Francesco Mangano.

Mary Jane and Bob Tritsch Chair, Division of Pediatric Neurosurgery

Division Chief, Division of Pediatric Neurosurgery 

Director of the Pediatric Epilepsy Surgery Program, Division of Pediatric Neurosurgery

Professor, UC Department of Neurosurgery



My Biography & Research


Dr. Francesco Mangano is currently the Mary Jane and Bob Tritsch Chair and professor of Neurological Surgery and Pediatrics. He joined the Division of Pediatric Neurosurgery at Cincinnati Children's in July 2005, with an appointment as assistant professor of neurosurgery in the College of Medicine at the University of Cincinnati.

A graduate of the Philadelphia College of Osteopathic Medicine, Dr. Mangano completed his neurosurgical residency at Long Island Jewish Medical Center in 2004 followed by a fellowship in pediatric neurosurgery at St. Louis Children's Hospital in St. Louis, Missouri. Since joining the faculty of the division of pediatric neurosurgery at Cincinnati Children's Hospital Medical Center, he has been instrumental in developing our nationally renowned Pediatric Epilepsy Program and is Director of the Pediatric Epilepsy Surgery Program.

In addition, he has been a co-principal investigator for an NIH-funded multi-institutional research study investigating advanced MRI imaging techniques in children with congenital hydrocephalus. This study established DTI as a non-invasive biomarker for white matter injury in this condition. Additionally, he currently heads a basic science lab primarily focused on studying new models of hydrocephalus in combination to advanced MR imaging.

His academic endeavors have accounted for 111 publications as well as numerous book chapters. He has presented his work nationally and internationally and continues to teach locally as the site PI for pediatric neurosurgery residencies of the University of Cincinnati and the Henry Ford Medical Center.

He is also fellowship director for the Cincinnati Children’s pediatric neurosurgery fellowship program which has graduated 15 fellows and continues to recruit nationally every year. Dr. Mangano is a member of the American Society of Pediatric Neurosurgeons, the AANS/CNS Section of Pediatric Neurosurgery, and the International Society of Pediatric Neurosurgery. He was board certified in 2008 in Neurological Surgery by the American Osteopathic Board of Surgery.

Additional Languages


Clinical Interests

Pediatric Epilepsy Program; Pediatric Epilepsy Surgery Program; imaging and monitoring of seizures; surgical intervention; vagal nerve stimulator implantation; brain resection; brain and spinal cord tumors; chiari malformations; tethered cord syndromes in patients with anorectal malformations.

Research Interests

Advanced MRI imaging techniques in children with congenital hydrocephalus.

Academic Affiliation

Professor, UC Department of Neurosurgery


Colorectal Disorders, Neurosurgery, Epilepsy, Brain Tumor, Neurosurgery

My Locations

My Education

DO: Philadelphia College of Osteopathic Medicine, Philadelphia, PA.

Residency: Neurosurgery, NYCOM-Long Island Jewish Medical Center/North Shore University Hospital Health System, New Hyde Park, NY.

Fellowship: Pediatric Neurosurgery, Washington University School of Medicine-St. Louis Children's Hospital, St. Louis, MO.

Board Certification: Neurological Surgery, American Osteopathic Board of Surgery, 2008.

My Publications

Yuan W, Holland SK, Shimony JS, Altaye M, Mangano FT, Limbrick DD, Jones BV, Nash T, Rajagopal A, Simpson S, Ragan D, McKinstry RC. Abnormal structural connectivity in the brain networks of children with hydrocephalus. Neuroimage Clin. 2015 Apr 29;8:483-92.

Kosnik-Infinger L, Carroll C, Greiner H, Leach J, Mangano FT. Management of cerebral cavernous malformations in the pediatric population: a literature review and case illustrations. J Neurosurg Sci. 2015 Sep;59(3):283-94.

Miles L, Greiner HM, Mangano FT, Horn PS, Leach JL, Miles MV. Cytochrome c oxidase deficit is associated with the seizure onset zone in young patients with focal cortical dysplasia Type II. Metab Brain Dis. 2015 Oct;30(5):1151-60.

Akbari SH, Limbrick DD Jr, McKinstry RC, Altaye M, Ragan DK, Yuan W, Mangano FT, Holland SK, Shimony JS. Periventricular hyperintensity in children with hydrocephalus. Pediatr Radiol. 2015 Jul;45(8):1189-97.

Ragan DK, Cerqua J, Nash T, McKinstry RC, Shimony JS, Jones BV, Mangano FT, Holland SK, Yuan W, Limbrick DD Jr. The accuracy of linear indices of ventricular volume in pediatric hydrocephalus: technical note. J Neurosurg Pediatr. 2015 Jun;15(6):547-51.

Arya R, Wilson JA, Vannest J, Byars AW, Greiner HM, Buroker J, Fujiwara H, Mangano FT, Holland KD, Horn PS, Crone NE, Rose DF. Electrocorticographic language mapping in children by high-gamma synchronization during spontaneous conversation: comparison with conventional electrical cortical stimulation. Epilepsy Res. 2015 Feb;110:78-87.

Arya R, Greiner HM, Horn PS, Turner M, Holland KD, Mangano FT. Corpus callosotomy for childhood-onset drug-resistant epilepsy unresponsive to vagus nerve stimulation. Pediatr Neurol. 2014 Dec;51(6):800-5.

Arya R, Tenney JR, Horn PS, Greiner HM, Holland KD, Leach JL, Gelfand MJ, Rozhkov L, Fujiwara H, Rose DF, Franz DN, Mangano FT. Long-term outcomes of resective epilepsy surgery after invasive presurgical evaluation in children with tuberous sclerosis complex and bilateral multiple lesions. J Neurosurg Pediatr. 2015 Jan;15(1):26-33.

Leach JL, Miles L, Henkel DM, Greiner HM, Kukreja MK, Holland KD, Rose DF, Zhang B, Mangano FT. Magnetic resonance imaging abnormalities in the resection region correlate with histopathological type, gliosis extent, and postoperative outcome in pediatric cortical dysplasia. J Neurosurg Pediatr. 2014 Jul;14(1):68-80.

Brahimaj B, Greiner HM, Leach JL, Horn PS, Stevenson CB, Miles L, Byars A, Holland K, Sutton M,Mangano FT. The surgical management of pediatric brain tumors causing epilepsy: consideration of the epileptogenic zone. Childs Nerv Syst. 2014 Aug;30(8):1383-91.