A photo of Mark Mitsnefes.

Director, Clinical and Translational Research Center

Pediatric Nephrologist, Division of Nephrology

Professor, UC Department of Pediatrics



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"I believe that every patient is unique and requires an individualized approach, and every member of our team is dedicated to providing the best possible care."

My Biography & Research


As a pediatric nephrologist, I specialize in treating hypertension and chronic kidney disease (CKD) with a focus on cardiovascular risk factors. I believe that every patient is unique and requires an individualized approach, and every member of our team is dedicated to providing the best possible care.

In my practice, we use a team approach that includes an excellent group of nurses, dietitians, medical assistants, CKD nurse managers, social workers and pharmacists who have worked together for many years. We understand how important it is to get input from the family, and we emphasize family involvement in each child’s care.

We are one of very few practices in the U.S. that includes a team of both cardiologists and nephrologists taking care of patients with hypertension. Our chronic kidney disease program is one of the largest in the country providing complex care.

In addition to caring for patients, I’m involved in research. One of my major goals is to reduce the frequency of cardiovascular risk in children with CKD. Cardiovascular disease is one of their major complications, and many children with advanced CKD develop hypertension, high cholesterol levels, heart abnormalities and stiff arteries.

Since 2003, I have been involved in the Chronic Kidney Disease in Children (CKiD) study, which is a large, multicenter study of children with CKD. More than 1,000 children have been participating in this study from more than 50 centers in the U.S. and Canada. I lead the cardiovascular arm of this large study, with the main goals of identifying cardiovascular risk factors and finding the best approach to prevent the development of cardiovascular disease and reduce its frequency.

I’m honored to have received numerous awards, including the Procter Scholar Award from the Cincinnati Children’s Research Foundation, the Pediatrician Scientist Award from the Children’s Health Research Center at the National Institutes of Health (NIH), and the Clinical Scientist Award from the National Kidney Foundation. I’ve also received multiple grants from the NIH, the American Heart Association and the National Kidney Foundation. I’ve been invited to speak about my research and the clinical aspects of hypertension at centers around the world. I have also been on the list of Cincinnati Magazine’s list of Best Doctors since 2007.

In my free time, I enjoy traveling, reading and spending time with my family.

Additional Languages


Clinical Interests

Chronic renal disease, dialysis, renal transplantation, hypertension

Research Interests

Cardiovascular complications of chronic renal disease, clinical trials in hypertension

Academic Affiliation

Professor, UC Department of Pediatrics

Clinical Divisions

Nephrology and Hypertension, Kidney Disease, End-Stage Renal Disease

Research Divisions

Nephrology and Hypertension

My Locations

My Education

MD: Gorky Medical Institute, Gorky, Russia, 1985.

Residency: Miami Children's Hospital, Miami, FL, 1997.

Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2000.

MS: Epidemiology and Biostatistics, University of Cincinnati, Cincinnati, OH, 2001.

Certifications: Educational Commission for Foreign Medical Graduates (ECFMG), 1995; Pediatrics, 1996; Pediatric Nephrology, 2001, 2008.

My Publications

Discordances between pediatric and adult thresholds in the diagnosis of hypertension in adolescents with CKD. Black, E; Lee, J; Flynn, JT; McCulloch, CE; Samuels, JA; Seth, D; Warady, B; Furth, S; Mitsnefes, M; Ku, E. Pediatric Nephrology. 2021.

Team Science: American Heart Association's Hypertension Strategically Focused Research Network Experience. Santillan, MK; Becker, RC; Calhoun, DA; Cowley, AW; Flynn, JT; Grobe, JL; Kotchen, TA; Lackland, DT; Leslie, KK; Liang, M; et al. Hypertension. 2021; 77:1857-1866.

Factors associated with the absence of pharmacological treatment for common modifiable complications in children with chronic kidney disease. Xu, Y; Ng, DK; Furth, SL; Warady, BA; Mitsnefes, MM. Pediatric Nephrology. 2021.

The Cardiovascular Status of Pediatric Dialysis Patients. Shroff, R; Mitsnefes, MM. Pediatric Dialysis. 2021.

Recovery of kidney function after dialysis initiation in children and adults in the US: A retrospective study of United States Renal Data System data. Ku, E; Hsu, RK; Johansen, KL; McCulloch, CE; Mitsnefes, M; Grimes, BA; Liu, KD. PLoS Medicine. 2021; 18.

Dietary Approaches to Stop Hypertension Dietary Intervention Improves Blood Pressure and Vascular Health in Youth With Elevated Blood Pressure. Couch, SC; Saelens, BE; Khoury, PR; Dart, KB; Hinn, K; Mitsnefes, MM; Daniels, SR; Urbina, EM. Hypertension. 2021; 77:241-251.

Response to letter to the editor. Madueme, P; Mitsnefes, M. Pediatric Nephrology. 2020; 35:2013-2014.

Trends in Cardiovascular Mortality Among a Cohort of Children and Young Adults Starting Dialysis in 1995 to 2015. Ku, E; McCulloch, CE; Ahearn, P; Grimes, BA; Mitsnefes, MM. JAMA Network Open. 2020; 3.

Adiposity, Sex, and Cardiovascular Disease Risk in Children With CKD: A Longitudinal Study of Youth Enrolled in the Chronic Kidney Disease in Children (CKiD) Study. Brady, TM; Roem, J; Cox, C; Schneider, MF; Wilson, AC; Furth, SL; Warady, BA; Mitsnefes, M. American Journal of Kidney Diseases. 2020; 76:166-173.

Aortic dilatation in children with mild to moderate chronic kidney disease. Madueme, PC; Ng, DK; Guju, L; Longshore, L; Moore, V; Jefferies, L; Warady, BA; Furth, S; Mitsnefes, M. Pediatric Nephrology. 2020; 35:1023-1031.