A photo of Mark Mitsnefes.

Director, Clinical and Translational Research Center

Pediatric Nephrologist, Division of Nephrology

Professor, UC Department of Pediatrics



Board Certified

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My Biography & Research


As a pediatric nephrologist, I specialize in treating hypertension and chronic kidney disease (CKD) with a focus on cardiovascular risk factors. I believe that every patient is unique and requires an individualized approach, and every member of our team is dedicated to providing the best possible care.

In my practice, we use a team approach that includes an excellent group of nurses, dietitians, medical assistants, CKD nurse managers, social workers and pharmacists who have worked together for many years. We understand how important it is to get input from the family, and we emphasize family involvement in each child’s care.

We are one of very few practices in the U.S. that includes a team of both cardiologists and nephrologists taking care of patients with hypertension. Our chronic kidney disease program is one of the largest in the country providing complex care.

In addition to caring for patients, I’m involved in research. One of my major goals is to reduce the frequency of cardiovascular risk in children with CKD. Cardiovascular disease is one of their major complications, and many children with advanced CKD develop hypertension, high cholesterol levels, heart abnormalities and stiff arteries.

Since 2003, I have been involved in the Chronic Kidney Disease in Children (CKiD) study, which is a large, multicenter study of children with CKD. More than 1,000 children have been participating in this study from more than 50 centers in the U.S. and Canada. I lead the cardiovascular arm of this large study, with the main goals of identifying cardiovascular risk factors and finding the best approach to prevent the development of cardiovascular disease and reduce its frequency.

I’m honored to have received numerous awards, including the Procter Scholar Award from the Cincinnati Children’s Research Foundation, the Pediatrician Scientist Award from the Children’s Health Research Center at the National Institutes of Health (NIH), and the Clinical Scientist Award from the National Kidney Foundation. I’ve also received multiple grants from the NIH, the American Heart Association and the National Kidney Foundation. I’ve been invited to speak about my research and the clinical aspects of hypertension at centers around the world. I have also been on the list of Cincinnati Magazine’s list of Best Doctors since 2007.

In my free time, I enjoy traveling, reading and spending time with my family.

Additional Languages


Clinical Interests

Chronic renal disease, dialysis, renal transplantation, hypertension

Research Interests

Cardiovascular complications of chronic renal disease, clinical trials in hypertension

Academic Affiliation

Professor, UC Department of Pediatrics


Nephrology and Hypertension, Kidney Disease, End-Stage Renal Disease, Nephrology and Hypertension

My Locations

My Education

MD: Gorky Medical Institute, Gorky, Russia, 1985.

Residency: Miami Children's Hospital, Miami, FL, 1997.

Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2000.

MS: Epidemiology and Biostatistics, University of Cincinnati, Cincinnati, OH, 2001.

Certifications: Educational Commission for Foreign Medical Graduates (ECFMG), 1995; Pediatrics, 1996; Pediatric Nephrology, 2001, 2008.

My Publications

Effect of surgical versus medical therapy on diabetic kidney disease over 5 years in severely obese adolescents with type 2 diabetes. Bjornstad, P; Hughan, K; Kelsey, MM; Shah, AS; Lynch, J; Nehus, E; Mitsnefes, M; Jenkins, T; Xu, P; Xie, C; et al. Diabetes Care. 2020; 43:187-195.

Change in dyslipidemia with declining glomerular filtration rate and increasing proteinuria in children with ckd. Saland, JM; Kupferman, JC; Pierce, CB; Flynn, JT; Mitsnefes, MM; Warady, BA; Furth, SL. Clinical journal of the American Society of Nephrology : CJASN. 2019; 14:1711-1718.

Hypertensive crisis in children and adolescents. Seeman, T; Hamdani, G; Mitsnefes, M. Pediatric Nephrology. 2019; 34:2523-2537.

Using electronic health record data to rapidly identify children with glomerular disease for clinical research. Denburg, MR; Razzaghi, H; Bailey, LC; Soranno, DE; Pollack, AH; Dharnidharka, VR; Mitsnefes, MM; Smoyer, WE; Somers, MJ G; Zaritsky, JJ; et al. Journal of the American Society of Nephrology : JASN. 2019; 30:2427-2435.

Association between BMI changes and mortality risk in children with end-stage renal disease. Roberts, MJ; Mitsnefes, MM; McCulloch, CE; Greenbaum, LA; Grimes, BA; Ku, E. Pediatric Nephrology. 2019; 34:1557-1563.

Association of Blood Pressure Level With Left Ventricular Mass in Adolescents SHIP AHOY. Urbina, EM; Mendizabal, B; Becker, RC; Daniels, SR; Falkner, BE; Hamdani, G; Hanevold, C; Hooper, SR; Ingelfinger, JR; Lanade, M; et al. Hypertension. 2019; 74:590-596.

Cardiovascular disease in young adults with incident ESRD. Ku, E; Mitsnefes, MM. Nature Reviews Nephrology. 2019; 15:390-391.

When to Initiate Dialysis in Children and Adolescents: Is Waiting Worthwhile?. Nehus, E; Mitsnefes, MM. American Journal of Kidney Diseases. 2019; 73:762-764.

Cardiovascular Risk Reduction in High-Risk Pediatric Patients A Scientific Statement From the American Heart Association. de Ferranti, SD; Steinberger, J; Ameduri, R; Baker, A; Gooding, H; Kelly, AS; Mietus-Snyder, M; Mitsnefes, MM; Peterson, AL; St-Pierre, J; et al. Circulation. 2019; 139:E603-E634.

Ambulatory blood pressure monitoring tolerability and blood pressure status in adolescents: the SHIP AHOY study. Hamdani, G; Flynn, JT; Daniels, S; Falkner, B; Hanevold, C; Ingelfinger, J; Lande, MB; Martin, LJ; Meyers, KE; Mitsnefes, M; et al. Blood Pressure Monitoring. 2019; 24:12-17.