Mark M. Mitsnefes, MD, MS
- Interim Director, Division of Nephrology and Hypertension
- Director, Clinical and Translational Research Center
- Professor, UC Department of Pediatrics
- mark.mitsnefes@cchmc.org
- Board Certified
About
Biography
As a pediatric nephrologist, I specialize in treating hypertension and chronic kidney disease (CKD) with a focus on cardiovascular risk factors. I believe that every patient is unique and requires an individualized approach, and every member of our team is dedicated to providing the best possible care.
In my practice, we use a team approach that includes an excellent group of nurses, dietitians, medical assistants, CKD nurse managers, social workers and pharmacists who have worked together for many years. We understand how important it is to get input from the family, and we emphasize family involvement in each child’s care.
We are one of very few practices in the U.S. that includes a team of both cardiologists and nephrologists taking care of patients with hypertension. Our chronic kidney disease program is one of the largest in the country providing complex care.
In addition to caring for patients, I’m involved in research. One of my major goals is to reduce the frequency of cardiovascular risk in children with CKD. Cardiovascular disease is one of their major complications, and many children with advanced CKD develop hypertension, high cholesterol levels, heart abnormalities and stiff arteries.
Since 2003, I have been involved in the Chronic Kidney Disease in Children (CKiD) study, which is a large, multicenter study of children with CKD. More than 1,000 children have been participating in this study from more than 50 centers in the U.S. and Canada. I lead the cardiovascular arm of this large study, with the main goals of identifying cardiovascular risk factors and finding the best approach to prevent the development of cardiovascular disease and reduce its frequency.
I’m honored to have received numerous awards, including the Procter Scholar Award from the Cincinnati Children’s Research Foundation, the Pediatrician Scientist Award from the Children’s Health Research Center at the National Institutes of Health (NIH), and the Clinical Scientist Award from the National Kidney Foundation. I’ve also received multiple grants from the NIH, the American Heart Association and the National Kidney Foundation. I’ve been invited to speak about my research and the clinical aspects of hypertension at centers around the world. I have also been on the list of Cincinnati Magazine’s list of Best Doctors since 2007.
In my free time, I enjoy traveling, reading and spending time with my family.
MD: Gorky Medical Institute, Gorky, Russia, 1985.
Residency: Miami Children's Hospital, Miami, FL, 1997.
Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2000.
MS: Epidemiology and Biostatistics, University of Cincinnati, Cincinnati, OH, 2001.
Certifications: Educational Commission for Foreign Medical Graduates (ECFMG), 1995; Pediatrics, 1996; Pediatric Nephrology, 2001, 2008.
Interests
Chronic renal disease, dialysis, renal transplantation, hypertension
Services and Specialties
Interests
Cardiovascular complications of chronic renal disease, clinical trials in hypertension
Research Areas
Additional Languages
RussianLocations (3)
Insurance Information
Cincinnati Children's strives to accept a wide variety of health plans. Please contact your health insurance carrier to verify coverage for your specific benefit plan.
Publications
A Multiomics Approach to Defining Target-Organ Injury in Youths With Primary Hypertension: The SHIP AHOY Cohort. Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease. 2025; 14:e037649.
Metabolic syndrome-associated kidney disease in young adolescents and children. Kidney International. 2025; 108:791-798.
Sex Differences in Coronary Revascularization Strategies and Outcomes in Patients Undergoing Dialysis. Clinical journal of the American Society of Nephrology : CJASN. 2025; 20:1427-1438.
Accelerated GFR Decline at Time of Transition to Adult Care Is Preceded by Increases in Proteinuria and Risk of Hypertension in Pediatric CKD. Journal of the American Society of Nephrology : JASN. 2025; 36:10.1681/asn.20257xw11pgj.
Social Drivers of Health and Pediatric Kidney Transplant Allograft Outcomes: A PEDSnet Study. Journal of the American Society of Nephrology : JASN. 2025; 36:10.1681/asn.2025nj9r3rvk.
Utilization of anti-CD20 antibodies for treatment of childhood nephrotic syndrome, 2010 to 2022. Pediatric Nephrology. 2025; 40:3121-3127.
Left Ventricular Remodeling by Cardiac Magnetic Resonance in Children with Advanced CKD: Analysis of the CKD in Children (CKiD) Study. Journal of the American Society of Nephrology : JASN. 2025; 36:10.1681/asn.2025peh9njm2.
Left Atrial Strain in the CKD in Children (CKiD) Study. Journal of the American Society of Nephrology : JASN. 2025; 36:10.1681/asn.2025qkp8p220.
Home vs. Clinic Blood Pressures as Predictors of CKD Progression in the CKiD Study. Journal of the American Society of Nephrology : JASN. 2025; 36:10.1681/asn.2025h9v99kad.
CKD Progression in Children with Treated Controlled Hypertension Compared with CKD Progression in Normotensive Peers. Journal of the American Society of Nephrology : JASN. 2025; 36:10.1681/asn.2025tfysepwj.
3333 Burnet Avenue, Cincinnati, Ohio 45229-3026
© 1999-2025 Cincinnati Children's Hospital Medical Center. All rights reserved.
Patient Ratings and Comments
All patient satisfaction ratings and comments are submitted by actual patients and verified by a leading independent experience management company, Qualtrics. Patient identities are withheld to ensure confidentiality and privacy. Only those providers whose satisfaction surveys are administered through Cincinnati Children’s Hospital Medical Center are displayed. Click here to learn more about our survey