Anne Karina T. Perl, MS, PhD

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-636-6084

Fax 513-636-7868

Email anne.perl@cchmc.org

Clinical

Lung development and lung regeneration

PhD: University of Vienna, Austria, 1998.

View PubMed Publications

Green J, Endale M, Auer H, Perl AKT. Diversity of Interstitial Lung Fibroblasts is Regulated by PDGFRα Kinase Activity. Am J Respir Cell Mol Biol. 2016
April;54(4):5532-545.

Lange AW, Sridharan A, Xu Y, Stripp BR, Perl AK, Whitsett JA. Hippo/Yap signaling controls epithelial progenitor cell proliferation and differentiation in the embryonic and adult lung. J Mol Cell Biol. 2015 Feb;7(1):35-47.

Hardie WD, Hagood JS, Dave V, Perl AK, Whitsett JA, Korfhagen TR, Glasser S. Signaling pathways in the epithelial origins of pulmonary fibrosis. Cell Cycle. 2010 Jul 15;9(14):2769-76.

Chen L, Acciani T, Le Cras T, Lutzko C, Perl AK. Dynamic regulation of PDGFRa expression in alveolar fibroblasts during realveolarization. Am J Respir Cell Mol Biol. 2012 Oct;47(4):517-27.

Rawlins E, Perl AK (corresponding author). The a”MAZE”ing world of lung specific transgenic mice. Am J Respir Cell Mol Biol. 2012 Mar;46(3):269-82.

Perl AK (corresponding author), Riethmacher D, Whitsett JA. Conditional Depletion of Airway Progenitor Cells Induces Peribronchiolar Fibrosis. Am J Respir and Critical Care Medicine. 2011 Feb 15;183(4):511-21.

Perl AK, Zhang L, Whitsett JA. Conditional expression of genes in the respiratory epithelium in transgenic mice: cautionary notes and toward building a better mouse trap. Am J Respir Cell Mol Biol. 2009 Jan;40(1):1-3.

Whitsett JA, Perl AK. Conditional control of gene expression in the respiratory epithelium: A cautionary note. Am J Respir Cell Mol Biol. 2006 May;34(5):519-20.

Perl AK (corresponding author), Wert SE, Loudy DE, Shan Z, Blair PA, Whitsett JA. Conditional Recombination Reveals Distinct Subsets of Epithelial Cells in Trachea, Bronchi, Alveoli. Am J Respir Cell Mol Biol. 2005 Nov;33(5):455-62.

Perl AK, Wert SE, Nagy A, Lobe CG, Whitsett JA. Early restriction of peripheral and proximal cell lineages during formation of the lung. PNAS U S A. 2002 Aug 6;99(16):10482-7.

Interstitial resident fibroblasts direct alveolar epithelial differentiation. Principal Investigator. National Institutes of Health. Jan 2017-Aug 2021. R01 HL 131661-01A1.

LungMAP. Investigator. National Institutes of Health. Jun 2014–Apr 2019. U01 HL 122642.

Editing alveolar progenitor cells for correction of monogenic disease. Investigator. National Institutes of Health. Sept 2016-Sept 2023. U01 HL 134745.